GREMLIN Database
CDC69 - ORC1-type DNA replication protein 9
UniProt: O51974 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 354 (293)
Sequences: 7041 (4357)
Seq/√Len: 254.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_V23_G4.7691.00
14_I86_T4.0561.00
16_D84_E3.7811.00
15_R20_L2.9251.00
280_I283_Q2.4921.00
200_L226_A2.4141.00
305_Y309_V2.3761.00
91_W154_L2.3071.00
201_H223_D2.2441.00
302_Y305_Y2.2261.00
196_H199_Q2.2241.00
280_I284_R2.1801.00
298_P302_Y2.0691.00
291_R295_P1.9931.00
283_Q287_Y1.9831.00
315_K319_R1.9531.00
197_D226_A1.9201.00
301_I305_Y1.9201.00
322_L326_T1.8901.00
256_T259_I1.8821.00
146_E149_G1.8761.00
281_P284_R1.8721.00
194_K232_D1.8531.00
56_I142_V1.8461.00
265_E268_R1.8341.00
197_D230_A1.8311.00
202_D205_A1.8181.00
280_I290_V1.8091.00
264_A267_A1.7971.00
306_K310_D1.7901.00
296_L300_E1.7841.00
320_T324_K1.7501.00
299_S303_D1.7481.00
286_V290_V1.7421.00
106_D110_T1.7421.00
254_R257_D1.7341.00
260_L263_A1.7301.00
197_D227_D1.7271.00
314_T317_T1.7241.00
284_R288_D1.7111.00
263_A267_A1.7051.00
297_G302_Y1.6861.00
272_K275_N1.6851.00
201_H222_L1.6841.00
302_Y306_K1.6831.00
297_G305_Y1.6621.00
258_D262_N1.6171.00
261_L265_E1.6091.00
275_N279_L1.5841.00
305_Y308_K1.5731.00
297_G300_E1.5641.00
300_E304_H1.5531.00
280_I287_Y1.5371.00
208_V240_L1.5151.00
326_T329_N1.5131.00
201_H205_A1.5131.00
223_D227_D1.4871.00
299_S302_Y1.4851.00
252_R259_I1.4801.00
322_L325_M1.4721.00
279_L283_Q1.4661.00
272_K290_V1.4471.00
259_I263_A1.4461.00
296_L299_S1.4451.00
313_R321_Y1.4421.00
311_D315_K1.4411.00
304_H307_R1.4371.00
313_R318_I1.4361.00
204_L236_A1.4251.00
275_N290_V1.4181.00
11_N19_V1.4121.00
276_L280_I1.4021.00
269_A272_K1.3971.00
283_Q290_V1.3901.00
297_G301_I1.3741.00
257_D260_L1.3681.00
319_R322_L1.3671.00
282_H289_V1.3631.00
313_R322_L1.3481.00
303_D307_R1.3401.00
318_I322_L1.3361.00
208_V222_L1.3271.00
260_L267_A1.3231.00
298_P301_I1.3131.00
262_N265_E1.3051.00
282_H286_V1.3021.00
295_P299_S1.2981.00
313_R319_R1.2971.00
224_R227_D1.2951.00
264_A268_R1.2941.00
33_D199_Q1.2941.00
305_Y310_D1.2861.00
271_I275_N1.2861.00
256_T263_A1.2741.00
258_D261_L1.2701.00
139_L162_V1.2691.00
298_P305_Y1.2641.00
306_K309_V1.2631.00
26_P74_E1.2631.00
19_V22_A1.2631.00
315_K318_I1.2601.00
298_P309_V1.2581.00
142_V164_C1.2561.00
225_I240_L1.2491.00
315_K322_L1.2481.00
314_T318_I1.2471.00
275_N278_S1.2401.00
318_I325_M1.2351.00
257_D264_A1.2291.00
311_D314_T1.2221.00
262_N266_D1.2221.00
281_P285_L1.2181.00
279_L282_H1.2141.00
319_R323_S1.1971.00
256_T260_L1.1951.00
35_E193_D1.1921.00
278_S282_H1.1911.00
16_D19_V1.1761.00
128_Q131_D1.1731.00
294_G305_Y1.1711.00
321_Y325_M1.1691.00
272_K279_L1.1681.00
302_Y309_V1.1551.00
274_K278_S1.1481.00
314_T319_R1.1311.00
297_G308_K1.1261.00
287_Y290_V1.1251.00
282_H285_L1.1231.00
277_D280_I1.1231.00
278_S288_D1.1221.00
273_Q277_D1.1221.00
275_N280_I1.1211.00
317_T320_T1.1191.00
270_Q274_K1.1161.00
272_K276_L1.1101.00
279_L287_Y1.1091.00
32_R35_E1.0961.00
57_V192_M1.0911.00
284_R287_Y1.0911.00
254_R259_I1.0891.00
74_E78_E1.0881.00
68_I192_M1.0841.00
280_I285_L1.0831.00
275_N283_Q1.0741.00
275_N284_R1.0721.00
211_G214_Q1.0721.00
276_L290_V1.0701.00
