GREMLIN Database
F2Z6I7 - Putative 2-ketoglutarate ferredoxin oxidoreductase (Beta)
UniProt: F2Z6I7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 312 (263)
Sequences: 2671 (1351)
Seq/√Len: 83.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
126_D202_D4.7951.00
128_T205_A4.5681.00
183_T191_A3.5461.00
198_A207_V3.3801.00
169_L239_V3.2651.00
131_V206_H3.2501.00
57_L91_A3.1901.00
183_T194_I2.8721.00
222_Q225_P2.4431.00
196_V200_Q2.3961.00
148_S152_H2.3501.00
120_T127_I2.3071.00
130_I209_F2.2541.00
217_N273_P2.2501.00
121_A172_S2.1621.00
104_G129_Y2.1471.00
59_A91_A2.1371.00
84_S102_A2.0981.00
133_N208_D2.0811.00
55_E97_D2.0061.00
102_A127_I2.0031.00
167_R170_S1.9691.00
197_E265_R1.9671.00
130_I195_L1.9671.00
179_Y265_R1.9411.00
178_S201_H1.9411.00
35_D132_F1.9221.00
202_D277_A1.9161.00
129_Y204_F1.8951.00
40_K44_G1.8781.00
88_A102_A1.8621.00
24_E68_L1.8561.00
242_R245_A1.8351.00
264_G287_E1.8271.00
245_A249_M1.8061.00
42_L195_L1.8021.00
200_Q244_E1.7961.00
197_E268_Q1.7691.00
190_Q194_I1.7441.00
39_L103_A1.7291.00
182_R208_D1.7231.00
104_G109_G1.7161.00
285_M288_E1.7091.00
190_Q263_T1.7051.00
101_V199_I1.6571.00
56_I99_E1.6331.00
265_R268_Q1.5951.00
117_F172_S1.5671.00
121_A204_F1.5621.00
245_A250_T1.5591.00
109_G129_Y1.5411.00
183_T190_Q1.5261.00
128_T199_I1.5180.99
193_D196_V1.5010.99
38_V211_T1.4940.99
233_D261_V1.4880.99
226_Y269_D1.4850.99
79_T87_V1.4730.99
131_V168_P1.4510.99
195_L207_V1.4440.99
42_L103_A1.4400.99
88_A100_V1.4350.99
135_E165_P1.4320.99
85_L129_Y1.4320.99
101_V128_T1.4200.99
172_S206_H1.4170.99
59_A102_A1.3870.99
200_Q242_R1.3640.99
162_A285_M1.3620.99
150_K164_S1.3560.99
246_Q249_M1.3480.99
39_L68_L1.3280.99
149_P152_H1.3120.98
110_Y131_V1.3030.98
240_T243_R1.2960.98
59_A88_A1.2680.98
95_N98_L1.2680.98
77_F87_V1.2490.98
183_T195_L1.2460.98
254_E257_Y1.2440.98
42_L130_I1.2410.98
232_S260_T1.2350.98
57_L100_V1.2300.98
278_E281_S1.2250.98
191_A195_L1.2230.98
191_A209_F1.2180.98
253_E256_L1.2170.98
66_G69_N1.2130.97
181_A194_I1.2090.97
281_S284_D1.2060.97
62_I78_H1.1870.97
241_D244_E1.1740.97
109_G131_V1.1710.97
179_Y197_E1.1700.97
134_N138_G1.1670.97
67_K70_S1.1590.97
55_E99_E1.1490.96
39_L132_F1.1450.96
60_T76_G1.1440.96
170_S173_M1.1400.96
243_R247_E1.1350.96
194_I265_R1.1310.96
243_R248_L1.1300.96
197_E200_Q1.1240.96
42_L68_L1.1230.96
244_E247_E1.1150.96
223_Y227_V1.1090.96
193_D197_E1.1060.96
89_R125_H1.1040.96
192_K196_V1.0980.95
85_L120_T1.0970.95
234_E238_D1.0960.95
201_H205_A1.0940.95
92_K125_H1.0920.95
226_Y229_V1.0840.95
103_A132_F1.0800.95
39_L43_K1.0750.95
44_G192_K1.0730.95
241_D245_A1.0680.95
99_E199_I1.0620.95
273_P277_A1.0590.94
282_R285_M1.0540.94
91_A100_V1.0540.94
124_N204_F1.0480.94
184_A227_V1.0470.94
248_L251_E1.0430.94
228_D232_S1.0430.94
262_L265_R1.0420.94
132_F211_T1.0370.94
169_L206_H1.0330.94
46_M199_I1.0320.94
