GREMLIN Database
O51976 - Uncharacterized protein
UniProt: O51976 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 238 (214)
Sequences: 3145 (2240)
Seq/√Len: 153.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
49_L152_V4.1951.00
87_A155_L4.1511.00
106_S135_M4.0581.00
138_L153_T3.9901.00
51_V63_Y3.9361.00
40_R217_D3.5391.00
27_F134_A3.3481.00
103_L179_E3.2791.00
210_R218_D2.6431.00
121_Q206_E2.5691.00
96_A140_E2.5381.00
175_P178_D2.4561.00
108_G124_R2.4271.00
84_S155_L2.4171.00
53_T61_D2.3491.00
102_C137_G2.3081.00
126_Y203_T2.1521.00
91_R94_R2.1291.00
135_M154_I2.0821.00
126_Y205_Y2.0701.00
125_I166_I1.9221.00
141_V150_P1.8961.00
79_I92_S1.8311.00
81_N167_H1.7921.00
111_E167_H1.7901.00
103_L134_A1.7601.00
26_H179_E1.7391.00
68_L149_I1.7271.00
100_R140_E1.6901.00
125_I163_M1.6771.00
58_A180_E1.6571.00
43_I49_L1.6291.00
104_V152_V1.6101.00
220_T223_E1.5831.00
210_R221_V1.5611.00
144_G148_A1.5541.00
115_R119_P1.5421.00
14_N49_L1.5391.00
88_A97_W1.5351.00
18_V107_S1.5341.00
208_S212_N1.5321.00
109_F163_M1.5271.00
134_A179_E1.5271.00
84_S194_C1.5161.00
82_A153_T1.5051.00
210_R220_T1.4861.00
19_T22_D1.4741.00
160_N170_M1.4711.00
197_Y202_L1.4681.00
51_V152_V1.4641.00
133_F202_L1.4601.00
16_L43_I1.4591.00
127_R131_P1.4561.00
104_V154_I1.4501.00
15_A124_R1.4471.00
21_E25_K1.4211.00
178_D181_T1.3981.00
87_A97_W1.3971.00
173_V202_L1.3861.00
119_P209_T1.3521.00
161_D164_Q1.3421.00
88_A191_E1.3141.00
127_R133_F1.3141.00
157_T196_P1.2751.00
136_A172_V1.2641.00
53_T59_E1.2631.00
162_L200_E1.2561.00
40_R47_E1.2551.00
53_T139_W1.2511.00
18_V132_A1.2361.00
51_V102_C1.2251.00
112_W120_K1.2151.00
104_V137_G1.2131.00
86_T90_K1.2081.00
216_N221_V1.1761.00
176_D179_E1.1751.00
40_R43_I1.1701.00
203_T224_P1.1661.00
14_N106_S1.1621.00
113_Q123_Y1.1551.00
144_G147_S1.1321.00
85_E169_R1.1231.00
162_L202_L1.1171.00
157_T172_V1.1160.99
29_A60_I1.1050.99
103_L174_L1.0980.99
209_T212_N1.0930.99
123_Y206_E1.0740.99
12_G80_I1.0660.99
42_N122_P1.0560.99
81_N111_E1.0560.99
86_T93_F1.0550.99
128_E203_T1.0550.99
95_D98_D1.0490.99
49_L104_V1.0480.99
124_R205_Y1.0340.99
145_E148_A1.0330.99
67_L151_C1.0320.99
64_H75_P1.0290.99
100_R139_W1.0270.99
174_L178_D1.0090.99
133_F179_E1.0080.99
61_D150_P1.0070.99
142_W145_E1.0060.99
51_V104_V1.0060.99
199_E202_L0.9950.99
68_L79_I0.9920.99
125_I204_A0.9900.99
181_T189_E0.9830.99
63_Y150_P0.9800.99
95_D99_S0.9750.99
158_E168_D0.9750.99
102_C139_W0.9740.99
20_Q24_E0.9720.99
50_D60_I0.9660.99
46_G77_E0.9580.98
97_W190_R0.9540.98
162_L204_A0.9470.98
79_I93_F0.9340.98
11_C81_N0.9280.98
17_F107_S0.9250.98
68_L151_C0.9160.98
30_E57_A0.9140.98
218_D221_V0.9070.98
13_R112_W0.8990.98
181_T184_T0.8950.98
161_D165_P0.8910.98
116_D119_P0.8900.98
67_L140_E0.8890.97
46_G64_H0.8830.97
157_T170_M0.8770.97
74_D78_G0.8760.97
42_N112_W0.8750.97
217_D222_I0.8660.97
52_I58_A0.8600.97
157_T160_N0.8600.97
181_T192_E0.8570.97
29_A32_V0.8470.97
115_R118_G0.8460.97
109_F173_V0.8420.97
95_D140_E0.8400.96
110_Y221_V0.8360.96
180_E184_T0.8290.96
53_T150_P0.8210.96
13_R42_N0.8210.96
178_D195_Q0.8180.96
90_K93_F0.8140.96
133_F173_V0.8140.96
137_G153_T0.8120.96
67_L79_I0.8110.96
70_S140_E0.8080.96
96_A100_R0.8080.96
143_E148_A0.7980.95
84_S157_T0.7940.95
11_C167_H0.7930.95
38_A217_D0.7910.95
69_P72_A0.7880.95
26_H131_P0.7860.95
162_L165_P0.7820.95
66_G80_I0.7780.95
113_Q120_K0.7780.95
216_N220_T0.7780.95
112_W122_P0.7770.95
69_P73_D0.7730.94
127_R202_L0.7700.94
109_F160_N0.7700.94
76_G79_I0.7630.94
114_K120_K0.7610.94
