GREMLIN Database
DGOD - D-galactonate dehydratase
UniProt: Q6BF17 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG20050
Length: 382 (332)
Sequences: 11810 (6926)
Seq/√Len: 380.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
55_Q66_V3.6341.00
113_K339_F3.3111.00
245_R249_A3.2451.00
224_A253_S3.1891.00
189_S192_M3.0171.00
221_P225_A2.9731.00
59_R62_D2.9391.00
42_E46_H2.7121.00
216_Q219_Y2.7081.00
18_L85_G2.6701.00
244_K248_E2.6151.00
26_V93_I2.5401.00
21_E27_V2.2871.00
198_K201_E2.2871.00
22_T93_I2.2771.00
222_K225_A2.2681.00
5_K21_E2.2671.00
19_K27_V2.2421.00
7_T19_K2.2301.00
61_N270_K2.1941.00
198_K226_Q2.1761.00
133_K173_A2.1671.00
7_T21_E2.1401.00
197_I208_I2.0991.00
221_P249_A2.0801.00
247_L280_V2.0621.00
240_R267_E2.0311.00
87_D266_T2.0261.00
5_K49_G1.9971.00
222_K226_Q1.9861.00
254_I281_T1.9791.00
22_T26_V1.9221.00
262_A271_I1.9091.00
218_E249_A1.8981.00
24_E97_V1.8881.00
169_Q172_E1.8881.00
197_I227_T1.8821.00
115_K141_D1.8781.00
125_P129_I1.8651.00
55_Q62_D1.8421.00
179_E206_L1.8301.00
199_E202_P1.8231.00
63_L90_L1.8201.00
196_L200_L1.8151.00
168_A172_E1.8111.00
133_K137_E1.7991.00
26_V97_V1.7931.00
9_Y19_K1.7841.00
243_F271_I1.7501.00
95_G102_V1.7381.00
194_K226_Q1.7141.00
212_V223_L1.7001.00
336_V341_K1.6841.00
4_T21_E1.6841.00
168_A203_Y1.6601.00
248_E278_Y1.6491.00
101_P104_Q1.6441.00
74_R241_F1.6171.00
136_R178_I1.5961.00
43_A47_E1.5941.00
20_I90_L1.5851.00
274_M278_Y1.5851.00
165_N168_A1.5841.00
191_P222_K1.5791.00
273_G276_E1.5621.00
201_E228_H1.5561.00
164_V168_A1.5431.00
100_A104_Q1.5401.00
246_V252_I1.5361.00
47_E77_P1.5251.00
122_G181_G1.5221.00
11_L31_E1.5181.00
124_R127_D1.4941.00
164_V199_E1.4931.00
131_G134_T1.4871.00
129_I173_A1.4871.00
26_V96_K1.4691.00
134_T138_I1.4591.00
139_G178_I1.4531.00
6_I20_I1.4521.00
247_L274_M1.4491.00
129_I133_K1.4461.00
113_K341_K1.4281.00
171_R180_F1.4191.00
58_S97_V1.4171.00
102_V348_L1.4151.00
159_A162_A1.4131.00
301_F342_P1.4011.00
272_A303_S1.3981.00
323_L326_F1.3871.00
190_A222_K1.3831.00
269_Y273_G1.3711.00
19_K29_W1.3591.00
190_A223_L1.3581.00
168_A202_P1.3521.00
194_K222_K1.3431.00
65_Q69_R1.3331.00
133_K136_R1.3301.00
49_G53_I1.3231.00
162_A165_N1.3191.00
87_D91_W1.3101.00
109_L112_D1.3071.00
244_K274_M1.3071.00
245_R248_E1.3031.00
92_D96_K1.2951.00
169_Q173_A1.2941.00
67_M83_I1.2911.00
298_H325_D1.2881.00
161_D165_N1.2881.00
4_T23_D1.2851.00
55_Q63_L1.2821.00
158_R162_A1.2791.00
212_V219_Y1.2751.00
247_L278_Y1.2751.00
269_Y303_S1.2631.00
215_E242_D1.2461.00
143_F178_I1.2451.00
100_A105_L1.2401.00
62_D66_V1.2391.00
32_P85_G1.2221.00
181_G207_F1.2141.00
273_G277_A1.2081.00
