O51966 - HALSA - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

O51966 - Uncharacterized protein

UniProt:	O51966	Sequences: MRRLTTLFPSEFLEEHAEELGVVERDRKLQIPAFVWAFVFGFAAGESRTLAGFRRCYNSTADETISPGGFYQRLTPTLAEYLRDLVEHGLDEVAVPNAVDADIDRFRDVMIADGTVLRLHEFLSDQFEARHEEQAGAKLHLLHNATEQTIERLDTANEKTHDSTLFKTGPWLENRLVLFDLAYFKYRRFALIDENDGYFVSRLKQNANPLITRELREWRGRAIPLEGKQLRAVLDDLDRKYIDVEVEVEFKRGPYNGTRSLDTKRFRVVGVRDEDADDYHLYMTNLVRKEFFPADLAQIYRCRWEVELLFRELKTQYNLDEFNTSDEHVVKILLYAALLSLLVSRDLLDLVTEQADDELVFPTERWAATFRSHAQLFLHKLGEYLGYSPPPLLERLTEDAQKIHKQRPILQETLATATQPRCES	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	424 (346)
Sequences:	958 (781)
Seq/√Len:	42.0

ECOLI - INSG INSL1 INSL2 INSL3
HALSA - O51966 O52023 O51972 O54648 Q9HI34 Q9HI01 O54644

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
114_G	162_D	5.119	1.00
68_G	72_Q	4.539	1.00
198_Y	285_N	4.269	1.00
178_L	299_I	4.000	1.00
324_T	329_V	3.980	1.00
73_R	76_P	3.840	1.00
69_G	72_Q	3.664	1.00
172_L	175_R	3.606	1.00
140_H	183_Y	3.577	1.00
286_L	291_F	3.545	1.00
111_I	145_A	3.330	1.00
66_S	69_G	3.082	1.00
199_F	266_F	3.042	1.00
136_G	158_E	2.647	1.00
74_L	332_I	2.638	1.00
274_E	277_D	2.605	1.00
323_N	333_L	2.568	1.00
110_M	175_R	2.566	1.00
38_F	41_G	2.470	1.00
192_I	197_G	2.440	1.00
87_E	152_R	2.438	1.00
86_V	338_L	2.435	1.00
125_D	327_E	2.376	1.00
308_L	311_R	2.322	1.00
179_F	201_S	2.317	1.00
108_D	175_R	2.254	1.00
49_T	296_L	2.239	1.00
199_F	285_N	2.186	1.00
176_L	286_L	2.135	0.99
306_V	310_F	2.097	0.99
298_Q	301_R	2.086	0.99
93_V	346_D	2.064	0.99
311_R	315_T	2.012	0.99
79_A	331_K	2.009	0.99
31_I	81_Y	1.989	0.99
30_Q	33_A	1.968	0.99
203_L	207_A	1.935	0.99
141_L	310_F	1.896	0.99
191_L	195_N	1.889	0.99
270_G	279_Y	1.857	0.98
248_V	251_K	1.853	0.98
271_V	297_A	1.837	0.98
189_F	201_S	1.836	0.98
83_R	331_K	1.832	0.98
110_M	151_E	1.820	0.98
140_H	156_A	1.779	0.98
161_H	164_T	1.754	0.98
21_G	24_E	1.751	0.98
23_V	31_I	1.750	0.98
311_R	316_Q	1.743	0.98
156_A	160_T	1.740	0.98
152_R	170_P	1.728	0.97
277_D	284_T	1.711	0.97
153_L	338_L	1.664	0.97
284_T	296_L	1.662	0.97
107_R	198_Y	1.634	0.96
19_E	84_D	1.625	0.96
267_R	304_W	1.622	0.96
107_R	176_L	1.573	0.96
105_R	295_D	1.566	0.95
86_V	341_L	1.546	0.95
181_L	202_R	1.513	0.95
201_S	283_M	1.507	0.94
115_T	314_K	1.492	0.94
228_K	231_R	1.489	0.94
34_F	77_T	1.486	0.94
112_A	142_L	1.485	0.94
38_F	336_A	1.453	0.93
4_L	230_L	1.451	0.93
193_D	285_N	1.444	0.93
182_A	204_K	1.442	0.93
34_F	73_R	1.427	0.93
184_F	207_A	1.426	0.93
186_Y	207_A	1.415	0.92
180_D	307_E	1.414	0.92
8_F	15_E	1.411	0.92
272_R	277_D	1.404	0.92
327_E	331_K	1.398	0.92
34_F	74_L	1.384	0.91
