GREMLIN Database
F2Z6G9 - Peptidyl-prolyl cis-trans isomerase
UniProt: F2Z6G9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 303 (241)
Sequences: 267 (212)
Seq/√Len: 13.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_A41_V4.8251.00
78_E97_A4.5071.00
78_E81_I4.1101.00
174_G181_D3.4010.99
68_L78_E3.3520.99
191_E195_E3.2810.98
178_M181_D3.0440.97
174_G178_M3.0140.97
102_D105_E2.8000.96
181_D184_L2.7390.95
174_G179_M2.6570.94
189_V195_E2.5260.92
84_Q88_D2.5040.92
194_E198_T2.4920.92
84_Q90_G2.3180.88
193_V196_E2.2920.88
189_V198_T2.2760.88
23_G98_F2.1160.83
29_S45_D2.1150.83
187_D191_E2.0860.82
193_V198_T2.0300.81
74_F94_V2.0210.80
176_L181_D2.0100.80
27_E65_T1.9060.76
177_E181_D1.9000.76
80_D84_Q1.8920.76
217_T222_Q1.8600.74
41_V76_A1.8350.73
191_E199_E1.8140.72
158_E161_V1.7630.70
97_A109_V1.7480.69
275_A279_L1.7350.69
272_M276_G1.6660.66
192_T195_E1.6610.65
280_G283_E1.6490.65
191_E198_T1.6310.64
174_G184_L1.6150.63
175_F181_D1.6100.63
253_I257_I1.5890.62
188_L192_T1.5860.62
103_E106_V1.5810.61
19_G85_S1.5780.61
28_L111_A1.5760.61
73_I81_I1.5470.60
38_E89_D1.5230.58
252_V258_I1.5090.58
270_G280_G1.5000.57
278_D282_V1.4670.55
191_E196_E1.4580.55
41_V78_E1.4480.54
181_D193_V1.4410.54
141_R152_G1.4330.54
187_D198_T1.4280.53
187_D192_T1.4270.53
174_G177_E1.4210.53
250_D253_I1.4000.52
191_E194_E1.3960.52
267_G273_G1.3950.52
179_M184_L1.3900.51
20_F68_L1.3870.51
79_D96_E1.3810.51
136_A140_G1.3620.50
189_V194_E1.3610.50
188_L191_E1.3470.49
188_L196_E1.3460.49
169_E172_A1.3380.48
195_E198_T1.3310.48
199_E202_E1.3290.48
276_G282_V1.3160.47
97_A155_I1.3130.47
271_M277_G1.2970.46
269_G272_M1.2960.46
189_V193_V1.2680.45
224_P227_Q1.2590.44
41_V118_D1.2560.44
256_E261_Q1.2500.44
176_L195_E1.2380.43
273_G276_G1.2280.43
102_D106_V1.2270.43
21_Q259_D1.2270.43
68_L132_G1.2230.42
27_E94_V1.2020.41
74_F184_L1.1900.41
174_G193_V1.1650.39
165_I275_A1.1350.38
22_T82_V1.1340.38
257_I261_Q1.1290.38
68_L94_V1.1240.37
75_A97_A1.1190.37
73_I110_S1.1170.37
176_L179_M1.1130.37
178_M184_L1.1130.37
71_E76_A1.1070.36
192_T196_E1.1060.36
253_I261_Q1.1060.36
96_E111_A1.1040.36
175_F179_M1.1040.36
176_L184_L1.0990.36
168_R171_Q1.0890.36
280_G284_D1.0870.35
42_D139_G1.0820.35
207_E212_S1.0810.35
30_Y175_F1.0760.35
179_M242_Q1.0760.35
76_A111_A1.0750.35
154_D161_V1.0670.34
30_Y44_T1.0620.34
32_A123_A1.0620.34
77_V105_E1.0560.34
268_M274_G1.0540.34
268_M283_E1.0500.34
28_L253_I1.0460.33
84_Q139_G1.0360.33
82_V134_V1.0360.33
181_D192_T1.0340.33
159_Y162_L1.0340.33
77_V231_Q1.0320.33
111_A114_I1.0200.32
276_G281_D1.0180.32
274_G277_G1.0020.31
28_L32_A0.9950.31
191_E202_E0.9950.31
