GREMLIN Database
F2Z6F3 - Vng6319h
UniProt: F2Z6F3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 209 (189)
Sequences: 106 (78)
Seq/√Len: 5.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
118_H123_L4.2760.95
112_R116_Y3.7660.90
75_S79_A3.3930.84
118_H122_C3.3470.83
27_D123_L3.0270.76
27_D118_H2.9430.74
72_H75_S2.9110.73
6_C118_H2.8910.73
11_T56_L2.5920.64
6_C123_L2.5100.61
56_L112_R2.4060.58
71_V75_S2.3320.55
47_P201_I2.3080.54
52_F115_M2.3050.54
6_C27_D2.2010.51
114_T118_H2.1550.49
6_C122_C2.0850.47
112_R120_T2.0770.46
72_H78_D2.0370.45
36_G39_G1.9830.43
61_Y66_R1.9150.41
168_G185_G1.8690.39
72_H79_A1.8660.39
69_I141_I1.8420.39
145_R199_G1.8120.38
33_R43_T1.7850.37
27_D114_T1.7670.36
114_T123_L1.7490.36
181_C186_C1.7480.36
105_L114_T1.7300.35
190_T203_R1.6850.34
54_T74_Q1.6590.33
111_T115_M1.5840.31
69_I91_I1.5810.30
44_A113_S1.5630.30
120_T126_N1.5590.30
28_E156_L1.5550.30
149_R156_L1.5480.29
26_F128_S1.5420.29
81_Q195_A1.5390.29
71_V79_A1.5110.28
115_M148_M1.5100.28
92_I125_A1.5020.28
152_I191_R1.4910.28
27_D122_C1.4790.28
186_C202_C1.4700.27
75_S78_D1.4430.27
35_V90_E1.4110.26
171_A196_R1.4060.26
141_I196_R1.4060.26
8_I12_I1.3990.25
92_I115_M1.3870.25
181_C202_C1.3630.24
11_T108_D1.3620.24
12_I115_M1.3480.24
114_T122_C1.3410.24
13_A38_H1.3360.24
37_D55_E1.3350.24
106_T117_R1.3280.24
105_L155_V1.3230.23
33_R47_P1.3210.23
56_L60_V1.3030.23
18_G74_Q1.2600.22
141_I154_D1.2550.22
58_K197_T1.2500.22
105_L118_H1.2260.21
31_A52_F1.2240.21
140_K178_I1.2220.21
52_F117_R1.2180.21
60_V163_G1.2130.21
84_D103_T1.1770.20
112_R117_R1.1700.20
17_L56_L1.1500.19
174_R189_Q1.1480.19
57_L148_M1.1400.19
56_L108_D1.1350.19
31_A123_L1.1190.19
57_L109_F1.1120.19
71_V78_D1.0950.18
41_P156_L1.0880.18
78_D106_T1.0690.18
74_Q85_A1.0600.18
96_A195_A1.0460.17
6_C114_T1.0430.17
72_H91_I1.0390.17
13_A16_D1.0380.17
25_G56_L1.0290.17
118_H143_Y1.0200.17
70_D104_E1.0140.17
9_G94_D1.0060.17
36_G189_Q0.9960.16
78_D164_E0.9740.16
12_I117_R0.9740.16
50_D126_N0.9730.16
84_D163_G0.9670.16
110_A117_R0.9460.15
46_R80_L0.9430.15
145_R168_G0.9420.15
92_I106_T0.9410.15
125_A152_I0.9360.15
142_E197_T0.9340.15
104_E107_T0.9320.15
56_L59_S0.9310.15
116_Y172_T0.9300.15
32_A194_R0.9250.15
111_T122_C0.9240.15
86_V97_D0.9210.15
107_T124_G0.9180.15
91_I125_A0.9170.15
9_G112_R0.9160.15
124_G160_D0.9140.15
60_V64_H0.9100.15
28_E31_A0.9050.15
79_A90_E0.9010.15
56_L124_G0.8920.14
79_A111_T0.8870.14
67_K124_G0.8800.14
105_L148_M0.8790.14
102_G166_P0.8760.14
44_A195_A0.8740.14
103_T163_G0.8690.14
138_S176_Q0.8690.14
9_G116_Y0.8650.14
30_L111_T0.8650.14
105_L123_L0.8560.14
15_Y64_H0.8540.14
68_A170_D0.8540.14
36_G41_P0.8490.14
36_G139_D0.8430.14
61_Y151_N0.8430.14
145_R149_R0.8380.14
34_W127_K0.8330.13
39_G196_R0.8280.13
42_E127_K0.8200.13
134_S141_I0.8180.13
11_T31_A0.8180.13
152_I182_H0.8180.13
78_D82_S0.8130.13
30_L119_L0.8070.13
69_I140_K0.8070.13
177_I188_T0.8010.13
11_T102_G0.8010.13
12_I31_A0.7970.13
44_A147_T0.7930.13
8_I31_A0.7870.13
89_G105_L0.7810.13
107_T165_L0.7790.13
55_E103_T0.7770.13
74_Q128_S0.7770.13
132_S189_Q0.7720.13