332_I	336_A	1.367	0.91
155_T	331_K	1.363	0.91
120_H	333_L	1.360	0.91
29_L	37_A	1.345	0.90
23_V	27_R	1.341	0.90
83_R	87_E	1.334	0.90
22_V	31_I	1.327	0.90
50_L	71_Y	1.308	0.89
104_D	109_V	1.304	0.89
162_D	182_A	1.299	0.89
24_E	27_R	1.299	0.89
49_T	53_F	1.291	0.88
345_R	348_L	1.290	0.88
57_Y	195_N	1.285	0.88
113_D	307_E	1.279	0.88
348_L	366_W	1.277	0.88
138_K	285_N	1.274	0.88
116_V	138_K	1.272	0.88
89_G	342_L	1.268	0.87
110_M	142_L	1.266	0.87
282_Y	296_L	1.260	0.87
180_D	300_Y	1.245	0.86
181_L	201_S	1.222	0.85
141_L	150_I	1.222	0.85
169_G	341_L	1.209	0.85
190_A	194_E	1.207	0.85
77_T	332_I	1.206	0.85
271_V	282_Y	1.205	0.85
291_F	296_L	1.202	0.84
74_L	77_T	1.200	0.84
127_F	309_L	1.196	0.84
270_G	281_L	1.192	0.84
120_H	330_V	1.186	0.84
115_T	139_L	1.179	0.83
82_L	332_I	1.175	0.83
142_L	151_E	1.173	0.83
32_P	36_W	1.173	0.83
29_L	69_G	1.170	0.83
74_L	333_L	1.161	0.82
86_V	169_G	1.160	0.82
34_F	37_A	1.159	0.82
139_L	334_L	1.152	0.82
309_L	317_Y	1.150	0.82
12_F	16_H	1.147	0.81
77_T	82_L	1.146	0.81
216_R	275_D	1.143	0.81
315_T	343_V	1.143	0.81
143_H	335_Y	1.133	0.81
67_P	326_D	1.126	0.80
31_I	77_T	1.122	0.80
312_E	345_R	1.118	0.80
193_D	199_F	1.116	0.80
22_V	81_Y	1.110	0.79
27_R	77_T	1.109	0.79
50_L	53_F	1.104	0.79
150_I	309_L	1.099	0.79
79_A	328_H	1.098	0.78
13_L	16_H	1.093	0.78
13_L	17_A	1.092	0.78
21_G	277_D	1.091	0.78
4_L	18_E	1.080	0.77
167_K	188_R	1.077	0.77
312_E	341_L	1.076	0.77
176_L	200_V	1.066	0.76
230_L	293_P	1.062	0.76
8_F	189_F	1.055	0.76
119_L	137_A	1.050	0.75
113_D	180_D	1.049	0.75
205_Q	330_V	1.049	0.75
124_S	128_E	1.045	0.75
200_V	299_I	1.043	0.75
247_E	250_F	1.039	0.75
292_F	295_D	1.034	0.74
364_E	369_T	1.032	0.74
127_F	312_E	1.031	0.74
31_I	34_F	1.030	0.74
10_S	32_P	1.028	0.74
152_R	349_D	1.020	0.73
108_D	181_L	1.012	0.73
8_F	21_G	1.011	0.72
310_F	372_S	1.010	0.72
296_L	341_L	1.008	0.72
357_D	360_V	1.008	0.72
103_I	306_V	1.005	0.72
73_R	106_F	1.000	0.72
35_V	82_L	0.999	0.72
34_F	134_Q	0.995	0.71
122_F	135_A	0.993	0.71
227_G	230_L	0.990	0.71
376_L	379_H	0.988	0.71
74_L	324_T	0.985	0.70
214_E	217_E	0.980	0.70
135_A	333_L	0.975	0.70
8_F	89_G	0.974	0.70
14_E	35_V	0.971	0.69
271_V	280_H	0.970	0.69
364_E	371_R	0.970	0.69
151_E	330_V	0.966	0.69
311_R	317_Y	0.961	0.69
367_A	374_A	0.956	0.68
25_R	30_Q	0.952	0.68
324_T	333_L	0.952	0.68
295_D	306_V	0.946	0.67
70_F	311_R	0.944	0.67
15_E	275_D	0.935	0.66
304_W	307_E	0.934	0.66
180_D	314_K	0.933	0.66
117_L	139_L	0.931	0.66
287_V	291_F	0.930	0.66
359_L	362_P	0.930	0.66
163_S	204_K	0.929	0.66
166_F	188_R	0.929	0.66
7_L	12_F	0.926	0.66
162_D	180_D	0.921	0.65
75_T	326_D	0.919	0.65
110_M	177_V	0.918	0.65