221_P251_G1.2021.00
268_C299_I1.1991.00
130_D133_K1.1941.00
195_V199_E1.1911.00
190_A219_Y1.1901.00
146_N185_H1.1891.00
195_V198_K1.1891.00
22_T97_V1.1881.00
181_G206_L1.1881.00
94_K98_L1.1781.00
46_H49_G1.1751.00
88_Q265_I1.1711.00
46_H50_D1.1671.00
243_F255_L1.1651.00
26_V31_E1.1621.00
267_E270_K1.1561.00
92_D295_A1.1451.00
6_I49_G1.1421.00
325_D328_K1.1301.00
211_P231_L1.1291.00
331_E345_K1.1261.00
182_L205_P1.1201.00
192_M195_V1.1191.00
174_F180_F1.1151.00
115_K339_F1.1031.00
127_D130_D1.1011.00
232_A254_I1.0981.00
171_R175_G1.0951.00
240_R274_M1.0921.00
242_D245_R1.0881.00
132_I143_F1.0841.00
194_K223_L1.0841.00
164_V203_Y1.0821.00
211_P223_L1.0791.00
88_Q295_A1.0781.00
126_A135_L1.0691.00
95_G105_L1.0601.00
201_E229_I1.0591.00
259_L268_C1.0561.00
51_Y66_V1.0541.00
39_R42_E1.0531.00
276_E304_Y1.0521.00
58_S98_L1.0461.00
184_F208_I1.0441.00
223_L231_L1.0421.00
123_D127_D1.0361.00
145_L170_I1.0341.00
250_G280_V1.0331.00
233_A246_V1.0261.00
193_A197_I1.0251.00
56_D59_R1.0231.00
270_K273_G1.0221.00
161_D199_E1.0211.00
224_A250_G1.0151.00
124_R179_E1.0151.00
58_S94_K1.0131.00
27_V30_G1.0121.00
230_P307_V1.0091.00
136_R143_F1.0041.00
198_K228_H1.0041.00
188_V193_A1.0041.00
91_W266_T0.9871.00
258_D285_H0.9861.00
126_A130_D0.9851.00
262_A268_C0.9791.00
48_L86_I0.9761.00
61_N269_Y0.9721.00
255_L275_A0.9721.00
140_F314_G0.9641.00
247_L255_L0.9571.00
284_P305_N0.9551.00
176_N204_R0.9521.00
232_A256_Q0.9511.00
26_V30_G0.9471.00
6_I52_L0.9471.00
129_I172_E0.9451.00
132_I174_F0.9451.00
39_R47_E0.9371.00
165_N169_Q0.9361.00
167_V182_L0.9361.00
210_E256_Q0.9271.00
17_F291_I0.9271.00
42_E45_V0.9251.00
106_M269_Y0.9241.00
167_V203_Y0.9211.00
205_P229_I0.9191.00
184_F197_I0.9151.00
217_A251_G0.9141.00
55_Q59_R0.9101.00
270_K276_E0.9061.00
295_A348_L0.9021.00
17_F29_W0.9001.00
23_D57_P0.8971.00
134_T137_E0.8951.00
60_I94_K0.8951.00
188_V196_L0.8941.00
98_L105_L0.8941.00
161_D202_P0.8891.00
239_S242_D0.8881.00
27_V31_E0.8861.00
33_V38_A0.8831.00
252_I255_L0.8781.00
8_T46_H0.8771.00
212_V220_Y0.8751.00
104_Q344_T0.8661.00
144_K147_G0.8621.00
94_K105_L0.8601.00
129_I174_F0.8561.00
17_F328_K0.8541.00
125_P165_N0.8501.00
234_G258_D0.8451.00
193_A212_V0.8441.00
225_A250_G0.8411.00
272_A282_L0.8411.00
91_W265_I0.8341.00
191_P195_V0.8331.00
238_F242_D0.8301.00
171_R176_N0.8291.00
130_D134_T0.8271.00
201_E227_T0.8231.00
9_Y17_F0.8231.00
166_T169_Q0.8211.00
63_L66_V0.8151.00
102_V265_I0.8131.00
218_E245_R0.8121.00
170_I174_F0.8111.00
171_R177_Q0.8021.00
259_L296_C0.7981.00
284_P300_D0.7981.00
220_Y233_A0.7981.00
272_A284_P0.7981.00
35_E142_T0.7951.00
244_K278_Y0.7931.00
64_W87_D0.7931.00
