GREMLIN Database
DGOA - 2-dehydro-3-deoxy-6-phosphogalactonate aldolase
UniProt: Q6BF16 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11716
Length: 205 (197)
Sequences: 3729 (2640)
Seq/√Len: 188.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
53_V82_Q3.7031.00
189_T192_Q2.8401.00
91_S116_T2.6911.00
30_D194_A2.6851.00
69_K72_Q2.5591.00
26_G55_A2.4091.00
47_Q50_P2.4021.00
90_H119_E2.3461.00
25_V52_I2.3331.00
77_A102_M2.2731.00
46_E75_A2.1501.00
74_D96_R2.0301.00
27_A31_A2.0161.00
40_L46_E2.0111.00
22_L55_A2.0051.00
192_Q195_A2.0041.00
194_A198_K1.9991.00
50_P54_D1.9281.00
117_A125_L1.8821.00
163_A167_D1.8681.00
114_A149_I1.8481.00
94_I104_V1.8181.00
109_A133_F1.8131.00
74_D78_R1.7811.00
95_R120_A1.7691.00
29_I60_A1.7671.00
22_L51_A1.7661.00
86_T104_V1.7501.00
17_T20_E1.7491.00
133_F137_Y1.7331.00
137_Y141_L1.7291.00
71_E75_A1.7281.00
118_L149_I1.7171.00
26_G30_D1.7131.00
67_V84_I1.7121.00
49_I64_A1.7011.00
88_N115_F1.6611.00
108_C114_A1.6591.00
184_Q192_Q1.6421.00
76_L81_C1.6211.00
84_I97_A1.6211.00
98_V123_Q1.5981.00
108_C125_L1.5871.00
89_I94_I1.5731.00
110_T113_E1.5681.00
97_A104_V1.5611.00
89_I120_A1.5611.00
72_Q75_A1.5591.00
96_R100_Y1.5551.00
158_T161_N1.5501.00
73_V84_I1.5181.00
192_Q196_F1.5171.00
20_E188_R1.5011.00
63_G83_L1.4901.00
38_I52_I1.4861.00
18_P44_Q1.4761.00
92_E119_E1.4641.00
127_I151_V1.4451.00
118_L147_S1.4131.00
114_A145_L1.3951.00
26_G56_Y1.3931.00
44_Q47_Q1.3901.00
111_A141_L1.3831.00
92_E95_R1.3791.00
31_A194_A1.3411.00
195_A199_A1.3361.00
13_L36_V1.3311.00
10_I152_F1.3241.00
138_I170_C1.3101.00
85_V105_C1.2901.00
127_I133_F1.2771.00
96_R99_G1.2631.00
91_S120_A1.2471.00
131_S140_A1.2281.00
132_A137_Y1.2091.00
198_K202_E1.2011.00
49_I62_I1.2001.00
73_V96_R1.2001.00
5_T150_A1.1881.00
73_V93_V1.1871.00
115_F145_L1.1861.00
89_I108_C1.1801.00
47_Q51_A1.1761.00
131_S136_Q1.1691.00
74_D100_Y1.1661.00
91_S95_R1.1411.00
51_A54_D1.1401.00
29_I34_D1.1251.00
40_L76_L1.1201.00
27_A194_A1.1131.00
7_L34_D1.1101.00
86_T106_P1.1041.00
131_S165_W1.0961.00
114_A141_L1.0761.00
29_I56_Y1.0751.00
181_R184_Q1.0721.00
25_V36_V1.0621.00
68_L72_Q1.0561.00
64_A76_L1.0441.00
159_P199_A1.0411.00
183_G187_E1.0301.00
195_A198_K1.0251.00
95_R99_G1.0201.00
109_A137_Y1.0141.00
61_L82_Q1.0131.00
76_L84_I1.0061.00
77_A96_R1.0030.99
51_A55_A1.0010.99
189_T193_A0.9880.99
130_S157_V0.9850.99
75_A78_R0.9830.99
191_Q195_A0.9780.99
77_A100_Y0.9770.99
164_Q167_D0.9760.99
190_A194_A0.9710.99
184_Q189_T0.9690.99
19_D51_A0.9690.99
132_A140_A0.9680.99
22_L56_Y0.9620.99
162_L173_A0.9610.99
153_A170_C0.9590.99
90_H115_F0.9570.99
68_L147_S0.9500.99
108_C117_A0.9480.99
70_P96_R0.9460.99
16_I182_A0.9420.99
193_A197_V0.9410.99
112_T116_T0.9130.99
