F2Z6F3 - HALSA - GREMLIN Contacts

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F2Z6F3 - Vng6319h

UniProt:	F2Z6F3	Sequences: MTDHCCKIGRTIATYDLGERAIEDGFDEELAARWVGDHGFPETATRPLTDWFNTELLKSVYDSHNRKAIDVHIQSEYDALQSDDAVTRGEIIDDLADDGIDGTELTTDFATRSTMYRHLTQCLGANKSKQRSNSDWESDKIEYARDTMRTNIEDVLQSLDRKGELPNGADATVRTQIILQCHVDGCSTQTRLSRARTRGFICRAHSDVA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	209 (189)
Sequences:	106 (78)
Seq/√Len:	5.7

HALSA - F2Z6F3 Q9HHY3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
118_H	123_L	4.276	0.95
112_R	116_Y	3.766	0.90
75_S	79_A	3.393	0.84
118_H	122_C	3.347	0.83
27_D	123_L	3.027	0.76
27_D	118_H	2.943	0.74
72_H	75_S	2.911	0.73
6_C	118_H	2.891	0.73
11_T	56_L	2.592	0.64
6_C	123_L	2.510	0.61
56_L	112_R	2.406	0.58
71_V	75_S	2.332	0.55
47_P	201_I	2.308	0.54
52_F	115_M	2.305	0.54
6_C	27_D	2.201	0.51
114_T	118_H	2.155	0.49
6_C	122_C	2.085	0.47
112_R	120_T	2.077	0.46
72_H	78_D	2.037	0.45
36_G	39_G	1.983	0.43
61_Y	66_R	1.915	0.41
168_G	185_G	1.869	0.39
72_H	79_A	1.866	0.39
69_I	141_I	1.842	0.39
145_R	199_G	1.812	0.38
33_R	43_T	1.785	0.37
27_D	114_T	1.767	0.36
114_T	123_L	1.749	0.36
181_C	186_C	1.748	0.36
105_L	114_T	1.730	0.35
190_T	203_R	1.685	0.34
54_T	74_Q	1.659	0.33
111_T	115_M	1.584	0.31
69_I	91_I	1.581	0.30
44_A	113_S	1.563	0.30
120_T	126_N	1.559	0.30
28_E	156_L	1.555	0.30
149_R	156_L	1.548	0.29
26_F	128_S	1.542	0.29
81_Q	195_A	1.539	0.29
71_V	79_A	1.511	0.28
115_M	148_M	1.510	0.28
92_I	125_A	1.502	0.28
152_I	191_R	1.491	0.28
27_D	122_C	1.479	0.28
186_C	202_C	1.470	0.27
75_S	78_D	1.443	0.27
35_V	90_E	1.411	0.26
171_A	196_R	1.406	0.26
141_I	196_R	1.406	0.26
8_I	12_I	1.399	0.25
92_I	115_M	1.387	0.25
181_C	202_C	1.363	0.24
11_T	108_D	1.362	0.24
12_I	115_M	1.348	0.24
114_T	122_C	1.341	0.24
13_A	38_H	1.336	0.24
37_D	55_E	1.335	0.24
106_T	117_R	1.328	0.24
105_L	155_V	1.323	0.23
33_R	47_P	1.321	0.23
56_L	60_V	1.303	0.23
18_G	74_Q	1.260	0.22
141_I	154_D	1.255	0.22
58_K	197_T	1.250	0.22
105_L	118_H	1.226	0.21
31_A	52_F	1.224	0.21
140_K	178_I	1.222	0.21
52_F	117_R	1.218	0.21
60_V	163_G	1.213	0.21
84_D	103_T	1.177	0.20
112_R	117_R	1.170	0.20
17_L	56_L	1.150	0.19
174_R	189_Q	1.148	0.19
57_L	148_M	1.140	0.19
56_L	108_D	1.135	0.19
31_A	123_L	1.119	0.19
57_L	109_F	1.112	0.19
71_V	78_D	1.095	0.18
41_P	156_L	1.088	0.18
78_D	106_T	1.069	0.18
74_Q	85_A	1.060	0.18
96_A	195_A	1.046	0.17
6_C	114_T	1.043	0.17
72_H	91_I	1.039	0.17
13_A	16_D	1.038	0.17
25_G	56_L	1.029	0.17
