O51972 - HALSA - GREMLIN Contacts

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O51972 - Uncharacterized protein

UniProt:	O51972	Sequences: MRRLTTLFPSEFLEDHAEELGVVERDRKLQIPAFVWAFVFGFAAGESRTLAGFRRCYNSTADETISPGGFYQRLTPTLAEYLRDLVEHGLDEVAVPNAVDADIDRFRDVMIADGTVLRLHEFLSDQFEARHEEQAGAKLHLLHNATEQTIEQLDTANEKTHDSTLFKTGPWLENRLMLFDLAYFKYRRFALIDENDGYFVSRLKQNANPLITGELREWRGRAIPLEGKQLRAVLDDLDRKYIDVEVEVEFKRGPYNGTQSLDTKRFRVVGVRDEDADDYHLYMTNLARKEFFPADLAEIYRCRWEVELLFRELKTQYELDEFDTSDEHVVRILLYAALLSLLVSRDLLDLVTEQADDELVFPTERWAATFRSHAQLILHELGEFLGYSPPPLLDRLIEDAQKIHKQRPILQETLATTTQPRCEA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	424 (341)
Sequences:	958 (766)
Seq/√Len:	41.5

ECOLI - INSG INSL1 INSL2 INSL3
HALSA - O51972 O52023 O51966 O54648 Q9HI34 Q9HI01 O54644

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
114_G	162_D	5.218	1.00
198_Y	285_N	4.938	1.00
68_G	72_Q	4.772	1.00
178_L	299_I	4.214	1.00
324_T	329_V	3.903	1.00
69_G	72_Q	3.889	1.00
73_R	76_P	3.843	1.00
111_I	145_A	3.684	1.00
172_L	175_R	3.495	1.00
199_F	266_F	3.453	1.00
140_H	183_Y	3.360	1.00
66_S	69_G	3.249	1.00
176_L	286_L	2.906	1.00
74_L	332_I	2.780	1.00
323_D	333_L	2.745	1.00
110_M	175_R	2.728	1.00
87_E	152_Q	2.669	1.00
38_F	41_G	2.651	1.00
86_V	338_L	2.541	1.00
136_G	158_E	2.493	1.00
308_L	311_R	2.466	1.00
125_D	327_E	2.400	1.00
108_D	175_R	2.393	1.00
199_F	285_N	2.387	1.00
298_E	301_R	2.386	1.00
179_F	201_S	2.248	1.00
192_I	197_G	2.239	1.00
274_E	277_D	2.227	1.00
79_A	331_R	2.202	1.00
306_V	310_F	2.078	0.99
270_G	279_Y	2.073	0.99
30_Q	33_A	2.053	0.99
141_L	310_F	2.040	0.99
189_F	201_S	2.005	0.99
311_R	315_T	1.972	0.99
203_L	207_A	1.949	0.99
31_I	81_Y	1.946	0.99
161_H	164_T	1.945	0.99
21_G	24_E	1.915	0.99
286_L	291_F	1.902	0.99
93_V	346_D	1.900	0.99
152_Q	170_P	1.869	0.98
23_V	31_I	1.856	0.98
83_R	331_R	1.852	0.98
156_A	160_T	1.806	0.98
153_L	338_L	1.736	0.97
311_R	316_Q	1.727	0.97
140_H	156_A	1.725	0.97
110_M	151_E	1.716	0.97
107_R	198_Y	1.712	0.97
282_Y	296_L	1.688	0.97
49_T	296_L	1.655	0.97
112_A	142_L	1.631	0.96
271_V	297_A	1.622	0.96
107_R	176_L	1.604	0.96
49_T	53_F	1.592	0.96
201_S	283_M	1.586	0.96
357_D	360_V	1.575	0.95
186_Y	207_A	1.574	0.95
182_A	204_K	1.552	0.95
105_R	295_D	1.538	0.95
272_R	277_D	1.525	0.95
191_L	195_N	1.524	0.95
24_E	27_R	1.515	0.94
181_L	202_R	1.512	0.94
89_G	342_L	1.498	0.94
50_L	71_Y	1.472	0.94
19_E	84_D	1.469	0.93
86_V	341_L	1.466	0.93
83_R	87_E	1.456	0.93
38_F	336_A	1.453	0.93
181_L	201_S	1.441	0.93
332_I	336_A	1.422	0.92
155_T	331_R	1.416	0.92
327_E	331_R	1.411	0.92
13_L	16_H	1.410	0.92
176_L	200_V	1.394	0.92
34_F	73_R	1.359	0.90