271_M276_G0.9930.31
97_A105_E0.9920.31
21_Q144_V0.9870.31
206_A209_T0.9800.30
175_F178_M0.9800.30
187_D195_E0.9790.30
120_Y143_R0.9750.30
85_S88_D0.9670.30
99_G170_Q0.9670.30
20_F66_I0.9640.30
159_Y174_G0.9630.30
68_L126_D0.9630.30
264_G278_D0.9610.30
279_L283_E0.9600.30
72_H83_G0.9560.29
273_G283_E0.9550.29
168_R172_A0.9530.29
273_G277_G0.9530.29
179_M183_E0.9500.29
177_E184_L0.9450.29
221_E225_Q0.9450.29
122_G128_D0.9350.28
188_L195_E0.9350.28
226_L229_N0.9340.28
32_A76_A0.9290.28
258_I261_Q0.9270.28
268_M272_M0.9250.28
155_I162_L0.9230.28
67_V106_V0.9140.28
113_K116_E0.9110.27
101_Y140_G0.9090.27
276_G279_L0.9010.27
264_G268_M0.8980.27
84_Q159_Y0.8950.27
67_V73_I0.8940.27
251_R254_V0.8780.26
64_R232_W0.8760.26
78_E139_G0.8720.26
94_V184_L0.8690.26
178_M193_V0.8690.26
176_L193_V0.8660.25
109_V263_A0.8600.25
263_A269_G0.8580.25
123_A154_D0.8580.25
278_D281_D0.8570.25
181_D194_E0.8490.25
155_I158_E0.8480.25
240_L246_M0.8480.25
181_D191_E0.8480.25
270_G274_G0.8470.25
243_V247_L0.8460.25
279_L282_V0.8430.25
189_V196_E0.8420.25
267_G275_A0.8360.24
93_L125_V0.8310.24
66_I96_E0.8220.24
187_D193_V0.8170.24
105_E134_V0.8150.23
44_T146_F0.8040.23
137_I163_D0.8010.23
26_V88_D0.8000.23
42_D85_S0.7970.23
264_G267_G0.7940.23
24_D148_H0.7870.22
34_T110_S0.7870.22
148_H165_I0.7860.22
273_G280_G0.7860.22
178_M182_V0.7860.22
94_V227_Q0.7850.22
21_Q166_T0.7820.22
279_L284_D0.7760.22
20_F88_D0.7720.22
203_D208_T0.7710.22
199_E205_D0.7690.22
184_L188_L0.7640.22
21_Q116_E0.7580.21
272_M277_G0.7560.21
167_D170_Q0.7540.21
73_I78_E0.7530.21
126_D184_L0.7490.21
275_A283_E0.7480.21
32_A139_G0.7430.21
178_M196_E0.7390.21
41_V123_A0.7380.21
45_D64_R0.7320.20
66_I94_V0.7270.20
272_M280_G0.7260.20
130_E173_V0.7250.20
264_G276_G0.7230.20
76_A114_I0.7220.20
206_A246_M0.7210.20
31_T209_T0.7180.20
77_V95_E0.7170.20
195_E199_E0.7160.20
80_D88_D0.7120.20
37_S133_H0.7080.20
122_G129_G0.7080.20
121_P127_V0.7060.20
281_D284_D0.7010.19
38_E267_G0.7010.19
73_I83_G0.6990.19
114_I144_V0.6930.19
81_I84_Q0.6930.19
231_Q235_G0.6880.19
181_D196_E0.6860.19
108_T113_K0.6860.19
273_G278_D0.6830.19
114_I123_A0.6830.19
143_R157_Y0.6820.19
250_D254_V0.6820.19
119_R142_A0.6810.19
139_G150_L0.6780.19
85_S89_D0.6770.19
73_I224_P0.6760.19
76_A139_G0.6730.18
170_Q184_L0.6700.18
155_I160_E0.6690.18
88_D107_R0.6650.18
184_L195_E0.6630.18
43_T141_R0.6620.18
274_G281_D0.6620.18
91_T141_R0.6610.18
44_T216_E0.6590.18
265_M270_G0.6590.18
266_P270_G0.6570.18
271_M279_L0.6560.18
91_T127_V0.6510.18
94_V225_Q0.6480.18
97_A237_S0.6460.18
277_G284_D0.6460.18
26_V222_Q0.6450.18
272_M283_E0.6440.18
267_G270_G0.6440.18
