GREMLIN Database
O51961 - Uncharacterized protein
UniProt: O51961 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 65 (59)
Sequences: 1900 (1192)
Seq/√Len: 155.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_E21_K2.8311.00
22_E51_Y2.6531.00
4_E7_V2.3901.00
46_F56_I2.2871.00
55_S58_D2.2081.00
9_R34_E2.0031.00
14_L51_Y1.9911.00
7_V10_A1.7021.00
8_Y59_I1.6971.00
8_Y54_C1.6571.00
18_D22_E1.6551.00
54_C58_D1.6031.00
6_K10_A1.5871.00
15_T18_D1.4641.00
23_V51_Y1.4581.00
7_V13_D1.4121.00
7_V11_K1.3741.00
43_E47_K1.3731.00
25_V30_I1.3071.00
48_L59_I1.2911.00
31_N35_A1.2841.00
12_H53_D1.2781.00
29_T38_Y1.2311.00
49_A56_I1.2301.00
45_A56_I1.2071.00
8_Y11_K1.1961.00
4_E61_S1.1961.00
19_L30_I1.1791.00
33_L38_Y1.1501.00
18_D21_K1.0540.99
10_A13_D1.0270.99
14_L18_D1.0210.99
39_D42_L0.9990.99
39_D43_E0.9890.99
23_V52_F0.9850.99
4_E8_Y0.9300.98
28_Q32_A0.9220.98
27_R60_F0.8970.98
12_H22_E0.8880.98
54_C59_I0.8760.97
16_Q30_I0.8630.97
26_T32_A0.8630.97
14_L22_E0.8440.97
6_K13_D0.8210.96
47_K50_I0.8200.96
19_L52_F0.8180.96
23_V30_I0.7910.95
5_L61_S0.7820.95
15_T31_N0.7720.95
38_Y44_L0.7390.93
11_K54_C0.7260.93
25_V33_L0.7220.92
4_E11_K0.7160.92
3_N26_T0.7150.92
37_R42_L0.6910.91
5_L48_L0.6820.90
16_Q27_R0.6790.90
19_L23_V0.6530.88
48_L54_C0.6460.87
8_Y12_H0.6420.87
3_N45_A0.6380.87
41_S44_L0.6370.87
25_V29_T0.6190.85
46_F50_I0.6130.85
23_V44_L0.6100.84
17_E27_R0.6050.84
3_N60_F0.5890.82
56_I61_S0.5800.81
46_F61_S0.5780.81
24_G36_E0.5720.80
4_E55_S0.5710.80
6_K36_E0.5600.79
26_T40_P0.5570.79
32_A37_R0.5460.77
55_S61_S0.5380.76
5_L19_L0.5320.75
15_T35_A0.5290.75
3_N28_Q0.5260.75
33_L42_L0.5250.74
6_K35_A0.5230.74
44_L47_K0.5210.74
27_R37_R0.5170.73
40_P44_L0.5140.73
46_F57_E0.5130.73
4_E54_C0.5120.73
38_Y41_S0.5090.72
33_L44_L0.5030.71
4_E22_E0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1y9qA 1 1 99.5 0.24 Contact Map
3u3wA 2 0.9846 99.5 0.243 Contact Map
2p5tA 2 0.0462 99.5 0.245 Contact Map
4yarA 2 1 99.5 0.25 Contact Map
4o8bA 2 1 99.5 0.253 Contact Map
4ichA 2 0 99.5 0.26 Contact Map
3tysA 2 0.9846 99.5 0.262 Contact Map
3mlfA 2 1 99.5 0.263 Contact Map
3ivpA 2 1 99.5 0.264 Contact Map
4ndwA 2 1 99.5 0.266 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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