GREMLIN Database
O51971 - TbpA
UniProt: O51971 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 100 (86)
Sequences: 1021 (631)
Seq/√Len: 68.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
54_V69_G3.7221.00
42_F59_F3.6961.00
49_L52_P3.1141.00
15_A75_A2.9971.00
54_V78_A2.7071.00
42_F57_L2.2531.00
23_L28_V2.1251.00
46_V57_L2.0471.00
59_F67_T2.0251.00
57_L65_V2.0171.00
17_T64_L1.8471.00
13_V75_A1.8251.00
35_A45_L1.8201.00
13_V71_H1.5620.99
66_I75_A1.5590.99
33_E40_E1.5320.99
54_V82_I1.4890.99
80_D84_S1.4810.99
44_G59_F1.4720.99
70_K74_D1.4690.99
26_S30_M1.4570.98
80_D88_D1.4360.98
66_I79_V1.3740.98
12_N67_T1.3670.98
27_R31_D1.3480.97
22_E60_G1.2850.97
36_D48_R1.2840.97
31_D89_L1.2830.97
43_P47_Y1.2760.96
18_A63_K1.2730.96
59_F65_V1.2690.96
44_G48_R1.2140.95
56_A82_I1.1870.95
54_V70_K1.1780.95
49_L82_I1.1720.94
13_V18_A1.1440.94
48_R61_S1.0670.91
28_V36_D1.0650.91
11_E70_K1.0630.91
14_V65_V1.0520.90
69_G78_A1.0260.89
72_P76_E1.0060.88
36_D49_L1.0020.88
66_I69_G0.9970.88
44_G57_L0.9740.87
14_V42_F0.9510.85
42_F46_V0.9500.85
21_Q82_I0.9490.85
38_D41_Q0.9360.84
49_L81_T0.9160.83
84_S87_E0.9120.83
85_R88_D0.8950.82
50_D77_H0.8700.80
10_I91_L0.8640.79
28_V32_L0.8630.79
48_R55_V0.8610.79
32_L85_R0.8230.76
51_E77_H0.8170.75
19_I64_L0.8150.75
52_P74_D0.8140.75
49_L78_A0.8120.75
19_I86_L0.8100.75
41_Q70_K0.8020.74
72_P80_D0.7960.73
29_A35_A0.7940.73
84_S89_L0.7900.73
46_V59_F0.7750.71
34_G64_L0.7730.71
38_D47_Y0.7620.70
11_E45_L0.7590.70
53_S70_K0.7570.70
49_L54_V0.7440.68
48_R57_L0.7370.68
74_D77_H0.7220.66
17_T75_A0.7160.65
44_G61_S0.7140.65
47_Y85_R0.7070.64
28_V45_L0.7060.64
59_F63_K0.7040.64
11_E14_V0.6960.63
24_D27_R0.6960.63
8_I86_L0.6960.63
41_Q45_L0.6830.62
15_A19_I0.6800.61
9_T76_E0.6600.59
66_I91_L0.6560.59
13_V72_P0.6450.57
17_T20_E0.6370.56
47_Y57_L0.6270.55
39_P44_G0.6260.55
46_V63_K0.6260.55
37_Y40_E0.6220.55
16_S19_I0.6100.53
24_D60_G0.6080.53
76_E83_D0.5960.52
55_V61_S0.5900.51
56_A73_V0.5860.50
43_P65_V0.5840.50
11_E15_A0.5810.50
22_E32_L0.5790.50
6_D64_L0.5770.49
20_E71_H0.5740.49
77_H81_T0.5680.48
35_A47_Y0.5670.48
54_V66_I0.5610.47
64_L84_S0.5610.47
76_E80_D0.5590.47
11_E78_A0.5520.46
61_S86_L0.5490.46
7_T31_D0.5430.45
43_P57_L0.5410.45
9_T21_Q0.5400.45
42_F63_K0.5400.45
27_R80_D0.5380.45
13_V81_T0.5320.44
9_T82_I0.5310.44
8_I79_V0.5310.44
13_V50_D0.5280.43
10_I14_V0.5240.43
25_L63_K0.5220.43
32_L41_Q0.5210.43
21_Q83_D0.5190.42
13_V74_D0.5180.42
57_L63_K0.5140.42
40_E60_G0.5110.41
26_S45_L0.5100.41
7_T79_V0.5050.41
60_G74_D0.5050.41
42_F61_S0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2z8uA 2 0.9 99.9 0.125 Contact Map
3eikA 2 0.94 99.9 0.126 Contact Map
1aisA 1 1 99.9 0.128 Contact Map
4b0aA 1 0.92 99.9 0.129 Contact Map
1rm1A 1 0.92 99.9 0.132 Contact Map
1ytbA 1 0.96 99.9 0.139 Contact Map
1mp9A 2 1 99.9 0.148 Contact Map
2d0bA 1 0.83 89.9 0.828 Contact Map
3vn5A 1 0.76 84.5 0.842 Contact Map
4py5A 1 0.81 80.5 0.849 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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