GREMLIN Database
O51987 - Uncharacterized protein
UniProt: O51987 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 193 (159)
Sequences: 193 (144)
Seq/√Len: 11.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
40_A76_L4.0810.99
102_L112_L2.5270.88
127_E133_E2.5240.88
119_M165_L2.5000.88
36_V59_S2.4350.86
114_D130_F2.4280.86
132_V159_A2.1770.79
118_D131_D2.1580.78
32_G59_S2.0410.74
125_D132_V2.0350.74
34_D174_F1.9870.72
138_L159_A1.9000.68
128_D136_N1.8280.65
66_V70_L1.7800.63
129_E132_V1.7700.63
33_E66_V1.7680.63
131_D180_D1.7630.62
168_R172_V1.7350.61
93_R97_Q1.7310.61
81_S108_T1.7260.61
120_K169_I1.7190.60
129_E137_Q1.6880.59
90_D96_M1.6870.59
96_M103_R1.6780.58
130_F158_I1.5250.51
71_V118_D1.5250.51
21_N52_I1.5130.50
128_D131_D1.5030.50
94_Q159_A1.5000.50
94_Q102_L1.4820.49
118_D136_N1.4750.49
108_T111_E1.4440.47
116_L169_I1.4380.47
151_E154_R1.4170.46
81_S159_A1.3990.45
73_D93_R1.3770.44
43_L116_L1.3750.44
46_P87_Y1.3680.43
45_E51_W1.3680.43
59_S62_P1.3540.43
78_R99_A1.3530.43
33_E70_L1.3400.42
98_E156_P1.3380.42
36_V44_S1.3350.42
39_T110_E1.3010.40
71_V76_L1.2860.40
59_S70_L1.2830.39
110_E128_D1.2730.39
133_E154_R1.2720.39
34_D62_P1.2600.38
51_W125_D1.2550.38
48_T86_T1.2330.37
80_D176_I1.2050.36
32_G138_L1.2040.36
125_D128_D1.2040.36
71_V148_D1.1980.35
128_D151_E1.1930.35
54_S118_D1.1890.35
106_G146_D1.1750.34
58_W62_P1.1750.34
28_R154_R1.1640.34
39_T70_L1.1600.34
93_R96_M1.1590.34
127_E134_S1.1560.34
125_D146_D1.1540.34
62_P66_V1.1530.33
64_K135_P1.1510.33
116_L156_P1.1450.33
27_E57_G1.1420.33
65_R68_E1.1390.33
36_V70_L1.1210.32
129_E154_R1.1060.31
36_V69_R1.1050.31
146_D150_D1.1020.31
28_R124_R1.0750.30
31_T65_R1.0720.30
54_S133_E1.0670.30
77_H108_T1.0470.29
117_A145_G1.0390.29
42_Q179_W1.0350.29
52_I108_T1.0330.28
25_L134_S1.0310.28
31_T48_T1.0270.28
35_R59_S1.0240.28
49_A127_E1.0210.28
31_T36_V1.0180.28
140_G160_R1.0140.28
37_R95_A1.0100.28
126_W158_I1.0070.27
111_E133_E1.0050.27
90_D138_L0.9910.27
33_E153_D0.9890.27
130_F157_E0.9890.27
60_H64_K0.9810.26
40_A43_L0.9740.26
123_I165_L0.9660.26
23_V125_D0.9630.26
58_W63_T0.9620.26
51_W150_D0.9590.26
121_T132_V0.9480.25
136_N154_R0.9390.25
42_Q96_M0.9370.25
84_H93_R0.9360.25
121_T129_E0.9330.25
74_G89_P0.9300.25
82_G137_Q0.9260.24
64_K98_E0.9200.24
72_D148_D0.9200.24
47_R90_D0.9070.24
47_R138_L0.8970.23
82_G144_E0.8960.23
54_S57_G0.8920.23
108_T145_G0.8890.23
113_T127_E0.8850.23
34_D68_E0.8840.23
125_D134_S0.8820.23
133_E146_D0.8800.23
90_D93_R0.8770.23
78_R154_R0.8750.23
33_E65_R0.8740.23
99_A107_H0.8680.22
21_N105_S0.8660.22
92_R126_W0.8560.22
89_P94_Q0.8540.22
84_H138_L0.8430.22
89_P159_A0.8350.21
21_N28_R0.8320.21
