GREMLIN Database
O52010 - Uncharacterized protein
UniProt: O52010 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 442 (378)
Sequences: 663 (578)
Seq/√Len: 29.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
285_A303_F7.5451.00
363_C366_C5.3631.00
349_C366_C4.8831.00
349_C363_C4.6181.00
179_P278_R4.1901.00
295_N298_D3.5671.00
289_A316_I3.3271.00
77_T110_A3.0681.00
211_R304_G2.9951.00
262_F280_F2.9411.00
188_W226_K2.8931.00
130_K133_H2.8441.00
289_A299_L2.8431.00
182_E211_R2.7291.00
376_E416_L2.6861.00
316_I322_E2.6801.00
171_V222_L2.6091.00
290_S322_E2.5981.00
172_Q277_P2.5610.99
176_G303_F2.5580.99
284_R302_H2.5200.99
200_L203_P2.4530.99
300_E308_G2.4340.99
347_V357_P2.2710.99
128_A132_S2.2510.99
225_W229_H2.2390.99
305_W312_A2.2150.98
357_P363_C2.1930.98
155_I173_W2.0950.98
167_A221_Y2.0420.97
147_R150_D2.0340.97
282_R317_S2.0180.97
324_G328_A2.0120.97
369_P372_A1.9950.97
90_S99_K1.9620.97
178_R281_R1.9510.96
176_G285_A1.9210.96
78_G81_A1.9130.96
286_S304_G1.9090.96
146_L275_C1.9050.96
59_A85_I1.8930.96
411_K415_V1.8820.96
398_D401_V1.8750.96
214_Y302_H1.8680.95
85_I89_V1.8680.95
262_F266_R1.8570.95
410_K414_P1.8010.94
120_D125_R1.7890.94
188_W243_V1.7690.94
407_R413_E1.7570.94
278_R282_R1.7540.94
79_A83_D1.7400.93
285_A290_S1.6970.92
131_T135_T1.6830.92
390_R406_L1.6800.92
307_R311_A1.6700.92
130_K136_N1.6670.92
406_L413_E1.6630.92
289_A319_F1.6330.91
178_R207_K1.6230.91
121_D124_E1.6010.90
285_A302_H1.5650.89
27_R31_Q1.5600.89
408_A412_L1.5580.89
119_A122_L1.5570.89
82_V86_T1.5510.89
65_G68_R1.5490.88
151_V155_I1.5430.88
126_F130_K1.5400.88
50_S54_T1.5350.88
182_E304_G1.5340.88
225_W230_P1.5230.88
126_F132_S1.5180.87
294_I298_D1.5180.87
131_T134_A1.5080.87
276_N279_N1.4960.87
387_D413_E1.4870.86
155_I158_R1.4470.85
110_A113_M1.4400.84
396_V403_A1.4360.84
73_L222_L1.4340.84
394_E406_L1.4250.84
113_M121_D1.4180.84
121_D125_R1.3800.82
77_T285_A1.3780.82
311_A314_H1.3760.82
349_C357_P1.3720.81
302_H324_G1.3690.81
57_R261_P1.3680.81
48_G52_H1.3640.81
281_R315_Y1.3620.81
207_K281_R1.3620.81
347_V366_C1.3600.81
401_V405_D1.3500.80
413_E416_L1.3490.80
51_R101_S1.3450.80
379_T415_V1.3290.79
128_A133_H1.3230.79
391_N394_E1.3230.79
191_V274_P1.3120.78
405_D408_A1.3110.78
32_T113_M1.3010.78
376_E387_D1.2940.77
386_I389_D1.2930.77
282_R311_A1.2840.77
176_G288_L1.2820.77
376_E379_T1.2790.77
34_D109_F1.2790.77
164_R167_A1.2780.77
