GREMLIN Database
O51997 - DNA repair protein
UniProt: O51997 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 469 (384)
Sequences: 17749 (11632)
Seq/√Len: 593.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
117_V144_L3.9401.00
196_V218_G3.7491.00
265_D448_D3.5541.00
120_I127_T3.3031.00
258_E439_P3.1331.00
361_S365_I3.0881.00
345_D409_N3.0361.00
334_T337_N2.9341.00
411_G430_I2.9061.00
383_E387_T2.8921.00
380_E384_R2.8391.00
91_A115_L2.8121.00
386_R407_A2.7941.00
377_E380_E2.6571.00
139_Q404_D2.6271.00
245_N248_E2.6151.00
256_E439_P2.5971.00
379_T383_E2.5891.00
116_A219_L2.5541.00
360_I414_L2.5461.00
116_A192_V2.4621.00
141_H145_T2.4281.00
361_S368_C2.4151.00
249_L252_E2.3031.00
155_E168_D2.2781.00
144_L169_I2.2731.00
413_I427_L2.2061.00
367_P384_R2.1941.00
205_Q209_E2.1911.00
367_P390_Y2.1741.00
343_Y391_S2.1371.00
95_W119_A2.1331.00
89_Q93_A2.1041.00
374_Q377_E2.0941.00
263_K448_D2.0921.00
141_H158_V2.0831.00
271_R275_D2.0591.00
358_Y368_C2.0541.00
127_T190_L2.0131.00
141_H171_V1.9991.00
351_T357_A1.9631.00
373_T381_I1.9581.00
384_R389_E1.9231.00
196_V233_L1.9191.00
266_L447_T1.9061.00
92_L118_Q1.8911.00
130_V172_T1.8851.00
209_E235_D1.8821.00
136_L402_G1.8691.00
174_Y193_V1.8431.00
260_I441_R1.8361.00
342_H410_V1.8221.00
427_L442_L1.7971.00
339_L347_T1.7801.00
125_V189_G1.7781.00
410_V443_Y1.7741.00
84_P118_Q1.7661.00
95_W102_G1.7511.00
367_P381_I1.7351.00
347_T412_I1.7241.00
117_V148_F1.7041.00
142_A383_E1.6871.00
348_I430_I1.6531.00
356_F414_L1.6311.00
338_L412_I1.6251.00
205_Q208_P1.6111.00
447_T450_T1.5921.00
399_L403_I1.5851.00
203_T206_Q1.5831.00
80_V114_F1.5691.00
190_L217_L1.5661.00
257_Y428_G1.5661.00
121_A148_F1.5611.00
354_N372_Q1.5511.00
304_R307_Y1.5451.00
116_A217_L1.5441.00
191_L213_A1.5301.00
144_L156_I1.5161.00
137_L171_V1.5121.00
157_G167_T1.4961.00
175_D178_Y1.4931.00
384_R388_G1.4921.00
349_I392_M1.4841.00
412_I445_L1.4741.00
336_D363_E1.4691.00
193_V199_L1.4671.00
336_D340_K1.4551.00
126_S189_G1.4481.00
206_Q210_M1.4401.00
275_D279_Q1.4291.00
395_T398_V1.4191.00
82_I147_A1.4091.00
108_T221_A1.4021.00
95_W217_L1.4021.00
413_I426_R1.3931.00
300_E303_K1.3861.00
213_A216_R1.3741.00
142_A379_T1.3741.00
346_R407_A1.3711.00
193_V208_P1.3611.00
267_T270_E1.3431.00
143_T146_N1.3391.00
338_L443_Y1.3321.00
191_L211_T1.3321.00
197_H401_E1.3311.00
277_E308_D1.3181.00
262_L443_Y1.3121.00
410_V441_R1.3031.00
204_Y207_I1.3001.00
264_V330_K1.2921.00
377_E381_I1.2921.00