282_H290_V1.0691.00
257_D261_L1.0681.00
269_A273_Q1.0671.00
197_D201_H1.0661.00
314_T322_L1.0611.00
319_R325_M1.0601.00
250_E259_I1.0601.00
255_I259_I1.0591.00
313_R325_M1.0561.00
20_L25_V1.0541.00
217_I244_A1.0531.00
272_K280_I1.0471.00
326_T330_V1.0401.00
205_A219_T1.0351.00
323_S327_Q1.0341.00
325_M329_N1.0341.00
301_I309_V1.0321.00
318_I321_Y1.0311.00
138_I165_I1.0271.00
22_A84_E1.0271.00
232_D236_A1.0271.00
269_A275_N1.0221.00
259_I262_N1.0161.00
324_K328_Y1.0141.00
314_T329_N1.0121.00
280_I286_V1.0091.00
321_Y326_T1.0081.00
322_L329_N1.0071.00
313_R326_T1.0061.00
250_E262_N1.0021.00
322_L328_Y0.9961.00
263_A268_R0.9951.00
302_Y310_D0.9921.00
260_L268_R0.9911.00
301_I304_H0.9911.00
295_P302_Y0.9881.00
273_Q280_I0.9861.00
153_D157_L0.9861.00
41_S246_K0.9851.00
240_L260_L0.9831.00
93_N126_R0.9761.00
273_Q282_H0.9751.00
90_C93_N0.9751.00
278_S287_Y0.9601.00
246_K250_E0.9591.00
279_L284_R0.9471.00
319_R326_T0.9451.00
204_L222_L0.9391.00
273_Q283_Q0.9371.00
303_D309_V0.9351.00
270_Q273_Q0.9341.00
39_L190_V0.9321.00
278_S281_P0.9191.00
277_D281_P0.8981.00
278_S284_R0.8951.00
304_H309_V0.8901.00
297_G304_H0.8871.00
284_R290_V0.8771.00
299_S305_Y0.8751.00
278_S285_L0.8731.00
300_E303_D0.8721.00
280_I288_D0.8681.00
204_L225_I0.8651.00
303_D306_K0.8641.00
318_I328_Y0.8621.00
315_K321_Y0.8600.99
317_T321_Y0.8590.99
274_K277_D0.8580.99
281_P288_D0.8580.99
38_H242_T0.8580.99
313_R327_Q0.8530.99
275_N282_H0.8510.99
316_R319_R0.8490.99
311_D322_L0.8450.99
78_E82_N0.8440.99
313_R317_T0.8440.99
281_P287_Y0.8430.99
248_D252_R0.8400.99
11_N14_I0.8370.99
279_L286_V0.8360.99
15_R87_Y0.8360.99
323_S326_T0.8350.99
317_T322_L0.8340.99
325_M328_Y0.8300.99
294_G297_G0.8220.99
321_Y329_N0.8200.99
318_I327_Q0.8190.99
263_A266_D0.8150.99
302_Y308_K0.8100.99
316_R320_T0.8090.99
311_D316_R0.8090.99
275_N289_V0.8080.99
282_H287_Y0.8070.99
322_L327_Q0.8060.99
285_L289_V0.8040.99
278_S283_Q0.8020.99
321_Y328_Y0.7980.99
321_Y324_K0.7950.99
311_D319_R0.7940.99
318_I323_S0.7910.99
254_R264_A0.7890.99
314_T326_T0.7840.99
283_Q288_D0.7840.99
282_H288_D0.7830.99
232_D235_L0.7830.99
276_L285_L0.7820.99
279_L288_D0.7810.99
269_A290_V0.7760.99
286_V289_V0.7730.99
311_D318_I0.7720.99
312_P316_R0.7720.99
304_H308_K0.7690.99
327_Q330_V0.7660.99
320_T323_S0.7640.99
61_S181_V0.7620.99
273_Q276_L0.7610.99
314_T325_M0.7600.99
285_L290_V0.7590.99
259_I268_R0.7570.99
319_R328_Y0.7570.99
38_H41_S0.7560.99
260_L264_A0.7530.99
257_D268_R0.7510.99
319_R329_N0.7510.99
318_I326_T0.7510.99
259_I265_E0.7490.99
271_I274_K0.7460.99
272_K283_Q0.7430.99
276_L287_Y0.7430.99
296_L305_Y0.7410.98
254_R258_D0.7410.98
229_A239_I0.7390.98
295_P309_V0.7390.98
254_R263_A0.7390.98
273_Q281_P0.7380.98
200_L233_A0.7380.98
277_D288_D0.7290.98
58_T189_H0.7230.98
273_Q284_R0.7230.98
224_R228_A0.7220.98
325_M330_V0.7210.98
246_K249_R0.7210.98
279_L289_V0.7190.98
275_N288_D0.7190.98
41_S245_S0.7170.98
328_Y331_L0.7160.98
143_D167_N0.7150.98
145_L152_Y0.7140.98
11_N86_T0.7110.98
75_R82_N0.7100.98
127_L158_P0.7100.98
231_G234_R0.7100.98
76_L85_A0.7080.98
257_D263_A0.7080.98
20_L23_G0.7060.98
279_L290_V0.7050.98
257_D262_N0.7040.98
312_P315_K0.7000.98
323_S329_N0.6990.98
