CDC69 - HALSA - GREMLIN Contacts

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CDC69 - ORC1-type DNA replication protein 9

UniProt:	O51974	Sequences: MTCRRITFVPNFMIRDARVLRAGFVPREVEHRDAEVNHLSSVLEPITNGEPADTAIVTGPSGTGKTCISQFVTERLREEVLNVEATYVNCWRNYTRFRTLYQILDDFGETIDIHRQSTPHDELIDRLQQYDGPRTVIILDEVDQLEDPGIIYDLHSLPHFAVICIANKEEDLFSRVDDRLVSRLRSSEHVRMDKYHDEQLHDILAARVKGGLDQDVITTNQLDRIADAAAGDARLAIGILRTAASKADRESRERITDDILLNAAEDARAQIKQKNLDSLIPHQRLVYDVVREHGPLGPSEIYDHYKRKVDDPRTKRTIRTYLSKMTQYNVLEAEGTSRDREYSLVDSTAPSVTQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	354 (293)
Sequences:	7041 (4357)
Seq/√Len:	254.5

ECOLI - FTSH
BACSU - FTSH
HALSA - CDC69 CDC68 CDC6A CDC66 CDC65 CDC64 Q9HNS7 CDC61 CDC67 CDC62 PAN1 Q9HPV0 CDCH Q9HPG1 Q9HPU1 PAN2 Q9HNK6
SULSO - CDC61 CDC62 CDC63 Q97V06 Q97W25 Q97ZJ7 Q97ZZ9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
19_V	23_G	4.769	1.00
14_I	86_T	4.056	1.00
16_D	84_E	3.781	1.00
15_R	20_L	2.925	1.00
280_I	283_Q	2.492	1.00
200_L	226_A	2.414	1.00
305_Y	309_V	2.376	1.00
91_W	154_L	2.307	1.00
201_H	223_D	2.244	1.00
302_Y	305_Y	2.226	1.00
196_H	199_Q	2.224	1.00
280_I	284_R	2.180	1.00
298_P	302_Y	2.069	1.00
291_R	295_P	1.993	1.00
283_Q	287_Y	1.983	1.00
315_K	319_R	1.953	1.00
197_D	226_A	1.920	1.00
301_I	305_Y	1.920	1.00
322_L	326_T	1.890	1.00
256_T	259_I	1.882	1.00
146_E	149_G	1.876	1.00
281_P	284_R	1.872	1.00
194_K	232_D	1.853	1.00
56_I	142_V	1.846	1.00
265_E	268_R	1.834	1.00
197_D	230_A	1.831	1.00
202_D	205_A	1.818	1.00
280_I	290_V	1.809	1.00
264_A	267_A	1.797	1.00
306_K	310_D	1.790	1.00
296_L	300_E	1.784	1.00
320_T	324_K	1.750	1.00
299_S	303_D	1.748	1.00
286_V	290_V	1.742	1.00
106_D	110_T	1.742	1.00
254_R	257_D	1.734	1.00
260_L	263_A	1.730	1.00
197_D	227_D	1.727	1.00
314_T	317_T	1.724	1.00
284_R	288_D	1.711	1.00
263_A	267_A	1.705	1.00
297_G	302_Y	1.686	1.00
272_K	275_N	1.685	1.00
201_H	222_L	1.684	1.00
302_Y	306_K	1.683	1.00
297_G	305_Y	1.662	1.00
258_D	262_N	1.617	1.00
261_L	265_E	1.609	1.00
275_N	279_L	1.584	1.00
305_Y	308_K	1.573	1.00
297_G	300_E	1.564	1.00
300_E	304_H	1.553	1.00
280_I	287_Y	1.537	1.00
208_V	240_L	1.515	1.00
326_T	329_N	1.513	1.00
201_H	205_A	1.513	1.00
223_D	227_D	1.487	1.00
299_S	302_Y	1.485	1.00
252_R	259_I	1.480	1.00
322_L	325_M	1.472	1.00
279_L	283_Q	1.466	1.00
272_K	290_V	1.447	1.00