118_H	143_Y	1.020	0.17
70_D	104_E	1.014	0.17
9_G	94_D	1.006	0.17
36_G	189_Q	0.996	0.16
78_D	164_E	0.974	0.16
12_I	117_R	0.974	0.16
50_D	126_N	0.973	0.16
84_D	163_G	0.967	0.16
110_A	117_R	0.946	0.15
46_R	80_L	0.943	0.15
145_R	168_G	0.942	0.15
92_I	106_T	0.941	0.15
125_A	152_I	0.936	0.15
142_E	197_T	0.934	0.15
104_E	107_T	0.932	0.15
56_L	59_S	0.931	0.15
116_Y	172_T	0.930	0.15
32_A	194_R	0.925	0.15
111_T	122_C	0.924	0.15
86_V	97_D	0.921	0.15
107_T	124_G	0.918	0.15
91_I	125_A	0.917	0.15
9_G	112_R	0.916	0.15
124_G	160_D	0.914	0.15
60_V	64_H	0.910	0.15
28_E	31_A	0.905	0.15
79_A	90_E	0.901	0.15
56_L	124_G	0.892	0.14
79_A	111_T	0.887	0.14
67_K	124_G	0.880	0.14
105_L	148_M	0.879	0.14
102_G	166_P	0.876	0.14
44_A	195_A	0.874	0.14
103_T	163_G	0.869	0.14
138_S	176_Q	0.869	0.14
9_G	116_Y	0.865	0.14
30_L	111_T	0.865	0.14
105_L	123_L	0.856	0.14
15_Y	64_H	0.854	0.14
68_A	170_D	0.854	0.14
36_G	41_P	0.849	0.14
36_G	139_D	0.843	0.14
61_Y	151_N	0.843	0.14
145_R	149_R	0.838	0.14
34_W	127_K	0.833	0.13
39_G	196_R	0.828	0.13
42_E	127_K	0.820	0.13
134_S	141_I	0.818	0.13
11_T	31_A	0.818	0.13
152_I	182_H	0.818	0.13
78_D	82_S	0.813	0.13
30_L	119_L	0.807	0.13
69_I	140_K	0.807	0.13
177_I	188_T	0.801	0.13
11_T	102_G	0.801	0.13
12_I	31_A	0.797	0.13
44_A	147_T	0.793	0.13
8_I	31_A	0.787	0.13
89_G	105_L	0.781	0.13
107_T	165_L	0.779	0.13
55_E	103_T	0.777	0.13
74_Q	128_S	0.777	0.13
132_S	189_Q	0.772	0.13
13_A	25_G	0.764	0.12
133_N	163_G	0.763	0.12
153_E	167_N	0.761	0.12
55_E	197_T	0.753	0.12
6_C	143_Y	0.752	0.12
154_D	198_R	0.749	0.12
17_L	137_E	0.747	0.12
100_I	152_I	0.746	0.12
31_A	118_H	0.746	0.12
44_A	151_N	0.746	0.12
56_L	148_M	0.740	0.12
160_D	164_E	0.737	0.12
31_A	125_A	0.730	0.12
55_E	79_A	0.722	0.12
98_D	103_T	0.718	0.12
88_R	107_T	0.718	0.12
63_S	156_L	0.711	0.12
56_L	116_Y	0.711	0.12
32_A	36_G	0.709	0.12
79_A	91_I	0.708	0.12
112_R	177_I	0.707	0.12
29_E	166_P	0.706	0.12
70_D	100_I	0.702	0.12
150_T	158_S	0.699	0.11
156_L	165_L	0.697	0.11
85_A	173_V	0.696	0.11
18_G	97_D	0.694	0.11
100_I	180_Q	0.691	0.11
38_H	88_R	0.686	0.11
187_S	201_I	0.683	0.11
61_Y	72_H	0.682	0.11
44_A	201_I	0.677	0.11
28_E	187_S	0.673	0.11
49_T	112_R	0.672	0.11
33_R	135_D	0.670	0.11
43_T	111_T	0.667	0.11
54_T	85_A	0.666	0.11
145_R	156_L	0.656	0.11
45_T	123_L	0.654	0.11
69_I	99_G	0.653	0.11
172_T	182_H	0.653	0.11
52_F	116_Y	0.652	0.11
12_I	121_Q	0.646	0.11
103_T	106_T	0.645	0.11
11_T	194_R	0.643	0.11
132_S	146_D	0.642	0.11
36_G	155_V	0.640	0.11
113_S	147_T	0.640	0.11
