GREMLIN Database
RL14 - 50S ribosomal protein L14
UniProt: O24787 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 132 (117)
Sequences: 1540 (553)
Seq/√Len: 51.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
55_V69_L4.8321.00
29_L95_A4.0691.00
31_I53_I3.7481.00
29_L55_V3.1541.00
17_L28_E2.9631.00
12_L31_I2.7681.00
30_K58_T2.7061.00
71_A95_A2.6551.00
15_G30_K2.6541.00
81_R87_R2.3691.00
35_M54_T2.2671.00
28_E59_K2.1331.00
12_L16_S2.0981.00
97_I105_R2.0391.00
54_T70_E2.0091.00
56_S66_R1.9260.99
13_E16_S1.8870.99
47_A73_V1.8600.99
19_T92_D1.8330.99
29_L57_V1.8290.99
117_V125_A1.7830.99
17_L30_K1.7620.99
99_D103_E1.7530.99
48_G80_I1.7410.99
70_E100_D1.7370.99
20_C29_L1.7050.99
14_K33_S1.7030.99
19_T28_E1.6250.98
48_G79_P1.5210.97
105_R119_E1.4450.96
30_K56_S1.4100.95
82_R116_E1.3860.95
52_T121_Y1.3610.94
52_T98_I1.2570.92
74_V113_I1.1930.89
102_G121_Y1.1680.88
123_T126_S1.1530.88
118_A122_G1.1500.88
113_I117_V1.1460.87
17_L58_T1.1400.87
14_K30_K1.1310.87
38_Q42_N1.0890.85
18_I29_L1.0880.85
94_A119_E1.0720.84
82_R85_G1.0590.83
21_A112_P1.0420.82
34_V47_A1.0410.82
20_C95_A1.0330.81
49_L80_I1.0310.81
53_I73_V1.0140.80
64_M67_Q1.0130.80
71_A97_I0.9900.78
122_G125_A0.9860.78
37_Y45_P0.9720.77
24_T105_R0.9590.76
75_R111_G0.9590.76
33_S42_N0.9140.73
75_R92_D0.9000.71
21_A74_V0.8990.71
52_T102_G0.8940.71
59_K112_P0.8870.70
113_I124_I0.8780.70
24_T106_G0.8680.69
29_L73_V0.8610.68
83_P119_E0.8570.68
28_E58_T0.8520.67
75_R94_A0.8420.66
98_I102_G0.8400.66
32_T67_Q0.8400.66
27_R61_T0.8370.66
18_I53_I0.8270.65
49_L79_P0.8200.64
99_D105_R0.8020.63
114_S119_E0.7980.62
12_L18_I0.7830.61
18_I95_A0.7820.61
38_Q45_P0.7780.60
55_V97_I0.7670.59
33_S38_Q0.7670.59
11_G108_E0.7650.59
17_L56_S0.7640.59
69_L105_R0.7630.59
24_T33_S0.7590.58
125_A129_T0.7550.58
66_R86_T0.7460.57
36_G115_R0.7460.57
63_E67_Q0.7390.56
59_K65_R0.7380.56
55_V95_A0.7350.56
74_V96_V0.7340.56
24_T61_T0.7320.56
82_R94_A0.7300.55
27_R32_T0.7230.55
79_P89_K0.7200.54
76_Q80_I0.7200.54
79_P87_R0.7070.53
99_D102_G0.7030.53
72_V121_Y0.6950.52
34_V45_P0.6910.51
117_V120_R0.6900.51
69_L97_I0.6820.50
85_G94_A0.6810.50
55_V71_A0.6770.50
65_R112_P0.6770.50
21_A104_P0.6740.50
75_R112_P0.6730.49
72_V110_K0.6650.49
116_E124_I0.6510.47
110_K130_M0.6490.47
43_R109_I0.6480.47
113_I118_A0.6450.47
108_E127_T0.6380.46
92_D112_P0.6380.46
66_R76_Q0.6320.45
104_P127_T0.6310.45
33_S66_R0.6280.45
38_Q46_K0.6250.44
72_V124_I0.6230.44
70_E107_T0.6180.44
13_E45_P0.6170.44
115_R130_M0.6150.43
26_A98_I0.6140.43
18_I31_I0.6130.43
66_R105_R0.6120.43
14_K56_S0.6100.43
90_F112_P0.6070.43
46_K106_G0.6070.43
42_N45_P0.6050.42
99_D123_T0.5940.41
26_A60_G0.5870.41
80_I87_R0.5850.40
35_M70_E0.5830.40
43_R125_A0.5800.40
47_A84_D0.5790.40
124_I127_T0.5780.40
21_A75_R0.5760.40
31_I35_M0.5760.40
83_P86_T0.5730.39
38_Q123_T0.5700.39
42_N109_I0.5690.39
29_L69_L0.5680.39
104_P129_T0.5630.38
127_T130_M0.5610.38
15_G77_R0.5570.38
26_A121_Y0.5550.37
20_C26_A0.5540.37
101_L105_R0.5540.37
98_I101_L0.5500.37
19_T77_R0.5470.37
12_L52_T0.5440.36
11_G76_Q0.5430.36
117_V127_T0.5400.36
118_A131_I0.5370.36
57_V63_E0.5360.36
61_T101_L0.5350.36
16_S78_K0.5340.35
115_R121_Y0.5340.35
87_R109_I0.5340.35
108_E123_T0.5330.35
56_S101_L0.5290.35
87_R114_S0.5280.35
58_T62_P0.5240.35
49_L76_Q0.5230.34
24_T97_I0.5220.34
65_R118_A0.5200.34
34_V43_R0.5180.34
16_S31_I0.5130.33
75_R82_R0.5130.33
43_R46_K0.5120.33
90_F114_S0.5100.33
29_L97_I0.5100.33
79_P84_D0.5090.33
24_T104_P0.5090.33
72_V114_S0.5090.33
15_G59_K0.5000.32
31_I95_A0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vq8K 1 1 100 0.037 Contact Map
3zf7W 1 1 100 0.053 Contact Map
3j21J 1 0.9924 100 0.059 Contact Map
1vx7M 1 1 100 0.071 Contact Map
4ujrI 1 1 100 0.071 Contact Map
3bboM 1 0.8939 100 0.121 Contact Map
1whiA 2 0.8939 100 0.127 Contact Map
4rb6O 1 0.8939 100 0.128 Contact Map
4tp9K 1 0.8864 100 0.141 Contact Map
1vw4I 1 0.8788 100 0.143 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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