GREMLIN Database
O52006 - Uncharacterized protein
UniProt: O52006 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 93 (87)
Sequences: 293 (130)
Seq/√Len: 13.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
82_R85_E2.8900.97
41_G45_P2.6040.94
81_R85_E2.5980.94
40_H43_L2.3280.89
73_R77_E2.1680.85
24_L30_L2.1560.85
38_I52_D2.1360.84
22_H25_A1.9890.80
61_I67_S1.9840.80
5_T74_G1.9810.80
31_E38_I1.9730.79
6_G9_R1.7850.72
53_K76_R1.7810.72
73_R76_R1.7710.71
15_I28_D1.6880.67
59_G67_S1.6880.67
6_G10_D1.6700.66
45_P58_K1.6070.63
19_D87_Q1.5920.63
29_E41_G1.5150.59
35_E48_D1.5020.58
21_P67_S1.4940.58
45_P74_G1.4530.55
5_T42_R1.4260.54
60_E72_R1.4150.53
41_G58_K1.3690.51
22_H30_L1.2960.47
15_I70_L1.2900.47
10_D81_R1.2710.46
5_T8_Q1.2510.45
58_K84_W1.2220.43
38_I73_R1.2040.42
13_Y81_R1.1970.42
22_H61_I1.1970.42
45_P48_D1.1530.39
56_V79_T1.1480.39
2_H74_G1.1290.38
16_A26_V1.1110.37
15_I21_P1.1040.37
4_L8_Q1.0840.36
29_E80_A1.0650.35
8_Q27_K1.0480.34
17_G85_E1.0160.33
54_G73_R1.0130.32
39_H63_Q0.9970.32
35_E78_L0.9920.31
9_R49_T0.9660.30
77_E80_A0.9650.30
15_I56_V0.9460.29
17_G21_P0.9410.29
81_R84_W0.9250.28
2_H35_E0.9140.28
20_E69_A0.9080.28
49_T53_K0.9080.28
20_E56_V0.9070.28
29_E55_L0.9020.27
45_P49_T0.8850.27
34_Y38_I0.8810.26
33_Y84_W0.8770.26
9_R21_P0.8660.26
56_V75_R0.8650.26
68_Y71_T0.8540.25
51_V56_V0.8520.25
7_F64_R0.8470.25
3_D40_H0.8140.24
3_D87_Q0.8120.24
74_G79_T0.8070.23
29_E33_Y0.8020.23
43_L62_D0.8020.23
34_Y39_H0.7940.23
6_G21_P0.7930.23
4_L31_E0.7810.22
48_D74_G0.7800.22
23_G66_N0.7650.22
19_D26_V0.7650.22
38_I59_G0.7650.22
18_L56_V0.7490.21
82_R86_H0.7450.21
20_E70_L0.7300.21
58_K81_R0.7260.20
15_I18_L0.7220.20
80_A85_E0.6950.19
58_K66_N0.6900.19
11_L49_T0.6860.19
48_D83_E0.6820.19
3_D34_Y0.6790.19
11_L37_E0.6790.19
79_T83_E0.6760.19
53_K88_Y0.6730.19
61_I75_R0.6670.18
47_L65_T0.6650.18
39_H62_D0.6560.18
20_E30_L0.6540.18
41_G65_T0.6530.18
9_R15_I0.6470.18
78_L86_H0.6420.18
17_G84_W0.6380.18
54_G70_L0.6360.17
40_H62_D0.6350.17
17_G88_Y0.6300.17
18_L21_P0.6190.17
42_R55_L0.6150.17
29_E53_K0.6130.17
13_Y85_E0.6000.16
10_D13_Y0.5950.16
51_V65_T0.5870.16
20_E24_L0.5860.16
41_G66_N0.5830.16
54_G80_A0.5810.16
14_A71_T0.5800.16
23_G64_R0.5690.16
28_D76_R0.5640.15
26_V47_L0.5620.15
48_D60_E0.5560.15
30_L71_T0.5530.15
40_H55_L0.5510.15
20_E67_S0.5500.15
37_E73_R0.5470.15
9_R12_L0.5380.15
24_L62_D0.5370.15
60_E63_Q0.5340.15
41_G51_V0.5330.15
5_T46_N0.5330.15
3_D85_E0.5330.15
13_Y17_G0.5310.14
33_Y71_T0.5270.14
51_V58_K0.5140.14
51_V81_R0.5120.14
17_G33_Y0.5030.14
32_N35_E0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2co5A 2 0.9785 98.8 0.742 Contact Map
3l9fA 2 0.9032 98.6 0.756 Contact Map
1yg2A 2 0.8495 98.4 0.77 Contact Map
3elkA 3 0.9677 98.3 0.777 Contact Map
2e1nA 2 0.957 98.3 0.779 Contact Map
3f8bA 2 0.9462 98.3 0.779 Contact Map
1xmaA 2 0.9247 98.3 0.779 Contact Map
2zfwA 2 0.9247 98.3 0.78 Contact Map
2eshA 2 0.9785 98.2 0.782 Contact Map
2dqlA 2 0.9785 98.1 0.788 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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