O51976 - HALSA - GREMLIN Contacts

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O51976 - Uncharacterized protein

UniProt:	O51976	Sequences: MLTLLEKRDMCGRNALFVTQEDLEKHFGAEVVTDGGYAPRYNIAPGEQLDVITNRAAAEIDQYHWGLLPSWADDPGEGIINARSETAAEKRSFRDAWDSRPCLVLSSGFYEWQKRDSGPKQPYRIYREDAPAFAMAGLWEVWEGEESAIPCVTILTTEPNDLMQPIHDRMPVVLPDGDEETWLTASPDEREELCQPYPEEDLTAYEVSTRVNNSGNDDATVIEPLDHEQSGLDEFSSR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	238 (214)
Sequences:	3145 (2240)
Seq/√Len:	153.1

ECOLI - YEDK
BACSU - YOAM YOBE YOQW
HALSA - O51976 Q9HRI0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
49_L	152_V	4.195	1.00
87_A	155_L	4.151	1.00
106_S	135_M	4.058	1.00
138_L	153_T	3.990	1.00
51_V	63_Y	3.936	1.00
40_R	217_D	3.539	1.00
27_F	134_A	3.348	1.00
103_L	179_E	3.279	1.00
210_R	218_D	2.643	1.00
121_Q	206_E	2.569	1.00
96_A	140_E	2.538	1.00
175_P	178_D	2.456	1.00
108_G	124_R	2.427	1.00
84_S	155_L	2.417	1.00
53_T	61_D	2.349	1.00
102_C	137_G	2.308	1.00
126_Y	203_T	2.152	1.00
91_R	94_R	2.129	1.00
135_M	154_I	2.082	1.00
126_Y	205_Y	2.070	1.00
125_I	166_I	1.922	1.00
141_V	150_P	1.896	1.00
79_I	92_S	1.831	1.00
81_N	167_H	1.792	1.00
111_E	167_H	1.790	1.00
103_L	134_A	1.760	1.00
26_H	179_E	1.739	1.00
68_L	149_I	1.727	1.00
100_R	140_E	1.690	1.00
125_I	163_M	1.677	1.00
58_A	180_E	1.657	1.00
43_I	49_L	1.629	1.00
104_V	152_V	1.610	1.00
220_T	223_E	1.583	1.00
210_R	221_V	1.561	1.00
144_G	148_A	1.554	1.00
115_R	119_P	1.542	1.00
14_N	49_L	1.539	1.00
88_A	97_W	1.535	1.00
18_V	107_S	1.534	1.00
208_S	212_N	1.532	1.00
109_F	163_M	1.527	1.00
134_A	179_E	1.527	1.00
84_S	194_C	1.516	1.00
82_A	153_T	1.505	1.00
210_R	220_T	1.486	1.00
19_T	22_D	1.474	1.00
160_N	170_M	1.471	1.00
197_Y	202_L	1.468	1.00
51_V	152_V	1.464	1.00
133_F	202_L	1.460	1.00
16_L	43_I	1.459	1.00
127_R	131_P	1.456	1.00
104_V	154_I	1.450	1.00
15_A	124_R	1.447	1.00
21_E	25_K	1.421	1.00
178_D	181_T	1.398	1.00
87_A	97_W	1.397	1.00
173_V	202_L	1.386	1.00
119_P	209_T	1.352	1.00
161_D	164_Q	1.342	1.00
88_A	191_E	1.314	1.00
127_R	133_F	1.314	1.00
157_T	196_P	1.275	1.00
136_A	172_V	1.264	1.00
53_T	59_E	1.263	1.00
162_L	200_E	1.256	1.00
40_R	47_E	1.255	1.00
53_T	139_W	1.251	1.00
18_V	132_A	1.236	1.00
51_V	102_C	1.225	1.00
112_W	120_K	1.215	1.00
104_V	137_G	1.213	1.00
86_T	90_K	1.208	1.00
216_N	221_V	1.176	1.00
176_D	179_E	1.175	1.00
40_R	43_I	1.170	1.00
203_T	224_P	1.166	1.00
14_N	106_S	1.162	1.00
113_Q	123_Y	1.155	1.00
144_G	147_S	1.132	1.00
85_E	169_R	1.123	1.00
162_L	202_L	1.117	1.00
157_T	172_V	1.116	0.99
29_A	60_I	1.105	0.99
103_L	174_L	1.098	0.99
209_T	212_N	1.093	0.99
123_Y	206_E	1.074	0.99
12_G	80_I	1.066	0.99
42_N	122_P	1.056	0.99
81_N	111_E	1.056	0.99
86_T	93_F	1.055	0.99
128_E	203_T	1.055	0.99
95_D	98_D	1.049	0.99
49_L	104_V	1.048	0.99
124_R	205_Y	1.034	0.99
