GREMLIN Database
ADPP - ADP-ribose pyrophosphatase
UniProt: Q93K97 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12184
Length: 209 (170)
Sequences: 5682 (4013)
Seq/√Len: 307.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
61_V94_M3.0961.00
106_E110_R2.7341.00
123_R147_E2.5821.00
66_D71_E2.5571.00
114_I120_I2.5291.00
122_K148_V2.4631.00
71_E172_S2.3901.00
177_Y198_Q2.3511.00
176_A194_L2.3461.00
92_L169_H2.2891.00
71_E170_V2.1971.00
178_Q182_E2.1691.00
125_K147_E2.1681.00
126_P142_S2.1151.00
55_E138_S2.0881.00
129_S140_R2.0871.00
104_S107_D2.0601.00
73_V170_V2.0551.00
76_E167_R2.0171.00
66_D170_V1.9761.00
99_I108_V1.9701.00
122_K150_A1.9431.00
179_W184_K1.9351.00
126_P129_S1.9071.00
30_S35_R1.8671.00
103_E111_R1.8421.00
77_Q93_E1.8421.00
62_L109_A1.8261.00
110_R124_T1.8001.00
105_V142_S1.7701.00
76_E169_H1.7681.00
171_V179_W1.7511.00
195_Q199_L1.7221.00
37_R55_E1.7141.00
129_S142_S1.7021.00
172_S175_Q1.7021.00
123_R148_V1.6721.00
107_D110_R1.6331.00
113_A121_V1.6021.00
40_L48_E1.5971.00
175_Q178_Q1.5901.00
63_L193_A1.5721.00
94_M193_A1.5561.00
106_E124_T1.5401.00
120_I150_A1.5021.00
131_L186_D1.4761.00
154_S160_A1.4031.00
66_D69_R1.4011.00
84_D186_D1.3191.00
40_L50_R1.3051.00
63_L197_L1.3041.00
73_V119_L1.2941.00
80_I83_Y1.2931.00
21_R24_L1.2901.00
108_V111_R1.2801.00
130_F192_I1.2771.00
99_I105_V1.2741.00
39_R80_I1.2511.00
95_V117_A1.2421.00
120_I152_T1.1951.00
82_A91_L1.1951.00
126_P144_M1.1891.00
82_A131_L1.1781.00
42_N48_E1.1681.00
171_V176_A1.1541.00
105_V144_M1.1471.00
78_I83_Y1.1421.00
22_E33_L1.1341.00
114_I152_T1.1281.00
119_L151_T1.1251.00
130_F143_I1.1231.00
178_Q181_E1.1121.00
114_I159_L1.1061.00
58_H99_I1.1051.00
38_H52_E1.1041.00
110_R114_I1.0991.00
38_H50_R1.0881.00
22_E42_N1.0811.00
23_T26_R1.0651.00
64_P113_A1.0511.00
127_V145_V1.0411.00
175_Q179_W1.0371.00
76_E90_W1.0251.00
67_P148_V1.0241.00
60_A109_A1.0241.00
181_E199_L1.0191.00
103_E108_V1.0191.00
73_V168_V1.0171.00
177_Y181_E1.0161.00
28_F36_F1.0131.00
70_D173_R0.9991.00
31_L52_E0.9961.00
180_V191_V0.9951.00
44_Q165_D0.9831.00
143_I193_A0.9801.00
24_L27_G0.9721.00
133_S139_E0.9671.00
109_A124_T0.9671.00
33_L50_R0.9581.00
59_A141_S0.9531.00
61_V141_S0.9321.00
91_L134_P0.9301.00
192_I195_Q0.9171.00
84_D91_L0.8901.00
21_R32_D0.8891.00
121_V124_T0.8821.00
74_L92_L0.8811.00
54_F136_G0.8781.00
114_I153_A0.8771.00
67_P147_E0.8661.00
72_V94_M0.8591.00
72_V194_L0.8551.00
53_I80_I0.8541.00
131_L140_R0.8491.00
180_V185_I0.8451.00
56_R139_E0.8411.00
187_N190_S0.8361.00
177_Y194_L0.8341.00
65_F145_V0.8311.00
21_R26_R0.8311.00
27_G38_H0.8271.00
160_A163_N0.8251.00
63_L72_V0.8211.00
79_R93_E0.8191.00
24_L40_L0.8171.00
130_F188_A0.8101.00
61_V143_I0.8101.00
63_L94_M0.8081.00
28_F38_H0.7921.00
25_Y40_L0.7901.00
106_E126_P0.7891.00
21_R27_G0.7851.00
94_M194_L0.7841.00
132_A136_G0.7730.99