66_G78_H1.0300.94
237_F240_T1.0290.94
133_N165_P1.0270.93
184_A231_E1.0260.93
118_M171_L1.0140.93
172_S180_V1.0130.93
38_V209_F1.0130.93
283_G287_E1.0130.93
60_T69_N1.0050.93
238_D241_D0.9980.92
66_G70_S0.9970.92
57_L98_L0.9890.92
264_G268_Q0.9860.92
62_I67_K0.9830.92
110_Y168_P0.9810.92
118_M166_I0.9770.92
169_L180_V0.9760.92
242_R249_M0.9750.92
117_F206_H0.9750.92
183_T209_F0.9730.92
29_W36_F0.9730.92
241_D249_M0.9720.91
237_F241_D0.9610.91
92_K96_H0.9610.91
62_I83_R0.9590.91
99_E126_D0.9530.91
238_D243_R0.9440.90
184_A210_L0.9430.90
62_I66_G0.9360.90
229_V269_D0.9290.90
68_L132_F0.9260.89
42_L101_V0.9250.89
279_K287_E0.9230.89
46_M56_I0.9170.89
130_I207_V0.9150.89
247_E251_E0.9140.89
245_A248_L0.9130.89
212_Q223_Y0.9090.88
284_D288_E0.9080.88
144_T157_Q0.9070.88
169_L182_R0.8940.88
171_L174_T0.8850.87
168_P206_H0.8820.87
244_E253_E0.8790.87
239_V245_A0.8720.86
128_T195_L0.8680.86
236_D242_R0.8640.86
169_L266_Y0.8640.86
177_A180_V0.8630.86
117_F129_Y0.8620.86
243_R249_M0.8590.85
185_A191_A0.8580.85
220_A224_V0.8580.85
110_Y147_T0.8540.85
148_S154_S0.8490.85
235_Y266_Y0.8490.85
118_M175_S0.8450.85
154_S157_Q0.8410.84
41_A188_P0.8400.84
64_C112_I0.8400.84
57_L95_N0.8390.84
237_F244_E0.8360.84
185_A212_Q0.8350.84
257_Y261_V0.8320.84
210_L261_V0.8320.84
240_T244_E0.8300.83
28_T70_S0.8280.83
246_Q250_T0.8260.83
242_R247_E0.8200.83
247_E250_T0.8160.82
219_D223_Y0.8120.82
264_G267_Y0.8090.82
66_G83_R0.8040.82
62_I76_G0.8020.81
120_T204_F0.8010.81
67_K78_H0.8010.81
231_E238_D0.7970.81
220_A223_Y0.7940.81
254_E258_D0.7870.80
219_D222_Q0.7870.80
90_A94_A0.7850.80
115_N118_M0.7820.80
92_K100_V0.7810.80
121_A206_H0.7750.79
224_V227_V0.7740.79
65_S132_F0.7740.79
88_A127_I0.7740.79
89_R123_E0.7720.79
136_V215_T0.7710.79
243_R246_Q0.7660.78
236_D239_V0.7620.78
173_M180_V0.7590.78
264_G279_K0.7580.78
27_P36_F0.7570.77
92_K126_D0.7480.77
194_I207_V0.7480.77
59_A84_S0.7480.77
221_K225_P0.7470.77
165_P182_R0.7440.76
236_D240_T0.7410.76
47_A54_E0.7410.76
128_T198_A0.7390.76
239_V243_R0.7370.76
268_Q279_K0.7320.75
236_D243_R0.7190.74
77_F91_A0.7120.73
263_T267_Y0.7090.73
159_H162_A0.7060.72
245_A253_E0.7060.72
242_R253_E0.7060.72
42_L58_L0.7060.72
67_K71_Y0.7040.72
232_S261_V0.7020.72
234_E237_F0.6990.72
63_G83_R0.6990.72
239_V242_R0.6980.72
142_G217_N0.6970.71
185_A224_V0.6960.71
37_G41_A0.6960.71
233_D262_L0.6950.71
229_V232_S0.6940.71
93_L176_G0.6940.71
65_S211_T0.6930.71
84_S104_G0.6890.71
200_Q250_T0.6850.70
163_K177_A0.6850.70
46_M101_V0.6820.70
80_I83_R0.6820.70
235_Y263_T0.6810.70
135_E149_P0.6770.69
110_Y208_D0.6750.69
37_G40_K0.6710.69
120_T129_Y0.6700.68
84_S108_D0.6690.68
240_T247_E0.6680.68
68_L103_A0.6670.68
107_G145_S0.6660.68
96_H125_H0.6650.68
128_T207_V0.6630.68
241_D247_E0.6590.67
237_F247_E0.6570.67
190_Q262_L0.6520.66
67_K111_G0.6510.66
62_I81_H0.6490.66
