GREMLIN Database
GVPO1 - Protein GvpO 1
UniProt: O51968 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 119 (100)
Sequences: 210 (168)
Seq/√Len: 16.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
108_E116_K2.9270.98
78_R86_D2.5380.96
41_Q71_T2.4710.95
60_I86_D2.4630.95
52_L105_E2.3300.93
81_V85_Q2.1130.89
86_D116_K1.8980.83
17_D20_T1.8660.82
45_R102_T1.8320.81
41_Q58_G1.8150.80
88_I100_D1.8130.80
44_A101_V1.7880.79
58_G70_R1.7810.79
87_I115_M1.7350.77
41_Q52_L1.7310.77
57_E64_S1.6910.75
52_L71_T1.6890.75
58_G71_T1.6670.74
74_E110_Y1.6450.73
71_T74_E1.6300.72
48_A90_R1.6200.72
70_R94_T1.5740.70
80_A89_G1.5660.69
39_N66_D1.5460.68
111_R114_D1.5420.68
72_V90_R1.4450.63
50_D74_E1.4160.61
78_R85_Q1.4120.61
25_D31_S1.3660.58
33_N36_T1.3580.58
42_T50_D1.3470.57
86_D90_R1.3360.57
22_P25_D1.3330.57
22_P26_G1.3000.55
54_H111_R1.2990.55
60_I116_K1.2850.54
71_T114_D1.2840.54
48_A86_D1.2750.53
85_Q111_R1.2740.53
105_E115_M1.2690.53
58_G111_R1.2520.52
37_L80_A1.2030.49
84_T104_Y1.2000.49
18_D24_S1.1960.48
18_D22_P1.1800.47
62_A111_R1.1620.46
92_E105_E1.1530.46
57_E76_V1.1480.46
19_E67_E1.1410.45
19_E29_S1.1290.44
40_A73_V1.0970.43
19_E26_G1.0900.42
89_G106_L1.0450.40
56_F92_E1.0400.39
61_K90_R1.0140.38
23_A98_T1.0100.38
89_G93_I0.9970.37
40_A44_A0.9800.36
83_D113_G0.9720.36
29_S97_G0.9720.36
22_P32_A0.9550.35
78_R90_R0.9310.33
47_A89_G0.9260.33
54_H58_G0.9250.33
71_T111_R0.8950.31
71_T87_I0.8910.31
53_E95_L0.8780.31
74_E114_D0.8780.31
46_E97_G0.8720.30
61_K94_T0.8710.30
17_D22_P0.8640.30
64_S88_I0.8380.29
80_A106_L0.8170.28
21_P24_S0.8130.27
63_E105_E0.8080.27
87_I111_R0.7970.27
57_E83_D0.7930.26
23_A27_N0.7850.26
80_A101_V0.7840.26
73_V108_E0.7830.26
33_N57_E0.7780.26
24_S98_T0.7670.25
33_N98_T0.7540.25
26_G30_P0.7440.24
102_T114_D0.7410.24
62_A72_V0.7340.24
87_I105_E0.7260.23
36_T83_D0.7220.23
18_D66_D0.7180.23
54_H71_T0.7160.23
101_V108_E0.7140.23
42_T59_M0.7100.23
46_E55_Q0.7090.23
52_L111_R0.7080.23
51_L73_V0.7070.23
61_K74_E0.7030.22
103_G107_L0.7030.22
42_T75_V0.7020.22
56_F85_Q0.6990.22
96_D113_G0.6870.22
53_E68_G0.6780.21
28_P66_D0.6780.21
25_D32_A0.6720.21
24_S103_G0.6690.21
63_E87_I0.6520.20
20_T25_D0.6490.20
27_N43_R0.6460.20
64_S115_M0.6440.20
48_A93_I0.6410.20
73_V90_R0.6400.20
88_I113_G0.6380.20
72_V114_D0.6340.20
19_E24_S0.6330.20
60_I90_R0.6310.20
38_S81_V0.6300.20
41_Q85_Q0.6270.20
26_G46_E0.6270.20
61_K71_T0.6260.19
37_L93_I0.6230.19
22_P96_D0.6100.19
80_A90_R0.6060.19
22_P28_P0.6050.19
37_L40_A0.5890.18
79_N84_T0.5860.18
27_N97_G0.5840.18
66_D100_D0.5820.18
21_P28_P0.5820.18
84_T87_I0.5770.18
90_R116_K0.5720.18
20_T67_E0.5620.17
54_H87_I0.5500.17
41_Q78_R0.5490.17
19_E30_P0.5480.17
57_E88_I0.5460.17
44_A63_E0.5440.17
31_S66_D0.5410.16
18_D30_P0.5410.16
80_A85_Q0.5370.16
45_R67_E0.5290.16
74_E85_Q0.5200.16
47_A50_D0.5180.16
39_N107_L0.5180.16
24_S66_D0.5160.16
101_V116_K0.5150.16
105_E114_D0.5140.16
32_A98_T0.5100.15
48_A87_I0.5070.15
52_L63_E0.5050.15
79_N107_L0.5050.15
63_E81_V0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2glwA 1 0.2941 9.5 0.935 Contact Map
2km7A 1 0.2857 4.7 0.944 Contact Map
2ci2I 3 0.5378 4 0.946 Contact Map
4exrA 2 0.7647 3.9 0.946 Contact Map
2fggA 2 0.437 3.8 0.946 Contact Map
4hhjA 1 0.5042 3.7 0.947 Contact Map
3p2hA 1 0.6387 2.7 0.95 Contact Map
1xwrA 4 0.6639 2.4 0.951 Contact Map
4ffjA 2 0.7731 2 0.953 Contact Map
1x3lA 1 0.8739 2 0.953 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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