10_S	14_E	0.915	0.65
157_N	182_A	0.915	0.65
366_W	377_F	0.915	0.65
74_L	134_Q	0.915	0.65
39_V	336_A	0.914	0.65
35_V	39_V	0.914	0.65
113_D	284_T	0.913	0.65
367_A	371_R	0.913	0.65
156_A	165_L	0.912	0.64
77_T	181_L	0.907	0.64
128_E	309_L	0.902	0.64
144_N	181_L	0.902	0.64
127_F	331_K	0.900	0.63
68_G	118_R	0.900	0.63
183_Y	343_V	0.896	0.63
162_D	166_F	0.892	0.63
178_L	210_L	0.890	0.63
161_H	347_L	0.890	0.63
173_E	196_D	0.887	0.62
20_L	23_V	0.885	0.62
356_D	368_A	0.882	0.62
155_T	294_A	0.879	0.62
157_N	372_S	0.876	0.61
302_C	305_E	0.874	0.61
101_A	105_R	0.873	0.61
68_G	71_Y	0.871	0.61
29_L	33_A	0.871	0.61
150_I	342_L	0.867	0.61
123_L	325_S	0.865	0.60
73_R	77_T	0.865	0.60
11_E	15_E	0.864	0.60
91_D	193_D	0.862	0.60
171_W	177_V	0.860	0.60
33_A	149_T	0.858	0.60
196_D	277_D	0.857	0.60
173_E	299_I	0.856	0.60
177_V	283_M	0.855	0.59
171_W	197_G	0.854	0.59
35_V	336_A	0.850	0.59
73_R	329_V	0.843	0.58
179_F	182_A	0.840	0.58
113_D	304_W	0.838	0.58
113_D	202_R	0.837	0.58
84_D	88_H	0.833	0.57
138_K	161_H	0.832	0.57
79_A	334_L	0.831	0.57
8_F	49_T	0.827	0.57
82_L	102_D	0.824	0.57
303_R	307_E	0.823	0.56
146_T	302_C	0.822	0.56
132_E	205_Q	0.822	0.56
141_L	334_L	0.821	0.56
360_V	378_L	0.820	0.56
79_A	83_R	0.815	0.56
80_E	194_E	0.815	0.56
26_D	35_V	0.812	0.55
362_P	365_R	0.805	0.55
361_F	366_W	0.805	0.55
274_E	306_V	0.803	0.55
273_D	280_H	0.801	0.54
115_T	182_A	0.800	0.54
312_E	330_V	0.798	0.54
128_E	136_G	0.796	0.54
82_L	328_H	0.792	0.54
108_D	172_L	0.792	0.54
52_G	368_A	0.788	0.53
135_A	332_I	0.788	0.53
141_L	341_L	0.787	0.53
71_Y	329_V	0.787	0.53
9_P	12_F	0.785	0.53
110_M	162_D	0.783	0.53
307_E	314_K	0.781	0.53
203_L	206_N	0.778	0.52
49_T	68_G	0.776	0.52
155_T	334_L	0.773	0.52
134_Q	158_E	0.772	0.52
241_Y	298_Q	0.772	0.52
319_L	337_A	0.770	0.52
161_H	182_A	0.770	0.52
274_E	281_L	0.770	0.52
178_L	193_D	0.769	0.51
8_F	133_E	0.768	0.51
104_D	339_L	0.767	0.51
251_K	338_L	0.765	0.51
306_V	374_A	0.762	0.51
347_L	351_V	0.758	0.50
287_V	348_L	0.753	0.50
312_E	316_Q	0.749	0.50
166_F	177_V	0.749	0.50
162_D	342_L	0.748	0.49
202_R	307_E	0.746	0.49
182_A	203_L	0.744	0.49
113_D	303_R	0.743	0.49
247_E	251_K	0.742	0.49
155_T	266_F	0.741	0.49
196_D	292_F	0.739	0.49
194_E	265_R	0.737	0.48
80_E	103_I	0.736	0.48
295_D	345_R	0.736	0.48
18_E	272_R	0.734	0.48
175_R	192_I	0.729	0.48
137_A	334_L	0.729	0.48
12_F	88_H	0.728	0.48
142_L	177_V	0.728	0.48
77_T	342_L	0.728	0.48
311_R	314_K	0.727	0.48
110_M	172_L	0.725	0.47
187_R	338_L	0.723	0.47
114_G	180_D	0.723	0.47
29_L	70_F	0.722	0.47
179_F	192_I	0.721	0.47
81_Y	85_L	0.721	0.47
181_L	207_A	0.720	0.47
153_L	215_L	0.719	0.47
133_E	160_T	0.718	0.47