238_D242_R0.6460.66
182_R237_F0.6460.66
35_D112_I0.6460.66
264_G280_Q0.6440.65
136_V152_H0.6440.65
42_L56_I0.6430.65
243_R251_E0.6430.65
197_E240_T0.6430.65
124_N177_A0.6420.65
148_S160_G0.6390.65
179_Y266_Y0.6360.64
30_C33_C0.6360.64
280_Q283_G0.6300.64
135_E148_S0.6290.64
228_D231_E0.6280.63
147_T165_P0.6280.63
286_P289_P0.6270.63
79_T83_R0.6260.63
85_L102_A0.6200.62
42_L132_F0.6190.62
93_L125_H0.6180.62
114_G118_M0.6170.62
60_T66_G0.6130.62
225_P228_D0.6130.62
234_E260_T0.6130.62
41_A192_K0.6130.62
60_T70_S0.6120.61
240_T246_Q0.6120.61
277_A281_S0.6110.61
253_E257_Y0.6080.61
274_S278_E0.6070.61
85_L109_G0.6070.61
29_W68_L0.6000.60
273_P278_E0.5990.60
130_I198_A0.5980.60
122_R144_T0.5980.60
28_T66_G0.5960.59
231_E234_E0.5930.59
18_A22_G0.5920.59
240_T245_A0.5920.59
142_G153_K0.5890.59
246_Q251_E0.5890.59
150_K278_E0.5890.59
23_V69_N0.5870.58
241_D246_Q0.5860.58
197_E243_R0.5860.58
135_E152_H0.5850.58
278_E286_P0.5810.58
89_R120_T0.5790.57
99_E102_A0.5780.57
244_E248_L0.5760.57
28_T67_K0.5750.57
186_V216_W0.5730.56
70_S83_R0.5730.56
71_Y92_K0.5730.56
64_C213_C0.5730.56
171_L175_S0.5720.56
170_S174_T0.5720.56
182_R239_V0.5710.56
112_I115_N0.5690.56
148_S217_N0.5680.56
58_L74_S0.5660.56
75_Y145_S0.5650.55
267_Y275_Y0.5640.55
27_P78_H0.5630.55
81_H112_I0.5620.55
55_E98_L0.5620.55
93_L279_K0.5610.55
69_N78_H0.5610.55
102_A129_Y0.5560.54
226_Y270_E0.5560.54
157_Q161_S0.5540.54
202_D274_S0.5530.54
70_S78_H0.5530.54
233_D236_D0.5520.54
261_V265_R0.5510.54
117_F121_A0.5480.53
242_R250_T0.5440.53
89_R119_H0.5430.53
235_Y238_D0.5420.52
61_G108_D0.5390.52
234_E239_V0.5380.52
91_A94_A0.5360.52
166_I175_S0.5320.51
85_L116_H0.5290.51
78_H87_V0.5280.51
225_P229_V0.5270.50
168_P180_V0.5260.50
245_A251_E0.5250.50
244_E249_M0.5250.50
60_T65_S0.5240.50
85_L131_V0.5240.50
28_T78_H0.5220.50
262_L266_Y0.5220.50
264_G281_S0.5220.50
92_K127_I0.5220.50
110_Y146_P0.5210.50
237_F243_R0.5200.49
58_L91_A0.5190.49
274_S277_A0.5180.49
240_T249_M0.5180.49
121_A129_Y0.5160.49
185_A202_D0.5160.49
136_V142_G0.5140.49
62_I82_G0.5140.49
170_S239_V0.5130.49
177_A204_F0.5120.48
95_N281_S0.5120.48
258_D273_P0.5110.48
201_H244_E0.5090.48
173_M241_D0.5080.48
229_V261_V0.5070.48
123_E177_A0.5060.48
24_E39_L0.5060.48
65_S112_I0.5050.48
219_D226_Y0.5050.48
35_D211_T0.5040.47
150_K153_K0.5010.47
34_G37_G0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2c42A 2 0.9712 100 0.411 Contact Map
5c4iC 2 0.9135 100 0.549 Contact Map
4kgdA 4 0.7853 99.9 0.757 Contact Map
1v5eA 4 0.7885 99.9 0.776 Contact Map
2panA 3 0.766 99.9 0.779 Contact Map
1ybhA 4 0.7083 99.9 0.781 Contact Map
4rjjA 5 0.6859 99.9 0.792 Contact Map
2pgnA 4 0.7436 99.9 0.793 Contact Map
1t9bA 2 0.75 99.9 0.796 Contact Map
1ozhA 4 0.6699 99.8 0.797 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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