GREMLIN Database
O52003 - ATP-dependent RNA helicase
UniProt: O52003 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 979 (810)
Sequences: 1291 (984)
Seq/√Len: 34.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
66_I69_P5.1601.00
698_I703_R3.1731.00
882_D885_R2.7761.00
66_I70_I2.7591.00
165_M199_L2.7581.00
769_P774_L2.7471.00
114_S119_Y2.6671.00
698_I701_L2.5751.00
901_Q905_E2.5611.00
900_E904_E2.5291.00
847_G850_G2.5251.00
79_T83_L2.4481.00
902_H906_E2.4381.00
894_I898_H2.4251.00
902_H907_I2.4181.00
92_S95_N2.3911.00
101_E314_Y2.3580.99
46_S54_I2.3210.99
895_K901_Q2.3030.99
912_E920_Q2.2970.99
674_L677_E2.2880.99
919_Q922_E2.2750.99
848_E852_T2.2530.99
926_D929_A2.2410.99
65_Q69_P2.2270.99
895_K898_H2.2260.99
50_H55_D2.2220.99
766_L769_P2.2190.99
673_D676_D2.1800.99
899_A902_H2.1660.99
890_R893_E2.1600.99
766_L770_L2.1600.99
900_E905_E2.1570.99
722_R725_G2.1350.99
900_E909_E2.0960.99
906_E911_E2.0920.99
903_F906_E2.0830.99
892_V895_K2.0760.99
770_L774_L2.0730.99
926_D930_P2.0560.98
839_E845_P2.0480.98
844_L848_E2.0410.98
45_P50_H2.0330.98
888_R893_E2.0240.98
903_F907_I2.0160.98
86_R89_R1.9990.98
766_L774_L1.9950.98
907_I915_E1.9880.98
72_H75_R1.9870.98
46_S50_H1.9850.98
42_R46_S1.9810.98
863_E869_A1.9730.98
869_A873_A1.9720.98
768_H780_D1.9680.98
843_T847_G1.9610.98
900_E907_I1.9590.98
925_K928_S1.9550.98
920_Q924_G1.9470.98
871_M874_W1.9420.98
909_E920_Q1.9210.98
774_L777_F1.9150.98
898_H903_F1.9110.98
904_E907_I1.9110.98
864_D867_S1.8980.97
915_E918_E1.8960.97
733_P736_L1.8950.97
796_G800_P1.8870.97
766_L775_I1.8820.97
891_E895_K1.8660.97
867_S870_E1.8530.97
118_R285_L1.8480.97
767_D774_L1.8470.97
865_L868_I1.8430.97
751_T755_A1.8340.97
911_E914_L1.8300.97
558_L600_L1.8300.97
877_V881_A1.8270.97
701_L707_D1.8110.97
841_V844_L1.8100.97
178_R210_D1.8030.96
896_R899_A1.8000.96
772_Q783_R1.7950.96
906_E910_W1.7890.96
925_K929_A1.7880.96
174_V178_R1.7850.96
676_D679_D1.7830.96
813_G817_A1.7810.96
919_Q924_G1.7810.96
923_Q929_A1.7800.96
768_H774_L1.7760.96
819_T823_V1.7740.96
72_H79_T1.7570.96
789_A792_V1.7570.96
905_E917_Y1.7400.96
794_S798_P1.7390.96
895_K899_A1.7350.96
78_A83_L1.7350.96
721_A724_G1.7230.95
913_R918_E1.7230.95
774_L782_N1.7200.95
815_G819_T1.7150.95
902_H909_E1.7070.95
607_I612_G1.7020.95
768_H773_S1.7020.95
816_E822_L1.7010.95
880_F883_E1.7000.95
43_K50_H1.6930.95
50_H54_I1.6880.95
911_E918_E1.6870.95
924_G928_S1.6840.95
903_F912_E1.6840.95
907_I911_E1.6820.95
474_V486_I1.6790.95
916_S922_E1.6790.95
869_A872_E1.6610.94
903_F908_S1.6600.94
907_I913_R1.6580.94
471_K502_R1.6550.94
828_T833_V1.6510.94
797_E800_P1.6450.94
909_E917_Y1.6400.94
171_R178_R1.6390.94
698_I702_V1.6370.94
910_W915_E1.6370.94
827_V834_S1.6350.94
753_Q756_M1.6300.94
832_E835_T1.6300.94
