GREMLIN Database
O51966 - Uncharacterized protein
UniProt: O51966 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 424 (346)
Sequences: 958 (781)
Seq/√Len: 42.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
114_G162_D5.1191.00
68_G72_Q4.5391.00
198_Y285_N4.2691.00
178_L299_I4.0001.00
324_T329_V3.9801.00
73_R76_P3.8401.00
69_G72_Q3.6641.00
172_L175_R3.6061.00
140_H183_Y3.5771.00
286_L291_F3.5451.00
111_I145_A3.3301.00
66_S69_G3.0821.00
199_F266_F3.0421.00
136_G158_E2.6471.00
74_L332_I2.6381.00
274_E277_D2.6051.00
323_N333_L2.5681.00
110_M175_R2.5661.00
38_F41_G2.4701.00
192_I197_G2.4401.00
87_E152_R2.4381.00
86_V338_L2.4351.00
125_D327_E2.3761.00
308_L311_R2.3221.00
179_F201_S2.3171.00
108_D175_R2.2541.00
49_T296_L2.2391.00
199_F285_N2.1861.00
176_L286_L2.1350.99
306_V310_F2.0970.99
298_Q301_R2.0860.99
93_V346_D2.0640.99
311_R315_T2.0120.99
79_A331_K2.0090.99
31_I81_Y1.9890.99
30_Q33_A1.9680.99
203_L207_A1.9350.99
141_L310_F1.8960.99
191_L195_N1.8890.99
270_G279_Y1.8570.98
248_V251_K1.8530.98
271_V297_A1.8370.98
189_F201_S1.8360.98
83_R331_K1.8320.98
110_M151_E1.8200.98
140_H156_A1.7790.98
161_H164_T1.7540.98
21_G24_E1.7510.98
23_V31_I1.7500.98
311_R316_Q1.7430.98
156_A160_T1.7400.98
152_R170_P1.7280.97
277_D284_T1.7110.97
153_L338_L1.6640.97
284_T296_L1.6620.97
107_R198_Y1.6340.96
19_E84_D1.6250.96
267_R304_W1.6220.96
107_R176_L1.5730.96
105_R295_D1.5660.95
86_V341_L1.5460.95
181_L202_R1.5130.95
201_S283_M1.5070.94
115_T314_K1.4920.94
228_K231_R1.4890.94
34_F77_T1.4860.94
112_A142_L1.4850.94
38_F336_A1.4530.93
4_L230_L1.4510.93
193_D285_N1.4440.93
182_A204_K1.4420.93
34_F73_R1.4270.93
184_F207_A1.4260.93
186_Y207_A1.4150.92
180_D307_E1.4140.92
8_F15_E1.4110.92
272_R277_D1.4040.92
327_E331_K1.3980.92
34_F74_L1.3840.91
332_I336_A1.3670.91
155_T331_K1.3630.91
120_H333_L1.3600.91
29_L37_A1.3450.90
23_V27_R1.3410.90
83_R87_E1.3340.90
22_V31_I1.3270.90
50_L71_Y1.3080.89
104_D109_V1.3040.89
162_D182_A1.2990.89
24_E27_R1.2990.89
49_T53_F1.2910.88
345_R348_L1.2900.88
57_Y195_N1.2850.88
113_D307_E1.2790.88
348_L366_W1.2770.88
138_K285_N1.2740.88
116_V138_K1.2720.88
89_G342_L1.2680.87
110_M142_L1.2660.87
282_Y296_L1.2600.87
180_D300_Y1.2450.86
181_L201_S1.2220.85
141_L150_I1.2220.85
169_G341_L1.2090.85
190_A194_E1.2070.85
77_T332_I1.2060.85
271_V282_Y1.2050.85
291_F296_L1.2020.84
74_L77_T1.2000.84
127_F309_L1.1960.84
270_G281_L1.1920.84
120_H330_V1.1860.84
115_T139_L1.1790.83
82_L332_I1.1750.83
142_L151_E1.1730.83
32_P36_W1.1730.83
29_L69_G1.1700.83
74_L333_L1.1610.82
86_V169_G1.1600.82
34_F37_A1.1590.82
139_L334_L1.1520.82
309_L317_Y1.1500.82
12_F16_H1.1470.81
77_T82_L1.1460.81
216_R275_D1.1430.81
315_T343_V1.1430.81
143_H335_Y1.1330.81
67_P326_D1.1260.80