259_I	263_A	1.446	1.00
296_L	299_S	1.445	1.00
313_R	321_Y	1.442	1.00
311_D	315_K	1.441	1.00
304_H	307_R	1.437	1.00
313_R	318_I	1.436	1.00
204_L	236_A	1.425	1.00
275_N	290_V	1.418	1.00
11_N	19_V	1.412	1.00
276_L	280_I	1.402	1.00
269_A	272_K	1.397	1.00
283_Q	290_V	1.390	1.00
297_G	301_I	1.374	1.00
257_D	260_L	1.368	1.00
319_R	322_L	1.367	1.00
282_H	289_V	1.363	1.00
313_R	322_L	1.348	1.00
303_D	307_R	1.340	1.00
318_I	322_L	1.336	1.00
208_V	222_L	1.327	1.00
260_L	267_A	1.323	1.00
298_P	301_I	1.313	1.00
262_N	265_E	1.305	1.00
282_H	286_V	1.302	1.00
295_P	299_S	1.298	1.00
313_R	319_R	1.297	1.00
224_R	227_D	1.295	1.00
264_A	268_R	1.294	1.00
33_D	199_Q	1.294	1.00
305_Y	310_D	1.286	1.00
271_I	275_N	1.286	1.00
256_T	263_A	1.274	1.00
258_D	261_L	1.270	1.00
139_L	162_V	1.269	1.00
298_P	305_Y	1.264	1.00
306_K	309_V	1.263	1.00
26_P	74_E	1.263	1.00
19_V	22_A	1.263	1.00
315_K	318_I	1.260	1.00
298_P	309_V	1.258	1.00
142_V	164_C	1.256	1.00
225_I	240_L	1.249	1.00
315_K	322_L	1.248	1.00
314_T	318_I	1.247	1.00
275_N	278_S	1.240	1.00
318_I	325_M	1.235	1.00
257_D	264_A	1.229	1.00
311_D	314_T	1.222	1.00
262_N	266_D	1.222	1.00
281_P	285_L	1.218	1.00
279_L	282_H	1.214	1.00
319_R	323_S	1.197	1.00
256_T	260_L	1.195	1.00
35_E	193_D	1.192	1.00
278_S	282_H	1.191	1.00
16_D	19_V	1.176	1.00
128_Q	131_D	1.173	1.00
294_G	305_Y	1.171	1.00
321_Y	325_M	1.169	1.00
272_K	279_L	1.168	1.00
302_Y	309_V	1.155	1.00
274_K	278_S	1.148	1.00
314_T	319_R	1.131	1.00
297_G	308_K	1.126	1.00
287_Y	290_V	1.125	1.00
282_H	285_L	1.123	1.00
277_D	280_I	1.123	1.00
278_S	288_D	1.122	1.00
273_Q	277_D	1.122	1.00
275_N	280_I	1.121	1.00
317_T	320_T	1.119	1.00
270_Q	274_K	1.116	1.00
272_K	276_L	1.110	1.00
279_L	287_Y	1.109	1.00
32_R	35_E	1.096	1.00
57_V	192_M	1.091	1.00
284_R	287_Y	1.091	1.00
254_R	259_I	1.089	1.00
74_E	78_E	1.088	1.00
68_I	192_M	1.084	1.00
280_I	285_L	1.083	1.00
275_N	283_Q	1.074	1.00
275_N	284_R	1.072	1.00
211_G	214_Q	1.072	1.00
276_L	290_V	1.070	1.00
282_H	290_V	1.069	1.00
257_D	261_L	1.068	1.00
269_A	273_Q	1.067	1.00
197_D	201_H	1.066	1.00
314_T	322_L	1.061	1.00
319_R	325_M	1.060	1.00
250_E	259_I	1.060	1.00
255_I	259_I	1.059	1.00
313_R	325_M	1.056	1.00
20_L	25_V	1.054	1.00
217_I	244_A	1.053	1.00
272_K	280_I	1.047	1.00
326_T	330_V	1.040	1.00
205_A	219_T	1.035	1.00
323_S	327_Q	1.034	1.00