905_E912_E1.6270.94
46_S55_D1.6250.94
723_A726_D1.6240.94
896_R905_E1.6220.94
891_E894_I1.6200.94
887_E891_E1.6200.94
764_I767_D1.6150.93
678_D681_I1.6130.93
861_M878_E1.6110.93
873_A876_Q1.6100.93
205_D233_H1.6040.93
846_P850_G1.6040.93
908_S920_Q1.6000.93
780_D783_R1.5990.93
860_S864_D1.5960.93
853_P858_L1.5940.93
699_E703_R1.5910.93
878_E882_D1.5830.93
893_E896_R1.5780.93
909_E912_E1.5700.92
484_E551_H1.5700.92
766_L773_S1.5690.92
921_D928_S1.5630.92
889_E904_E1.5520.92
723_A732_V1.5450.92
889_E894_I1.5440.92
176_Y188_H1.5400.92
902_H910_W1.5360.92
897_Q901_Q1.5340.92
873_A878_E1.5320.92
802_I806_Y1.5270.91
845_P848_E1.5180.91
915_E923_Q1.5150.91
763_F766_L1.5080.91
776_E781_S1.5040.91
809_G816_E1.5040.91
894_I897_Q1.5020.91
279_Y296_I1.4970.91
918_E922_E1.4960.91
863_E866_H1.4910.90
704_E708_E1.4890.90
774_L781_S1.4890.90
904_E912_E1.4880.90
917_Y920_Q1.4880.90
875_E879_S1.4860.90
858_L863_E1.4850.90
900_E906_E1.4820.90
740_Q743_G1.4750.90
774_L780_D1.4740.90
747_Q750_F1.4730.90
90_F93_L1.4710.90
775_I779_L1.4690.90
913_R916_S1.4660.90
131_I134_G1.4630.89
915_E927_M1.4610.89
490_T496_L1.4600.89
84_A87_Y1.4600.89
888_R895_K1.4590.89
818_V825_L1.4550.89
827_V831_S1.4480.89
877_V880_F1.4410.89
839_E843_T1.4360.89
803_L806_Y1.4340.89
72_H76_E1.4340.89
741_V744_R1.4320.88
816_E819_T1.4310.88
839_E842_D1.4190.88
761_V766_L1.4190.88
827_V833_V1.4180.88
83_L86_R1.4170.88
904_E913_R1.4160.88
769_P777_F1.4130.88
852_T856_D1.4130.88
853_P857_Q1.4130.88
891_E900_E1.4120.88
45_P55_D1.4120.88
862_A865_L1.4110.88
921_D925_K1.4100.88
907_I910_W1.4100.88
858_L866_H1.4090.88
178_R185_R1.4080.88
921_D926_D1.4060.88
754_V757_E1.3990.87
838_P844_L1.3970.87
748_A752_R1.3820.87
842_D851_S1.3790.86
895_K900_E1.3760.86
920_Q928_S1.3650.86
334_M591_T1.3640.86
896_R901_Q1.3640.86
908_S914_L1.3640.86
766_L771_V1.3640.86
868_I874_W1.3630.86
888_R891_E1.3620.86
773_S776_E1.3590.86
812_S815_G1.3560.86
908_S911_E1.3560.86
484_E552_I1.3530.85
707_D710_G1.3490.85
42_R45_P1.3490.85
911_E915_E1.3480.85
904_E909_E1.3470.85
816_E829_S1.3460.85
795_D798_P1.3460.85
881_A884_A1.3440.85
777_F783_R1.3440.85
676_D681_I1.3410.85
866_H870_E1.3400.85
889_E893_E1.3390.85
917_Y924_G1.3380.85
842_D845_P1.3370.85
922_E927_M1.3280.84
896_R900_E1.3270.84
778_C781_S1.3190.84
777_F780_D1.3170.84
829_S832_E1.3140.84
889_E896_R1.3060.83
771_V782_N1.3020.83
510_A527_D1.2990.83
876_Q879_S1.2990.83
905_E909_E1.2960.83
899_A903_F1.2950.83
765_A770_L1.2930.83
770_L777_F1.2920.83
231_A265_L1.2910.83
889_E907_I1.2890.82
630_T633_A1.2850.82
893_E897_Q1.2830.82
845_P850_G1.2830.82
876_Q880_F1.2810.82
48_L55_D1.2810.82
826_Y829_S1.2810.82
920_Q930_P1.2800.82
822_L826_Y1.2790.82
924_G930_P1.2780.82
814_A817_A1.2750.82
822_L828_T1.2750.82
771_V775_I1.2700.82