249_I252_V0.6390.17
175_F191_E0.6370.17
39_E220_I0.6360.17
269_G273_G0.6340.17
33_Y73_I0.6330.17
42_D72_H0.6320.17
269_G274_G0.6320.17
219_Y226_L0.6310.17
249_I260_G0.6310.17
268_M271_M0.6290.17
257_I260_G0.6290.17
216_E254_V0.6280.17
247_L252_V0.6280.17
23_G97_A0.6270.17
73_I101_Y0.6240.17
40_L93_L0.6240.17
212_S215_K0.6220.17
84_Q116_E0.6220.17
179_M246_M0.6200.17
32_A40_L0.6190.17
262_P272_M0.6180.17
43_T152_G0.6120.17
276_G280_G0.6090.16
32_A114_I0.6080.16
236_K240_L0.6080.16
33_Y98_F0.6080.16
20_F80_D0.6080.16
136_A154_D0.6060.16
192_T198_T0.6060.16
204_G207_E0.6050.16
71_E219_Y0.6050.16
44_T78_E0.6020.16
204_G208_T0.5990.16
147_N157_Y0.5980.16
131_H134_V0.5980.16
41_V254_V0.5960.16
230_Q236_K0.5950.16
193_V202_E0.5930.16
188_L194_E0.5930.16
231_Q238_Q0.5930.16
268_M276_G0.5920.16
123_A160_E0.5880.16
106_V145_D0.5850.16
272_M275_A0.5840.16
198_T202_E0.5840.16
107_R119_R0.5810.16
132_G145_D0.5790.16
207_E218_L0.5780.16
215_K266_P0.5770.16
181_D195_E0.5770.16
23_G239_V0.5760.16
174_G196_E0.5750.16
149_P164_E0.5740.15
277_G283_E0.5710.15
217_T253_I0.5700.15
114_I119_R0.5650.15
42_D97_A0.5650.15
90_G101_Y0.5620.15
38_E214_E0.5620.15
99_G151_A0.5610.15
212_S226_L0.5600.15
84_Q161_V0.5580.15
240_L248_D0.5560.15
273_G284_D0.5550.15
75_A221_E0.5520.15
212_S216_E0.5510.15
77_V277_G0.5510.15
219_Y253_I0.5500.15
118_D124_H0.5490.15
184_L193_V0.5470.15
111_A116_E0.5450.15
92_V175_F0.5450.15
170_Q173_V0.5440.15
73_I203_D0.5420.15
90_G107_R0.5400.15
194_E199_E0.5360.14
75_A89_D0.5360.14
242_Q252_V0.5310.14
37_S80_D0.5310.14
42_D71_E0.5300.14
121_P144_V0.5240.14
180_F184_L0.5240.14
220_I239_V0.5240.14
240_L254_V0.5220.14
180_F191_E0.5210.14
101_Y142_A0.5200.14
238_Q241_S0.5200.14
224_P235_G0.5190.14
166_T170_Q0.5190.14
76_A81_I0.5190.14
219_Y224_P0.5180.14
90_G161_V0.5170.14
40_L274_G0.5160.14
144_V262_P0.5150.14
86_V94_V0.5130.14
236_K247_L0.5110.14
134_V274_G0.5090.14
255_Q260_G0.5080.14
266_P269_G0.5080.14
68_L169_E0.5070.14
88_D136_A0.5060.14
37_S43_T0.5040.14
171_Q214_E0.5040.14
70_E88_D0.5030.14
185_D192_T0.5030.14
271_M275_A0.5010.14
193_V199_E0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3prbA 2 0.7228 100 0.493 Contact Map
1ix5A 1 0.4851 100 0.611 Contact Map
3pr9A 1 0.4818 100 0.621 Contact Map
4dt4A 1 0.5017 100 0.673 Contact Map
4odkA 1 0.4851 100 0.68 Contact Map
2kr7A 1 0.4719 100 0.682 Contact Map
2k8iA 1 0.5413 100 0.683 Contact Map
2kfwA 1 0.5578 99.9 0.687 Contact Map
4it4A 5 0.6073 99.9 0.699 Contact Map
1p5qA 5 0.8086 99.9 0.717 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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