161_H	181_L	0.715	0.46
97_N	187_R	0.710	0.46
117_L	334_L	0.708	0.46
144_N	147_E	0.708	0.46
202_R	304_W	0.707	0.46
34_F	129_A	0.707	0.46
322_F	360_V	0.705	0.45
169_G	241_Y	0.704	0.45
163_S	167_K	0.703	0.45
147_E	159_K	0.702	0.45
76_P	269_V	0.701	0.45
107_R	291_F	0.695	0.45
131_H	199_F	0.693	0.44
53_F	336_A	0.690	0.44
299_I	317_Y	0.686	0.44
300_Y	307_E	0.685	0.44
109_V	299_I	0.685	0.44
82_L	336_A	0.684	0.44
23_V	26_D	0.683	0.43
128_E	316_Q	0.682	0.43
16_H	84_D	0.681	0.43
90_L	342_L	0.678	0.43
80_E	83_R	0.676	0.43
180_D	304_W	0.675	0.43
273_D	277_D	0.675	0.43
74_L	81_Y	0.673	0.42
38_F	324_T	0.672	0.42
120_H	135_A	0.672	0.42
4_L	347_L	0.672	0.42
118_R	136_G	0.671	0.42
284_T	307_E	0.671	0.42
344_S	367_A	0.670	0.42
111_I	332_I	0.669	0.42
41_G	70_F	0.668	0.42
15_E	292_F	0.666	0.42
251_K	290_E	0.666	0.42
325_S	333_L	0.666	0.42
113_D	314_K	0.663	0.42
309_L	341_L	0.662	0.41
58_N	66_S	0.661	0.41
366_W	372_S	0.661	0.41
24_E	31_I	0.661	0.41
204_K	334_L	0.660	0.41
121_E	135_A	0.659	0.41
138_K	150_I	0.657	0.41
134_Q	333_L	0.657	0.41
5_T	35_V	0.655	0.41
150_I	185_K	0.654	0.41
144_N	202_R	0.654	0.41
53_F	153_L	0.649	0.40
142_L	171_W	0.647	0.40
55_R	64_T	0.646	0.40
188_R	282_Y	0.645	0.40
369_T	375_Q	0.645	0.40
171_W	295_D	0.644	0.40
82_L	173_E	0.640	0.40
364_E	379_H	0.640	0.40
279_Y	285_N	0.640	0.40
185_K	324_T	0.639	0.39
139_L	155_T	0.639	0.39
14_E	18_E	0.637	0.39
309_L	359_L	0.635	0.39
77_T	341_L	0.635	0.39
62_D	150_I	0.632	0.39
290_E	294_A	0.631	0.39
66_S	192_I	0.631	0.39
180_D	303_R	0.631	0.39
352_T	361_F	0.631	0.39
104_D	198_Y	0.629	0.39
5_T	36_W	0.628	0.38
53_F	362_P	0.627	0.38
268_V	286_L	0.626	0.38
138_K	158_E	0.626	0.38
139_L	302_C	0.626	0.38
15_E	18_E	0.625	0.38
66_S	72_Q	0.624	0.38
296_L	310_F	0.624	0.38
14_E	265_R	0.624	0.38
122_F	366_W	0.623	0.38
88_H	298_Q	0.621	0.38
142_L	186_Y	0.621	0.38
38_F	110_M	0.620	0.38
55_R	164_T	0.620	0.38
364_E	368_A	0.620	0.38
277_D	285_N	0.620	0.38
10_S	13_L	0.618	0.38
16_H	37_A	0.618	0.38
28_K	33_A	0.617	0.37
128_E	158_E	0.617	0.37
128_E	133_E	0.615	0.37
181_L	284_T	0.613	0.37
247_E	252_R	0.613	0.37
200_V	296_L	0.612	0.37
181_L	204_K	0.611	0.37
23_V	72_Q	0.610	0.37
156_A	330_V	0.610	0.37
145_A	295_D	0.607	0.37
278_D	308_L	0.606	0.36
140_H	162_D	0.606	0.36
200_V	337_A	0.606	0.36
205_Q	283_M	0.604	0.36
128_E	167_K	0.604	0.36
47_S	109_V	0.604	0.36
274_E	355_A	0.602	0.36
85_L	292_F	0.601	0.36
98_A	105_R	0.600	0.36
34_F	71_Y	0.598	0.36
6_T	10_S	0.598	0.36
206_N	350_L	0.597	0.36
65_I	334_L	0.594	0.35
365_R	368_A	0.591	0.35
292_F	361_F	0.589	0.35
140_H	333_L	0.586	0.35
28_K	64_T	0.586	0.35
90_L	172_L	0.585	0.35
