GREMLIN Database
O51972 - Uncharacterized protein
UniProt: O51972 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 424 (341)
Sequences: 958 (766)
Seq/√Len: 41.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
114_G162_D5.2181.00
198_Y285_N4.9381.00
68_G72_Q4.7721.00
178_L299_I4.2141.00
324_T329_V3.9031.00
69_G72_Q3.8891.00
73_R76_P3.8431.00
111_I145_A3.6841.00
172_L175_R3.4951.00
199_F266_F3.4531.00
140_H183_Y3.3601.00
66_S69_G3.2491.00
176_L286_L2.9061.00
74_L332_I2.7801.00
323_D333_L2.7451.00
110_M175_R2.7281.00
87_E152_Q2.6691.00
38_F41_G2.6511.00
86_V338_L2.5411.00
136_G158_E2.4931.00
308_L311_R2.4661.00
125_D327_E2.4001.00
108_D175_R2.3931.00
199_F285_N2.3871.00
298_E301_R2.3861.00
179_F201_S2.2481.00
192_I197_G2.2391.00
274_E277_D2.2271.00
79_A331_R2.2021.00
306_V310_F2.0780.99
270_G279_Y2.0730.99
30_Q33_A2.0530.99
141_L310_F2.0400.99
189_F201_S2.0050.99
311_R315_T1.9720.99
203_L207_A1.9490.99
31_I81_Y1.9460.99
161_H164_T1.9450.99
21_G24_E1.9150.99
286_L291_F1.9020.99
93_V346_D1.9000.99
152_Q170_P1.8690.98
23_V31_I1.8560.98
83_R331_R1.8520.98
156_A160_T1.8060.98
153_L338_L1.7360.97
311_R316_Q1.7270.97
140_H156_A1.7250.97
110_M151_E1.7160.97
107_R198_Y1.7120.97
282_Y296_L1.6880.97
49_T296_L1.6550.97
112_A142_L1.6310.96
271_V297_A1.6220.96
107_R176_L1.6040.96
49_T53_F1.5920.96
201_S283_M1.5860.96
357_D360_V1.5750.95
186_Y207_A1.5740.95
182_A204_K1.5520.95
105_R295_D1.5380.95
272_R277_D1.5250.95
191_L195_N1.5240.95
24_E27_R1.5150.94
181_L202_R1.5120.94
89_G342_L1.4980.94
50_L71_Y1.4720.94
19_E84_D1.4690.93
86_V341_L1.4660.93
83_R87_E1.4560.93
38_F336_A1.4530.93
181_L201_S1.4410.93
332_I336_A1.4220.92
155_T331_R1.4160.92
327_E331_R1.4110.92
13_L16_H1.4100.92
176_L200_V1.3940.92
34_F73_R1.3590.90
184_F207_A1.3580.90
180_D307_E1.3460.90
138_K285_N1.3420.90
34_F77_T1.3410.90
180_D300_Y1.3290.89
193_D285_N1.3210.89
267_R304_W1.3170.89
34_F74_L1.3130.89
274_E306_V1.3090.89
115_T314_K1.3050.89
79_A328_H1.3020.88
116_V138_K1.2870.88
120_H330_V1.2870.88
29_L37_A1.2860.88
120_H333_L1.2810.88
142_L151_E1.2750.87
91_D269_V1.2670.87
74_L77_T1.2570.87
127_F309_L1.2550.86
273_D280_H1.2480.86
77_T332_I1.2450.86
143_H335_Y1.2400.86
110_M142_L1.2300.85
284_T296_L1.2290.85
312_E345_R1.2250.85
291_F296_L1.2250.85
345_R348_L1.2160.85
13_L17_A1.2000.84
162_D182_A1.1960.84
91_D193_D1.1910.83
361_F366_W1.1890.83
362_P365_R1.1890.83
115_T139_L1.1870.83
309_L317_Y1.1830.83
200_V299_I1.1760.83
190_A194_E1.1740.83
113_D307_E1.1710.82
74_L333_L1.1680.82
366_W377_I1.1650.82
8_F15_D1.1580.82
23_V27_R1.1570.82
292_F295_D1.1540.81
324_T333_L1.1510.81
157_N372_S1.1290.80
141_L150_I1.1270.80
359_L362_P1.1110.79
312_E341_L1.1060.79
193_D199_F1.1020.78