138_N379_T1.2901.00
457_K461_Q1.2891.00
189_G214_P1.2891.00
345_D410_V1.2811.00
198_H401_E1.2801.00
170_T188_F1.2711.00
310_D356_F1.2711.00
458_R461_Q1.2651.00
96_T122_D1.2631.00
254_L257_Y1.2631.00
409_N437_R1.2621.00
204_Y208_P1.2531.00
335_L349_I1.2521.00
309_P312_R1.2461.00
262_L334_T1.2391.00
120_I192_V1.2361.00
370_T373_T1.2171.00
271_R449_D1.2061.00
331_K339_L1.1961.00
363_E366_V1.1961.00
178_Y203_T1.1891.00
102_G217_L1.1881.00
187_Q212_I1.1781.00
356_F359_D1.1781.00
136_L139_Q1.1731.00
177_A208_P1.1671.00
380_E383_E1.1671.00
335_L339_L1.1671.00
295_Q299_Q1.1651.00
82_I114_F1.1651.00
159_L180_Y1.1591.00
382_L386_R1.1571.00
234_E237_I1.1541.00
299_Q303_K1.1511.00
142_A146_N1.1501.00
156_I171_V1.1461.00
130_V177_A1.1461.00
136_L403_I1.1461.00
354_N358_Y1.1441.00
446_I456_S1.1401.00
354_N357_A1.1331.00
83_E89_Q1.1311.00
275_D278_Y1.1311.00
306_S309_P1.1251.00
345_D437_R1.1251.00
85_R433_P1.1191.00
335_L412_I1.1091.00
131_V137_L1.1061.00
357_A368_C1.1031.00
120_I190_L1.1021.00
385_F408_A1.1011.00
208_P211_T1.0941.00
199_L236_L1.0931.00
283_D287_N1.0871.00
357_A361_S1.0861.00
264_V334_T1.0841.00
157_G170_T1.0781.00
128_L188_F1.0751.00
203_T207_I1.0731.00
178_Y204_Y1.0681.00
413_I444_E1.0671.00
190_L215_Y1.0671.00
454_Y457_K1.0651.00
221_A428_G1.0621.00
335_L414_L1.0601.00
93_A97_D1.0561.00
243_E248_E1.0551.00
187_Q214_P1.0521.00
266_L274_Y1.0511.00
264_V447_T1.0481.00
92_L119_A1.0471.00
243_E246_V1.0391.00
128_L191_L1.0371.00
308_D311_G1.0361.00
395_T399_L1.0341.00
265_D271_R1.0331.00
338_L445_L1.0271.00
268_P272_N1.0261.00
74_L77_T1.0251.00
335_L360_I1.0251.00
430_I440_A1.0251.00
218_G233_L1.0241.00
347_T410_V1.0241.00
227_D230_H1.0181.00
353_N356_F1.0121.00
346_R388_G1.0111.00
120_I144_L1.0091.00
258_E441_R1.0051.00
369_I373_T1.0041.00
226_T230_H1.0011.00
119_A190_L1.0001.00
381_I384_R0.9931.00
351_T360_I0.9891.00
86_D89_Q0.9881.00
338_L342_H0.9871.00
306_S310_D0.9861.00
305_T312_R0.9761.00
94_A102_G0.9701.00
417_S422_Q0.9661.00
175_D198_H0.9651.00
346_R350_F0.9641.00
181_I210_M0.9631.00
296_D299_Q0.9581.00
423_Y444_E0.9581.00
295_Q298_Y0.9571.00
129_V169_I0.9541.00
359_D362_Q0.9521.00
361_S394_V0.9521.00
344_N391_S0.9511.00
77_T80_V0.9471.00
334_T338_L0.9451.00
388_G407_A0.9411.00
364_F394_V0.9361.00
417_S423_Y0.9361.00
368_C372_Q0.9361.00
359_D363_E0.9351.00
299_Q302_L0.9331.00
133_T175_D0.9321.00
206_Q209_E0.9291.00
225_R419_S0.9281.00
448_D453_Q0.9261.00
216_R236_L0.9241.00
342_H345_D0.9231.00