13_A25_G0.7640.12
133_N163_G0.7630.12
153_E167_N0.7610.12
55_E197_T0.7530.12
6_C143_Y0.7520.12
154_D198_R0.7490.12
17_L137_E0.7470.12
100_I152_I0.7460.12
31_A118_H0.7460.12
44_A151_N0.7460.12
56_L148_M0.7400.12
160_D164_E0.7370.12
31_A125_A0.7300.12
55_E79_A0.7220.12
98_D103_T0.7180.12
88_R107_T0.7180.12
63_S156_L0.7110.12
56_L116_Y0.7110.12
32_A36_G0.7090.12
79_A91_I0.7080.12
112_R177_I0.7070.12
29_E166_P0.7060.12
70_D100_I0.7020.12
150_T158_S0.6990.11
156_L165_L0.6970.11
85_A173_V0.6960.11
18_G97_D0.6940.11
100_I180_Q0.6910.11
38_H88_R0.6860.11
187_S201_I0.6830.11
61_Y72_H0.6820.11
44_A201_I0.6770.11
28_E187_S0.6730.11
49_T112_R0.6720.11
33_R135_D0.6700.11
43_T111_T0.6670.11
54_T85_A0.6660.11
145_R156_L0.6560.11
45_T123_L0.6540.11
69_I99_G0.6530.11
172_T182_H0.6530.11
52_F116_Y0.6520.11
12_I121_Q0.6460.11
103_T106_T0.6450.11
11_T194_R0.6430.11
132_S146_D0.6420.11
36_G155_V0.6400.11
113_S147_T0.6400.11
70_D78_D0.6380.11
27_D105_L0.6320.11
116_Y140_K0.6300.11
6_C142_E0.6290.11
37_D85_A0.6290.11
100_I131_R0.6250.10
27_D176_Q0.6200.10
71_V111_T0.6190.10
26_F36_G0.6180.10
47_P111_T0.6180.10
54_T195_A0.6160.10
111_T146_D0.6120.10
156_L185_G0.6090.10
16_D64_H0.6070.10
39_G124_G0.6070.10
140_K158_S0.6040.10
17_L88_R0.6030.10
117_R192_L0.6020.10
78_D83_D0.6000.10
57_L187_S0.5980.10
62_D141_I0.5940.10
165_L194_R0.5930.10
45_T101_D0.5910.10
35_V125_A0.5890.10
32_A83_D0.5890.10
141_I177_I0.5880.10
10_R173_V0.5860.10
153_E163_G0.5860.10
65_N174_R0.5840.10
27_D89_G0.5780.10
60_V100_I0.5770.10
86_V139_D0.5770.10
39_G156_L0.5750.10
124_G146_D0.5750.10
45_T187_S0.5750.10
96_A100_I0.5720.10
112_R150_T0.5710.10
108_D194_R0.5690.10
25_G123_L0.5670.10
60_V147_T0.5660.10
17_L144_A0.5610.10
74_Q81_Q0.5590.10
126_N152_I0.5590.10
137_E165_L0.5580.10
9_G31_A0.5570.10
98_D165_L0.5560.10
12_I84_D0.5560.10
111_T149_R0.5540.10
120_T127_K0.5500.10
109_F174_R0.5480.10
49_T201_I0.5480.10
126_N150_T0.5470.10
87_T196_R0.5460.10
74_Q109_F0.5450.09
34_W126_N0.5440.09
50_D122_C0.5440.09
141_I151_N0.5390.09
42_E132_S0.5380.09
10_R147_T0.5360.09
18_G58_K0.5350.09
68_A177_I0.5340.09
26_F156_L0.5330.09
129_K164_E0.5310.09
167_N171_A0.5310.09
116_Y120_T0.5270.09
71_V113_S0.5270.09
59_S168_G0.5250.09
31_A120_T0.5230.09
13_A196_R0.5190.09
90_E125_A0.5180.09
13_A193_S0.5170.09
100_I124_G0.5170.09
5_C68_A0.5170.09
135_D182_H0.5170.09
9_G69_I0.5150.09
114_T192_L0.5140.09
11_T116_Y0.5090.09
10_R204_A0.5080.09
12_I88_R0.5080.09
67_K145_R0.5060.09
133_N197_T0.5050.09
90_E126_N0.5040.09
18_G117_R0.5020.09
140_K182_H0.5000.09
31_A152_I0.5000.09
77_Y109_F0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hyiA 1 0.3349 36 0.958 Contact Map
4cb9A 1 0.6029 24.2 0.962 Contact Map
1pdnC 1 0.445 22.5 0.962 Contact Map
3nuhB 1 0.2823 20.5 0.963 Contact Map
4mfuA 2 0.5885 19.4 0.963 Contact Map
4bn4A 1 0.6699 18.1 0.964 Contact Map
1l8qA 1 0.689 17.8 0.964 Contact Map
2dfaA 4 0.4354 16.7 0.965 Contact Map
3fesA 1 0.488 15.7 0.965 Contact Map
3j21O 1 0.488 15.6 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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