31_I77_T1.1220.80
312_E345_R1.1180.80
193_D199_F1.1160.80
22_V81_Y1.1100.79
27_R77_T1.1090.79
50_L53_F1.1040.79
150_I309_L1.0990.79
79_A328_H1.0980.78
13_L16_H1.0930.78
13_L17_A1.0920.78
21_G277_D1.0910.78
4_L18_E1.0800.77
167_K188_R1.0770.77
312_E341_L1.0760.77
176_L200_V1.0660.76
230_L293_P1.0620.76
8_F189_F1.0550.76
119_L137_A1.0500.75
113_D180_D1.0490.75
205_Q330_V1.0490.75
124_S128_E1.0450.75
200_V299_I1.0430.75
247_E250_F1.0390.75
292_F295_D1.0340.74
364_E369_T1.0320.74
127_F312_E1.0310.74
31_I34_F1.0300.74
10_S32_P1.0280.74
152_R349_D1.0200.73
108_D181_L1.0120.73
8_F21_G1.0110.72
310_F372_S1.0100.72
296_L341_L1.0080.72
357_D360_V1.0080.72
103_I306_V1.0050.72
73_R106_F1.0000.72
35_V82_L0.9990.72
34_F134_Q0.9950.71
122_F135_A0.9930.71
227_G230_L0.9900.71
376_L379_H0.9880.71
74_L324_T0.9850.70
214_E217_E0.9800.70
135_A333_L0.9750.70
8_F89_G0.9740.70
14_E35_V0.9710.69
271_V280_H0.9700.69
364_E371_R0.9700.69
151_E330_V0.9660.69
311_R317_Y0.9610.69
367_A374_A0.9560.68
25_R30_Q0.9520.68
324_T333_L0.9520.68
295_D306_V0.9460.67
70_F311_R0.9440.67
15_E275_D0.9350.66
304_W307_E0.9340.66
180_D314_K0.9330.66
117_L139_L0.9310.66
287_V291_F0.9300.66
359_L362_P0.9300.66
163_S204_K0.9290.66
166_F188_R0.9290.66
7_L12_F0.9260.66
162_D180_D0.9210.65
75_T326_D0.9190.65
110_M177_V0.9180.65
10_S14_E0.9150.65
157_N182_A0.9150.65
366_W377_F0.9150.65
74_L134_Q0.9150.65
39_V336_A0.9140.65
35_V39_V0.9140.65
113_D284_T0.9130.65
367_A371_R0.9130.65
156_A165_L0.9120.64
77_T181_L0.9070.64
128_E309_L0.9020.64
144_N181_L0.9020.64
127_F331_K0.9000.63
68_G118_R0.9000.63
183_Y343_V0.8960.63
162_D166_F0.8920.63
178_L210_L0.8900.63
161_H347_L0.8900.63
173_E196_D0.8870.62
20_L23_V0.8850.62
356_D368_A0.8820.62
155_T294_A0.8790.62
157_N372_S0.8760.61
302_C305_E0.8740.61
101_A105_R0.8730.61
68_G71_Y0.8710.61
29_L33_A0.8710.61
150_I342_L0.8670.61
123_L325_S0.8650.60
73_R77_T0.8650.60
11_E15_E0.8640.60
91_D193_D0.8620.60
171_W177_V0.8600.60
33_A149_T0.8580.60
196_D277_D0.8570.60
173_E299_I0.8560.60
177_V283_M0.8550.59
171_W197_G0.8540.59
35_V336_A0.8500.59
73_R329_V0.8430.58
179_F182_A0.8400.58
113_D304_W0.8380.58
113_D202_R0.8370.58
84_D88_H0.8330.57
138_K161_H0.8320.57
79_A334_L0.8310.57
8_F49_T0.8270.57
82_L102_D0.8240.57
303_R307_E0.8230.56
146_T302_C0.8220.56
132_E205_Q0.8220.56
141_L334_L0.8210.56
360_V378_L0.8200.56
79_A83_R0.8150.56
80_E194_E0.8150.56
26_D35_V0.8120.55
362_P365_R0.8050.55
361_F366_W0.8050.55
274_E306_V0.8030.55
273_D280_H0.8010.54
115_T182_A0.8000.54
312_E330_V0.7980.54
128_E136_G0.7960.54
82_L328_H0.7920.54
108_D172_L0.7920.54
52_G368_A0.7880.53
135_A332_I0.7880.53
141_L341_L0.7870.53
71_Y329_V0.7870.53
9_P12_F0.7850.53
110_M162_D0.7830.53
307_E314_K0.7810.53