237_M243_F0.7911.00
174_F178_I0.7901.00
274_M277_A0.7881.00
47_E50_D0.7871.00
44_A82_A0.7861.00
218_E221_P0.7861.00
4_T24_E0.7851.00
269_Y302_V0.7811.00
57_P94_K0.7791.00
68_Y267_E0.7781.00
341_K344_T0.7761.00
103_W298_H0.7761.00
142_T181_G0.7751.00
103_W342_P0.7751.00
190_A194_K0.7721.00
118_S140_F0.7691.00
265_I295_A0.7631.00
40_T43_A0.7621.00
57_P90_L0.7611.00
259_L299_I0.7561.00
257_P268_C0.7541.00
63_L67_M0.7531.00
194_K212_V0.7531.00
323_L327_V0.7501.00
164_V202_P0.7481.00
57_P97_V0.7471.00
135_L138_I0.7451.00
322_E326_F0.7441.00
160_V196_L0.7411.00
217_A246_V0.7411.00
39_R43_A0.7381.00
167_V200_L0.7381.00
240_R270_K0.7371.00
265_I269_Y0.7371.00
125_P169_Q0.7371.00
195_V226_Q0.7351.00
217_A245_R0.7291.00
233_A252_I0.7271.00
45_V49_G0.7271.00
190_A212_V0.7261.00
220_Y231_L0.7251.00
143_F174_F0.7251.00
223_L227_T0.7241.00
40_T47_E0.7211.00
119_W122_G0.7211.00
52_L55_Q0.7201.00
321_A327_V0.7171.00
99_N346_P0.7141.00
51_Y70_A0.7101.00
64_W266_T0.7101.00
224_A231_L0.7061.00
129_I327_V0.7061.00
237_M242_D0.7041.00
219_Y222_K0.7041.00
335_M340_F0.7041.00
272_A276_E0.7031.00
276_E305_N0.7031.00
61_N266_T0.7031.00
91_W102_V0.7000.99
243_F275_A0.7000.99
21_E29_W0.6990.99
152_G163_A0.6980.99
322_E325_D0.6970.99
240_R271_I0.6960.99
243_F280_V0.6930.99
257_P272_A0.6920.99
109_L344_T0.6920.99
20_I52_L0.6900.99
22_T57_P0.6890.99
297_L342_P0.6890.99
8_T45_V0.6890.99
51_Y55_Q0.6880.99
43_A46_H0.6870.99
194_K227_T0.6860.99
222_K250_G0.6840.99
65_Q270_K0.6840.99
98_L101_P0.6840.99
336_V339_F0.6820.99
184_F188_V0.6810.99
41_V45_V0.6780.99
147_G184_F0.6780.99
217_A249_A0.6780.99
61_N65_Q0.6770.99
133_K327_V0.6760.99
48_L67_M0.6750.99
168_A171_R0.6750.99
11_L291_I0.6720.99
172_E176_N0.6720.99
57_P93_I0.6690.99
281_T307_V0.6690.99
188_V208_I0.6680.99
59_R104_Q0.6680.99
127_D131_G0.6670.99
295_A299_I0.6650.99
301_F343_L0.6640.99
10_R38_A0.6600.99
64_W68_Y0.6580.99
106_M265_I0.6560.99
130_D173_A0.6540.99
163_A188_V0.6540.99
93_I97_V0.6530.99
83_I264_G0.6490.99
50_D53_I0.6470.99
45_V50_D0.6460.99
132_I136_R0.6460.99
66_V69_R0.6450.99
241_F244_K0.6450.99
132_I170_I0.6450.99
255_L280_V0.6440.99
323_L328_K0.6420.99
241_F245_R0.6400.99
193_A223_L0.6370.99
31_E291_I0.6370.99
240_R244_K0.6370.99
113_K337_G0.6350.99
171_R204_R0.6340.99
140_F312_S0.6330.99
10_R130_D0.6320.99
197_I229_I0.6260.99
321_A324_L0.6240.99
286_C293_L0.6230.99
95_G98_L0.6220.99
91_W106_M0.6220.99
60_I90_L0.6220.99
102_V105_L0.6210.99
64_W67_M0.6200.99
94_K97_V0.6180.99
118_S135_L0.6160.99
162_A166_T0.6160.99
29_W291_I0.6130.99
237_M246_V0.6130.99
243_F257_P0.6130.99
95_G346_P0.6120.99
220_Y223_L0.6120.99