70_D	78_D	0.638	0.11
27_D	105_L	0.632	0.11
116_Y	140_K	0.630	0.11
6_C	142_E	0.629	0.11
37_D	85_A	0.629	0.11
100_I	131_R	0.625	0.10
27_D	176_Q	0.620	0.10
71_V	111_T	0.619	0.10
26_F	36_G	0.618	0.10
47_P	111_T	0.618	0.10
54_T	195_A	0.616	0.10
111_T	146_D	0.612	0.10
156_L	185_G	0.609	0.10
16_D	64_H	0.607	0.10
39_G	124_G	0.607	0.10
140_K	158_S	0.604	0.10
17_L	88_R	0.603	0.10
117_R	192_L	0.602	0.10
78_D	83_D	0.600	0.10
57_L	187_S	0.598	0.10
62_D	141_I	0.594	0.10
165_L	194_R	0.593	0.10
45_T	101_D	0.591	0.10
35_V	125_A	0.589	0.10
32_A	83_D	0.589	0.10
141_I	177_I	0.588	0.10
10_R	173_V	0.586	0.10
153_E	163_G	0.586	0.10
65_N	174_R	0.584	0.10
27_D	89_G	0.578	0.10
60_V	100_I	0.577	0.10
86_V	139_D	0.577	0.10
39_G	156_L	0.575	0.10
124_G	146_D	0.575	0.10
45_T	187_S	0.575	0.10
96_A	100_I	0.572	0.10
112_R	150_T	0.571	0.10
108_D	194_R	0.569	0.10
25_G	123_L	0.567	0.10
60_V	147_T	0.566	0.10
17_L	144_A	0.561	0.10
74_Q	81_Q	0.559	0.10
126_N	152_I	0.559	0.10
137_E	165_L	0.558	0.10
9_G	31_A	0.557	0.10
98_D	165_L	0.556	0.10
12_I	84_D	0.556	0.10
111_T	149_R	0.554	0.10
120_T	127_K	0.550	0.10
109_F	174_R	0.548	0.10
49_T	201_I	0.548	0.10
126_N	150_T	0.547	0.10
87_T	196_R	0.546	0.10
74_Q	109_F	0.545	0.09
34_W	126_N	0.544	0.09
50_D	122_C	0.544	0.09
141_I	151_N	0.539	0.09
42_E	132_S	0.538	0.09
10_R	147_T	0.536	0.09
18_G	58_K	0.535	0.09
68_A	177_I	0.534	0.09
26_F	156_L	0.533	0.09
129_K	164_E	0.531	0.09
167_N	171_A	0.531	0.09
116_Y	120_T	0.527	0.09
71_V	113_S	0.527	0.09
59_S	168_G	0.525	0.09
31_A	120_T	0.523	0.09
13_A	196_R	0.519	0.09
90_E	125_A	0.518	0.09
13_A	193_S	0.517	0.09
100_I	124_G	0.517	0.09
5_C	68_A	0.517	0.09
135_D	182_H	0.517	0.09
9_G	69_I	0.515	0.09
114_T	192_L	0.514	0.09
11_T	116_Y	0.509	0.09
10_R	204_A	0.508	0.09
12_I	88_R	0.508	0.09
67_K	145_R	0.506	0.09
133_N	197_T	0.505	0.09
90_E	126_N	0.504	0.09
18_G	117_R	0.502	0.09
140_K	182_H	0.500	0.09
31_A	152_I	0.500	0.09
77_Y	109_F	0.500	0.09

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3hyiA	1	0.3349	36	0.958	Contact Map
4cb9A	1	0.6029	24.2	0.962	Contact Map
1pdnC	1	0.445	22.5	0.962	Contact Map
3nuhB	1	0.2823	20.5	0.963	Contact Map
4mfuA	2	0.5885	19.4	0.963	Contact Map
4bn4A	1	0.6699	18.1	0.964	Contact Map
1l8qA	1	0.689	17.8	0.964	Contact Map
2dfaA	4	0.4354	16.7	0.965	Contact Map
3fesA	1	0.488	15.7	0.965	Contact Map
3j21O	1	0.488	15.6	0.965	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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