GREMLIN Database
TBPC - TATA-box-binding protein C
UniProt: O52004 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 181 (161)
Sequences: 174 (127)
Seq/√Len: 10.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
115_N155_M3.0160.93
151_A157_I3.0140.93
115_N126_T2.8890.91
19_D23_L2.5240.84
22_P25_A2.4970.84
37_S40_H2.3240.79
51_P54_T2.2670.77
115_N122_G2.2070.75
171_E175_S2.1810.74
98_T151_A2.1810.74
106_A115_N2.1530.73
102_V155_M2.1310.72
126_T155_M2.1140.72
19_D25_A2.0440.69
61_Y64_T1.9920.67
151_A170_Y1.9890.67
81_G86_L1.9870.67
106_A155_M1.8480.61
21_E25_A1.7900.58
98_T170_Y1.7430.56
90_E93_T1.7170.55
104_C151_A1.7150.55
98_T144_G1.6960.54
171_E180_L1.6870.53
18_L22_P1.6470.52
32_S36_P1.5610.48
165_T176_K1.5550.47
58_S62_I1.5460.47
27_L31_Y1.5430.47
102_V115_N1.5290.46
96_G122_G1.5180.46
102_V126_T1.5130.46
122_G155_M1.5110.45
144_G170_Y1.5090.45
106_A126_T1.5030.45
48_E52_L1.5020.45
104_C116_A1.5000.45
28_S33_E1.4800.44
20_V165_T1.4640.43
168_S172_Y1.4580.43
154_K178_Q1.4450.42
29_T34_Y1.4260.42
38_N41_G1.3950.40
112_V117_L1.3650.39
90_E176_K1.3560.39
41_G44_V1.3550.38
85_D88_V1.3520.38
93_T176_K1.3470.38
31_Y34_Y1.3360.38
48_E54_T1.3350.38
171_E178_Q1.3210.37
19_D24_E1.3200.37
69_M72_L1.3060.36
71_S74_E1.2860.36
144_G157_I1.2770.35
50_G58_S1.2630.35
35_D39_Y1.2610.34
55_V60_K1.2500.34
29_T37_S1.2480.34
175_S178_Q1.2440.34
29_T38_N1.2370.33
36_P39_Y1.2030.32
32_S38_N1.1950.32
48_E60_K1.1940.32
58_S67_A1.1800.31
20_V25_A1.1720.31
47_E64_T1.1710.31
106_A122_G1.1680.31
137_V166_A1.1630.31
34_Y38_N1.1570.30
148_L156_V1.1460.30
144_G151_A1.1420.30
19_D22_P1.1290.29
19_D85_D1.1280.29
30_P38_N1.1210.29
19_D26_D1.1200.29
102_V122_G1.1110.29
42_L46_L1.1000.28
38_N68_S1.0940.28
59_G66_C1.0940.28
83_L86_L1.0860.28
132_Q156_V1.0770.27
104_C144_G1.0720.27
34_Y37_S1.0690.27
22_P26_D1.0530.26
30_P37_S1.0490.26
111_L116_A1.0420.26
33_E53_I1.0400.26
47_E51_P1.0360.26
18_L25_A1.0350.26
97_F139_R1.0290.26
33_E43_Y0.9900.24
31_Y36_P0.9800.24
129_E135_G0.9790.24
104_C170_Y0.9710.24
26_D31_Y0.9700.24
89_T111_L0.9700.24
55_V59_G0.9680.24
25_A46_L0.9670.23
168_S178_Q0.9530.23
25_A34_Y0.9520.23
26_D33_E0.9490.23
49_N55_V0.9480.23
131_E139_R0.9480.23
49_N53_I0.9270.22
51_P62_I0.9260.22
18_L96_G0.9180.22
69_M75_T0.9110.22
54_T65_G0.9080.22
87_G144_G0.9080.22
132_Q135_G0.9060.22
157_I170_Y0.8970.21
18_L26_D0.8970.21
127_E158_T0.8780.21
175_S180_L0.8760.21
17_E30_P0.8630.20
35_D40_H0.8600.20
51_P59_G0.8590.20
33_E36_P0.8440.20
30_P60_K0.8390.20
112_V145_A0.8330.19
123_L137_V0.8260.19
138_Y145_A0.8250.19
111_L151_A0.8050.19
174_Q179_E0.8020.18
87_G151_A0.7910.18
135_G139_R0.7910.18
49_N77_E0.7900.18
134_P155_M0.7860.18