176_G278_R1.2740.76
357_P366_C1.2710.76
62_I107_R1.2660.76
126_F136_N1.2630.76
286_S293_E1.2530.75
222_L243_V1.2350.74
263_Y270_D1.2320.74
279_N284_R1.2270.73
243_V363_C1.2240.73
174_S216_Y1.2150.73
361_K371_E1.2140.73
383_V416_L1.2080.72
412_L415_V1.1960.72
146_L150_D1.1840.71
347_V363_C1.1830.71
55_V98_S1.1810.71
346_P352_C1.1800.70
66_T270_D1.1800.70
227_E329_A1.1790.70
207_K315_Y1.1740.70
178_R315_Y1.1740.70
169_L280_F1.1720.70
259_G277_P1.1720.70
411_K414_P1.1700.70
278_R286_S1.1650.69
300_E313_A1.1640.69
326_H329_A1.1630.69
294_I303_F1.1610.69
47_I54_T1.1590.69
127_A130_K1.1580.69
353_G369_P1.1560.69
296_Q313_A1.1440.68
388_A399_E1.1430.68
404_D411_K1.1300.67
132_S135_T1.1290.67
100_D104_N1.1280.67
281_R305_W1.1270.67
286_S317_S1.1210.66
381_R385_E1.1180.66
388_A391_N1.1140.66
414_P418_S1.1090.66
45_G48_G1.1010.65
248_T256_T1.0960.65
401_V408_A1.0870.64
126_F133_H1.0850.64
30_L38_K1.0820.64
79_A283_S1.0780.63
278_R288_L1.0770.63
127_A132_S1.0770.63
146_L153_P1.0740.63
168_I383_V1.0730.63
346_P371_E1.0650.62
297_V300_E1.0630.62
150_D153_P1.0540.62
93_S97_T1.0510.61
131_T136_N1.0490.61
265_A269_V1.0470.61
225_W243_V1.0470.61
296_Q300_E1.0410.61
408_A411_K1.0410.61
390_R394_E1.0410.61
369_P382_H1.0390.60
188_W230_P1.0310.60
342_A360_R1.0240.59
410_K413_E1.0230.59
51_R55_V1.0160.59
130_K135_T1.0060.58
24_S28_E1.0030.58
407_R410_K1.0010.58
91_S156_E1.0010.58
47_I97_T0.9990.57
364_L369_P0.9980.57
282_R314_H0.9900.57
171_V244_W0.9880.57
345_A364_L0.9870.56
164_R225_W0.9860.56
194_R198_V0.9820.56
384_S417_R0.9710.55
303_F307_R0.9690.55
182_E327_I0.9690.55
296_Q312_A0.9660.55
62_I66_T0.9620.55
218_G302_H0.9540.54
312_A317_S0.9510.54
383_V409_V0.9500.54
284_R303_F0.9490.53
48_G51_R0.9470.53
95_A221_Y0.9460.53
301_N323_T0.9440.53
379_T382_H0.9390.53
397_M407_R0.9350.52
407_R416_L0.9340.52
146_L283_S0.9310.52
130_K134_A0.9280.52
47_I51_R0.9240.52
394_E402_N0.9220.51
202_I205_D0.9200.51
278_R351_E0.9170.51
150_D155_I0.9170.51
215_L218_G0.9160.51
244_W307_R0.9140.51
406_L411_K0.9130.51
403_A407_R0.9120.51
404_D415_V0.9120.51
397_M403_A0.9110.51
167_A225_W0.9110.51
344_I349_C0.9100.50
33_L38_K0.9080.50
402_N406_L0.9050.50
170_A308_G0.9050.50
186_L316_I0.9030.50
150_D190_D0.9030.50
146_L284_R0.9000.50
296_Q311_A0.8970.49
28_E135_T0.8970.49
26_D38_K0.8930.49
318_A322_E0.8910.49
413_E417_R0.8900.49
133_H136_N0.8880.49
371_E375_D0.8870.49
278_R303_F0.8850.48