325_M	329_N	1.034	1.00
301_I	309_V	1.032	1.00
318_I	321_Y	1.031	1.00
138_I	165_I	1.027	1.00
22_A	84_E	1.027	1.00
232_D	236_A	1.027	1.00
269_A	275_N	1.022	1.00
259_I	262_N	1.016	1.00
324_K	328_Y	1.014	1.00
314_T	329_N	1.012	1.00
280_I	286_V	1.009	1.00
321_Y	326_T	1.008	1.00
322_L	329_N	1.007	1.00
313_R	326_T	1.006	1.00
250_E	262_N	1.002	1.00
322_L	328_Y	0.996	1.00
263_A	268_R	0.995	1.00
302_Y	310_D	0.992	1.00
260_L	268_R	0.991	1.00
301_I	304_H	0.991	1.00
295_P	302_Y	0.988	1.00
273_Q	280_I	0.986	1.00
153_D	157_L	0.986	1.00
41_S	246_K	0.985	1.00
240_L	260_L	0.983	1.00
93_N	126_R	0.976	1.00
273_Q	282_H	0.975	1.00
90_C	93_N	0.975	1.00
278_S	287_Y	0.960	1.00
246_K	250_E	0.959	1.00
279_L	284_R	0.947	1.00
319_R	326_T	0.945	1.00
204_L	222_L	0.939	1.00
273_Q	283_Q	0.937	1.00
303_D	309_V	0.935	1.00
270_Q	273_Q	0.934	1.00
39_L	190_V	0.932	1.00
278_S	281_P	0.919	1.00
277_D	281_P	0.898	1.00
278_S	284_R	0.895	1.00
304_H	309_V	0.890	1.00
297_G	304_H	0.887	1.00
284_R	290_V	0.877	1.00
299_S	305_Y	0.875	1.00
278_S	285_L	0.873	1.00
300_E	303_D	0.872	1.00
280_I	288_D	0.868	1.00
204_L	225_I	0.865	1.00
303_D	306_K	0.864	1.00
318_I	328_Y	0.862	1.00
315_K	321_Y	0.860	0.99
317_T	321_Y	0.859	0.99
274_K	277_D	0.858	0.99
281_P	288_D	0.858	0.99
38_H	242_T	0.858	0.99
313_R	327_Q	0.853	0.99
275_N	282_H	0.851	0.99
316_R	319_R	0.849	0.99
311_D	322_L	0.845	0.99
78_E	82_N	0.844	0.99
313_R	317_T	0.844	0.99
281_P	287_Y	0.843	0.99
248_D	252_R	0.840	0.99
11_N	14_I	0.837	0.99
279_L	286_V	0.836	0.99
15_R	87_Y	0.836	0.99
323_S	326_T	0.835	0.99
317_T	322_L	0.834	0.99
325_M	328_Y	0.830	0.99
294_G	297_G	0.822	0.99
321_Y	329_N	0.820	0.99
318_I	327_Q	0.819	0.99
263_A	266_D	0.815	0.99
302_Y	308_K	0.810	0.99
316_R	320_T	0.809	0.99
311_D	316_R	0.809	0.99
275_N	289_V	0.808	0.99
282_H	287_Y	0.807	0.99
322_L	327_Q	0.806	0.99
285_L	289_V	0.804	0.99
278_S	283_Q	0.802	0.99
321_Y	328_Y	0.798	0.99
321_Y	324_K	0.795	0.99
311_D	319_R	0.794	0.99
318_I	323_S	0.791	0.99
254_R	264_A	0.789	0.99
314_T	326_T	0.784	0.99
283_Q	288_D	0.784	0.99
282_H	288_D	0.783	0.99
232_D	235_L	0.783	0.99
276_L	285_L	0.782	0.99
279_L	288_D	0.781	0.99
269_A	290_V	0.776	0.99
286_V	289_V	0.773	0.99
311_D	318_I	0.772	0.99
312_P	316_R	0.772	0.99
304_H	308_K	0.769	0.99
327_Q	330_V	0.766	0.99
320_T	323_S	0.764	0.99
61_S	181_V	0.762	0.99
