O51987 - HALSA - GREMLIN Contacts

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O51987 - Uncharacterized protein

UniProt:	O51987	Sequences: MASTYIKTKRERCCMTEDESNSVGLMERQTTGEDRVRMTARQLSEPRTANWIASEAGWSHEPTKRVLERLVDDGILHRDDSGTHTTYYPDHRRQAMQEAMRLRDSGHTVEELTDRLADMKTQIRDWEDEFDVESPNQLRGTLAEGDLDADEEDRRPEIAREWEHLQRRIQIVGFAIREWDFLAPTTEPAEASS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	193 (159)
Sequences:	193 (144)
Seq/√Len:	11.4

HALSA - O51987 Q9HHK1 Q9HHH4 Q9HHH1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
40_A	76_L	4.081	0.99
102_L	112_L	2.527	0.88
127_E	133_E	2.524	0.88
119_M	165_L	2.500	0.88
36_V	59_S	2.435	0.86
114_D	130_F	2.428	0.86
132_V	159_A	2.177	0.79
118_D	131_D	2.158	0.78
32_G	59_S	2.041	0.74
125_D	132_V	2.035	0.74
34_D	174_F	1.987	0.72
138_L	159_A	1.900	0.68
128_D	136_N	1.828	0.65
66_V	70_L	1.780	0.63
129_E	132_V	1.770	0.63
33_E	66_V	1.768	0.63
131_D	180_D	1.763	0.62
168_R	172_V	1.735	0.61
93_R	97_Q	1.731	0.61
81_S	108_T	1.726	0.61
120_K	169_I	1.719	0.60
129_E	137_Q	1.688	0.59
90_D	96_M	1.687	0.59
96_M	103_R	1.678	0.58
130_F	158_I	1.525	0.51
71_V	118_D	1.525	0.51
21_N	52_I	1.513	0.50
128_D	131_D	1.503	0.50
94_Q	159_A	1.500	0.50
94_Q	102_L	1.482	0.49
118_D	136_N	1.475	0.49
108_T	111_E	1.444	0.47
116_L	169_I	1.438	0.47
151_E	154_R	1.417	0.46
81_S	159_A	1.399	0.45
73_D	93_R	1.377	0.44
43_L	116_L	1.375	0.44
46_P	87_Y	1.368	0.43
45_E	51_W	1.368	0.43
59_S	62_P	1.354	0.43
78_R	99_A	1.353	0.43
33_E	70_L	1.340	0.42
98_E	156_P	1.338	0.42
36_V	44_S	1.335	0.42
39_T	110_E	1.301	0.40
71_V	76_L	1.286	0.40
59_S	70_L	1.283	0.39
110_E	128_D	1.273	0.39
133_E	154_R	1.272	0.39
34_D	62_P	1.260	0.38
51_W	125_D	1.255	0.38
48_T	86_T	1.233	0.37
80_D	176_I	1.205	0.36
32_G	138_L	1.204	0.36
125_D	128_D	1.204	0.36
71_V	148_D	1.198	0.35
128_D	151_E	1.193	0.35
54_S	118_D	1.189	0.35
106_G	146_D	1.175	0.34
58_W	62_P	1.175	0.34
28_R	154_R	1.164	0.34
39_T	70_L	1.160	0.34
93_R	96_M	1.159	0.34
127_E	134_S	1.156	0.34
125_D	146_D	1.154	0.34
62_P	66_V	1.153	0.33
64_K	135_P	1.151	0.33
116_L	156_P	1.145	0.33
27_E	57_G	1.142	0.33
65_R	68_E	1.139	0.33
36_V	70_L	1.121	0.32
129_E	154_R	1.106	0.31
36_V	69_R	1.105	0.31
146_D	150_D	1.102	0.31
28_R	124_R	1.075	0.30
31_T	65_R	1.072	0.30
54_S	133_E	1.067	0.30
77_H	108_T	1.047	0.29
117_A	145_G	1.039	0.29
42_Q	179_W	1.035	0.29
52_I	108_T	1.033	0.28
25_L	134_S	1.031	0.28
31_T	48_T	1.027	0.28
35_R	59_S	1.024	0.28
49_A	127_E	1.021	0.28
31_T	36_V	1.018	0.28
140_G	160_R	1.014	0.28
37_R	95_A	1.010	0.28
126_W	158_I	1.007	0.27
111_E	133_E	1.005	0.27
90_D	138_L	0.991	0.27
33_E	153_D	0.989	0.27
130_F	157_E	0.989	0.27
60_H	64_K	0.981	0.26
40_A	43_L	0.974	0.26
123_I	165_L	0.966	0.26
23_V	125_D	0.963	0.26
58_W	63_T	0.962	0.26
51_W	150_D	0.959	0.26
121_T	132_V	0.948	0.25
136_N	154_R	0.939	0.25
42_Q	96_M	0.937	0.25
84_H	93_R	0.936	0.25
121_T	129_E	0.933	0.25
74_G	89_P	0.930	0.25
82_G	137_Q	0.926	0.24
64_K	98_E	0.920	0.24
72_D	148_D	0.920	0.24
47_R	90_D	0.907	0.24
47_R	138_L	0.897	0.23
82_G	144_E	0.896	0.23
54_S	57_G	0.892	0.23
108_T	145_G	0.889	0.23
113_T	127_E	0.885	0.23
34_D	68_E	0.884	0.23
125_D	134_S	0.882	0.23
133_E	146_D	0.880	0.23
90_D	93_R	0.877	0.23
78_R	154_R	0.875	0.23