175_P201_D0.7590.94
210_R216_N0.7580.94
178_D193_L0.7570.94
16_L50_D0.7560.94
80_I214_S0.7540.94
109_F165_P0.7530.94
198_P201_D0.7530.94
114_K119_P0.7500.93
87_A138_L0.7500.93
154_I171_P0.7490.93
159_P164_Q0.7470.93
44_A47_E0.7460.93
197_Y201_D0.7450.93
70_S95_D0.7410.93
189_E192_E0.7330.93
48_Q62_Q0.7330.93
160_N165_P0.7320.93
75_P149_I0.7280.92
72_A76_G0.7240.92
27_F179_E0.7240.92
65_W101_P0.7220.92
115_R121_Q0.7170.92
11_C111_E0.7170.92
55_R59_E0.7110.92
86_T89_E0.7090.91
128_E200_E0.7060.91
14_N50_D0.7050.91
22_D25_K0.7010.91
207_V211_V0.7010.91
127_R175_P0.7010.91
111_E169_R0.6980.91
107_S124_R0.6870.90
44_A112_W0.6850.90
65_W171_P0.6790.90
106_S154_I0.6760.89
127_R201_D0.6730.89
37_Y50_D0.6710.89
67_L92_S0.6700.89
24_E31_V0.6700.89
205_Y224_P0.6690.89
126_Y130_A0.6620.88
188_D192_E0.6600.88
159_P168_D0.6590.88
208_S211_V0.6590.88
14_N43_I0.6560.88
18_V22_D0.6550.88
52_I105_L0.6520.88
83_R111_E0.6510.88
131_P176_D0.6510.88
160_N196_P0.6500.87
68_L142_W0.6490.87
79_I153_T0.6480.87
158_E161_D0.6440.87
155_L172_V0.6430.87
64_H149_I0.6420.87
49_L65_W0.6410.87
113_Q116_D0.6400.87
54_N58_A0.6390.87
219_A223_E0.6380.86
172_V197_Y0.6300.86
63_Y152_V0.6220.85
155_L194_C0.6210.85
94_R98_D0.6210.85
27_F52_I0.6200.85
21_E30_E0.6190.85
142_W149_I0.6170.85
26_H176_D0.6170.85
12_G112_W0.6150.84
159_P162_L0.6140.84
50_D152_V0.6130.84
166_I204_A0.6110.84
84_S172_V0.6100.84
12_G45_P0.6100.84
14_N104_V0.6100.84
127_R130_A0.6080.84
108_G126_Y0.6070.84
193_L196_P0.6040.83
67_L77_E0.6040.83
206_E224_P0.6030.83
124_R222_I0.6030.83
18_V21_E0.6010.83
28_G180_E0.5990.83
99_S140_E0.5920.82
13_R45_P0.5910.82
15_A108_G0.5870.82
50_D62_Q0.5870.82
85_E158_E0.5850.81
125_I168_D0.5850.81
23_L27_F0.5780.81
166_I170_M0.5780.81
85_E155_L0.5770.81
106_S133_F0.5760.80
82_A93_F0.5760.80
211_V216_N0.5750.80
213_N216_N0.5740.80
160_N173_V0.5740.80
158_E164_Q0.5730.80
42_N211_V0.5720.80
17_F32_V0.5710.80
44_A211_V0.5710.80
107_S132_A0.5700.80
68_L75_P0.5700.80
160_N202_L0.5690.80
89_E92_S0.5690.80
172_V196_P0.5680.79
119_P200_E0.5660.79
127_R132_A0.5660.79
44_A214_S0.5650.79
158_E177_G0.5630.79
29_A58_A0.5630.79
69_P151_C0.5620.79
82_A85_E0.5620.79
136_A174_L0.5620.79
14_N44_A0.5600.79
108_G123_Y0.5600.79
53_T57_A0.5570.78
80_I153_T0.5570.78
10_M13_R0.5540.78
68_L74_D0.5530.78
163_M166_I0.5530.78
110_Y122_P0.5520.78
146_E149_I0.5510.77
52_I180_E0.5480.77
14_N105_L0.5470.77
24_E29_A0.5460.77
67_L82_A0.5460.77
83_R167_H0.5430.76
71_W91_R0.5390.76
15_A110_Y0.5380.76
42_N108_G0.5310.75
122_P125_I0.5310.75
123_Y166_I0.5270.74
113_Q165_P0.5250.74
72_A77_E0.5220.74
14_N152_V0.5220.74
12_G83_R0.5180.73
197_Y200_E0.5150.73
20_Q32_V0.5140.72
27_F183_L0.5140.72
190_R194_C0.5130.72
46_G214_S0.5130.72
41_Y211_V0.5120.72
15_A107_S0.5110.72
187_P191_E0.5090.72
205_Y222_I0.5080.72
216_N219_A0.5070.71
18_V23_L0.5060.71
70_S73_D0.5050.71
115_R123_Y0.5050.71
101_P185_A0.5040.71
82_A138_L0.5030.71
104_V135_M0.5020.71
114_K168_D0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2icuA 1 0.8571 100 0.162 Contact Map
2bdvA 1 0.8529 100 0.173 Contact Map
2f20A 1 0.8992 100 0.177 Contact Map
2aegA 1 0.8445 100 0.204 Contact Map
1zn6A 1 0.8151 100 0.232 Contact Map
2gs0B 1 0.0546 21.6 0.957 Contact Map
3bsuA 1 0.2059 11.9 0.962 Contact Map
2b3gB 2 0.1008 8.1 0.965 Contact Map
3aj1A 5 0.6218 6.7 0.966 Contact Map
1qhkA 1 0.1975 6.2 0.967 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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