273_Q	276_L	0.761	0.99
314_T	325_M	0.760	0.99
285_L	290_V	0.759	0.99
259_I	268_R	0.757	0.99
319_R	328_Y	0.757	0.99
38_H	41_S	0.756	0.99
260_L	264_A	0.753	0.99
257_D	268_R	0.751	0.99
319_R	329_N	0.751	0.99
318_I	326_T	0.751	0.99
259_I	265_E	0.749	0.99
271_I	274_K	0.746	0.99
272_K	283_Q	0.743	0.99
276_L	287_Y	0.743	0.99
296_L	305_Y	0.741	0.98
254_R	258_D	0.741	0.98
229_A	239_I	0.739	0.98
295_P	309_V	0.739	0.98
254_R	263_A	0.739	0.98
273_Q	281_P	0.738	0.98
200_L	233_A	0.738	0.98
277_D	288_D	0.729	0.98
58_T	189_H	0.723	0.98
273_Q	284_R	0.723	0.98
224_R	228_A	0.722	0.98
325_M	330_V	0.721	0.98
246_K	249_R	0.721	0.98
279_L	289_V	0.719	0.98
275_N	288_D	0.719	0.98
41_S	245_S	0.717	0.98
328_Y	331_L	0.716	0.98
143_D	167_N	0.715	0.98
145_L	152_Y	0.714	0.98
11_N	86_T	0.711	0.98
75_R	82_N	0.710	0.98
127_L	158_P	0.710	0.98
231_G	234_R	0.710	0.98
76_L	85_A	0.708	0.98
257_D	263_A	0.708	0.98
20_L	23_G	0.706	0.98
279_L	290_V	0.705	0.98
257_D	262_N	0.704	0.98
312_P	315_K	0.700	0.98
323_S	329_N	0.699	0.98
259_I	264_A	0.698	0.98
327_Q	331_L	0.697	0.98
314_T	321_Y	0.696	0.98
102_Q	105_D	0.694	0.98
231_G	235_L	0.691	0.98
319_R	330_V	0.688	0.98
296_L	302_Y	0.685	0.97
322_L	330_V	0.681	0.97
271_I	276_L	0.678	0.97
315_K	325_M	0.676	0.97
17_A	87_Y	0.674	0.97
283_Q	286_V	0.674	0.97
257_D	265_E	0.671	0.97
90_C	145_L	0.670	0.97
315_K	328_Y	0.667	0.97
276_L	289_V	0.665	0.97
29_V	36_V	0.665	0.97
229_A	232_D	0.658	0.97
276_L	286_V	0.653	0.97
274_K	280_I	0.652	0.97
269_A	276_L	0.649	0.97
168_K	191_R	0.645	0.96
295_P	305_Y	0.637	0.96
296_L	310_D	0.636	0.96
84_E	134_R	0.634	0.96
277_D	285_L	0.632	0.96
255_I	260_L	0.631	0.96
121_D	125_D	0.631	0.96
60_P	168_K	0.628	0.96
256_T	262_N	0.628	0.96
214_Q	255_I	0.628	0.96
314_T	323_S	0.625	0.96
254_R	267_A	0.622	0.96
299_S	309_V	0.622	0.96
284_R	289_V	0.622	0.96
325_M	331_L	0.622	0.96
272_K	278_S	0.621	0.96
313_R	316_R	0.620	0.95
279_L	285_L	0.618	0.95
277_D	290_V	0.613	0.95
323_S	328_Y	0.612	0.95
274_K	279_L	0.612	0.95
270_Q	283_Q	0.612	0.95
222_L	240_L	0.611	0.95
270_Q	282_H	0.611	0.95
276_L	283_Q	0.610	0.95
276_L	282_H	0.609	0.95
316_R	322_L	0.606	0.95
201_H	226_A	0.606	0.95
272_K	284_R	0.606	0.95
150_I	153_D	0.605	0.95
322_L	331_L	0.605	0.95
314_T	327_Q	0.604	0.95
311_D	317_T	0.603	0.95
319_R	327_Q	0.602	0.95
256_T	268_R	0.601	0.95