101_R237_I0.9221.00
368_C371_H0.9211.00
158_V171_V0.9151.00
308_D312_R0.9091.00
236_L239_P0.9071.00
246_V428_G0.9071.00
296_D300_E0.9061.00
453_Q457_K0.9001.00
397_Q422_Q0.8931.00
272_N276_D0.8911.00
240_V243_E0.8891.00
358_Y362_Q0.8881.00
298_Y301_F0.8841.00
332_L336_D0.8831.00
155_E158_V0.8801.00
176_S179_R0.8791.00
180_Y183_E0.8771.00
285_L289_D0.8771.00
127_T189_G0.8741.00
138_N142_A0.8731.00
333_D363_E0.8731.00
106_L115_L0.8711.00
141_H156_I0.8691.00
266_L450_T0.8681.00
428_G431_L0.8661.00
388_G391_S0.8641.00
339_L343_Y0.8631.00
123_A190_L0.8611.00
138_N141_H0.8601.00
373_T378_R0.8581.00
192_V219_L0.8551.00
362_Q366_V0.8481.00
276_D280_I0.8481.00
123_A189_G0.8421.00
196_V220_T0.8371.00
143_T404_D0.8361.00
167_T170_T0.8361.00
133_T173_T0.8361.00
261_H446_I0.8351.00
270_E330_K0.8341.00
137_L158_V0.8331.00
350_F426_R0.8331.00
342_H347_T0.8311.00
369_I398_V0.8281.00
400_D422_Q0.8271.00
207_I211_T0.8231.00
172_T176_S0.8221.00
86_D90_A0.8221.00
411_G442_L0.8201.00
129_V140_W0.8181.00
456_S460_R0.8181.00
396_S426_R0.8171.00
106_L244_E0.8161.00
358_Y370_T0.8161.00
384_R390_Y0.8151.00
103_S233_L0.8141.00
234_E239_P0.8131.00
456_S459_R0.8121.00
106_L110_S0.8111.00
80_V121_A0.8061.00
297_G300_E0.8061.00
457_K460_R0.8041.00
327_T331_K0.8031.00
307_Y311_G0.8001.00
70_A73_D0.7971.00
128_L172_T0.7961.00
69_R72_R0.7951.00
132_P136_L0.7941.00
84_P92_L0.7911.00
298_Y302_L0.7911.00
139_Q143_T0.7911.00
287_N290_V0.7891.00
386_R406_P0.7791.00
172_T177_A0.7781.00
300_E304_R0.7761.00
200_P230_H0.7711.00
231_N235_D0.7651.00
98_H102_G0.7641.00
92_L122_D0.7601.00
107_P431_L0.7591.00
376_D380_E0.7581.00
331_K335_L0.7581.00
307_Y312_R0.7551.00
331_K336_D0.7551.00
350_F411_G0.7531.00
371_H378_R0.7521.00
131_V173_T0.7521.00
337_N341_R0.7511.00
328_A333_D0.7491.00
382_L403_I0.7491.00
270_E274_Y0.7421.00
114_F143_T0.7411.00
332_L363_E0.7381.00
454_Y458_R0.7361.00
91_A106_L0.7351.00
114_F118_Q0.7261.00
340_K343_Y0.7261.00
302_L311_G0.7251.00
70_A74_L0.7251.00
303_K306_S0.7211.00
120_I169_I0.7201.00
369_I399_L0.7191.00
328_A331_K0.7181.00
135_D398_V0.7181.00
331_K343_Y0.7151.00
205_Q232_V0.7151.00
137_L160_G0.7131.00
108_T428_G0.7131.00
259_T444_E0.7131.00
241_V244_E0.7121.00
154_H168_D0.7111.00
367_P371_H0.7101.00
286_D289_D0.7101.00
283_D286_D0.7091.00
276_D279_Q0.7081.00
261_H444_E0.7081.00
100_R215_Y0.7081.00
305_T308_D0.7071.00
280_I284_Y0.7041.00
347_T351_T0.7041.00
304_R311_G0.7031.00
358_Y361_S0.7031.00
