F2Z6G9 - HALSA - GREMLIN Contacts

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F2Z6G9 - Peptidyl-prolyl cis-trans isomerase

UniProt:	F2Z6G9	Sequences: MSDEPEAEQADSSSDEQDGFQTGDFVELSYTAYTVDSEELVDTTDEEIAESEGVDTDEQEFSPRTIVLGEEHIFAAVEDDIVGQSVGDDGTVLVEEAFGEYDEDEVRTVSANKIPEDDRYPGAHVDVDGEHGHVEAIIGGRARVDFNHPLAGEDIEYEYEVLDEITDREQQAVGFLEMMFDVELDVDLVTETVEEEVTEETEDGDAETTTESVEKETLYIEQSPQLQFNQQWMMGKSQVLSQVIDMLDIDRVIVQEIIDGQPAGMPGMGGMMGGAGGDLGDVEDALEDADVDADEIVDELDDE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	303 (241)
Sequences:	267 (212)
Seq/√Len:	13.7

HALSA - F2Z6G9
SULSO - Q7LYL6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
32_A	41_V	4.825	1.00
78_E	97_A	4.507	1.00
78_E	81_I	4.110	1.00
174_G	181_D	3.401	0.99
68_L	78_E	3.352	0.99
191_E	195_E	3.281	0.98
178_M	181_D	3.044	0.97
174_G	178_M	3.014	0.97
102_D	105_E	2.800	0.96
181_D	184_L	2.739	0.95
174_G	179_M	2.657	0.94
189_V	195_E	2.526	0.92
84_Q	88_D	2.504	0.92
194_E	198_T	2.492	0.92
84_Q	90_G	2.318	0.88
193_V	196_E	2.292	0.88
189_V	198_T	2.276	0.88
23_G	98_F	2.116	0.83
29_S	45_D	2.115	0.83
187_D	191_E	2.086	0.82
193_V	198_T	2.030	0.81
74_F	94_V	2.021	0.80
176_L	181_D	2.010	0.80
27_E	65_T	1.906	0.76
177_E	181_D	1.900	0.76
80_D	84_Q	1.892	0.76
217_T	222_Q	1.860	0.74
41_V	76_A	1.835	0.73
191_E	199_E	1.814	0.72
158_E	161_V	1.763	0.70
97_A	109_V	1.748	0.69
275_A	279_L	1.735	0.69
272_M	276_G	1.666	0.66
192_T	195_E	1.661	0.65
280_G	283_E	1.649	0.65
191_E	198_T	1.631	0.64
174_G	184_L	1.615	0.63
175_F	181_D	1.610	0.63
253_I	257_I	1.589	0.62
188_L	192_T	1.586	0.62
103_E	106_V	1.581	0.61
19_G	85_S	1.578	0.61
28_L	111_A	1.576	0.61
73_I	81_I	1.547	0.60
38_E	89_D	1.523	0.58
252_V	258_I	1.509	0.58
270_G	280_G	1.500	0.57
278_D	282_V	1.467	0.55
191_E	196_E	1.458	0.55
41_V	78_E	1.448	0.54
181_D	193_V	1.441	0.54
141_R	152_G	1.433	0.54
187_D	198_T	1.428	0.53
187_D	192_T	1.427	0.53
174_G	177_E	1.421	0.53
250_D	253_I	1.400	0.52
191_E	194_E	1.396	0.52
267_G	273_G	1.395	0.52
179_M	184_L	1.390	0.51
20_F	68_L	1.387	0.51
79_D	96_E	1.381	0.51
136_A	140_G	1.362	0.50
189_V	194_E	1.361	0.50
188_L	191_E	1.347	0.49
188_L	196_E	1.346	0.49
169_E	172_A	1.338	0.48
195_E	198_T	1.331	0.48
199_E	202_E	1.329	0.48
276_G	282_V	1.316	0.47
97_A	155_I	1.313	0.47
271_M	277_G	1.297	0.46
269_G	272_M	1.296	0.46
189_V	193_V	1.268	0.45
224_P	227_Q	1.259	0.44
41_V	118_D	1.256	0.44
