GREMLIN Database
O51955 - Uncharacterized protein
UniProt: O51955 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 149 (116)
Sequences: 225 (162)
Seq/√Len: 15.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
71_V103_E4.8371.00
70_R73_E4.2691.00
74_L89_T2.5540.94
87_N96_D2.4150.92
39_S43_L2.3150.91
68_T71_V2.1670.88
71_V127_W1.9320.81
41_A44_E1.9230.80
97_V101_H1.8690.78
103_E106_R1.8360.77
42_A47_D1.8060.76
91_R97_V1.7510.73
59_S76_E1.7470.73
80_Q126_V1.7350.73
78_I113_I1.7080.71
104_L113_I1.6000.66
38_D41_A1.5940.66
47_D61_D1.5550.64
87_N91_R1.5380.63
89_T112_I1.5060.61
104_L121_R1.4950.61
36_I39_S1.4690.59
88_E93_V1.4510.58
97_V128_F1.4390.58
32_F36_I1.4360.58
39_S66_T1.4110.56
103_E127_W1.4090.56
100_V107_L1.4020.56
84_A108_A1.3880.55
31_E113_I1.3700.54
64_M133_I1.3680.54
46_G75_I1.3430.52
96_D119_G1.3420.52
74_L78_I1.3030.50
70_R98_K1.3010.50
87_N97_V1.2760.49
22_L75_I1.2750.49
40_I74_L1.2640.48
108_A121_R1.2620.48
78_I108_A1.2620.48
93_V100_V1.2470.47
76_E94_D1.2430.47
88_E91_R1.2420.47
98_K102_E1.2400.47
44_E112_I1.2180.45
74_L128_F1.2070.45
59_S138_D1.2060.45
90_A100_V1.1880.44
114_F131_L1.1710.43
70_R135_L1.1590.42
97_V112_I1.1500.42
51_S56_S1.1450.41
24_V89_T1.1020.39
110_L126_V1.0780.38
81_E92_V1.0770.38
99_N102_E1.0720.37
53_P58_T1.0660.37
94_D120_Q1.0480.36
60_Y64_M1.0410.36
87_N119_G1.0400.36
24_V112_I1.0220.35
68_T103_E1.0180.35
60_Y72_L1.0120.34
40_I131_L1.0010.34
73_E105_S1.0010.34
20_S53_P0.9930.33
83_P118_D0.9900.33
60_Y133_I0.9630.32
71_V89_T0.9630.32
78_I83_P0.9570.32
89_T93_V0.9570.32
82_E127_W0.9560.32
41_A113_I0.9540.31
21_T119_G0.9220.30
55_L85_S0.9150.30
71_V106_R0.9070.29
109_H114_F0.9060.29
63_L96_D0.9020.29
60_Y137_F0.8970.29
110_L131_L0.8960.29
37_T47_D0.8840.28
25_T56_S0.8750.28
21_T59_S0.8730.28
27_T58_T0.8550.27
80_Q135_L0.8440.26
57_F127_W0.8430.26
99_N103_E0.8410.26
88_E92_V0.8350.26
27_T31_E0.8250.26
79_R99_N0.8130.25
128_F132_V0.8080.25
80_Q92_V0.8040.25
86_I112_I0.8020.25
35_D49_M0.7960.24
93_V103_E0.7930.24
35_D75_I0.7890.24
78_I116_E0.7880.24
24_V31_E0.7880.24
22_L55_L0.7870.24
47_D113_I0.7800.24
89_T104_L0.7730.23
64_M89_T0.7630.23
43_L96_D0.7580.23
25_T54_T0.7580.23
88_E125_V0.7540.23
60_Y129_D0.7540.23
23_V118_D0.7510.23
78_I82_E0.7480.22
85_S104_L0.7370.22
109_H113_I0.7370.22
89_T103_E0.7250.22
63_L67_L0.7250.22
90_A119_G0.7000.21
28_P56_S0.6980.21
131_L136_P0.6980.21
69_P136_P0.6960.20
40_I115_F0.6920.20
85_S121_R0.6900.20
47_D75_I0.6890.20
57_F67_L0.6860.20
108_A118_D0.6830.20
99_N106_R0.6820.20
59_S62_D0.6680.19
31_E109_H0.6670.19
36_I63_L0.6650.19
59_S72_L0.6590.19
95_R113_I0.6540.19
75_I120_Q0.6520.19
72_L138_D0.6450.19
46_G55_L0.6420.19
105_S108_A0.6400.19
24_V98_K0.6340.18
82_E121_R0.6320.18
68_T101_H0.6280.18
103_E132_V0.6230.18
74_L137_F0.6190.18
51_S113_I0.6170.18
104_L108_A0.5900.17
117_E127_W0.5890.17
96_D101_H0.5750.16
31_E120_Q0.5730.16
71_V104_L0.5690.16
93_V104_L0.5680.16
105_S139_P0.5680.16
28_P63_L0.5680.16
38_D81_E0.5660.16
72_L116_E0.5620.16
88_E119_G0.5570.16
60_Y75_I0.5550.16
28_P55_L0.5530.16
82_E92_V0.5490.16
37_T59_S0.5480.16
22_L70_R0.5470.16
90_A117_E0.5460.16
46_G113_I0.5420.15
49_M67_L0.5390.15
80_Q84_A0.5370.15
39_S100_V0.5360.15
61_D111_G0.5340.15
112_I127_W0.5340.15
34_D42_A0.5340.15
20_S93_V0.5330.15
30_S39_S0.5320.15
81_E115_F0.5250.15
34_D129_D0.5220.15
21_T118_D0.5190.15
64_M128_F0.5150.15
74_L117_E0.5130.15
37_T61_D0.5110.15
111_G135_L0.5110.15
20_S74_L0.5090.14
40_I44_E0.5080.14
33_H70_R0.5040.14
40_I85_S0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lb6B 2 0.4228 97.3 0.847 Contact Map
1i1gA 5 0.5503 97 0.856 Contact Map
1r1uA 2 0.6242 96.9 0.857 Contact Map
3f6vA 2 0.5436 96.9 0.857 Contact Map
2k4bA 1 0.4362 96.9 0.857 Contact Map
2fu4A 2 0.4698 96.9 0.858 Contact Map
2w25A 6 0.5503 96.8 0.859 Contact Map
1u2wA 2 0.698 96.8 0.859 Contact Map
1p6rA 1 0.5235 96.8 0.86 Contact Map
2oqgA 4 0.6577 96.8 0.86 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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