184_F	207_A	1.358	0.90
180_D	307_E	1.346	0.90
138_K	285_N	1.342	0.90
34_F	77_T	1.341	0.90
180_D	300_Y	1.329	0.89
193_D	285_N	1.321	0.89
267_R	304_W	1.317	0.89
34_F	74_L	1.313	0.89
274_E	306_V	1.309	0.89
115_T	314_K	1.305	0.89
79_A	328_H	1.302	0.88
116_V	138_K	1.287	0.88
120_H	330_V	1.287	0.88
29_L	37_A	1.286	0.88
120_H	333_L	1.281	0.88
142_L	151_E	1.275	0.87
91_D	269_V	1.267	0.87
74_L	77_T	1.257	0.87
127_F	309_L	1.255	0.86
273_D	280_H	1.248	0.86
77_T	332_I	1.245	0.86
143_H	335_Y	1.240	0.86
110_M	142_L	1.230	0.85
284_T	296_L	1.229	0.85
312_E	345_R	1.225	0.85
291_F	296_L	1.225	0.85
345_R	348_L	1.216	0.85
13_L	17_A	1.200	0.84
162_D	182_A	1.196	0.84
91_D	193_D	1.191	0.83
361_F	366_W	1.189	0.83
362_P	365_R	1.189	0.83
115_T	139_L	1.187	0.83
309_L	317_Y	1.183	0.83
200_V	299_I	1.176	0.83
190_A	194_E	1.174	0.83
113_D	307_E	1.171	0.82
74_L	333_L	1.168	0.82
366_W	377_I	1.165	0.82
8_F	15_D	1.158	0.82
23_V	27_R	1.157	0.82
292_F	295_D	1.154	0.81
324_T	333_L	1.151	0.81
157_N	372_S	1.129	0.80
141_L	150_I	1.127	0.80
359_L	362_P	1.111	0.79
312_E	341_L	1.106	0.79
193_D	199_F	1.102	0.78
271_V	282_Y	1.089	0.78
39_V	336_A	1.089	0.78
8_F	89_G	1.089	0.78
156_A	165_L	1.086	0.77
73_R	77_T	1.082	0.77
113_D	180_D	1.082	0.77
119_L	137_A	1.079	0.77
34_F	37_A	1.061	0.76
11_E	15_D	1.061	0.76
32_P	36_W	1.048	0.75
315_T	343_V	1.045	0.75
144_N	181_L	1.043	0.74
108_D	181_L	1.037	0.74
367_A	375_Q	1.036	0.74
157_N	356_D	1.030	0.73
68_G	71_Y	1.020	0.73
85_L	292_F	1.020	0.73
54_R	70_F	1.017	0.72
49_T	54_R	1.016	0.72
110_M	177_M	1.015	0.72
15_D	292_F	1.013	0.72
150_I	309_L	1.013	0.72
124_S	128_E	1.011	0.72
12_F	16_H	1.003	0.71
179_F	182_A	1.001	0.71
117_L	139_L	1.000	0.71
4_L	18_E	1.000	0.71
74_L	324_T	0.999	0.71
8_F	35_V	0.998	0.71
296_L	341_L	0.998	0.71
82_L	332_I	0.997	0.71
73_R	106_F	0.992	0.71
10_S	32_P	0.992	0.71
194_E	265_R	0.990	0.70
101_A	105_R	0.990	0.70
367_A	374_A	0.986	0.70
307_E	314_K	0.985	0.70
135_A	333_L	0.974	0.69
20_L	23_V	0.972	0.69
271_V	280_H	0.972	0.69
77_T	82_L	0.969	0.69
163_S	204_K	0.967	0.69
138_K	161_H	0.965	0.68
214_E	217_E	0.963	0.68
142_L	177_M	0.961	0.68
205_Q	283_M	0.956	0.68
67_P	326_D	0.954	0.68
75_T	326_D	0.950	0.67
22_V	31_I	0.948	0.67
35_V	39_V	0.946	0.67
358_E	363_T	0.945	0.67
127_F	331_R	0.945	0.67
205_Q	330_V	0.945	0.67
113_D	304_W	0.944	0.67
196_D	274_E	0.943	0.67
31_I	77_T	0.940	0.66
104_D	109_V	0.938	0.66
10_S	14_E	0.938	0.66
364_E	369_T	0.934	0.66
362_P	370_F	0.929	0.65
150_I	342_L	0.927	0.65
310_F	372_S	0.925	0.65
135_A	332_I	0.924	0.65
186_Y	258_T	0.923	0.65
8_F	49_T	0.920	0.65
155_T	208_N	0.917	0.64