145_E	148_A	1.033	0.99
67_L	151_C	1.032	0.99
64_H	75_P	1.029	0.99
100_R	139_W	1.027	0.99
174_L	178_D	1.009	0.99
133_F	179_E	1.008	0.99
61_D	150_P	1.007	0.99
142_W	145_E	1.006	0.99
51_V	104_V	1.006	0.99
199_E	202_L	0.995	0.99
68_L	79_I	0.992	0.99
125_I	204_A	0.990	0.99
181_T	189_E	0.983	0.99
63_Y	150_P	0.980	0.99
95_D	99_S	0.975	0.99
158_E	168_D	0.975	0.99
102_C	139_W	0.974	0.99
20_Q	24_E	0.972	0.99
50_D	60_I	0.966	0.99
46_G	77_E	0.958	0.98
97_W	190_R	0.954	0.98
162_L	204_A	0.947	0.98
79_I	93_F	0.934	0.98
11_C	81_N	0.928	0.98
17_F	107_S	0.925	0.98
68_L	151_C	0.916	0.98
30_E	57_A	0.914	0.98
218_D	221_V	0.907	0.98
13_R	112_W	0.899	0.98
181_T	184_T	0.895	0.98
161_D	165_P	0.891	0.98
116_D	119_P	0.890	0.98
67_L	140_E	0.889	0.97
46_G	64_H	0.883	0.97
157_T	170_M	0.877	0.97
74_D	78_G	0.876	0.97
42_N	112_W	0.875	0.97
217_D	222_I	0.866	0.97
52_I	58_A	0.860	0.97
157_T	160_N	0.860	0.97
181_T	192_E	0.857	0.97
29_A	32_V	0.847	0.97
115_R	118_G	0.846	0.97
109_F	173_V	0.842	0.97
95_D	140_E	0.840	0.96
110_Y	221_V	0.836	0.96
180_E	184_T	0.829	0.96
53_T	150_P	0.821	0.96
13_R	42_N	0.821	0.96
178_D	195_Q	0.818	0.96
90_K	93_F	0.814	0.96
133_F	173_V	0.814	0.96
137_G	153_T	0.812	0.96
67_L	79_I	0.811	0.96
70_S	140_E	0.808	0.96
96_A	100_R	0.808	0.96
143_E	148_A	0.798	0.95
84_S	157_T	0.794	0.95
11_C	167_H	0.793	0.95
38_A	217_D	0.791	0.95
69_P	72_A	0.788	0.95
26_H	131_P	0.786	0.95
162_L	165_P	0.782	0.95
66_G	80_I	0.778	0.95
113_Q	120_K	0.778	0.95
216_N	220_T	0.778	0.95
112_W	122_P	0.777	0.95
69_P	73_D	0.773	0.94
127_R	202_L	0.770	0.94
109_F	160_N	0.770	0.94
76_G	79_I	0.763	0.94
114_K	120_K	0.761	0.94
175_P	201_D	0.759	0.94
210_R	216_N	0.758	0.94
178_D	193_L	0.757	0.94
16_L	50_D	0.756	0.94
80_I	214_S	0.754	0.94
109_F	165_P	0.753	0.94
198_P	201_D	0.753	0.94
114_K	119_P	0.750	0.93
87_A	138_L	0.750	0.93
154_I	171_P	0.749	0.93
159_P	164_Q	0.747	0.93
44_A	47_E	0.746	0.93
197_Y	201_D	0.745	0.93
70_S	95_D	0.741	0.93
189_E	192_E	0.733	0.93
48_Q	62_Q	0.733	0.93
160_N	165_P	0.732	0.93
75_P	149_I	0.728	0.92
72_A	76_G	0.724	0.92
27_F	179_E	0.724	0.92
65_W	101_P	0.722	0.92
115_R	121_Q	0.717	0.92
11_C	111_E	0.717	0.92
55_R	59_E	0.711	0.92
86_T	89_E	0.709	0.91
128_E	200_E	0.706	0.91
14_N	50_D	0.705	0.91
22_D	25_K	0.701	0.91
207_V	211_V	0.701	0.91
127_R	175_P	0.701	0.91
111_E	169_R	0.698	0.91
107_S	124_R	0.687	0.90
44_A	112_W	0.685	0.90
65_W	171_P	0.679	0.90
106_S	154_I	0.676	0.89
127_R	201_D	0.673	0.89
37_Y	50_D	0.671	0.89
67_L	92_S	0.670	0.89
24_E	31_V	0.670	0.89
205_Y	224_P	0.669	0.89
126_Y	130_A	0.662	0.88
188_D	192_E	0.660	0.88
159_P	168_D	0.659	0.88
208_S	211_V	0.659	0.88
14_N	43_I	0.656	0.88
18_V	22_D	0.655	0.88
52_I	105_L	0.652	0.88
83_R	111_E	0.651	0.88
131_P	176_D	0.651	0.88
160_N	196_P	0.650	0.87
68_L	142_W	0.649	0.87
79_I	153_T	0.648	0.87