887_E900_E1.2700.82
764_I776_E1.2610.81
787_Q790_V1.2580.81
858_L861_M1.2580.81
848_E856_D1.2560.81
892_V896_R1.2560.81
896_R909_E1.2550.81
771_V779_L1.2530.81
870_E873_A1.2510.81
900_E908_S1.2470.80
818_V829_S1.2470.80
857_Q864_D1.2470.80
81_L84_A1.2440.80
749_T755_A1.2430.80
766_L782_N1.2400.80
734_D743_G1.2400.80
907_I912_E1.2370.80
72_H78_A1.2340.80
854_T857_Q1.2320.79
917_Y925_K1.2280.79
766_L783_R1.2280.79
776_E779_L1.2270.79
906_E912_E1.2270.79
919_Q925_K1.2260.79
913_R920_Q1.2240.79
857_Q863_E1.2240.79
922_E926_D1.2230.79
898_H909_E1.2220.79
79_T82_D1.2220.79
874_W877_V1.2200.79
739_D743_G1.2200.79
817_A823_V1.2170.79
903_F911_E1.2140.78
900_E903_F1.2120.78
890_R894_I1.2120.78
909_E923_Q1.2100.78
42_R50_H1.2090.78
915_E924_G1.2080.78
875_E882_D1.2080.78
899_A907_I1.2020.78
677_E680_E1.2010.78
777_F781_S1.2000.78
905_E924_G1.2000.78
912_E921_D1.1980.78
701_L706_F1.1970.77
91_L94_T1.1970.77
875_E880_F1.1960.77
831_S836_R1.1960.77
738_G741_V1.1900.77
901_Q908_S1.1850.77
730_L733_P1.1850.77
898_H915_E1.1840.77
864_D868_I1.1840.77
843_T846_P1.1830.77
774_L778_C1.1830.77
923_Q927_M1.1830.77
914_L918_E1.1810.77
42_R55_D1.1800.76
864_D870_E1.1800.76
79_T89_R1.1780.76
43_K46_S1.1760.76
911_E926_D1.1720.76
766_L772_Q1.1700.76
869_A874_W1.1700.76
671_R676_D1.1700.76
913_R921_D1.1690.76
890_R909_E1.1690.76
171_R180_T1.1660.76
894_I900_E1.1630.75
922_E925_K1.1620.75
866_H871_M1.1620.75
829_S836_R1.1610.75
878_E881_A1.1610.75
84_A89_R1.1610.75
847_G852_T1.1600.75
897_Q905_E1.1600.75
876_Q881_A1.1600.75
75_R79_T1.1590.75
50_H53_R1.1570.75
672_F679_D1.1570.75
77_R83_L1.1550.75
766_L778_C1.1540.75
916_S924_G1.1540.75
850_G856_D1.1510.75
817_A830_E1.1490.74
904_E908_S1.1480.74
819_T827_V1.1460.74
908_S915_E1.1420.74
770_L781_S1.1400.74
827_V832_E1.1370.74
657_N664_N1.1360.74
772_Q776_E1.1330.73
765_A774_L1.1330.73
902_H913_R1.1320.73
843_T850_G1.1300.73
914_L927_M1.1290.73
915_E921_D1.1290.73
898_H902_H1.1290.73
916_S921_D1.1280.73
843_T852_T1.1280.73
771_V781_S1.1280.73
890_R901_Q1.1260.73
859_T865_L1.1260.73
843_T848_E1.1240.73
905_E908_S1.1230.73
902_H918_E1.1230.73
732_V735_V1.1220.73
771_V774_L1.1210.73
899_A905_E1.1210.73
36_T40_K1.1210.73
283_N290_F1.1210.73
927_M930_P1.1150.72
857_Q865_L1.1150.72
911_E916_S1.1130.72
918_E921_D1.1110.72
871_M881_A1.1110.72
868_I871_M1.1100.72
163_Q526_A1.1090.72
859_T864_D1.1080.72
907_I923_Q1.1070.72
812_S819_T1.1030.71
789_A793_A1.1010.71
779_L783_R1.0960.71
180_T185_R1.0940.71
73_D88_D1.0940.71
840_F846_P1.0930.71
874_W881_A1.0930.71
83_L89_R1.0920.71
850_G854_T1.0920.71
69_P73_D1.0910.71
843_T849_V1.0910.71
736_L740_Q1.0890.70
918_E926_D1.0890.70
817_A820_E1.0890.70
896_R903_F1.0880.70
82_D87_Y1.0880.70
775_I782_N1.0870.70
858_L862_A1.0860.70