321_A326_F0.6120.99
95_G100_A0.6100.99
118_S122_G0.6100.99
310_E313_M0.6100.99
252_I280_V0.6090.99
129_I169_Q0.6080.99
6_I86_I0.6060.99
320_G324_L0.6060.99
90_L94_K0.6060.99
102_V106_M0.6020.98
61_N112_D0.5980.98
256_Q285_H0.5980.98
10_R42_E0.5980.98
275_A280_V0.5970.98
145_L167_V0.5950.98
146_N166_T0.5940.98
331_E334_S0.5920.98
171_R174_F0.5920.98
47_E51_Y0.5900.98
309_Q312_S0.5890.98
328_K331_E0.5880.98
251_G280_V0.5860.98
40_T44_A0.5830.98
175_G178_I0.5820.98
269_Y299_I0.5790.98
45_V86_I0.5790.98
132_I173_A0.5790.98
136_R174_F0.5770.98
127_D135_L0.5760.98
68_Y83_I0.5760.98
334_S341_K0.5750.98
8_T42_E0.5750.98
257_P282_L0.5750.98
106_M302_V0.5730.98
207_F283_A0.5720.98
104_Q109_L0.5700.98
103_W344_T0.5700.98
60_I105_L0.5680.98
52_L63_L0.5670.98
227_T231_L0.5640.98
131_G135_L0.5640.98
9_Y29_W0.5610.98
224_A251_G0.5590.98
210_E236_R0.5570.97
10_R14_R0.5560.97
275_A282_L0.5550.97
27_V96_K0.5520.97
324_L328_K0.5510.97
40_T45_V0.5490.97
300_D309_Q0.5490.97
259_L265_I0.5480.97
92_D294_A0.5470.97
30_G85_G0.5470.97
52_L90_L0.5470.97
65_Q68_Y0.5470.97
16_M41_V0.5460.97
276_E282_L0.5460.97
242_D251_G0.5460.97
297_L340_F0.5440.97
103_W109_L0.5440.97
141_D337_G0.5430.97
60_I266_T0.5420.97
3_I20_I0.5400.97
164_V200_L0.5390.97
294_A298_H0.5380.97
268_C284_P0.5380.97
52_L86_I0.5380.97
142_T179_E0.5370.97
96_K99_N0.5370.97
16_M42_E0.5360.97
164_V167_V0.5360.97
48_L71_G0.5340.97
102_V298_H0.5330.97
17_F325_D0.5330.97
108_G112_D0.5320.97
321_A325_D0.5310.97
210_E235_E0.5300.97
24_E57_P0.5290.97
21_E25_G0.5280.97
322_E327_V0.5280.97
141_D177_Q0.5260.96
282_L305_N0.5260.96
116_A340_F0.5230.96
255_L271_I0.5230.96
63_L86_I0.5230.96
113_K336_V0.5210.96
160_V164_V0.5210.96
292_A321_A0.5210.96
265_I299_I0.5160.96
129_I132_I0.5150.96
320_G323_L0.5150.96
119_W163_A0.5140.96
110_V304_Y0.5140.96
60_I63_L0.5140.96
194_K198_K0.5140.96
33_V37_R0.5130.96
56_D104_Q0.5120.96
210_E234_G0.5110.96
184_F193_A0.5090.96
32_P81_S0.5090.96
167_V205_P0.5060.96
67_M264_G0.5060.96
282_L303_S0.5050.96
168_A199_E0.5050.96
308_L311_Q0.5050.96
305_N310_E0.5030.95
165_N203_Y0.5000.95
128_V166_T0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rr1A 5 0.9764 100 0.151 Contact Map
3rcyA 5 0.9581 100 0.158 Contact Map
3t6cA 5 0.9817 100 0.164 Contact Map
3tjiA 5 0.9817 100 0.168 Contact Map
3v3wA 5 0.9712 100 0.172 Contact Map
3sbfA 6 0.9817 100 0.175 Contact Map
3vcnA 5 0.9764 100 0.175 Contact Map
4k8gA 5 0.9712 100 0.195 Contact Map
4il2A 5 0.9738 100 0.197 Contact Map
4it1A 3 0.9424 100 0.199 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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