GREMLIN Database
YGHX - Putative uncharacterized protein YghX
UniProt: Q7DFU6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13008
Length: 278 (219)
Sequences: 22574 (16074)
Seq/√Len: 1086.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
179_A188_A3.6371.00
164_G187_C3.1961.00
57_T66_E2.8681.00
117_L145_D2.7831.00
152_F156_Y2.7581.00
214_E243_P2.4911.00
59_P66_E2.4651.00
107_A270_L2.3881.00
175_S188_A2.3201.00
190_P193_G2.2181.00
240_Y268_R2.1821.00
238_E268_R2.1501.00
61_P148_A2.1471.00
224_P241_I2.1431.00
81_T110_I2.1271.00
227_E237_Y2.1161.00
83_A153_M2.0771.00
189_V269_T2.0471.00
164_G273_F2.0471.00
71_L110_I1.9891.00
264_L268_R1.9211.00
83_A159_A1.9111.00
74_P110_I1.9111.00
109_Y274_D1.8911.00
69_G112_L1.8491.00
83_A110_I1.8441.00
165_I175_S1.8431.00
151_E184_E1.8411.00
154_Q184_E1.7731.00
103_R107_A1.7651.00
200_D203_K1.7641.00
56_I69_G1.7561.00
242_Y268_R1.7511.00
73_K110_I1.7491.00
54_E73_K1.7451.00
214_E241_I1.7161.00
152_F155_R1.7051.00
89_E169_C1.6911.00
87_V146_F1.6861.00
112_L149_A1.6851.00
227_E239_A1.6661.00
107_A274_D1.6601.00
147_F151_E1.6581.00
147_F182_Y1.6341.00
189_V273_F1.6181.00
74_P81_T1.5951.00
227_E231_K1.5911.00
267_Q271_K1.5851.00
242_Y264_L1.5641.00
168_F192_Y1.5501.00
58_Y149_A1.5421.00
176_N190_P1.5261.00
150_I163_V1.5221.00
150_I185_L1.5191.00
228_A232_A1.5111.00
112_L153_M1.4981.00
268_R271_K1.4651.00
165_I178_A1.4311.00
55_Y68_R1.3951.00
58_Y69_G1.3921.00
84_V109_Y1.3711.00
187_C272_W1.3591.00
83_A112_L1.3591.00
224_P228_A1.3491.00
72_V113_A1.3131.00
139_P142_L1.3091.00
71_L112_L1.2881.00
110_I159_A1.2661.00
189_V209_L1.2611.00
231_K237_Y1.2491.00
168_F191_F1.2441.00
212_F223_W1.2411.00
263_D267_Q1.2321.00
238_E275_K1.2151.00
215_L244_G1.2141.00
86_V166_T1.2091.00
146_F178_A1.1991.00
179_A206_A1.1981.00
101_A113_A1.1981.00
86_V101_A1.1931.00
187_C276_Y1.1901.00
229_A232_A1.1791.00
162_K186_A1.1771.00
57_T68_R1.1681.00
188_A208_L1.1651.00
236_V276_Y1.1571.00
270_L274_D1.1541.00
87_V165_I1.1521.00
137_V140_T1.1511.00
84_V166_T1.1371.00
88_H116_G1.1361.00
176_N226_Y1.1361.00
214_E244_G1.1331.00
190_P210_L1.1301.00
137_V141_N1.1201.00
151_E155_R1.1031.00
211_H240_Y1.0981.00
102_R106_K1.0721.00
62_N65_G1.0541.00
87_V116_G1.0521.00
225_A228_A1.0501.00
143_M177_A1.0461.00
176_N208_L1.0461.00
209_L240_Y1.0391.00
141_N144_N1.0371.00
230_L237_Y1.0341.00
61_P144_N1.0301.00
68_R115_D1.0301.00
165_I188_A1.0251.00