916_S927_M1.0860.70
813_G829_S1.0860.70
751_T754_V1.0820.70
898_H906_E1.0800.70
855_L858_L1.0790.70
773_S782_N1.0780.70
768_H771_V1.0730.69
861_M866_H1.0730.69
806_Y810_Y1.0730.69
871_M875_E1.0720.69
672_F676_D1.0720.69
862_A869_A1.0700.69
915_E922_E1.0690.69
879_S882_D1.0680.69
871_M879_S1.0680.69
767_D778_C1.0680.69
50_H56_S1.0670.69
701_L710_G1.0660.69
887_E895_K1.0650.69
78_A82_D1.0640.69
816_E826_Y1.0640.69
500_R509_I1.0630.69
673_D677_E1.0620.68
733_P737_S1.0590.68
878_E886_E1.0550.68
746_E750_F1.0550.68
902_H914_L1.0530.68
914_L921_D1.0470.67
727_V732_V1.0460.67
916_S920_Q1.0440.67
729_Q732_V1.0430.67
910_W913_R1.0420.67
860_S873_A1.0420.67
851_S856_D1.0420.67
915_E919_Q1.0410.67
763_F767_D1.0410.67
819_T822_L1.0400.67
864_D869_A1.0400.67
924_G929_A1.0390.67
756_M760_D1.0380.67
673_D681_I1.0370.67
770_L775_I1.0360.67
822_L827_V1.0350.66
792_V799_A1.0350.66
825_L830_E1.0330.66
909_E913_R1.0320.66
893_E905_E1.0320.66
788_V796_G1.0300.66
296_I376_V1.0260.66
788_V791_K1.0260.66
866_H869_A1.0240.66
724_G727_V1.0230.66
920_Q929_A1.0210.65
710_G717_R1.0210.65
781_S784_I1.0170.65
840_F845_P1.0170.65
727_V730_L1.0170.65
48_L51_I1.0160.65
730_L739_D1.0130.65
774_L783_R1.0130.65
839_E858_L1.0130.65
737_S740_Q1.0120.65
792_V801_G1.0100.65
916_S926_D1.0080.64
825_L833_V1.0070.64
891_E899_A1.0070.64
901_Q909_E1.0060.64
725_G732_V1.0050.64
720_P727_V1.0040.64
107_A132_E1.0030.64
671_R675_S1.0010.64
913_R917_Y1.0010.64
777_F782_N1.0010.64
922_E928_S1.0000.64
767_D775_I0.9990.64
919_Q926_D0.9980.64
823_V826_Y0.9960.63
860_S865_L0.9950.63
886_E889_E0.9950.63
716_V719_G0.9940.63
101_E315_E0.9940.63
894_I914_L0.9920.63
766_L781_S0.9910.63
48_L54_I0.9900.63
67_D70_I0.9890.63
919_Q923_Q0.9870.63
879_S883_E0.9850.63
820_E842_D0.9850.63
761_V777_F0.9850.63
769_P781_S0.9850.63
818_V826_Y0.9830.62
886_E909_E0.9830.62
301_L309_L0.9820.62
42_R54_I0.9770.62
812_S818_V0.9750.62
861_M868_I0.9740.62
923_Q928_S0.9730.62
185_R188_H0.9710.61
914_L919_Q0.9680.61
792_V795_D0.9660.61
867_S871_M0.9660.61
909_E919_Q0.9660.61
749_T752_R0.9650.61
772_Q775_I0.9640.61
867_S872_E0.9640.61
914_L929_A0.9630.61
899_A908_S0.9610.61
851_S857_Q0.9610.61
733_P740_Q0.9600.61
798_P807_R0.9600.61
900_E919_Q0.9590.60
727_V733_P0.9580.60
849_V854_T0.9570.60
906_E913_R0.9570.60
900_E914_L0.9560.60
862_A867_S0.9560.60
736_L739_D0.9560.60
72_H81_L0.9540.60
73_D78_A0.9530.60
856_D860_S0.9530.60
761_V779_L0.9520.60
815_G836_R0.9490.60
897_Q903_F0.9480.60
178_R189_P0.9470.59
917_Y921_D0.9450.59
915_E929_A0.9430.59
761_V765_A0.9410.59
699_E707_D0.9400.59
819_T832_E0.9400.59
735_V744_R0.9390.59
840_F852_T0.9370.59
923_Q926_D0.9370.59
828_T831_S0.9350.58
902_H905_E0.9310.58
903_F915_E0.9290.58
45_P48_L0.9290.58
766_L779_L0.9280.58
821_K830_E0.9270.58