285_A289_A0.8840.48
405_D415_V0.8820.48
63_A72_S0.8790.48
333_H336_D0.8780.48
401_V404_D0.8780.48
407_R411_K0.8770.48
398_D411_K0.8770.48
396_V402_N0.8730.47
400_E404_D0.8710.47
28_E31_Q0.8690.47
214_Y290_S0.8670.47
178_R366_C0.8650.47
109_F113_M0.8620.47
179_P320_A0.8580.46
305_W316_I0.8570.46
227_E231_A0.8510.46
387_D410_K0.8500.46
229_H245_T0.8500.46
295_N326_H0.8490.46
141_S303_F0.8470.45
382_H389_D0.8460.45
359_H362_T0.8430.45
44_S48_G0.8400.45
246_K253_I0.8390.45
407_R417_R0.8390.45
176_G200_L0.8390.45
170_A221_Y0.8390.45
176_G284_R0.8380.45
81_A85_I0.8370.45
77_T83_D0.8370.45
405_D412_L0.8340.44
336_D341_R0.8340.44
347_V352_C0.8330.44
29_T33_L0.8310.44
295_N362_T0.8290.44
30_L33_L0.8290.44
58_A186_L0.8250.44
59_A93_S0.8250.44
374_I391_N0.8240.44
89_V92_K0.8220.44
171_V218_G0.8220.44
285_A299_L0.8190.43
129_L135_T0.8190.43
181_S187_T0.8170.43
93_S131_T0.8170.43
126_F129_L0.8140.43
103_Y112_V0.8130.43
393_L401_V0.8090.42
284_R324_G0.8090.42
260_Y267_D0.8080.42
106_F122_L0.8060.42
85_I218_G0.8040.42
47_I98_S0.8030.42
283_S347_V0.8010.42
402_N411_K0.7990.42
352_C363_C0.7990.42
288_L330_A0.7970.42
26_D33_L0.7950.41
318_A344_I0.7900.41
122_L125_R0.7870.41
344_I369_P0.7870.41
305_W362_T0.7860.41
28_E249_Q0.7830.41
45_G197_H0.7790.40
346_P357_P0.7740.40
214_Y352_C0.7730.40
129_L134_A0.7670.39
158_R284_R0.7670.39
214_Y305_W0.7670.39
218_G221_Y0.7660.39
278_R307_R0.7620.39
290_S303_F0.7600.39
386_I405_D0.7600.39
382_H385_E0.7600.39
171_V377_Q0.7590.39
31_Q38_K0.7570.39
85_I385_E0.7570.39
290_S316_I0.7550.38
86_T103_Y0.7520.38
146_L395_L0.7520.38
106_F264_E0.7520.38
225_W245_T0.7510.38
118_D122_L0.7500.38
393_L398_D0.7500.38
375_D378_D0.7500.38
258_Y387_D0.7460.38
154_L266_R0.7460.38
272_T275_C0.7450.38
147_R173_W0.7450.38
400_E408_A0.7440.38
98_S414_P0.7420.37
219_A223_R0.7420.37
98_S102_Y0.7420.37
153_P253_I0.7400.37
63_A80_D0.7380.37
300_E312_A0.7350.37
178_R305_W0.7350.37
168_I255_Y0.7330.37
129_L133_H0.7310.37
290_S300_E0.7300.37
155_I169_L0.7290.36
160_E269_V0.7280.36
178_R363_C0.7250.36
327_I379_T0.7250.36
394_E410_K0.7240.36
288_L303_F0.7240.36
394_E397_M0.7210.36
148_W249_Q0.7200.36
97_T101_S0.7150.35
351_E359_H0.7130.35
357_P361_K0.7130.35
68_R72_S0.7120.35
103_Y194_R0.7120.35
344_I351_E0.7110.35
133_H148_W0.7090.35
46_E202_I0.7090.35
35_A38_K0.7060.35
162_N165_D0.7050.35
48_G59_A0.7020.35
345_A361_K0.7010.34
167_A182_E0.7000.34
