GREMLIN Database
O52012 - Uncharacterized protein
UniProt: O52012 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 114 (100)
Sequences: 542 (409)
Seq/√Len: 40.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
37_E41_I5.2511.00
87_A91_T4.2881.00
14_R42_E3.4991.00
17_R20_L3.1621.00
15_R66_H2.7801.00
45_L54_E2.7381.00
21_S29_V2.6091.00
51_G54_E2.5901.00
59_Y64_Q2.5181.00
17_R41_I2.4931.00
12_N64_Q2.2811.00
18_V34_L2.1430.99
43_N54_E2.1310.99
9_A58_T1.9640.99
50_V63_I1.8000.98
56_A64_Q1.5530.95
84_T87_A1.4490.93
55_R58_T1.4420.93
64_Q71_D1.4340.92
77_D86_T1.4120.92
98_I101_L1.4080.92
36_V50_V1.2940.88
88_T91_T1.2620.86
35_A58_T1.2610.86
32_G56_A1.2560.86
13_S93_P1.2050.84
71_D77_D1.1990.83
58_T67_L1.1440.80
39_A42_E1.1440.80
20_L24_R1.1420.80
40_A45_L1.1100.78
8_D11_S1.1030.78
23_S95_A1.0690.76
17_R38_I1.0440.74
20_L41_I1.0440.74
96_E100_R1.0420.74
4_A76_V1.0270.73
43_N59_Y1.0220.72
36_V55_R1.0150.72
16_R39_A1.0150.72
9_A75_A1.0090.71
17_R60_I0.9930.70
8_D69_T0.9800.69
19_V37_E0.9710.68
39_A64_Q0.9610.68
11_S61_S0.9520.67
89_D99_R0.9500.67
8_D70_L0.9420.66
70_L78_Y0.9120.63
77_D88_T0.9030.63
30_P38_I0.8950.62
81_R84_T0.8890.61
35_A73_V0.8890.61
32_G82_S0.8880.61
34_L80_D0.8780.60
19_V80_D0.8700.60
22_L30_P0.8670.59
80_D83_K0.8550.58
35_A52_N0.8440.57
38_I58_T0.8410.57
35_A80_D0.8310.56
74_S99_R0.8290.56
27_G84_T0.8270.56
3_P64_Q0.8260.56
60_I63_I0.8230.55
8_D58_T0.8210.55
31_V78_Y0.8150.55
30_P35_A0.8130.55
40_A50_V0.8110.54
29_V87_A0.8030.54
5_A99_R0.8020.54
36_V47_P0.8020.54
61_S65_R0.7980.53
50_V54_E0.7910.53
14_R58_T0.7850.52
28_D77_D0.7820.52
32_G64_Q0.7800.52
21_S37_E0.7780.51
71_D76_V0.7770.51
62_L67_L0.7700.51
46_D58_T0.7690.50
22_L68_D0.7620.50
30_P48_S0.7600.50
3_P76_V0.7590.50
87_A90_A0.7560.49
44_E50_V0.7490.49
52_N60_I0.7430.48
19_V91_T0.7420.48
11_S52_N0.7310.47
31_V74_S0.7170.46
56_A60_I0.7140.45
13_S17_R0.7090.45
74_S102_Q0.7060.45
25_S77_D0.6940.44
38_I45_L0.6910.43
3_P68_D0.6810.42
54_E57_S0.6780.42
12_N17_R0.6760.42
21_S69_T0.6750.42
63_I101_L0.6720.42
30_P92_E0.6710.41
12_N57_S0.6670.41
57_S64_Q0.6460.39
54_E59_Y0.6430.39
57_S98_I0.6430.39
33_D47_P0.6410.39
60_I92_E0.6390.39
96_E101_L0.6360.38
63_I69_T0.6290.38
67_L97_Y0.6270.38
90_A93_P0.6210.37
65_R81_R0.6210.37
4_A47_P0.6180.37
65_R71_D0.6180.37
34_L61_S0.6170.37
51_G58_T0.6130.36
22_L62_L0.6110.36
90_A100_R0.6040.36
30_P86_T0.6020.35
33_D48_S0.6020.35
53_N72_G0.6020.35
32_G53_N0.5970.35
20_L26_S0.5970.35
35_A77_D0.5960.35
24_R30_P0.5760.33
56_A59_Y0.5750.33
26_S44_E0.5720.33
45_L69_T0.5610.32
52_N83_K0.5600.32
9_A86_T0.5600.32
64_Q68_D0.5590.32
31_V67_L0.5540.31
23_S33_D0.5510.31
11_S20_L0.5490.31
75_A94_L0.5470.31
35_A98_I0.5370.30
33_D84_T0.5360.30
29_V38_I0.5290.30
56_A77_D0.5280.29
35_A102_Q0.5270.29
4_A77_D0.5250.29
33_D93_P0.5220.29
24_R37_E0.5200.29
65_R69_T0.5190.29
9_A73_V0.5160.29
70_L77_D0.5160.29
49_K73_V0.5120.28
61_S70_L0.5060.28
18_V98_I0.5040.28
19_V23_S0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4k2eA 2 0.7368 96.6 0.802 Contact Map
1q1hA 1 0.6754 96.6 0.802 Contact Map
3pqkA 2 0.807 96.6 0.802 Contact Map
1r1tA 2 0.7719 96.6 0.802 Contact Map
2jscA 2 0.8158 96.5 0.804 Contact Map
3cuoA 2 0.7632 96.4 0.805 Contact Map
2kkoA 2 0.8246 96.4 0.806 Contact Map
2zkzA 2 0.7368 96.1 0.811 Contact Map
1r1uA 2 0.7895 96.1 0.811 Contact Map
1u2wA 2 0.7895 96.1 0.811 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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