230_L235_K1.0211.00
161_G186_A1.0191.00
86_V111_A1.0181.00
114_P149_A1.0151.00
56_I152_F1.0081.00
52_V73_K1.0041.00
210_L227_E0.9961.00
210_L223_W0.9951.00
101_A105_A0.9921.00
123_Y126_N0.9881.00
211_H265_A0.9821.00
272_W276_Y0.9801.00
98_E102_R0.9791.00
84_V104_V0.9751.00
53_A72_V0.9691.00
229_A233_N0.9571.00
210_L226_Y0.9481.00
73_K158_Q0.9391.00
148_A151_E0.9371.00
177_A181_A0.9311.00
54_E156_Y0.9241.00
265_A269_T0.9181.00
146_F174_V0.9161.00
224_P239_A0.9161.00
103_R270_L0.9111.00
165_I185_L0.9041.00
87_V114_P0.9041.00
166_T189_V0.9031.00
90_N170_Y0.8931.00
191_F269_T0.8901.00
77_M81_T0.8901.00
192_Y213_A0.8861.00
188_A206_A0.8751.00
211_H242_Y0.8741.00
77_M80_K0.8671.00
80_K160_T0.8661.00
82_P162_K0.8611.00
69_G149_A0.8601.00
207_P276_Y0.8531.00
103_R106_K0.8521.00
187_C273_F0.8511.00
222_G225_A0.8491.00
173_G177_A0.8481.00
192_Y249_F0.8471.00
166_T191_F0.8471.00
80_K158_Q0.8441.00
172_G190_P0.8411.00
166_T269_T0.8341.00
208_L230_L0.8291.00
225_A229_A0.8291.00
78_S81_T0.8241.00
242_Y245_V0.8241.00
72_V105_A0.8221.00
212_F239_A0.8221.00
212_F219_I0.8201.00
82_P160_T0.8171.00
72_V111_A0.8141.00
169_C247_H0.8081.00
177_A180_V0.8081.00
271_K275_K0.8071.00
147_F185_L0.8001.00
221_E224_P0.7981.00
151_E154_Q0.7981.00
176_N193_G0.7961.00
83_A163_V0.7941.00
183_P205_E0.7931.00
144_N148_A0.7851.00
202_A233_N0.7851.00
143_M147_F0.7831.00
104_V269_T0.7811.00
212_F241_I0.7801.00
86_V113_A0.7801.00
224_P227_E0.7791.00
223_W227_E0.7781.00
110_I158_Q0.7771.00
103_R266_W0.7751.00
172_G193_G0.7751.00
85_V150_I0.7731.00
76_K81_T0.7721.00
68_R122_G0.7701.00
53_A70_Y0.7681.00
147_F184_E0.7671.00
175_S190_P0.7651.00
85_V149_A0.7631.00
173_G194_R0.7631.00
189_V211_H0.7621.00
84_V273_F0.7581.00
85_V112_L0.7531.00
201_V229_A0.7451.00
104_V166_T0.7441.00
87_V174_V0.7401.00
60_S65_G0.7401.00
85_V185_L0.7391.00
240_Y264_L0.7371.00
140_T144_N0.7361.00
147_F178_A0.7361.00
84_V111_A0.7351.00
223_W239_A0.7311.00
217_T246_N0.7281.00
86_V97_I0.7271.00
109_Y273_F0.7241.00
52_V75_A0.7241.00
105_A111_A0.7231.00
191_F265_A0.7211.00
180_V200_D0.7201.00
58_Y148_A0.7121.00
72_V101_A0.7101.00
142_L174_V0.7091.00
55_Y70_Y0.7081.00
271_K274_D0.7041.00
138_D141_N0.7021.00
221_E225_A0.7001.00
194_R219_I0.6981.00
191_F211_H0.6931.00
198_T201_V0.6881.00
192_Y248_G0.6861.00
164_G276_Y0.6781.00
122_G125_G0.6711.00
94_N115_D0.6701.00
264_L267_Q0.6681.00
209_L272_W0.6641.00
245_V254_T0.6611.00
164_G186_A0.6601.00