203_L206_N0.7780.52
49_T68_G0.7760.52
155_T334_L0.7730.52
134_Q158_E0.7720.52
241_Y298_Q0.7720.52
319_L337_A0.7700.52
161_H182_A0.7700.52
274_E281_L0.7700.52
178_L193_D0.7690.51
8_F133_E0.7680.51
104_D339_L0.7670.51
251_K338_L0.7650.51
306_V374_A0.7620.51
347_L351_V0.7580.50
287_V348_L0.7530.50
312_E316_Q0.7490.50
166_F177_V0.7490.50
162_D342_L0.7480.49
202_R307_E0.7460.49
182_A203_L0.7440.49
113_D303_R0.7430.49
247_E251_K0.7420.49
155_T266_F0.7410.49
196_D292_F0.7390.49
194_E265_R0.7370.48
80_E103_I0.7360.48
295_D345_R0.7360.48
18_E272_R0.7340.48
175_R192_I0.7290.48
137_A334_L0.7290.48
12_F88_H0.7280.48
142_L177_V0.7280.48
77_T342_L0.7280.48
311_R314_K0.7270.48
110_M172_L0.7250.47
187_R338_L0.7230.47
114_G180_D0.7230.47
29_L70_F0.7220.47
179_F192_I0.7210.47
81_Y85_L0.7210.47
181_L207_A0.7200.47
153_L215_L0.7190.47
133_E160_T0.7180.47
161_H181_L0.7150.46
97_N187_R0.7100.46
117_L334_L0.7080.46
144_N147_E0.7080.46
202_R304_W0.7070.46
34_F129_A0.7070.46
322_F360_V0.7050.45
169_G241_Y0.7040.45
163_S167_K0.7030.45
147_E159_K0.7020.45
76_P269_V0.7010.45
107_R291_F0.6950.45
131_H199_F0.6930.44
53_F336_A0.6900.44
299_I317_Y0.6860.44
300_Y307_E0.6850.44
109_V299_I0.6850.44
82_L336_A0.6840.44
23_V26_D0.6830.43
128_E316_Q0.6820.43
16_H84_D0.6810.43
90_L342_L0.6780.43
80_E83_R0.6760.43
180_D304_W0.6750.43
273_D277_D0.6750.43
74_L81_Y0.6730.42
38_F324_T0.6720.42
120_H135_A0.6720.42
4_L347_L0.6720.42
118_R136_G0.6710.42
284_T307_E0.6710.42
344_S367_A0.6700.42
111_I332_I0.6690.42
41_G70_F0.6680.42
15_E292_F0.6660.42
251_K290_E0.6660.42
325_S333_L0.6660.42
113_D314_K0.6630.42
309_L341_L0.6620.41
58_N66_S0.6610.41
366_W372_S0.6610.41
24_E31_I0.6610.41
204_K334_L0.6600.41
121_E135_A0.6590.41
138_K150_I0.6570.41
134_Q333_L0.6570.41
5_T35_V0.6550.41
150_I185_K0.6540.41
144_N202_R0.6540.41
53_F153_L0.6490.40
142_L171_W0.6470.40
55_R64_T0.6460.40
188_R282_Y0.6450.40
369_T375_Q0.6450.40
171_W295_D0.6440.40
82_L173_E0.6400.40
364_E379_H0.6400.40
279_Y285_N0.6400.40
185_K324_T0.6390.39
139_L155_T0.6390.39
14_E18_E0.6370.39
309_L359_L0.6350.39
77_T341_L0.6350.39
62_D150_I0.6320.39
290_E294_A0.6310.39
66_S192_I0.6310.39
180_D303_R0.6310.39
352_T361_F0.6310.39
104_D198_Y0.6290.39
5_T36_W0.6280.38
53_F362_P0.6270.38
268_V286_L0.6260.38
138_K158_E0.6260.38
139_L302_C0.6260.38
15_E18_E0.6250.38
66_S72_Q0.6240.38
296_L310_F0.6240.38
14_E265_R0.6240.38
122_F366_W0.6230.38
88_H298_Q0.6210.38
142_L186_Y0.6210.38
38_F110_M0.6200.38
55_R164_T0.6200.38
364_E368_A0.6200.38
277_D285_N0.6200.38
10_S13_L0.6180.38
16_H37_A0.6180.38
28_K33_A0.6170.37
128_E158_E0.6170.37
128_E133_E0.6150.37
181_L284_T0.6130.37
247_E252_R0.6130.37
200_V296_L0.6120.37
181_L204_K0.6110.37
23_V72_Q0.6100.37
156_A330_V0.6100.37