271_V282_Y1.0890.78
39_V336_A1.0890.78
8_F89_G1.0890.78
156_A165_L1.0860.77
73_R77_T1.0820.77
113_D180_D1.0820.77
119_L137_A1.0790.77
34_F37_A1.0610.76
11_E15_D1.0610.76
32_P36_W1.0480.75
315_T343_V1.0450.75
144_N181_L1.0430.74
108_D181_L1.0370.74
367_A375_Q1.0360.74
157_N356_D1.0300.73
68_G71_Y1.0200.73
85_L292_F1.0200.73
54_R70_F1.0170.72
49_T54_R1.0160.72
110_M177_M1.0150.72
15_D292_F1.0130.72
150_I309_L1.0130.72
124_S128_E1.0110.72
12_F16_H1.0030.71
179_F182_A1.0010.71
117_L139_L1.0000.71
4_L18_E1.0000.71
74_L324_T0.9990.71
8_F35_V0.9980.71
296_L341_L0.9980.71
82_L332_I0.9970.71
73_R106_F0.9920.71
10_S32_P0.9920.71
194_E265_R0.9900.70
101_A105_R0.9900.70
367_A374_A0.9860.70
307_E314_K0.9850.70
135_A333_L0.9740.69
20_L23_V0.9720.69
271_V280_H0.9720.69
77_T82_L0.9690.69
163_S204_K0.9670.69
138_K161_H0.9650.68
214_E217_E0.9630.68
142_L177_M0.9610.68
205_Q283_M0.9560.68
67_P326_D0.9540.68
75_T326_D0.9500.67
22_V31_I0.9480.67
35_V39_V0.9460.67
358_E363_T0.9450.67
127_F331_R0.9450.67
205_Q330_V0.9450.67
113_D304_W0.9440.67
196_D274_E0.9430.67
31_I77_T0.9400.66
104_D109_V0.9380.66
10_S14_E0.9380.66
364_E369_T0.9340.66
362_P370_F0.9290.65
150_I342_L0.9270.65
310_F372_S0.9250.65
135_A332_I0.9240.65
186_Y258_T0.9230.65
8_F49_T0.9200.65
155_T208_N0.9170.64
302_C305_E0.9170.64
362_P367_A0.9160.64
109_V299_I0.9130.64
304_W307_E0.9080.64
155_T266_F0.9000.63
113_D202_R0.8990.63
202_R304_W0.8940.62
113_D284_T0.8920.62
367_A371_R0.8840.62
182_A203_L0.8840.62
31_I34_F0.8830.61
55_R164_T0.8790.61
14_E35_V0.8770.61
8_F189_F0.8750.61
122_F135_A0.8710.60
161_H347_L0.8690.60
139_L334_L0.8680.60
128_E133_E0.8680.60
138_K158_E0.8670.60
112_A166_F0.8610.60
53_F58_N0.8600.59
180_D314_K0.8590.59
74_L134_Q0.8580.59
152_Q349_D0.8560.59
76_P269_V0.8550.59
310_F366_W0.8520.59
173_E299_I0.8520.59
167_K188_R0.8520.59
365_R368_A0.8510.59
33_A149_T0.8510.59
29_L70_F0.8500.59
70_F311_R0.8470.58
22_V81_Y0.8450.58
64_T133_E0.8440.58
110_M172_L0.8430.58
53_F362_P0.8410.58
171_W197_G0.8390.58
150_I185_K0.8390.58
77_T342_L0.8300.57
200_V296_L0.8300.57
35_V82_L0.8280.57
128_E136_G0.8270.56
50_L53_F0.8190.56
311_R317_Y0.8190.56
79_A83_R0.8160.55
299_I317_Y0.8160.55
68_G118_R0.8160.55
180_D304_W0.8120.55
25_R30_Q0.8120.55
173_E196_D0.8110.55
153_L215_L0.8100.55
299_I326_D0.8080.55
151_E330_V0.8080.55
34_F134_Q0.8070.55
319_L337_A0.8070.55
39_V340_S0.8060.54
11_E151_E0.8010.54
57_Y195_N0.8010.54
35_V336_A0.8010.54
29_L33_A0.8000.54
90_L342_L0.7990.54
114_G136_G0.7990.54
175_R192_I0.7980.54
361_F370_F0.7980.54
171_W295_D0.7970.54
290_E294_A0.7960.54
8_F21_G0.7950.53
171_W177_M0.7940.53
157_N182_A0.7940.53
6_T10_S0.7930.53
55_R64_T0.7900.53
162_D180_D0.7890.53