896_R913_R0.9260.58
817_A829_S0.9260.58
85_Y89_R0.9260.58
893_E901_Q0.9250.58
800_P806_Y0.9240.58
915_E920_Q0.9240.58
770_L773_S0.9230.57
896_R907_I0.9230.57
749_T753_Q0.9230.57
44_L54_I0.9220.57
902_H911_E0.9220.57
905_E910_W0.9210.57
792_V800_P0.9210.57
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310_K575_Y0.5420.27
918_E928_S0.5420.27
44_L50_H0.5410.27
844_L854_T0.5410.27
727_V738_G0.5410.27
871_M883_E0.5410.27
898_H916_S0.5400.27
780_D808_L0.5400.27
679_D682_L0.5400.27
853_P862_A0.5390.27
765_A771_V0.5390.27
795_D800_P0.5390.27
186_N295_Q0.5390.27
841_V845_P0.5380.27
894_I917_Y0.5370.27
265_L285_L0.5370.27
694_S697_D0.5360.27
711_G715_G0.5360.27
775_I781_S0.5350.26
889_E913_R0.5350.26
768_H783_R0.5340.26
841_V847_G0.5340.26
768_H784_I0.5340.26
325_K521_R0.5340.26
897_Q904_E0.5340.26
892_V904_E0.5330.26
78_A81_L0.5320.26
863_E868_I0.5320.26
231_A564_R0.5310.26
814_A835_T0.5310.26
820_E825_L0.5310.26
675_S678_D0.5310.26
77_R81_L0.5300.26
921_D929_A0.5300.26
887_E907_I0.5300.26
40_K44_L0.5290.26
852_T855_L0.5280.26
904_E929_A0.5280.26
154_P571_R0.5270.26
892_V918_E0.5260.26
848_E851_S0.5260.26
904_E911_E0.5260.26
768_H772_Q0.5250.26
762_D781_S0.5250.26
885_R892_V0.5250.26
918_E930_P0.5250.26
890_R903_F0.5250.26
899_A916_S0.5240.26
848_E853_P0.5240.26
677_E681_I0.5240.26
854_T859_T0.5230.26
901_Q907_I0.5230.26
909_E925_K0.5220.26
111_I136_V0.5220.26
793_A802_I0.5220.26
732_V737_S0.5210.26
903_F929_A0.5210.26
913_R930_P0.5200.25
860_S879_S0.5200.25
888_R900_E0.5180.25
905_E925_K0.5180.25
838_P853_P0.5180.25
786_G802_I0.5170.25
786_G793_A0.5170.25
803_L809_G0.5150.25
820_E826_Y0.5150.25
829_S835_T0.5150.25
910_W918_E0.5150.25
876_Q884_A0.5140.25
902_H923_Q0.5140.25
876_Q885_R0.5140.25
694_S698_I0.5140.25
732_V738_G0.5130.25
814_A819_T0.5130.25
874_W879_S0.5120.25
906_E916_S0.5110.25
887_E897_Q0.5100.25
171_R176_Y0.5100.25
799_A806_Y0.5100.25
908_S913_R0.5100.25
118_R228_F0.5090.25
906_E919_Q0.5090.25
817_A827_V0.5080.25
905_E920_Q0.5080.25
76_E87_Y0.5080.25
865_L873_A0.5070.25
898_H908_S0.5070.25
894_I905_E0.5060.25
898_H905_E0.5060.25
752_R758_E0.5050.25
788_V800_P0.5050.25
879_S885_R0.5020.24
905_E922_E0.5020.24
112_L139_E0.5010.24
877_V882_D0.5010.24
78_A87_Y0.5010.24
921_D930_P0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mwyW 2 0.5843 100 0.465 Contact Map
1z3iX 4 0.6016 100 0.552 Contact Map
1z63A 1 0.4505 100 0.57 Contact Map
3dmqA 1 0.8315 100 0.663 Contact Map
4a2qA 1 0.5046 100 0.69 Contact Map
2ykgA 1 0.5975 100 0.693 Contact Map
4a2wA 1 0.5046 100 0.708 Contact Map
1wp9A 1 0.4525 100 0.709 Contact Map
4a2pA 1 0.4505 100 0.734 Contact Map
3tbkA 1 0.4831 100 0.74 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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