256_E	261_Q	1.250	0.44
176_L	195_E	1.238	0.43
273_G	276_G	1.228	0.43
102_D	106_V	1.227	0.43
21_Q	259_D	1.227	0.43
68_L	132_G	1.223	0.42
27_E	94_V	1.202	0.41
74_F	184_L	1.190	0.41
174_G	193_V	1.165	0.39
165_I	275_A	1.135	0.38
22_T	82_V	1.134	0.38
257_I	261_Q	1.129	0.38
68_L	94_V	1.124	0.37
75_A	97_A	1.119	0.37
73_I	110_S	1.117	0.37
176_L	179_M	1.113	0.37
178_M	184_L	1.113	0.37
71_E	76_A	1.107	0.36
192_T	196_E	1.106	0.36
253_I	261_Q	1.106	0.36
96_E	111_A	1.104	0.36
175_F	179_M	1.104	0.36
176_L	184_L	1.099	0.36
168_R	171_Q	1.089	0.36
280_G	284_D	1.087	0.35
42_D	139_G	1.082	0.35
207_E	212_S	1.081	0.35
30_Y	175_F	1.076	0.35
179_M	242_Q	1.076	0.35
76_A	111_A	1.075	0.35
154_D	161_V	1.067	0.34
30_Y	44_T	1.062	0.34
32_A	123_A	1.062	0.34
77_V	105_E	1.056	0.34
268_M	274_G	1.054	0.34
268_M	283_E	1.050	0.34
28_L	253_I	1.046	0.33
84_Q	139_G	1.036	0.33
82_V	134_V	1.036	0.33
181_D	192_T	1.034	0.33
159_Y	162_L	1.034	0.33
77_V	231_Q	1.032	0.33
111_A	114_I	1.020	0.32
276_G	281_D	1.018	0.32
274_G	277_G	1.002	0.31
28_L	32_A	0.995	0.31
191_E	202_E	0.995	0.31
271_M	276_G	0.993	0.31
97_A	105_E	0.992	0.31
21_Q	144_V	0.987	0.31
206_A	209_T	0.980	0.30
175_F	178_M	0.980	0.30
187_D	195_E	0.979	0.30
120_Y	143_R	0.975	0.30
85_S	88_D	0.967	0.30
99_G	170_Q	0.967	0.30
20_F	66_I	0.964	0.30
159_Y	174_G	0.963	0.30
68_L	126_D	0.963	0.30
264_G	278_D	0.961	0.30
279_L	283_E	0.960	0.30
72_H	83_G	0.956	0.29
273_G	283_E	0.955	0.29
168_R	172_A	0.953	0.29
273_G	277_G	0.953	0.29
179_M	183_E	0.950	0.29
177_E	184_L	0.945	0.29
221_E	225_Q	0.945	0.29
122_G	128_D	0.935	0.28
188_L	195_E	0.935	0.28
226_L	229_N	0.934	0.28
32_A	76_A	0.929	0.28
258_I	261_Q	0.927	0.28
268_M	272_M	0.925	0.28
155_I	162_L	0.923	0.28
67_V	106_V	0.914	0.28
113_K	116_E	0.911	0.27
101_Y	140_G	0.909	0.27
276_G	279_L	0.901	0.27
264_G	268_M	0.898	0.27
84_Q	159_Y	0.895	0.27
67_V	73_I	0.894	0.27
251_R	254_V	0.878	0.26
64_R	232_W	0.876	0.26
78_E	139_G	0.872	0.26
94_V	184_L	0.869	0.26
178_M	193_V	0.869	0.26
176_L	193_V	0.866	0.25
109_V	263_A	0.860	0.25
263_A	269_G	0.858	0.25
123_A	154_D	0.858	0.25
278_D	281_D	0.857	0.25
181_D	194_E	0.849	0.25
155_I	158_E	0.848	0.25
240_L	246_M	0.848	0.25
181_D	191_E	0.848	0.25
270_G	274_G	0.847	0.25
243_V	247_L	0.846	0.25
279_L	282_V	0.843	0.25
189_V	196_E	0.842	0.25
267_G	275_A	0.836	0.24
93_L	125_V	0.831	0.24
66_I	96_E	0.822	0.24