364_E371_R0.7880.53
146_T302_C0.7880.53
312_E316_Q0.7850.53
128_E158_E0.7830.52
216_R275_D0.7820.52
280_H297_A0.7760.52
141_L341_L0.7720.51
123_L325_S0.7720.51
127_F312_E0.7710.51
15_D18_E0.7700.51
311_R314_K0.7690.51
187_R338_L0.7670.51
196_D292_F0.7670.51
82_L328_H0.7670.51
284_T304_W0.7660.51
162_D342_L0.7650.51
22_V73_R0.7650.51
132_E205_Q0.7630.50
269_V284_T0.7610.50
306_V374_A0.7600.50
38_F324_T0.7600.50
181_L207_A0.7570.50
364_E367_A0.7560.50
104_D339_L0.7540.50
7_L12_F0.7530.50
365_R375_Q0.7530.50
362_P371_R0.7530.50
145_A299_I0.7520.49
113_D303_R0.7520.49
12_F88_H0.7520.49
205_Q210_L0.7510.49
29_L69_G0.7510.49
118_R136_G0.7440.49
125_D135_A0.7410.48
287_A348_L0.7400.48
16_H84_D0.7370.48
28_K33_A0.7360.48
303_R307_E0.7360.48
128_E167_K0.7320.48
312_E330_V0.7280.47
296_L310_F0.7270.47
52_G214_E0.7240.47
155_T334_L0.7230.47
179_F192_I0.7160.46
108_D172_L0.7150.46
27_R77_T0.7150.46
179_F282_Y0.7110.46
348_L366_W0.7070.45
142_L171_W0.7060.45
131_H317_Y0.7050.45
139_L331_R0.7020.45
274_E281_L0.7020.45
14_E32_P0.7010.45
178_L193_D0.6990.45
84_D88_H0.6990.45
67_P278_D0.6960.44
86_V169_G0.6960.44
369_T375_Q0.6940.44
66_S192_I0.6930.44
144_N147_E0.6920.44
80_E83_R0.6910.44
161_H182_A0.6900.44
179_F210_L0.6900.44
138_K150_I0.6890.44
181_L204_K0.6870.43
115_T182_A0.6860.43
203_L206_N0.6850.43
95_V265_R0.6830.43
213_G248_V0.6810.43
372_S377_I0.6800.43
166_F188_R0.6800.43
5_T10_S0.6780.43
77_T181_L0.6780.43
180_D303_R0.6750.42
9_P12_F0.6750.42
356_D374_A0.6710.42
202_R307_E0.6700.42
322_F360_V0.6700.42
23_V26_D0.6700.42
139_L302_C0.6700.42
357_D368_A0.6690.42
373_H378_L0.6680.42
122_F325_S0.6660.41
85_L338_L0.6600.41
128_E309_L0.6580.41
138_K363_T0.6560.41
86_V271_V0.6540.40
143_H152_Q0.6540.40
295_D345_R0.6530.40
133_E335_Y0.6520.40
71_Y329_V0.6500.40
41_G324_T0.6470.40
18_E353_E0.6470.40
49_T208_N0.6450.40
117_L334_L0.6450.40
107_R291_F0.6430.39
18_E43_A0.6420.39
284_T340_S0.6410.39
364_E370_F0.6410.39
26_D35_V0.6400.39
189_F199_F0.6370.39
169_G341_L0.6350.39
34_F71_Y0.6350.39
128_E132_E0.6320.38
12_F92_E0.6310.38
4_L9_P0.6310.38
373_H376_L0.6290.38
366_W372_S0.6290.38
162_D166_F0.6280.38
140_H333_L0.6270.38
309_L341_L0.6270.38
293_P329_V0.6260.38
161_H181_L0.6250.38
155_T294_A0.6250.38
142_L186_Y0.6210.37
111_I332_I0.6190.37
309_L359_L0.6170.37
269_V282_Y0.6170.37
295_D306_V0.6160.37
283_M296_L0.6150.37
368_A373_H0.6140.37
228_K242_I0.6130.37
53_F336_A0.6130.37
89_G150_I0.6100.37
131_H199_F0.6090.36
20_L81_Y0.6080.36
362_P366_W0.6080.36
65_I208_N0.6070.36
74_L81_Y0.6050.36
340_S369_T0.6050.36
14_E265_R0.6040.36
317_Y344_S0.6040.36
116_V166_F0.6030.36
108_D144_N0.6010.36
130_R134_Q0.5990.36
121_E135_A0.5990.36