278_Y281_Y0.7021.00
347_T350_F0.7011.00
273_Q277_E0.7001.00
451_M455_V0.6991.00
303_K307_Y0.6981.00
71_Y74_L0.6981.00
416_G444_E0.6971.00
246_V249_L0.6961.00
260_I443_Y0.6941.00
144_L171_V0.6941.00
242_Y245_N0.6921.00
344_N347_T0.6921.00
90_A93_A0.6921.00
286_D290_V0.6911.00
305_T309_P0.6901.00
352_A356_F0.6891.00
231_N234_E0.6891.00
142_A386_R0.6891.00
65_H68_A0.6881.00
143_T147_A0.6881.00
95_W104_V0.6841.00
191_L216_R0.6831.00
131_V171_V0.6811.00
264_V270_E0.6791.00
425_Q429_R0.6791.00
356_F415_S0.6791.00
409_N441_R0.6781.00
235_D238_G0.6781.00
299_Q304_R0.6771.00
75_D78_P0.6771.00
155_E166_V0.6771.00
156_I159_L0.6751.00
267_T330_K0.6751.00
69_R73_D0.6731.00
244_E248_E0.6731.00
263_K453_Q0.6701.00
80_V118_Q0.6691.00
158_V162_G0.6691.00
181_I185_G0.6691.00
269_E272_N0.6671.00
113_T129_V0.6651.00
124_S189_G0.6631.00
101_R216_R0.6621.00
297_G301_F0.6621.00
416_G459_R0.6591.00
351_T354_N0.6571.00
242_Y246_V0.6571.00
117_V169_I0.6561.00
302_L451_M0.6551.00
360_I363_E0.6541.00
327_T333_D0.6511.00
240_V244_E0.6511.00
155_E167_T0.6501.00
317_A321_A0.6491.00
261_H456_S0.6491.00
332_L360_I0.6481.00
357_A394_V0.6481.00
351_T356_F0.6451.00
118_Q121_A0.6451.00
355_D358_Y0.6431.00
368_C373_T0.6421.00
358_Y372_Q0.6421.00
413_I417_S0.6401.00
192_V217_L0.6391.00
197_H220_T0.6381.00
416_G456_S0.6381.00
404_D433_P0.6371.00
429_R432_R0.6361.00
244_E247_D0.6361.00
259_T427_L0.6351.00
334_T342_H0.6351.00
131_V136_L0.6351.00
124_S127_T0.6341.00
347_T391_S0.6341.00
131_V140_W0.6311.00
204_Y209_E0.6271.00
76_L79_A0.6261.00
383_E386_R0.6251.00
114_F147_A0.6221.00
386_R404_D0.6221.00
126_S168_D0.6201.00
157_G160_G0.6201.00
68_A71_Y0.6201.00
323_E327_T0.6191.00
110_S115_L0.6191.00
233_L239_P0.6181.00
339_L342_H0.6171.00
279_Q283_D0.6171.00
193_V236_L0.6171.00
331_K342_H0.6171.00
303_K353_N0.6171.00
232_V235_D0.6161.00
313_R317_A0.6151.00
197_H425_Q0.6151.00
304_R310_D0.6151.00
298_Y303_K0.6121.00
232_V236_L0.6121.00
342_H412_I0.6111.00
352_A357_A0.6111.00
104_V115_L0.6081.00
362_Q365_I0.6071.00
104_V219_L0.6041.00
373_T377_E0.6041.00
306_S312_R0.6021.00
73_D76_L0.5991.00
71_Y76_L0.5971.00
285_L288_H0.5941.00
232_V238_G0.5931.00
319_Q322_E0.5921.00
419_S422_Q0.5921.00
157_G163_S0.5911.00
203_T208_P0.5911.00
87_Y115_L0.5911.00
281_Y284_Y0.5891.00
266_L271_R0.5881.00
158_V161_G0.5871.00
427_L444_E0.5861.00
326_R333_D0.5861.00
203_T210_M0.5841.00
324_I327_T0.5841.00
232_V237_I0.5841.00
332_L414_L0.5831.00
306_S455_V0.5801.00