187_D	193_V	0.817	0.24
105_E	134_V	0.815	0.23
44_T	146_F	0.804	0.23
137_I	163_D	0.801	0.23
26_V	88_D	0.800	0.23
42_D	85_S	0.797	0.23
264_G	267_G	0.794	0.23
24_D	148_H	0.787	0.22
34_T	110_S	0.787	0.22
148_H	165_I	0.786	0.22
273_G	280_G	0.786	0.22
178_M	182_V	0.786	0.22
94_V	227_Q	0.785	0.22
21_Q	166_T	0.782	0.22
279_L	284_D	0.776	0.22
20_F	88_D	0.772	0.22
203_D	208_T	0.771	0.22
199_E	205_D	0.769	0.22
184_L	188_L	0.764	0.22
21_Q	116_E	0.758	0.21
272_M	277_G	0.756	0.21
167_D	170_Q	0.754	0.21
73_I	78_E	0.753	0.21
126_D	184_L	0.749	0.21
275_A	283_E	0.748	0.21
32_A	139_G	0.743	0.21
178_M	196_E	0.739	0.21
41_V	123_A	0.738	0.21
45_D	64_R	0.732	0.20
66_I	94_V	0.727	0.20
272_M	280_G	0.726	0.20
130_E	173_V	0.725	0.20
264_G	276_G	0.723	0.20
76_A	114_I	0.722	0.20
206_A	246_M	0.721	0.20
31_T	209_T	0.718	0.20
77_V	95_E	0.717	0.20
195_E	199_E	0.716	0.20
80_D	88_D	0.712	0.20
37_S	133_H	0.708	0.20
122_G	129_G	0.708	0.20
121_P	127_V	0.706	0.20
281_D	284_D	0.701	0.19
38_E	267_G	0.701	0.19
73_I	83_G	0.699	0.19
114_I	144_V	0.693	0.19
81_I	84_Q	0.693	0.19
231_Q	235_G	0.688	0.19
181_D	196_E	0.686	0.19
108_T	113_K	0.686	0.19
273_G	278_D	0.683	0.19
114_I	123_A	0.683	0.19
143_R	157_Y	0.682	0.19
250_D	254_V	0.682	0.19
119_R	142_A	0.681	0.19
139_G	150_L	0.678	0.19
85_S	89_D	0.677	0.19
73_I	224_P	0.676	0.19
76_A	139_G	0.673	0.18
170_Q	184_L	0.670	0.18
155_I	160_E	0.669	0.18
88_D	107_R	0.665	0.18
184_L	195_E	0.663	0.18
43_T	141_R	0.662	0.18
274_G	281_D	0.662	0.18
91_T	141_R	0.661	0.18
44_T	216_E	0.659	0.18
265_M	270_G	0.659	0.18
266_P	270_G	0.657	0.18
271_M	279_L	0.656	0.18
91_T	127_V	0.651	0.18
94_V	225_Q	0.648	0.18
97_A	237_S	0.646	0.18
277_G	284_D	0.646	0.18
26_V	222_Q	0.645	0.18
272_M	283_E	0.644	0.18
267_G	270_G	0.644	0.18
249_I	252_V	0.639	0.17
175_F	191_E	0.637	0.17
39_E	220_I	0.636	0.17
269_G	273_G	0.634	0.17
33_Y	73_I	0.633	0.17
42_D	72_H	0.632	0.17
269_G	274_G	0.632	0.17
219_Y	226_L	0.631	0.17
249_I	260_G	0.631	0.17
268_M	271_M	0.629	0.17
257_I	260_G	0.629	0.17
216_E	254_V	0.628	0.17
247_L	252_V	0.628	0.17
23_G	97_A	0.627	0.17
73_I	101_Y	0.624	0.17
40_L	93_L	0.624	0.17
212_S	215_K	0.622	0.17
84_Q	116_E	0.622	0.17
179_M	246_M	0.620	0.17
32_A	40_L	0.619	0.17
262_P	272_M	0.618	0.17
43_T	152_G	0.612	0.17
276_G	280_G	0.609	0.16
32_A	114_I	0.608	0.16
236_K	240_L	0.608	0.16
33_Y	98_F	0.608	0.16
20_F	80_D	0.608	0.16