150_I154_Q0.6581.00
90_N117_L0.6541.00
84_V164_G0.6531.00
60_S63_G0.6491.00
109_Y270_L0.6481.00
180_V204_I0.6441.00
92_G173_G0.6431.00
208_L235_K0.6411.00
120_V123_Y0.6391.00
266_W269_T0.6391.00
205_E235_K0.6361.00
207_P236_V0.6351.00
88_H114_P0.6351.00
181_A200_D0.6331.00
262_A265_A0.6311.00
228_A231_K0.6311.00
175_S179_A0.6311.00
85_V146_F0.6261.00
182_Y185_L0.6231.00
166_T273_F0.6201.00
137_V142_L0.6181.00
160_T186_A0.6181.00
142_L170_Y0.6171.00
97_I100_V0.6171.00
269_T273_F0.6151.00
201_V204_I0.6151.00
192_Y216_D0.6121.00
50_E106_K0.6111.00
69_G114_P0.6081.00
151_E182_Y0.6071.00
81_T158_Q0.6031.00
144_N147_F0.5961.00
104_V270_L0.5951.00
54_E158_Q0.5951.00
60_S67_V0.5921.00
75_A106_K0.5901.00
209_L238_E0.5891.00
82_P109_Y0.5881.00
60_S148_A0.5871.00
96_Y100_V0.5871.00
116_G170_Y0.5861.00
72_V102_R0.5861.00
154_Q157_P0.5821.00
199_A202_A0.5821.00
95_P98_E0.5811.00
202_A229_A0.5811.00
186_A207_P0.5811.00
105_A110_I0.5781.00
143_M174_V0.5771.00
149_A153_M0.5771.00
238_E241_I0.5751.00
196_A199_A0.5741.00
147_F181_A0.5731.00
166_T190_P0.5691.00
192_Y250_H0.5641.00
210_L237_Y0.5641.00
192_Y212_F0.5631.00
166_T175_S0.5611.00
46_F49_P0.5581.00
70_Y94_N0.5581.00
193_G212_F0.5571.00
154_Q186_A0.5561.00
69_G152_F0.5531.00
208_L226_Y0.5511.00
116_G142_L0.5501.00
58_Y114_P0.5471.00
56_I112_L0.5471.00
109_Y164_G0.5461.00
142_L145_D0.5461.00
209_L268_R0.5451.00
177_A200_D0.5391.00
87_V175_S0.5381.00
207_P272_W0.5381.00
234_N237_Y0.5351.00
170_Y174_V0.5321.00
207_P275_K0.5291.00
59_P62_N0.5261.00
216_D247_H0.5241.00
154_Q163_V0.5241.00
50_E75_A0.5221.00
103_R263_D0.5181.00
143_M178_A0.5161.00
76_K79_G0.5161.00
213_A216_D0.5161.00
270_L273_F0.5141.00
88_H113_A0.5141.00
122_G126_N0.5131.00
149_A152_F0.5111.00
144_N181_A0.5101.00
188_A226_Y0.5081.00
188_A193_G0.5071.00
62_N144_N0.5051.00
138_D142_L0.5021.00
90_N116_G0.5011.00
88_H91_R0.5011.00
51_I102_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4zv9A 1 0.8561 100 0.356 Contact Map
3f67A 1 0.8058 100 0.405 Contact Map
1xfdA 2 0.9496 100 0.407 Contact Map
1zi8A 1 0.7986 100 0.409 Contact Map
2hdwA 2 0.7878 100 0.412 Contact Map
4q1vA 2 0.9496 100 0.415 Contact Map
2z3zA 2 0.9173 100 0.415 Contact Map
4wjlA 2 0.9496 100 0.421 Contact Map
3azoA 1 0.9532 100 0.423 Contact Map
2ecfA 2 0.9532 100 0.423 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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