81_Y85_L0.5970.35
199_F315_T0.5960.35
10_S13_L0.5960.35
141_L334_L0.5960.35
193_D264_K0.5960.35
287_A291_F0.5950.35
352_T361_F0.5950.35
37_A50_L0.5950.35
365_R369_T0.5940.35
73_R329_V0.5900.35
324_T330_V0.5900.35
50_L70_F0.5900.35
107_R290_E0.5880.35
9_P14_E0.5870.35
364_E368_A0.5860.34
86_V333_L0.5860.34
19_E22_V0.5850.34
5_T15_D0.5810.34
40_F112_A0.5810.34
144_N202_R0.5790.34
50_L183_Y0.5780.34
213_G354_Q0.5770.34
152_Q176_L0.5760.34
14_E85_L0.5750.34
86_V90_L0.5750.34
300_Y307_E0.5750.34
160_T173_E0.5740.33
267_R307_E0.5720.33
16_H88_H0.5710.33
356_D360_V0.5710.33
16_H37_A0.5710.33
140_H311_R0.5700.33
24_E31_I0.5660.33
11_E21_G0.5650.33
367_A372_S0.5630.33
163_S167_K0.5630.33
359_L364_E0.5630.33
65_I119_L0.5610.32
137_A334_L0.5610.32
11_E213_G0.5600.32
357_D371_R0.5600.32
61_A287_A0.5590.32
178_L277_D0.5590.32
347_L351_V0.5560.32
369_T378_L0.5560.32
5_T8_F0.5550.32
25_R332_I0.5540.32
175_R197_G0.5530.32
103_I306_V0.5520.32
149_T346_D0.5510.32
82_L336_A0.5510.32
80_E194_E0.5510.32
288_R291_F0.5510.32
42_F128_E0.5510.32
249_E258_T0.5480.31
8_F214_E0.5480.31
196_D277_D0.5460.31
130_R158_E0.5450.31
113_D314_K0.5450.31
206_N350_L0.5450.31
17_A35_V0.5430.31
268_V286_L0.5420.31
5_T36_W0.5400.31
41_G70_F0.5400.31
34_F129_A0.5380.31
9_P85_L0.5370.30
140_H162_D0.5370.30
16_H19_E0.5330.30
163_S346_D0.5310.30
131_H330_V0.5290.30
53_F332_I0.5270.30
270_G281_L0.5250.30
174_N269_V0.5230.29
185_K324_T0.5220.29
361_F372_S0.5220.29
186_Y264_K0.5210.29
283_M351_V0.5210.29
176_L290_E0.5200.29
115_T322_F0.5200.29
21_G78_L0.5190.29
204_K334_L0.5190.29
363_T369_T0.5190.29
189_F262_D0.5180.29
6_T299_I0.5170.29
22_V34_F0.5170.29
104_D291_F0.5160.29
114_G138_K0.5160.29
300_Y304_W0.5160.29
199_F271_V0.5130.29
14_E18_E0.5130.29
288_R368_A0.5130.29
116_V204_K0.5130.29
128_E316_Q0.5120.29
12_F15_D0.5120.29
142_L169_G0.5120.29
312_E333_L0.5100.28
359_L367_A0.5090.28
163_S188_R0.5090.28
324_T371_R0.5090.28
120_H135_A0.5080.28
134_Q158_E0.5070.28
370_F373_H0.5060.28
158_E344_S0.5050.28
185_K342_L0.5040.28
72_Q137_A0.5040.28
68_G112_A0.5030.28
58_N65_I0.5030.28
66_S72_Q0.5020.28
161_H205_Q0.5010.28
85_L339_L0.5010.28
112_A158_E0.5010.28
278_D313_L0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1musA 2 0.8349 100 0.708 Contact Map
1w7jB 1 0.2476 17.2 0.968 Contact Map
1rroA 1 0.2476 17 0.968 Contact Map
2kycA 1 0.2476 16.7 0.968 Contact Map
4ociA 2 0.2689 16.3 0.968 Contact Map
3pm8A 2 0.2594 15.9 0.968 Contact Map
4u7bA 2 0.6061 15.6 0.969 Contact Map
1m45A 1 0.2524 14.2 0.969 Contact Map
4mvfA 1 0.2594 13.3 0.97 Contact Map
1s1eA 1 0.3019 12.7 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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