136_A	154_D	0.606	0.16
192_T	198_T	0.606	0.16
204_G	207_E	0.605	0.16
71_E	219_Y	0.605	0.16
44_T	78_E	0.602	0.16
204_G	208_T	0.599	0.16
147_N	157_Y	0.598	0.16
131_H	134_V	0.598	0.16
41_V	254_V	0.596	0.16
230_Q	236_K	0.595	0.16
193_V	202_E	0.593	0.16
188_L	194_E	0.593	0.16
231_Q	238_Q	0.593	0.16
268_M	276_G	0.592	0.16
123_A	160_E	0.588	0.16
106_V	145_D	0.585	0.16
272_M	275_A	0.584	0.16
198_T	202_E	0.584	0.16
107_R	119_R	0.581	0.16
132_G	145_D	0.579	0.16
207_E	218_L	0.578	0.16
215_K	266_P	0.577	0.16
181_D	195_E	0.577	0.16
23_G	239_V	0.576	0.16
174_G	196_E	0.575	0.16
149_P	164_E	0.574	0.15
277_G	283_E	0.571	0.15
217_T	253_I	0.570	0.15
114_I	119_R	0.565	0.15
42_D	97_A	0.565	0.15
90_G	101_Y	0.562	0.15
38_E	214_E	0.562	0.15
99_G	151_A	0.561	0.15
212_S	226_L	0.560	0.15
84_Q	161_V	0.558	0.15
240_L	248_D	0.556	0.15
273_G	284_D	0.555	0.15
75_A	221_E	0.552	0.15
212_S	216_E	0.551	0.15
77_V	277_G	0.551	0.15
219_Y	253_I	0.550	0.15
118_D	124_H	0.549	0.15
184_L	193_V	0.547	0.15
111_A	116_E	0.545	0.15
92_V	175_F	0.545	0.15
170_Q	173_V	0.544	0.15
73_I	203_D	0.542	0.15
90_G	107_R	0.540	0.15
194_E	199_E	0.536	0.14
75_A	89_D	0.536	0.14
242_Q	252_V	0.531	0.14
37_S	80_D	0.531	0.14
42_D	71_E	0.530	0.14
121_P	144_V	0.524	0.14
180_F	184_L	0.524	0.14
220_I	239_V	0.524	0.14
240_L	254_V	0.522	0.14
180_F	191_E	0.521	0.14
101_Y	142_A	0.520	0.14
238_Q	241_S	0.520	0.14
224_P	235_G	0.519	0.14
166_T	170_Q	0.519	0.14
76_A	81_I	0.519	0.14
219_Y	224_P	0.518	0.14
90_G	161_V	0.517	0.14
40_L	274_G	0.516	0.14
144_V	262_P	0.515	0.14
86_V	94_V	0.513	0.14
236_K	247_L	0.511	0.14
134_V	274_G	0.509	0.14
255_Q	260_G	0.508	0.14
266_P	269_G	0.508	0.14
68_L	169_E	0.507	0.14
88_D	136_A	0.506	0.14
37_S	43_T	0.504	0.14
171_Q	214_E	0.504	0.14
70_E	88_D	0.503	0.14
185_D	192_T	0.503	0.14
271_M	275_A	0.501	0.14
193_V	199_E	0.500	0.14

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3prbA	2	0.7228	100	0.493	Contact Map
1ix5A	1	0.4851	100	0.611	Contact Map
3pr9A	1	0.4818	100	0.621	Contact Map
4dt4A	1	0.5017	100	0.673	Contact Map
4odkA	1	0.4851	100	0.68	Contact Map
2kr7A	1	0.4719	100	0.682	Contact Map
2k8iA	1	0.5413	100	0.683	Contact Map
2kfwA	1	0.5578	99.9	0.687	Contact Map
4it4A	5	0.6073	99.9	0.699	Contact Map
1p5qA	5	0.8086	99.9	0.717	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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