353_N357_A0.5801.00
142_A145_T0.5791.00
330_K333_D0.5791.00
417_S426_R0.5791.00
307_Y310_D0.5781.00
159_L162_G0.5771.00
350_F357_A0.5761.00
135_D403_I0.5761.00
116_A120_I0.5741.00
296_D301_F0.5741.00
281_Y290_V0.5731.00
180_Y184_Y0.5711.00
198_H204_Y0.5711.00
240_V246_V0.5691.00
311_G359_D0.5681.00
241_V245_N0.5681.00
397_Q417_S0.5681.00
284_Y288_H0.5671.00
352_A396_S0.5671.00
284_Y287_N0.5651.00
382_L405_V0.5651.00
127_T192_V0.5641.00
68_A72_R0.5631.00
261_H460_R0.5621.00
364_F392_M0.5621.00
346_R409_N0.5611.00
349_I394_V0.5601.00
273_Q308_D0.5590.99
274_Y277_E0.5590.99
333_D340_K0.5580.99
273_Q276_D0.5570.99
295_Q300_E0.5550.99
336_D339_L0.5550.99
334_T445_L0.5530.99
72_R76_L0.5520.99
260_I263_K0.5520.99
274_Y450_T0.5490.99
351_T415_S0.5490.99
121_A150_D0.5490.99
207_I210_M0.5470.99
104_V217_L0.5460.99
139_Q428_G0.5460.99
277_E283_D0.5430.99
65_H70_A0.5430.99
175_D179_R0.5420.99
408_A430_I0.5420.99
177_A181_I0.5410.99
76_L80_V0.5400.99
260_I264_V0.5390.99
117_V143_T0.5380.99
125_V187_Q0.5370.99
191_L236_L0.5370.99
133_T375_T0.5360.99
357_A364_F0.5350.99
323_E326_R0.5330.99
274_Y278_Y0.5320.99
424_A427_L0.5320.99
430_I442_L0.5290.99
65_H69_R0.5280.99
177_A184_Y0.5270.99
330_K334_T0.5250.99
261_H265_D0.5240.99
272_N275_D0.5210.99
348_I408_A0.5210.99
234_E240_V0.5210.99
407_A435_E0.5190.99
306_S311_G0.5190.99
327_T339_L0.5180.99
269_E328_A0.5180.99
356_F360_I0.5170.99
409_N435_E0.5160.99
156_I160_G0.5150.99
413_I416_G0.5150.99
87_Y106_L0.5140.99
270_E273_Q0.5120.99
277_E285_L0.5110.99
413_I423_Y0.5100.99
181_I207_I0.5100.99
371_H377_E0.5100.99
79_A82_I0.5090.99
318_K321_A0.5080.99
345_D348_I0.5080.99
360_I394_V0.5070.99
135_D369_I0.5070.99
197_H225_R0.5070.99
348_I411_G0.5060.99
263_K446_I0.5050.99
338_L341_R0.5050.99
130_V174_Y0.5050.99
105_V223_Y0.5040.99
176_S180_Y0.5020.99
202_P232_V0.5020.99
126_S188_F0.5010.99
319_Q325_A0.5010.99
305_T311_G0.5000.99
345_D441_R0.5000.99
65_H71_Y0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mwyW 2 0.9467 100 0.289 Contact Map
1z3iX 4 0.9211 100 0.311 Contact Map
1z63A 1 0.8166 100 0.316 Contact Map
2fwrA 1 0.9275 100 0.323 Contact Map
4a2wA 1 0.7974 100 0.412 Contact Map
4a2qA 1 0.823 100 0.414 Contact Map
1wp9A 1 0.806 100 0.415 Contact Map
2ykgA 1 0.742 100 0.426 Contact Map
2ocaA 1 0.8891 100 0.426 Contact Map
3dmqA 1 0.9574 100 0.429 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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