80_E	274_E	0.585	0.35
299_I	326_D	0.583	0.35
227_G	231_R	0.583	0.35
14_E	155_T	0.582	0.34
111_I	203_L	0.582	0.34
65_I	208_N	0.582	0.34
9_P	14_E	0.581	0.34
25_R	332_I	0.581	0.34
182_A	308_L	0.580	0.34
127_F	198_Y	0.580	0.34
8_F	35_V	0.578	0.34
13_L	20_L	0.578	0.34
332_I	342_L	0.576	0.34
362_P	370_F	0.575	0.34
42_F	128_E	0.574	0.34
301_R	328_H	0.573	0.34
92_E	293_P	0.573	0.34
174_N	269_V	0.573	0.34
40_F	112_A	0.572	0.34
13_L	30_Q	0.571	0.34
104_D	107_R	0.571	0.34
162_D	323_N	0.571	0.34
166_F	169_G	0.570	0.33
284_T	304_W	0.570	0.33
138_K	162_D	0.569	0.33
185_K	342_L	0.568	0.33
145_A	299_I	0.568	0.33
83_R	171_W	0.566	0.33
105_R	248_V	0.566	0.33
293_P	299_I	0.562	0.33
344_S	368_A	0.562	0.33
285_N	329_V	0.561	0.33
41_G	332_I	0.560	0.33
91_D	230_L	0.560	0.33
205_Q	210_L	0.559	0.33
189_F	207_A	0.558	0.32
94_A	102_D	0.557	0.32
28_K	63_E	0.557	0.32
122_F	242_I	0.556	0.32
211_I	241_Y	0.556	0.32
37_A	50_L	0.554	0.32
155_T	208_N	0.554	0.32
151_E	350_L	0.554	0.32
19_E	22_V	0.552	0.32
97_N	100_D	0.551	0.32
18_E	353_E	0.549	0.32
293_P	329_V	0.548	0.32
53_F	58_N	0.547	0.32
86_V	90_L	0.547	0.32
172_L	197_G	0.545	0.31
27_R	345_R	0.545	0.31
20_L	81_Y	0.544	0.31
11_E	21_G	0.544	0.31
68_G	186_Y	0.543	0.31
14_E	85_L	0.541	0.31
138_K	325_S	0.541	0.31
324_T	371_R	0.541	0.31
82_L	361_F	0.541	0.31
310_F	366_W	0.536	0.31
181_L	332_I	0.535	0.31
163_S	188_R	0.535	0.31
131_H	330_V	0.534	0.30
176_L	203_L	0.534	0.30
212_T	298_Q	0.534	0.30
281_L	285_N	0.533	0.30
34_F	332_I	0.531	0.30
12_F	92_E	0.530	0.30
18_E	43_A	0.529	0.30
367_A	375_Q	0.527	0.30
60_T	311_R	0.526	0.30
199_F	271_V	0.525	0.30
109_V	213_R	0.525	0.30
135_A	261_L	0.524	0.30
39_V	104_D	0.524	0.30
114_G	136_G	0.523	0.30
39_V	299_I	0.522	0.30
357_D	371_R	0.522	0.30
138_K	363_T	0.522	0.30
278_D	283_M	0.520	0.29
179_F	210_L	0.519	0.29
112_A	158_E	0.519	0.29
189_F	328_H	0.518	0.29
139_L	331_K	0.517	0.29
165_L	323_N	0.515	0.29
68_G	340_S	0.514	0.29
364_E	367_A	0.510	0.29
279_Y	330_V	0.510	0.29
357_D	372_S	0.507	0.28
108_D	144_N	0.505	0.28
143_H	152_R	0.505	0.28
368_A	371_R	0.503	0.28
122_F	325_S	0.501	0.28
105_R	334_L	0.500	0.28
329_V	348_L	0.500	0.28

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1musA	2	0.8561	100	0.702	Contact Map
3pm8A	2	0.2642	20	0.967	Contact Map
1w7jB	1	0.2476	17.8	0.967	Contact Map
4u7bA	2	0.5896	17.7	0.968	Contact Map
4ociA	2	0.2689	17.3	0.968	Contact Map
2kycA	1	0.2476	17.3	0.968	Contact Map
1rroA	1	0.2476	16.8	0.968	Contact Map
4mvfA	1	0.2594	14.1	0.969	Contact Map
1rwyA	1	0.25	13.8	0.969	Contact Map
1m45A	1	0.2524	13.8	0.969	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0106 seconds.