GREMLIN Database
O46709 - Thioredoxin
UniProt: O46709 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 119 (99)
Sequences: 11633 (7605)
Seq/√Len: 764.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
71_V78_A2.7001.00
57_T107_E2.5021.00
27_D80_A2.2291.00
21_N67_A2.1771.00
23_Q76_A2.1751.00
61_Q107_E2.1231.00
106_D109_A2.0741.00
61_Q111_K2.0471.00
90_V100_E2.0341.00
62_T111_K1.8911.00
23_Q77_L1.8561.00
97_Q100_E1.8551.00
27_D31_S1.8281.00
81_Y92_F1.7751.00
90_V97_Q1.7641.00
45_C48_C1.7611.00
70_D73_E1.7611.00
36_V65_A1.7511.00
71_V86_V1.7201.00
111_K115_E1.6591.00
39_D68_K1.6331.00
55_V66_V1.6181.00
34_D65_A1.5901.00
109_A112_D1.5711.00
54_V57_T1.5331.00
23_Q74_N1.5251.00
58_L66_V1.5181.00
62_T115_E1.5051.00
101_V105_Q1.4691.00
54_V107_E1.4461.00
58_L111_K1.3821.00
37_L55_V1.3681.00
22_G25_E1.3681.00
51_L89_L1.3541.00
35_V91_L1.3481.00
99_E113_L1.2861.00
104_L109_A1.2851.00
43_D70_D1.2671.00
37_L89_L1.2651.00
107_E111_K1.2291.00
36_V67_A1.2081.00
101_V113_L1.1571.00
58_L107_E1.1461.00
29_V36_V1.1441.00
22_G74_N1.1351.00
69_I77_L1.1281.00
91_L113_L1.1201.00
21_N29_V1.0921.00
105_Q109_A1.0761.00
25_E28_D1.0741.00
38_A92_F1.0721.00
51_L54_V1.0681.00
19_Y65_A1.0681.00
39_D52_E1.0271.00
52_E56_E1.0141.00
75_Q79_S0.9961.00
89_L110_L0.9401.00
29_V65_A0.9271.00
93_A98_V0.9071.00
40_F81_Y0.9021.00
55_V89_L0.8981.00
58_L62_T0.8981.00
52_E68_K0.8861.00
50_M104_L0.8861.00
28_D32_D0.8801.00
56_E68_K0.8731.00
20_V68_K0.8681.00
20_V73_E0.8541.00
41_Y68_K0.8171.00
91_L114_I0.8141.00
69_I78_A0.8121.00
46_G49_Q0.8111.00
51_L110_L0.8091.00
41_Y86_V0.8001.00
19_Y29_V0.7931.00
76_A80_A0.7811.00
37_L66_V0.7741.00
51_L105_Q0.7731.00
40_F83_V0.7701.00
108_D112_D0.7681.00
35_V93_A0.7611.00
58_L110_L0.7561.00
29_V32_D0.7551.00
112_D115_E0.7501.00
33_N94_D0.7451.00
60_E63_D0.7331.00
25_E67_A0.7191.00
54_V106_D0.7171.00
41_Y70_D0.7141.00
43_D72_D0.7101.00
76_A79_S0.7051.00
34_D94_D0.7011.00
21_N25_E0.6851.00
38_A67_A0.6771.00
40_F90_V0.6731.00
59_A66_V0.6711.00
64_A114_I0.6701.00
54_V58_L0.6701.00
37_L110_L0.6621.00
51_L55_V0.6611.00
113_L116_S0.6601.00
40_F71_V0.6551.00
89_L101_V0.6451.00
43_D49_Q0.6421.00
105_Q113_L0.6381.00
93_A96_E0.6371.00
57_T60_E0.6361.00
51_L104_L0.6321.00
42_A72_D0.6291.00
21_N38_A0.6291.00
37_L91_L0.6271.00
54_V104_L0.6261.00
18_L59_A0.6241.00
39_D47_P0.6191.00
26_L81_Y0.6081.00
40_F69_I0.6071.00
92_F97_Q0.6071.00
77_L80_A0.5981.00
46_G50_M0.5961.00
43_D73_E0.5941.00
25_E29_V0.5911.00
30_T36_V0.5871.00
39_D51_L0.5851.00
47_P50_M0.5851.00
74_N77_L0.5821.00
75_Q78_A0.5821.00
84_R100_E0.5781.00
99_E116_S0.5721.00
47_P85_G0.5601.00
83_V88_T0.5551.00
26_L40_F0.5531.00
26_L77_L0.5531.00
26_L38_A0.5511.00
71_V83_V0.5501.00
69_I74_N0.5481.00
23_Q80_A0.5441.00
100_E103_G0.5441.00
18_L55_V0.5381.00
101_V104_L0.5371.00
44_W49_Q0.5321.00
19_Y36_V0.5271.00
55_V114_I0.5231.00
85_G102_V0.5171.00
37_L114_I0.5161.00
28_D31_S0.5151.00
21_N28_D0.5131.00
35_V94_D0.5091.00
44_W72_D0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2r2jA 2 0.8487 99.8 0.201 Contact Map
3f8uA 2 0.8739 99.8 0.206 Contact Map
2b5eA 1 0.958 99.8 0.213 Contact Map
4ekzA 1 1 99.8 0.235 Contact Map
3apoA 1 0.8908 99.8 0.235 Contact Map
3us3A 2 0.9664 99.8 0.247 Contact Map
1sjiA 2 0.9496 99.8 0.249 Contact Map
3ed3A 1 0.9328 99.8 0.268 Contact Map
3uemA 1 0.9832 99.8 0.277 Contact Map
3idvA 1 0.9328 99.8 0.284 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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