145_A295_D0.6070.37
278_D308_L0.6060.36
140_H162_D0.6060.36
200_V337_A0.6060.36
205_Q283_M0.6040.36
128_E167_K0.6040.36
47_S109_V0.6040.36
274_E355_A0.6020.36
85_L292_F0.6010.36
98_A105_R0.6000.36
34_F71_Y0.5980.36
6_T10_S0.5980.36
206_N350_L0.5970.36
65_I334_L0.5940.35
365_R368_A0.5910.35
292_F361_F0.5890.35
140_H333_L0.5860.35
28_K64_T0.5860.35
90_L172_L0.5850.35
80_E274_E0.5850.35
299_I326_D0.5830.35
227_G231_R0.5830.35
14_E155_T0.5820.34
111_I203_L0.5820.34
65_I208_N0.5820.34
9_P14_E0.5810.34
25_R332_I0.5810.34
182_A308_L0.5800.34
127_F198_Y0.5800.34
8_F35_V0.5780.34
13_L20_L0.5780.34
332_I342_L0.5760.34
362_P370_F0.5750.34
42_F128_E0.5740.34
301_R328_H0.5730.34
92_E293_P0.5730.34
174_N269_V0.5730.34
40_F112_A0.5720.34
13_L30_Q0.5710.34
104_D107_R0.5710.34
162_D323_N0.5710.34
166_F169_G0.5700.33
284_T304_W0.5700.33
138_K162_D0.5690.33
185_K342_L0.5680.33
145_A299_I0.5680.33
83_R171_W0.5660.33
105_R248_V0.5660.33
293_P299_I0.5620.33
344_S368_A0.5620.33
285_N329_V0.5610.33
41_G332_I0.5600.33
91_D230_L0.5600.33
205_Q210_L0.5590.33
189_F207_A0.5580.32
94_A102_D0.5570.32
28_K63_E0.5570.32
122_F242_I0.5560.32
211_I241_Y0.5560.32
37_A50_L0.5540.32
155_T208_N0.5540.32
151_E350_L0.5540.32
19_E22_V0.5520.32
97_N100_D0.5510.32
18_E353_E0.5490.32
293_P329_V0.5480.32
53_F58_N0.5470.32
86_V90_L0.5470.32
172_L197_G0.5450.31
27_R345_R0.5450.31
20_L81_Y0.5440.31
11_E21_G0.5440.31
68_G186_Y0.5430.31
14_E85_L0.5410.31
138_K325_S0.5410.31
324_T371_R0.5410.31
82_L361_F0.5410.31
310_F366_W0.5360.31
181_L332_I0.5350.31
163_S188_R0.5350.31
131_H330_V0.5340.30
176_L203_L0.5340.30
212_T298_Q0.5340.30
281_L285_N0.5330.30
34_F332_I0.5310.30
12_F92_E0.5300.30
18_E43_A0.5290.30
367_A375_Q0.5270.30
60_T311_R0.5260.30
199_F271_V0.5250.30
109_V213_R0.5250.30
135_A261_L0.5240.30
39_V104_D0.5240.30
114_G136_G0.5230.30
39_V299_I0.5220.30
357_D371_R0.5220.30
138_K363_T0.5220.30
278_D283_M0.5200.29
179_F210_L0.5190.29
112_A158_E0.5190.29
189_F328_H0.5180.29
139_L331_K0.5170.29
165_L323_N0.5150.29
68_G340_S0.5140.29
364_E367_A0.5100.29
279_Y330_V0.5100.29
357_D372_S0.5070.28
108_D144_N0.5050.28
143_H152_R0.5050.28
368_A371_R0.5030.28
122_F325_S0.5010.28
105_R334_L0.5000.28
329_V348_L0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1musA 2 0.8561 100 0.702 Contact Map
3pm8A 2 0.2642 20 0.967 Contact Map
1w7jB 1 0.2476 17.8 0.967 Contact Map
4u7bA 2 0.5896 17.7 0.968 Contact Map
4ociA 2 0.2689 17.3 0.968 Contact Map
2kycA 1 0.2476 17.3 0.968 Contact Map
1rroA 1 0.2476 16.8 0.968 Contact Map
4mvfA 1 0.2594 14.1 0.969 Contact Map
1rwyA 1 0.25 13.8 0.969 Contact Map
1m45A 1 0.2524 13.8 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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