123_I169_I0.8300.21
41_R95_A0.8290.21
54_S137_Q0.8280.21
58_W130_F0.8270.21
41_R86_T0.8260.21
64_K127_E0.8230.21
144_E155_R0.8210.21
129_E158_I0.8110.20
110_E127_E0.8110.20
26_M66_V0.8030.20
64_K164_H0.7940.20
146_D154_R0.7930.20
45_E167_R0.7920.20
54_S177_R0.7850.20
35_R58_W0.7730.19
109_V179_W0.7690.19
94_Q138_L0.7600.19
96_M138_L0.7540.19
64_K89_P0.7470.19
119_M172_V0.7470.19
49_A129_E0.7450.18
37_R84_H0.7430.18
33_E61_E0.7390.18
31_T173_G0.7370.18
163_E172_V0.7370.18
97_Q168_R0.7370.18
29_Q122_Q0.7350.18
24_G146_D0.7310.18
101_R106_G0.7270.18
123_I149_A0.7270.18
39_T56_A0.7250.18
111_E148_D0.7250.18
162_W175_A0.7230.18
44_S103_R0.7190.18
72_D125_D0.7190.18
58_W100_M0.7180.18
54_S129_E0.7160.18
112_L166_Q0.7150.18
53_A162_W0.7130.18
72_D77_H0.7110.17
131_D166_Q0.7090.17
111_E171_I0.7080.17
69_R92_R0.7070.17
46_P126_W0.7070.17
30_T150_D0.7010.17
89_P139_R0.6980.17
96_M100_M0.6960.17
66_V69_R0.6950.17
137_Q170_Q0.6940.17
128_D133_E0.6920.17
136_N166_Q0.6890.17
117_A159_A0.6870.17
115_R168_R0.6870.17
75_I93_R0.6870.17
77_H88_Y0.6840.17
28_R101_R0.6840.17
135_P166_Q0.6790.17
96_M119_M0.6770.17
25_L57_G0.6720.16
75_I135_P0.6620.16
102_L145_G0.6600.16
54_S79_D0.6490.16
89_P126_W0.6490.16
84_H172_V0.6480.16
45_E134_S0.6430.16
154_R163_E0.6410.16
99_A134_S0.6390.16
113_T126_W0.6390.16
99_A102_L0.6390.16
132_V143_A0.6320.15
109_V115_R0.6300.15
57_G170_Q0.6280.15
29_Q90_D0.6270.15
79_D132_V0.6210.15
131_D136_N0.6200.15
36_V57_G0.6140.15
57_G117_A0.6130.15
129_E144_E0.6100.15
99_A109_V0.6100.15
32_G70_L0.6010.15
31_T34_D0.6010.15
123_I126_W0.5970.14
34_D109_V0.5950.14
95_A176_I0.5940.14
39_T52_I0.5920.14
140_G164_H0.5920.14
122_Q126_W0.5900.14
123_I127_E0.5890.14
124_R151_E0.5810.14
131_D144_E0.5700.14
58_W138_L0.5700.14
66_V174_F0.5630.14
40_A127_E0.5590.14
27_E160_R0.5580.14
90_D94_Q0.5540.13
25_L171_I0.5510.13
52_I110_E0.5500.13
80_D123_I0.5470.13
29_Q88_Y0.5430.13
26_M70_L0.5420.13
28_R136_N0.5350.13
94_Q176_I0.5250.13
28_R48_T0.5220.13
82_G122_Q0.5200.13
110_E114_D0.5110.13
64_K156_P0.5060.12
43_L110_E0.5050.12
165_L169_I0.5030.12
59_S151_E0.5010.12
163_E179_W0.5010.12
24_G54_S0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1qbjA 1 0.3316 97.9 0.854 Contact Map
1r1uA 2 0.4922 97.6 0.864 Contact Map
2fu4A 2 0.3834 97.5 0.867 Contact Map
1sfuA 1 0.3523 97.4 0.869 Contact Map
1qgpA 1 0.3834 97.4 0.869 Contact Map
4g6qA 4 0.6788 97.3 0.872 Contact Map
1oyiA 1 0.3161 97.2 0.873 Contact Map
2mh2A 1 0.3109 97 0.876 Contact Map
3pqkA 2 0.5181 96.9 0.879 Contact Map
1r1tA 2 0.4611 96.9 0.879 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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