76_S97_T0.6990.34
101_S307_R0.6990.34
143_S276_N0.6980.34
298_D303_F0.6960.34
245_T282_R0.6950.34
289_A356_T0.6950.34
128_A135_T0.6930.34
134_A249_Q0.6880.34
347_V350_L0.6880.34
382_H386_I0.6880.34
179_P363_C0.6870.33
318_A360_R0.6850.33
312_A345_A0.6850.33
56_L60_L0.6850.33
134_A251_E0.6850.33
98_S101_S0.6840.33
284_R305_W0.6840.33
266_R269_V0.6820.33
184_W255_Y0.6820.33
48_G90_S0.6820.33
343_E357_P0.6820.33
190_D357_P0.6810.33
408_A413_E0.6790.33
63_A94_L0.6780.33
183_L304_G0.6780.33
243_V366_C0.6750.33
91_S258_Y0.6750.33
279_N283_S0.6740.33
60_L63_A0.6730.32
213_V336_D0.6720.32
360_R369_P0.6700.32
374_I395_L0.6700.32
143_S322_E0.6680.32
213_V317_S0.6680.32
207_K278_R0.6670.32
143_S214_Y0.6650.32
55_V126_F0.6620.32
353_G372_A0.6620.32
295_N312_A0.6610.32
177_G202_I0.6610.32
179_P277_P0.6600.32
315_Y366_C0.6600.32
38_K49_L0.6580.31
118_D124_E0.6580.31
213_V304_G0.6570.31
34_D53_L0.6570.31
229_H233_D0.6550.31
361_K364_L0.6540.31
201_S205_D0.6530.31
410_K417_R0.6530.31
290_S327_I0.6510.31
147_R397_M0.6510.31
91_S227_E0.6510.31
266_R275_C0.6490.31
324_G362_T0.6490.31
227_E277_P0.6480.31
299_L324_G0.6480.31
265_A270_D0.6470.31
188_W222_L0.6460.31
150_D252_S0.6460.31
62_I288_L0.6450.31
367_P371_E0.6450.31
126_F254_S0.6440.30
157_A269_V0.6440.30
399_E402_N0.6430.30
283_S322_E0.6420.30
299_L326_H0.6390.30
100_D132_S0.6380.30
210_A324_G0.6380.30
295_N379_T0.6360.30
168_I190_D0.6350.30
344_I375_D0.6300.30
300_E305_W0.6300.30
192_E257_Q0.6290.29
182_E295_N0.6280.29
404_D408_A0.6280.29
305_W332_G0.6280.29
48_G278_R0.6250.29
194_R197_H0.6250.29
164_R244_W0.6240.29
186_L290_S0.6220.29
91_S268_A0.6210.29
297_V308_G0.6210.29
406_L410_K0.6200.29
305_W311_A0.6190.29
76_S119_A0.6150.29
87_A394_E0.6140.29
97_T243_V0.6140.29
97_T136_N0.6110.28
226_K230_P0.6090.28
240_S245_T0.6090.28
38_K69_L0.6090.28
182_E207_K0.6090.28
188_W239_D0.6080.28
31_Q35_A0.6070.28
44_S95_A0.6050.28
48_G139_T0.6040.28
389_D396_V0.6030.28
408_A418_S0.6030.28
323_T326_H0.6030.28
172_Q214_Y0.6020.28
240_S268_A0.6000.28
352_C418_S0.5990.28
360_R386_I0.5980.27
78_G238_T0.5960.27
339_D378_D0.5950.27
304_G398_D0.5950.27
80_D156_E0.5950.27
392_L395_L0.5950.27
381_R395_L0.5940.27
184_W252_S0.5910.27
190_D347_V0.5900.27
290_S302_H0.5890.27
56_L61_L0.5870.27
25_A28_E0.5870.27
71_D76_S0.5850.27
369_P389_D0.5850.27
62_I85_I0.5840.27
40_I48_G0.5830.27
56_L109_F0.5790.26
119_A272_T0.5780.26