218_T	221_Q	0.600	0.95
259_I	267_A	0.597	0.94
315_K	323_S	0.595	0.94
131_D	135_T	0.591	0.94
317_T	326_T	0.590	0.94
312_P	319_R	0.588	0.94
229_A	235_L	0.587	0.94
26_P	29_V	0.587	0.94
255_I	265_E	0.585	0.94
221_Q	224_R	0.585	0.94
271_I	280_I	0.583	0.94
316_R	324_K	0.583	0.94
317_T	327_Q	0.583	0.94
314_T	328_Y	0.583	0.94
218_T	254_R	0.579	0.94
120_H	124_I	0.576	0.93
273_Q	290_V	0.570	0.93
301_I	308_K	0.568	0.93
104_L	120_H	0.568	0.93
225_I	236_A	0.565	0.93
318_I	329_N	0.563	0.93
277_D	282_H	0.562	0.93
275_N	287_Y	0.561	0.92
311_D	329_N	0.561	0.92
30_E	206_A	0.561	0.92
299_S	304_H	0.560	0.92
105_D	108_G	0.559	0.92
299_S	308_K	0.558	0.92
285_L	288_D	0.556	0.92
315_K	326_T	0.555	0.92
269_A	283_Q	0.554	0.92
312_P	317_T	0.552	0.92
311_D	321_Y	0.551	0.92
272_K	288_D	0.543	0.91
326_T	331_L	0.543	0.91
16_D	86_T	0.543	0.91
296_L	301_I	0.543	0.91
205_A	208_V	0.542	0.91
18_R	77_R	0.541	0.91
313_R	328_Y	0.535	0.91
146_E	174_S	0.532	0.90
247_A	250_E	0.532	0.90
298_P	304_H	0.532	0.90
273_Q	278_S	0.531	0.90
265_E	269_A	0.531	0.90
276_L	281_P	0.529	0.90
320_T	331_L	0.526	0.90
275_N	285_L	0.526	0.90
73_T	138_I	0.526	0.90
31_H	202_D	0.525	0.90
270_Q	280_I	0.525	0.90
107_F	121_D	0.522	0.90
102_Q	108_G	0.521	0.89
278_S	289_V	0.520	0.89
296_L	303_D	0.518	0.89
90_C	144_Q	0.518	0.89
18_R	21_R	0.517	0.89
317_T	330_V	0.513	0.89
324_K	327_Q	0.513	0.89
291_R	294_G	0.513	0.89
123_L	155_H	0.511	0.89
141_E	167_N	0.511	0.89
254_R	262_N	0.510	0.88
297_G	310_D	0.510	0.88
12_F	125_D	0.510	0.88
27_R	46_I	0.510	0.88
39_L	55_A	0.509	0.88
269_A	289_V	0.506	0.88
59_G	64_G	0.506	0.88
321_Y	327_Q	0.506	0.88
299_S	310_D	0.506	0.88
261_L	268_R	0.505	0.88
255_I	262_N	0.505	0.88
272_K	287_Y	0.503	0.88
307_R	310_D	0.503	0.88
228_A	264_A	0.502	0.88
89_N	92_R	0.501	0.88
198_E	223_D	0.500	0.87

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4xgcA	1	0.8107	100	0.368	Contact Map
2qbyA	1	0.9492	100	0.401	Contact Map
2v1uA	1	0.9633	100	0.403	Contact Map
2qbyB	1	0.935	100	0.432	Contact Map
1w5sA	1	0.9435	100	0.433	Contact Map
1fnnA	1	0.9435	100	0.466	Contact Map
3te6A	1	0.7203	100	0.528	Contact Map
4xgcD	1	0.9548	100	0.558	Contact Map
4cr2I	1	0.7062	100	0.56	Contact Map
2qp9X	1	0.6441	100	0.56	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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