158_E	161_D	0.644	0.87
155_L	172_V	0.643	0.87
64_H	149_I	0.642	0.87
49_L	65_W	0.641	0.87
113_Q	116_D	0.640	0.87
54_N	58_A	0.639	0.87
219_A	223_E	0.638	0.86
172_V	197_Y	0.630	0.86
63_Y	152_V	0.622	0.85
155_L	194_C	0.621	0.85
94_R	98_D	0.621	0.85
27_F	52_I	0.620	0.85
21_E	30_E	0.619	0.85
142_W	149_I	0.617	0.85
26_H	176_D	0.617	0.85
12_G	112_W	0.615	0.84
159_P	162_L	0.614	0.84
50_D	152_V	0.613	0.84
166_I	204_A	0.611	0.84
84_S	172_V	0.610	0.84
12_G	45_P	0.610	0.84
14_N	104_V	0.610	0.84
127_R	130_A	0.608	0.84
108_G	126_Y	0.607	0.84
193_L	196_P	0.604	0.83
67_L	77_E	0.604	0.83
206_E	224_P	0.603	0.83
124_R	222_I	0.603	0.83
18_V	21_E	0.601	0.83
28_G	180_E	0.599	0.83
99_S	140_E	0.592	0.82
13_R	45_P	0.591	0.82
15_A	108_G	0.587	0.82
50_D	62_Q	0.587	0.82
85_E	158_E	0.585	0.81
125_I	168_D	0.585	0.81
23_L	27_F	0.578	0.81
166_I	170_M	0.578	0.81
85_E	155_L	0.577	0.81
106_S	133_F	0.576	0.80
82_A	93_F	0.576	0.80
211_V	216_N	0.575	0.80
213_N	216_N	0.574	0.80
160_N	173_V	0.574	0.80
158_E	164_Q	0.573	0.80
42_N	211_V	0.572	0.80
17_F	32_V	0.571	0.80
44_A	211_V	0.571	0.80
107_S	132_A	0.570	0.80
68_L	75_P	0.570	0.80
160_N	202_L	0.569	0.80
89_E	92_S	0.569	0.80
172_V	196_P	0.568	0.79
119_P	200_E	0.566	0.79
127_R	132_A	0.566	0.79
44_A	214_S	0.565	0.79
158_E	177_G	0.563	0.79
29_A	58_A	0.563	0.79
69_P	151_C	0.562	0.79
82_A	85_E	0.562	0.79
136_A	174_L	0.562	0.79
14_N	44_A	0.560	0.79
108_G	123_Y	0.560	0.79
53_T	57_A	0.557	0.78
80_I	153_T	0.557	0.78
10_M	13_R	0.554	0.78
68_L	74_D	0.553	0.78
163_M	166_I	0.553	0.78
110_Y	122_P	0.552	0.78
146_E	149_I	0.551	0.77
52_I	180_E	0.548	0.77
14_N	105_L	0.547	0.77
24_E	29_A	0.546	0.77
67_L	82_A	0.546	0.77
83_R	167_H	0.543	0.76
71_W	91_R	0.539	0.76
15_A	110_Y	0.538	0.76
42_N	108_G	0.531	0.75
122_P	125_I	0.531	0.75
123_Y	166_I	0.527	0.74
113_Q	165_P	0.525	0.74
72_A	77_E	0.522	0.74
14_N	152_V	0.522	0.74
12_G	83_R	0.518	0.73
197_Y	200_E	0.515	0.73
20_Q	32_V	0.514	0.72
27_F	183_L	0.514	0.72
190_R	194_C	0.513	0.72
46_G	214_S	0.513	0.72
41_Y	211_V	0.512	0.72
15_A	107_S	0.511	0.72
187_P	191_E	0.509	0.72
205_Y	222_I	0.508	0.72
216_N	219_A	0.507	0.71
18_V	23_L	0.506	0.71
70_S	73_D	0.505	0.71
115_R	123_Y	0.505	0.71
101_P	185_A	0.504	0.71
82_A	138_L	0.503	0.71
104_V	135_M	0.502	0.71
114_K	168_D	0.500	0.70

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2icuA	1	0.8571	100	0.162	Contact Map
2bdvA	1	0.8529	100	0.173	Contact Map
2f20A	1	0.8992	100	0.177	Contact Map
2aegA	1	0.8445	100	0.204	Contact Map
1zn6A	1	0.8151	100	0.232	Contact Map
2gs0B	1	0.0546	21.6	0.957	Contact Map
3bsuA	1	0.2059	11.9	0.962	Contact Map
2b3gB	2	0.1008	8.1	0.965	Contact Map
3aj1A	5	0.6218	6.7	0.966	Contact Map
1qhkA	1	0.1975	6.2	0.967	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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