302_C	305_E	0.917	0.64
362_P	367_A	0.916	0.64
109_V	299_I	0.913	0.64
304_W	307_E	0.908	0.64
155_T	266_F	0.900	0.63
113_D	202_R	0.899	0.63
202_R	304_W	0.894	0.62
113_D	284_T	0.892	0.62
367_A	371_R	0.884	0.62
182_A	203_L	0.884	0.62
31_I	34_F	0.883	0.61
55_R	164_T	0.879	0.61
14_E	35_V	0.877	0.61
8_F	189_F	0.875	0.61
122_F	135_A	0.871	0.60
161_H	347_L	0.869	0.60
139_L	334_L	0.868	0.60
128_E	133_E	0.868	0.60
138_K	158_E	0.867	0.60
112_A	166_F	0.861	0.60
53_F	58_N	0.860	0.59
180_D	314_K	0.859	0.59
74_L	134_Q	0.858	0.59
152_Q	349_D	0.856	0.59
76_P	269_V	0.855	0.59
310_F	366_W	0.852	0.59
173_E	299_I	0.852	0.59
167_K	188_R	0.852	0.59
365_R	368_A	0.851	0.59
33_A	149_T	0.851	0.59
29_L	70_F	0.850	0.59
70_F	311_R	0.847	0.58
22_V	81_Y	0.845	0.58
64_T	133_E	0.844	0.58
110_M	172_L	0.843	0.58
53_F	362_P	0.841	0.58
171_W	197_G	0.839	0.58
150_I	185_K	0.839	0.58
77_T	342_L	0.830	0.57
200_V	296_L	0.830	0.57
35_V	82_L	0.828	0.57
128_E	136_G	0.827	0.56
50_L	53_F	0.819	0.56
311_R	317_Y	0.819	0.56
79_A	83_R	0.816	0.55
299_I	317_Y	0.816	0.55
68_G	118_R	0.816	0.55
180_D	304_W	0.812	0.55
25_R	30_Q	0.812	0.55
173_E	196_D	0.811	0.55
153_L	215_L	0.810	0.55
299_I	326_D	0.808	0.55
151_E	330_V	0.808	0.55
34_F	134_Q	0.807	0.55
319_L	337_A	0.807	0.55
39_V	340_S	0.806	0.54
11_E	151_E	0.801	0.54
57_Y	195_N	0.801	0.54
35_V	336_A	0.801	0.54
29_L	33_A	0.800	0.54
90_L	342_L	0.799	0.54
114_G	136_G	0.799	0.54
175_R	192_I	0.798	0.54
361_F	370_F	0.798	0.54
171_W	295_D	0.797	0.54
290_E	294_A	0.796	0.54
8_F	21_G	0.795	0.53
171_W	177_M	0.794	0.53
157_N	182_A	0.794	0.53
6_T	10_S	0.793	0.53
55_R	64_T	0.790	0.53
162_D	180_D	0.789	0.53
364_E	371_R	0.788	0.53
146_T	302_C	0.788	0.53
312_E	316_Q	0.785	0.53
128_E	158_E	0.783	0.52
216_R	275_D	0.782	0.52
280_H	297_A	0.776	0.52
141_L	341_L	0.772	0.51
123_L	325_S	0.772	0.51
127_F	312_E	0.771	0.51
15_D	18_E	0.770	0.51
311_R	314_K	0.769	0.51
187_R	338_L	0.767	0.51
196_D	292_F	0.767	0.51
82_L	328_H	0.767	0.51
284_T	304_W	0.766	0.51
162_D	342_L	0.765	0.51
22_V	73_R	0.765	0.51
132_E	205_Q	0.763	0.50
269_V	284_T	0.761	0.50
306_V	374_A	0.760	0.50
38_F	324_T	0.760	0.50
181_L	207_A	0.757	0.50
364_E	367_A	0.756	0.50
104_D	339_L	0.754	0.50
7_L	12_F	0.753	0.50
365_R	375_Q	0.753	0.50
362_P	371_R	0.753	0.50
145_A	299_I	0.752	0.49
113_D	303_R	0.752	0.49
12_F	88_H	0.752	0.49
205_Q	210_L	0.751	0.49
29_L	69_G	0.751	0.49
118_R	136_G	0.744	0.49
125_D	135_A	0.741	0.48
287_A	348_L	0.740	0.48
16_H	84_D	0.737	0.48
28_K	33_A	0.736	0.48
303_R	307_E	0.736	0.48
128_E	167_K	0.732	0.48
312_E	330_V	0.728	0.47
296_L	310_F	0.727	0.47
52_G	214_E	0.724	0.47