80_D402_N0.5770.26
53_L57_R0.5770.26
380_L416_L0.5750.26
80_D90_S0.5750.26
197_H243_V0.5750.26
348_K375_D0.5740.26
359_H404_D0.5740.26
200_L205_D0.5740.26
93_S99_K0.5730.26
361_K382_H0.5730.26
141_S144_D0.5710.26
395_L413_E0.5710.26
109_F244_W0.5710.26
136_N202_I0.5710.26
34_D40_I0.5700.26
342_A345_A0.5690.26
300_E323_T0.5680.26
55_V197_H0.5670.26
95_A111_S0.5650.25
103_Y142_A0.5650.25
297_V304_G0.5650.25
177_G218_G0.5650.25
79_A294_I0.5630.25
389_D405_D0.5610.25
129_L132_S0.5610.25
222_L226_K0.5570.25
182_E201_S0.5560.25
26_D35_A0.5560.25
169_L262_F0.5550.25
241_T245_T0.5540.25
146_L268_A0.5540.25
148_W151_V0.5540.25
48_G378_D0.5530.25
132_S136_N0.5520.25
320_A345_A0.5520.25
409_V413_E0.5520.25
57_R61_L0.5510.25
257_Q414_P0.5510.25
108_K274_P0.5490.25
174_S218_G0.5490.25
335_V342_A0.5470.24
97_T100_D0.5440.24
37_L52_H0.5430.24
316_I320_A0.5430.24
128_A314_H0.5400.24
29_T100_D0.5400.24
332_G335_V0.5400.24
406_L412_L0.5390.24
65_G268_A0.5390.24
312_A316_I0.5390.24
113_M222_L0.5380.24
184_W208_T0.5380.24
104_N264_E0.5380.24
55_V101_S0.5360.24
198_V201_S0.5360.24
27_R230_P0.5340.24
118_D144_D0.5340.24
154_L265_A0.5340.24
290_S330_A0.5330.24
51_R252_S0.5320.24
109_F114_L0.5310.23
299_L380_L0.5300.23
124_E134_A0.5280.23
24_S27_R0.5270.23
255_Y261_P0.5250.23
193_D242_L0.5240.23
114_L125_R0.5240.23
100_D299_L0.5220.23
194_R324_G0.5220.23
215_L385_E0.5200.23
239_D268_A0.5200.23
183_L258_Y0.5190.23
267_D395_L0.5170.23
190_D349_C0.5170.23
104_N259_G0.5170.23
385_E389_D0.5170.23
224_R417_R0.5160.23
406_L414_P0.5150.23
279_N303_F0.5140.23
387_D416_L0.5140.23
81_A175_S0.5140.23
285_A379_T0.5140.23
83_D318_A0.5100.22
311_A386_I0.5100.22
348_K412_L0.5090.22
332_G350_L0.5080.22
310_D313_A0.5070.22
288_L335_V0.5050.22
260_Y306_Q0.5040.22
178_R349_C0.5030.22
225_W349_C0.5020.22
224_R227_E0.5020.22
40_I98_S0.5010.22
397_M400_E0.5010.22
258_Y330_A0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1z1bA 3 0.6742 100 0.504 Contact Map
1a0pA 1 0.5995 100 0.509 Contact Map
2a3vA 3 0.638 100 0.519 Contact Map
1z19A 3 0.629 100 0.523 Contact Map
1xo0A 3 0.6493 100 0.531 Contact Map
4a8eA 2 0.5928 100 0.546 Contact Map
3nkhA 2 0.4321 100 0.619 Contact Map
1ae9A 4 0.3801 100 0.662 Contact Map
1aihA 2 0.3756 99.9 0.702 Contact Map
4e0gA 2 0.6471 99.9 0.721 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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