33_E	65_R	0.874	0.23
99_A	107_H	0.868	0.22
21_N	105_S	0.866	0.22
92_R	126_W	0.856	0.22
89_P	94_Q	0.854	0.22
84_H	138_L	0.843	0.22
89_P	159_A	0.835	0.21
21_N	28_R	0.832	0.21
123_I	169_I	0.830	0.21
41_R	95_A	0.829	0.21
54_S	137_Q	0.828	0.21
58_W	130_F	0.827	0.21
41_R	86_T	0.826	0.21
64_K	127_E	0.823	0.21
144_E	155_R	0.821	0.21
129_E	158_I	0.811	0.20
110_E	127_E	0.811	0.20
26_M	66_V	0.803	0.20
64_K	164_H	0.794	0.20
146_D	154_R	0.793	0.20
45_E	167_R	0.792	0.20
54_S	177_R	0.785	0.20
35_R	58_W	0.773	0.19
109_V	179_W	0.769	0.19
94_Q	138_L	0.760	0.19
96_M	138_L	0.754	0.19
64_K	89_P	0.747	0.19
119_M	172_V	0.747	0.19
49_A	129_E	0.745	0.18
37_R	84_H	0.743	0.18
33_E	61_E	0.739	0.18
31_T	173_G	0.737	0.18
163_E	172_V	0.737	0.18
97_Q	168_R	0.737	0.18
29_Q	122_Q	0.735	0.18
24_G	146_D	0.731	0.18
101_R	106_G	0.727	0.18
123_I	149_A	0.727	0.18
39_T	56_A	0.725	0.18
111_E	148_D	0.725	0.18
162_W	175_A	0.723	0.18
44_S	103_R	0.719	0.18
72_D	125_D	0.719	0.18
58_W	100_M	0.718	0.18
54_S	129_E	0.716	0.18
112_L	166_Q	0.715	0.18
53_A	162_W	0.713	0.18
72_D	77_H	0.711	0.17
131_D	166_Q	0.709	0.17
111_E	171_I	0.708	0.17
69_R	92_R	0.707	0.17
46_P	126_W	0.707	0.17
30_T	150_D	0.701	0.17
89_P	139_R	0.698	0.17
96_M	100_M	0.696	0.17
66_V	69_R	0.695	0.17
137_Q	170_Q	0.694	0.17
128_D	133_E	0.692	0.17
136_N	166_Q	0.689	0.17
117_A	159_A	0.687	0.17
115_R	168_R	0.687	0.17
75_I	93_R	0.687	0.17
77_H	88_Y	0.684	0.17
28_R	101_R	0.684	0.17
135_P	166_Q	0.679	0.17
96_M	119_M	0.677	0.17
25_L	57_G	0.672	0.16
75_I	135_P	0.662	0.16
102_L	145_G	0.660	0.16
54_S	79_D	0.649	0.16
89_P	126_W	0.649	0.16
84_H	172_V	0.648	0.16
45_E	134_S	0.643	0.16
154_R	163_E	0.641	0.16
99_A	134_S	0.639	0.16
113_T	126_W	0.639	0.16
99_A	102_L	0.639	0.16
132_V	143_A	0.632	0.15
109_V	115_R	0.630	0.15
57_G	170_Q	0.628	0.15
29_Q	90_D	0.627	0.15
79_D	132_V	0.621	0.15
131_D	136_N	0.620	0.15
36_V	57_G	0.614	0.15
57_G	117_A	0.613	0.15
129_E	144_E	0.610	0.15
99_A	109_V	0.610	0.15
32_G	70_L	0.601	0.15
31_T	34_D	0.601	0.15
123_I	126_W	0.597	0.14
34_D	109_V	0.595	0.14
95_A	176_I	0.594	0.14
39_T	52_I	0.592	0.14
140_G	164_H	0.592	0.14
122_Q	126_W	0.590	0.14
123_I	127_E	0.589	0.14
124_R	151_E	0.581	0.14
131_D	144_E	0.570	0.14
58_W	138_L	0.570	0.14
66_V	174_F	0.563	0.14
40_A	127_E	0.559	0.14
27_E	160_R	0.558	0.14
90_D	94_Q	0.554	0.13
25_L	171_I	0.551	0.13
52_I	110_E	0.550	0.13
80_D	123_I	0.547	0.13
29_Q	88_Y	0.543	0.13
26_M	70_L	0.542	0.13
28_R	136_N	0.535	0.13
94_Q	176_I	0.525	0.13
28_R	48_T	0.522	0.13
82_G	122_Q	0.520	0.13
110_E	114_D	0.511	0.13
64_K	156_P	0.506	0.12
43_L	110_E	0.505	0.12
165_L	169_I	0.503	0.12
59_S	151_E	0.501	0.12
163_E	179_W	0.501	0.12
24_G	54_S	0.500	0.12

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1qbjA	1	0.3316	97.9	0.854	Contact Map
1r1uA	2	0.4922	97.6	0.864	Contact Map
2fu4A	2	0.3834	97.5	0.867	Contact Map
1sfuA	1	0.3523	97.4	0.869	Contact Map
1qgpA	1	0.3834	97.4	0.869	Contact Map
4g6qA	4	0.6788	97.3	0.872	Contact Map
1oyiA	1	0.3161	97.2	0.873	Contact Map
2mh2A	1	0.3109	97	0.876	Contact Map
3pqkA	2	0.5181	96.9	0.879	Contact Map
1r1tA	2	0.4611	96.9	0.879	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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