155_T	334_L	0.723	0.47
179_F	192_I	0.716	0.46
108_D	172_L	0.715	0.46
27_R	77_T	0.715	0.46
179_F	282_Y	0.711	0.46
348_L	366_W	0.707	0.45
142_L	171_W	0.706	0.45
131_H	317_Y	0.705	0.45
139_L	331_R	0.702	0.45
274_E	281_L	0.702	0.45
14_E	32_P	0.701	0.45
178_L	193_D	0.699	0.45
84_D	88_H	0.699	0.45
67_P	278_D	0.696	0.44
86_V	169_G	0.696	0.44
369_T	375_Q	0.694	0.44
66_S	192_I	0.693	0.44
144_N	147_E	0.692	0.44
80_E	83_R	0.691	0.44
161_H	182_A	0.690	0.44
179_F	210_L	0.690	0.44
138_K	150_I	0.689	0.44
181_L	204_K	0.687	0.43
115_T	182_A	0.686	0.43
203_L	206_N	0.685	0.43
95_V	265_R	0.683	0.43
213_G	248_V	0.681	0.43
372_S	377_I	0.680	0.43
166_F	188_R	0.680	0.43
5_T	10_S	0.678	0.43
77_T	181_L	0.678	0.43
180_D	303_R	0.675	0.42
9_P	12_F	0.675	0.42
356_D	374_A	0.671	0.42
202_R	307_E	0.670	0.42
322_F	360_V	0.670	0.42
23_V	26_D	0.670	0.42
139_L	302_C	0.670	0.42
357_D	368_A	0.669	0.42
373_H	378_L	0.668	0.42
122_F	325_S	0.666	0.41
85_L	338_L	0.660	0.41
128_E	309_L	0.658	0.41
138_K	363_T	0.656	0.41
86_V	271_V	0.654	0.40
143_H	152_Q	0.654	0.40
295_D	345_R	0.653	0.40
133_E	335_Y	0.652	0.40
71_Y	329_V	0.650	0.40
41_G	324_T	0.647	0.40
18_E	353_E	0.647	0.40
49_T	208_N	0.645	0.40
117_L	334_L	0.645	0.40
107_R	291_F	0.643	0.39
18_E	43_A	0.642	0.39
284_T	340_S	0.641	0.39
364_E	370_F	0.641	0.39
26_D	35_V	0.640	0.39
189_F	199_F	0.637	0.39
169_G	341_L	0.635	0.39
34_F	71_Y	0.635	0.39
128_E	132_E	0.632	0.38
12_F	92_E	0.631	0.38
4_L	9_P	0.631	0.38
373_H	376_L	0.629	0.38
366_W	372_S	0.629	0.38
162_D	166_F	0.628	0.38
140_H	333_L	0.627	0.38
309_L	341_L	0.627	0.38
293_P	329_V	0.626	0.38
161_H	181_L	0.625	0.38
155_T	294_A	0.625	0.38
142_L	186_Y	0.621	0.37
111_I	332_I	0.619	0.37
309_L	359_L	0.617	0.37
269_V	282_Y	0.617	0.37
295_D	306_V	0.616	0.37
283_M	296_L	0.615	0.37
368_A	373_H	0.614	0.37
228_K	242_I	0.613	0.37
53_F	336_A	0.613	0.37
89_G	150_I	0.610	0.37
131_H	199_F	0.609	0.36
20_L	81_Y	0.608	0.36
362_P	366_W	0.608	0.36
65_I	208_N	0.607	0.36
74_L	81_Y	0.605	0.36
340_S	369_T	0.605	0.36
14_E	265_R	0.604	0.36
317_Y	344_S	0.604	0.36
116_V	166_F	0.603	0.36
108_D	144_N	0.601	0.36
130_R	134_Q	0.599	0.36
121_E	135_A	0.599	0.36
81_Y	85_L	0.597	0.35
199_F	315_T	0.596	0.35
10_S	13_L	0.596	0.35
141_L	334_L	0.596	0.35
193_D	264_K	0.596	0.35
287_A	291_F	0.595	0.35
352_T	361_F	0.595	0.35
37_A	50_L	0.595	0.35
365_R	369_T	0.594	0.35
73_R	329_V	0.590	0.35
324_T	330_V	0.590	0.35
50_L	70_F	0.590	0.35
107_R	290_E	0.588	0.35
9_P	14_E	0.587	0.35
364_E	368_A	0.586	0.34
86_V	333_L	0.586	0.34
19_E	22_V	0.585	0.34
5_T	15_D	0.581	0.34
40_F	112_A	0.581	0.34
144_N	202_R	0.579	0.34
50_L	183_Y	0.578	0.34