34_Y53_I0.7730.99
121_V149_D0.7700.99
27_G30_S0.7700.99
121_V148_V0.7630.99
62_L146_G0.7620.99
61_V189_A0.7600.99
74_L171_V0.7590.99
65_F173_R0.7580.99
58_H140_R0.7550.99
76_E92_L0.7500.99
130_F191_V0.7410.99
74_L169_H0.7400.99
128_L196_W0.7340.99
65_F72_V0.7340.99
75_I166_I0.7320.99
129_S186_D0.7310.99
106_E144_M0.7290.99
141_S189_A0.7270.99
110_R120_I0.7200.99
133_S137_T0.7070.99
95_V113_A0.7060.99
66_D119_L0.6980.99
67_P150_A0.6960.99
140_R186_D0.6850.99
33_L52_E0.6850.99
179_W182_E0.6830.99
161_D164_E0.6810.99
92_L171_V0.6800.99
58_H142_S0.6730.98
90_W165_D0.6720.98
26_R37_R0.6710.98
121_V146_G0.6690.98
174_E177_Y0.6630.98
70_D174_E0.6610.98
124_T146_G0.6600.98
74_L176_A0.6600.98
132_A188_A0.6570.98
154_S159_L0.6540.98
180_V194_L0.6520.98
125_K145_V0.6510.98
35_R55_E0.6470.98
60_A105_V0.6470.98
72_V173_R0.6370.98
128_L192_I0.6360.98
65_F70_D0.6300.98
124_T144_M0.6280.98
192_I196_W0.6240.98
29_F36_F0.6230.98
29_F33_L0.6220.97
171_V175_Q0.6220.97
42_N46_S0.6210.97
65_F197_L0.6160.97
173_R198_Q0.6150.97
22_E26_R0.6120.97
96_A189_A0.6080.97
57_G98_M0.6060.97
64_P121_V0.6060.97
96_A135_G0.6050.97
64_P145_V0.6040.97
64_P75_I0.6030.97
176_A180_V0.6010.97
179_W185_I0.6000.97
45_M165_D0.5990.97
43_G47_H0.5970.97
127_V197_L0.5950.97
91_L131_L0.5940.97
160_A166_I0.5940.97
36_F52_E0.5910.97
185_I190_S0.5890.97
72_V197_L0.5880.96
59_A98_M0.5880.96
96_A133_S0.5850.96
40_L46_S0.5800.96
69_R170_V0.5800.96
194_L198_Q0.5800.96
72_V176_A0.5780.96
123_R126_P0.5770.96
175_Q184_K0.5760.96
65_F147_E0.5750.96
84_D131_L0.5730.96
128_L183_G0.5720.96
66_D73_V0.5710.96
173_R177_Y0.5710.96
62_L95_V0.5660.96
154_S168_V0.5650.96
132_A137_T0.5640.96
26_R38_H0.5640.96
169_H179_W0.5600.95
26_R30_S0.5570.95
176_A198_Q0.5560.95
64_P149_D0.5560.95
56_R137_T0.5560.95
58_H98_M0.5560.95
39_R53_I0.5540.95
75_I91_L0.5540.95
79_R135_G0.5530.95
71_E175_Q0.5530.95
34_Y54_F0.5530.95
125_K128_L0.5510.95
21_R42_N0.5500.95
136_G141_S0.5490.95
99_I142_S0.5440.95
172_S177_Y0.5420.95
36_F54_F0.5410.94
22_E35_R0.5380.94
75_I92_L0.5360.94
92_L179_W0.5360.94
64_P94_M0.5360.94
104_S144_M0.5300.94
195_Q198_Q0.5230.93
43_G49_V0.5220.93
100_E108_V0.5190.93
176_A185_I0.5180.93
59_A139_E0.5140.93
109_A144_M0.5080.92
79_R96_A0.5030.92
54_F137_T0.5020.92
37_R48_E0.5020.92
118_G159_L0.5010.92
127_V196_W0.5000.92
96_A100_E0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1g0sA 2 0.9761 100 0.341 Contact Map
2dscA 2 0.8517 100 0.393 Contact Map
1vhzA 2 0.8852 100 0.4 Contact Map
1mk1A 2 0.799 100 0.442 Contact Map
3o6zA 2 0.8612 100 0.45 Contact Map
2yvpA 2 0.8565 100 0.468 Contact Map
1v8yA 2 0.7129 100 0.507 Contact Map
3q91A 2 0.6651 100 0.516 Contact Map
2w4eA 2 0.6555 99.9 0.559 Contact Map
2fvvA 1 0.6459 99.9 0.611 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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