259_I264_A0.6980.98
327_Q331_L0.6970.98
314_T321_Y0.6960.98
102_Q105_D0.6940.98
231_G235_L0.6910.98
319_R330_V0.6880.98
296_L302_Y0.6850.97
322_L330_V0.6810.97
271_I276_L0.6780.97
315_K325_M0.6760.97
17_A87_Y0.6740.97
283_Q286_V0.6740.97
257_D265_E0.6710.97
90_C145_L0.6700.97
315_K328_Y0.6670.97
276_L289_V0.6650.97
29_V36_V0.6650.97
229_A232_D0.6580.97
276_L286_V0.6530.97
274_K280_I0.6520.97
269_A276_L0.6490.97
168_K191_R0.6450.96
295_P305_Y0.6370.96
296_L310_D0.6360.96
84_E134_R0.6340.96
277_D285_L0.6320.96
255_I260_L0.6310.96
121_D125_D0.6310.96
60_P168_K0.6280.96
256_T262_N0.6280.96
214_Q255_I0.6280.96
314_T323_S0.6250.96
254_R267_A0.6220.96
299_S309_V0.6220.96
284_R289_V0.6220.96
325_M331_L0.6220.96
272_K278_S0.6210.96
313_R316_R0.6200.95
279_L285_L0.6180.95
277_D290_V0.6130.95
323_S328_Y0.6120.95
274_K279_L0.6120.95
270_Q283_Q0.6120.95
222_L240_L0.6110.95
270_Q282_H0.6110.95
276_L283_Q0.6100.95
276_L282_H0.6090.95
316_R322_L0.6060.95
201_H226_A0.6060.95
272_K284_R0.6060.95
150_I153_D0.6050.95
322_L331_L0.6050.95
314_T327_Q0.6040.95
311_D317_T0.6030.95
319_R327_Q0.6020.95
256_T268_R0.6010.95
218_T221_Q0.6000.95
259_I267_A0.5970.94
315_K323_S0.5950.94
131_D135_T0.5910.94
317_T326_T0.5900.94
312_P319_R0.5880.94
229_A235_L0.5870.94
26_P29_V0.5870.94
255_I265_E0.5850.94
221_Q224_R0.5850.94
271_I280_I0.5830.94
316_R324_K0.5830.94
317_T327_Q0.5830.94
314_T328_Y0.5830.94
218_T254_R0.5790.94
120_H124_I0.5760.93
273_Q290_V0.5700.93
301_I308_K0.5680.93
104_L120_H0.5680.93
225_I236_A0.5650.93
318_I329_N0.5630.93
277_D282_H0.5620.93
275_N287_Y0.5610.92
311_D329_N0.5610.92
30_E206_A0.5610.92
299_S304_H0.5600.92
105_D108_G0.5590.92
299_S308_K0.5580.92
285_L288_D0.5560.92
315_K326_T0.5550.92
269_A283_Q0.5540.92
312_P317_T0.5520.92
311_D321_Y0.5510.92
272_K288_D0.5430.91
326_T331_L0.5430.91
16_D86_T0.5430.91
296_L301_I0.5430.91
205_A208_V0.5420.91
18_R77_R0.5410.91
313_R328_Y0.5350.91
146_E174_S0.5320.90
247_A250_E0.5320.90
298_P304_H0.5320.90
273_Q278_S0.5310.90
265_E269_A0.5310.90
276_L281_P0.5290.90
320_T331_L0.5260.90
275_N285_L0.5260.90
73_T138_I0.5260.90
31_H202_D0.5250.90
270_Q280_I0.5250.90
107_F121_D0.5220.90
102_Q108_G0.5210.89
278_S289_V0.5200.89
296_L303_D0.5180.89
90_C144_Q0.5180.89
18_R21_R0.5170.89
317_T330_V0.5130.89
324_K327_Q0.5130.89
291_R294_G0.5130.89
123_L155_H0.5110.89
141_E167_N0.5110.89
254_R262_N0.5100.88
297_G310_D0.5100.88
12_F125_D0.5100.88
27_R46_I0.5100.88
39_L55_A0.5090.88
269_A289_V0.5060.88
59_G64_G0.5060.88
321_Y327_Q0.5060.88
299_S310_D0.5060.88
261_L268_R0.5050.88
255_I262_N0.5050.88
272_K287_Y0.5030.88
307_R310_D0.5030.88
228_A264_A0.5020.88
89_N92_R0.5010.88
198_E223_D0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4xgcA 1 0.8107 100 0.368 Contact Map
2qbyA 1 0.9492 100 0.401 Contact Map
2v1uA 1 0.9633 100 0.403 Contact Map
2qbyB 1 0.935 100 0.432 Contact Map
1w5sA 1 0.9435 100 0.433 Contact Map
1fnnA 1 0.9435 100 0.466 Contact Map
3te6A 1 0.7203 100 0.528 Contact Map
4xgcD 1 0.9548 100 0.558 Contact Map
4cr2I 1 0.7062 100 0.56 Contact Map
2qp9X 1 0.6441 100 0.56 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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