105_T156_V0.7810.18
68_S78_E0.7750.18
41_G45_R0.7730.18
48_E71_S0.7720.18
162_D169_A0.7720.18
44_V47_E0.7650.17
105_T142_E0.7580.17
38_N47_E0.7550.17
52_L59_G0.7520.17
50_G67_A0.7520.17
147_L158_T0.7520.17
145_A158_T0.7500.17
130_P139_R0.7440.17
170_Y175_S0.7330.17
96_G111_L0.7330.17
98_T116_A0.7300.17
97_F130_P0.7300.17
24_E27_L0.7230.16
104_C157_I0.7190.16
55_V58_S0.7100.16
129_E137_V0.7070.16
150_F156_V0.7040.16
131_E135_G0.7010.16
112_V160_A0.6990.16
54_T62_I0.6960.16
129_E140_P0.6940.16
88_V144_G0.6920.16
132_Q148_L0.6790.15
123_L135_G0.6790.15
68_S73_H0.6780.15
17_E109_D0.6780.15
80_L83_L0.6740.15
53_I58_S0.6730.15
36_P41_G0.6710.15
46_L51_P0.6680.15
46_L70_E0.6680.15
45_R48_E0.6640.15
138_Y147_L0.6570.15
55_V67_A0.6570.15
162_D171_E0.6560.15
129_E132_Q0.6550.15
105_T148_L0.6540.15
68_S74_E0.6520.15
51_P67_A0.6460.15
37_S41_G0.6440.15
105_T150_F0.6420.14
22_P32_S0.6350.14
97_F133_F0.6340.14
18_L28_S0.6280.14
98_T104_C0.6270.14
69_M73_H0.6270.14
121_L179_E0.6270.14
73_H76_N0.6210.14
39_Y50_G0.6180.14
127_E150_F0.6140.14
83_L87_G0.6130.14
62_I65_G0.6130.14
70_E73_H0.6120.14
17_E33_E0.6110.14
162_D175_S0.6110.14
76_N80_L0.6100.14
108_L126_T0.6090.14
18_L21_E0.6080.14
94_Q110_E0.6070.14
62_I67_A0.6040.14
60_K64_T0.6010.14
135_G156_V0.5990.14
130_P150_F0.5960.13
32_S35_D0.5960.13
48_E68_S0.5950.13
145_A160_A0.5930.13
37_S43_Y0.5910.13
26_D91_E0.5880.13
117_L160_A0.5860.13
102_V161_K0.5850.13
146_V158_T0.5840.13
129_E148_L0.5820.13
135_G150_F0.5800.13
60_K68_S0.5790.13
105_T161_K0.5740.13
127_E146_V0.5720.13
31_Y35_D0.5710.13
139_R150_F0.5690.13
57_R62_I0.5680.13
103_V151_A0.5640.13
171_E174_Q0.5620.13
33_E41_G0.5590.13
105_T127_E0.5560.13
50_G57_R0.5560.13
39_Y47_E0.5530.13
117_L145_A0.5530.13
68_S71_S0.5520.13
129_E144_G0.5520.13
20_V26_D0.5510.13
42_L45_R0.5510.13
69_M76_N0.5500.12
51_P69_M0.5490.12
70_E74_E0.5360.12
147_L160_A0.5360.12
107_M134_P0.5360.12
18_L29_T0.5330.12
111_L122_G0.5300.12
54_T58_S0.5290.12
145_A173_F0.5280.12
129_E139_R0.5250.12
36_P51_P0.5180.12
106_A140_P0.5150.12
165_T177_V0.5120.12
17_E21_E0.5120.12
56_Y77_E0.5110.12
42_L62_I0.5060.12
118_A159_G0.5030.12
51_P61_Y0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3eikA 2 0.4751 100 0.533 Contact Map
1ytbA 1 0.4807 100 0.544 Contact Map
1rm1A 1 0.4807 100 0.552 Contact Map
1aisA 1 0.5028 100 0.558 Contact Map
4b0aA 1 0.6851 100 0.562 Contact Map
1mp9A 2 0.5138 100 0.562 Contact Map
2z8uA 2 0.9724 100 0.579 Contact Map
4febA 3 0.1823 79.8 0.939 Contact Map
2d0bA 1 0.4199 72.7 0.943 Contact Map
4py5A 1 0.3978 53.9 0.949 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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