213_G	354_Q	0.577	0.34
152_Q	176_L	0.576	0.34
14_E	85_L	0.575	0.34
86_V	90_L	0.575	0.34
300_Y	307_E	0.575	0.34
160_T	173_E	0.574	0.33
267_R	307_E	0.572	0.33
16_H	88_H	0.571	0.33
356_D	360_V	0.571	0.33
16_H	37_A	0.571	0.33
140_H	311_R	0.570	0.33
24_E	31_I	0.566	0.33
11_E	21_G	0.565	0.33
367_A	372_S	0.563	0.33
163_S	167_K	0.563	0.33
359_L	364_E	0.563	0.33
65_I	119_L	0.561	0.32
137_A	334_L	0.561	0.32
11_E	213_G	0.560	0.32
357_D	371_R	0.560	0.32
61_A	287_A	0.559	0.32
178_L	277_D	0.559	0.32
347_L	351_V	0.556	0.32
369_T	378_L	0.556	0.32
5_T	8_F	0.555	0.32
25_R	332_I	0.554	0.32
175_R	197_G	0.553	0.32
103_I	306_V	0.552	0.32
149_T	346_D	0.551	0.32
82_L	336_A	0.551	0.32
80_E	194_E	0.551	0.32
288_R	291_F	0.551	0.32
42_F	128_E	0.551	0.32
249_E	258_T	0.548	0.31
8_F	214_E	0.548	0.31
196_D	277_D	0.546	0.31
130_R	158_E	0.545	0.31
113_D	314_K	0.545	0.31
206_N	350_L	0.545	0.31
17_A	35_V	0.543	0.31
268_V	286_L	0.542	0.31
5_T	36_W	0.540	0.31
41_G	70_F	0.540	0.31
34_F	129_A	0.538	0.31
9_P	85_L	0.537	0.30
140_H	162_D	0.537	0.30
16_H	19_E	0.533	0.30
163_S	346_D	0.531	0.30
131_H	330_V	0.529	0.30
53_F	332_I	0.527	0.30
270_G	281_L	0.525	0.30
174_N	269_V	0.523	0.29
185_K	324_T	0.522	0.29
361_F	372_S	0.522	0.29
186_Y	264_K	0.521	0.29
283_M	351_V	0.521	0.29
176_L	290_E	0.520	0.29
115_T	322_F	0.520	0.29
21_G	78_L	0.519	0.29
204_K	334_L	0.519	0.29
363_T	369_T	0.519	0.29
189_F	262_D	0.518	0.29
6_T	299_I	0.517	0.29
22_V	34_F	0.517	0.29
104_D	291_F	0.516	0.29
114_G	138_K	0.516	0.29
300_Y	304_W	0.516	0.29
199_F	271_V	0.513	0.29
14_E	18_E	0.513	0.29
288_R	368_A	0.513	0.29
116_V	204_K	0.513	0.29
128_E	316_Q	0.512	0.29
12_F	15_D	0.512	0.29
142_L	169_G	0.512	0.29
312_E	333_L	0.510	0.28
359_L	367_A	0.509	0.28
163_S	188_R	0.509	0.28
324_T	371_R	0.509	0.28
120_H	135_A	0.508	0.28
134_Q	158_E	0.507	0.28
370_F	373_H	0.506	0.28
158_E	344_S	0.505	0.28
185_K	342_L	0.504	0.28
72_Q	137_A	0.504	0.28
68_G	112_A	0.503	0.28
58_N	65_I	0.503	0.28
66_S	72_Q	0.502	0.28
161_H	205_Q	0.501	0.28
85_L	339_L	0.501	0.28
112_A	158_E	0.501	0.28
278_D	313_L	0.500	0.28

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1musA	2	0.8349	100	0.708	Contact Map
1w7jB	1	0.2476	17.2	0.968	Contact Map
1rroA	1	0.2476	17	0.968	Contact Map
2kycA	1	0.2476	16.7	0.968	Contact Map
4ociA	2	0.2689	16.3	0.968	Contact Map
3pm8A	2	0.2594	15.9	0.968	Contact Map
4u7bA	2	0.6061	15.6	0.969	Contact Map
1m45A	1	0.2524	14.2	0.969	Contact Map
4mvfA	1	0.2594	13.3	0.97	Contact Map
1s1eA	1	0.3019	12.7	0.97	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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