44_Q48_S0.9110.99
18_P48_S0.9100.99
7_L33_F0.9070.99
127_I137_Y0.9030.99
46_E76_L0.9010.99
73_V97_A0.8910.99
71_E74_D0.8840.99
89_I117_A0.8730.99
70_P92_E0.8680.99
84_I102_M0.8630.98
50_P78_R0.8630.98
15_G48_S0.8610.98
104_V122_A0.8610.98
185_S193_A0.8560.98
12_I85_V0.8520.98
152_F172_G0.8350.98
116_T120_A0.8310.98
35_A61_L0.8250.98
109_A141_L0.8240.98
136_Q140_A0.8240.98
69_K119_E0.8140.98
22_L26_G0.8130.98
161_N164_Q0.8120.98
94_I122_A0.8030.98
199_A202_E0.8000.97
7_L35_A0.7950.97
9_L33_F0.7830.97
12_I154_V0.7830.97
46_E79_M0.7820.97
76_L79_M0.7800.97
25_V56_Y0.7730.97
53_V79_M0.7730.97
197_V201_R0.7710.97
182_A186_V0.7680.97
23_A26_G0.7670.97
138_I151_V0.7650.97
41_N146_P0.7640.97
89_I116_T0.7470.96
28_V180_Y0.7460.96
70_P74_D0.7440.96
64_A84_I0.7400.96
114_A151_V0.7330.96
15_G41_N0.7300.96
48_S51_A0.7290.96
184_Q188_R0.7250.96
18_P51_A0.7250.96
153_A171_A0.7190.95
193_A196_F0.7150.95
9_L200_Y0.7140.95
158_T178_D0.7110.95
88_N93_V0.7040.95
117_A120_A0.7040.95
135_P168_A0.7030.95
136_Q164_Q0.6930.94
185_S190_A0.6890.94
22_L52_I0.6880.94
122_A125_L0.6860.94
42_S45_W0.6790.94
94_I120_A0.6780.94
22_L48_S0.6780.94
142_K171_A0.6780.94
35_A83_L0.6760.94
97_A102_M0.6740.93
191_Q194_A0.6700.93
12_I39_P0.6670.93
74_D77_A0.6670.93
41_N154_V0.6650.93
184_Q196_F0.6610.93
33_F197_V0.6600.93
20_E23_A0.6580.93
84_I104_V0.6580.93
154_V174_G0.6570.93
105_C124_A0.6550.92
127_I138_I0.6540.92
178_D200_Y0.6540.92
40_L72_Q0.6480.92
52_I62_I0.6470.92
21_A52_I0.6440.92
158_T162_L0.6430.92
95_R119_E0.6420.92
6_K34_D0.6380.91
36_V60_A0.6340.91
140_A154_V0.6320.91
33_F179_L0.6310.91
113_E145_L0.6240.91
116_T119_E0.6170.90
8_P166_I0.6170.90
155_G176_G0.6160.90
154_V175_L0.6130.90
186_V189_T0.6040.89
111_A145_L0.6040.89
90_H112_T0.6010.89
145_L149_I0.6010.89
50_P53_V0.6010.89
142_K151_V0.6000.89
20_E186_V0.6000.89
20_E185_S0.5960.88
9_L162_L0.5950.88
134_G137_Y0.5940.88
86_T97_A0.5940.88
89_I122_A0.5930.88
162_L166_I0.5930.88
78_R100_Y0.5930.88
184_Q193_A0.5930.88
15_G20_E0.5910.88
13_L180_Y0.5890.88
27_A190_A0.5890.88
56_Y62_I0.5870.88
196_F200_Y0.5860.88
136_Q139_K0.5850.88
124_A172_G0.5850.88
39_P143_A0.5840.87
38_I49_I0.5820.87
21_A48_S0.5800.87
40_L45_W0.5790.87
38_I45_W0.5760.87
181_R185_S0.5730.86
66_T87_P0.5690.86
175_L200_Y0.5680.86
73_V102_M0.5670.86
160_E164_Q0.5650.86
114_A125_L0.5580.85
157_V161_N0.5580.85
50_P79_M0.5570.85
23_A28_V0.5520.84
185_S188_R0.5520.84
71_E99_G0.5500.84
135_P170_C0.5490.84
111_A137_Y0.5490.84
12_I41_N0.5490.84
183_G192_Q0.5480.84
25_V62_I0.5450.84
46_E50_P0.5450.84
6_K61_L0.5430.83
130_S165_W0.5410.83
143_A170_C0.5400.83
14_R182_A0.5390.83
90_H93_V0.5380.83
29_I36_V0.5360.83
125_L149_I0.5340.82
24_H180_Y0.5330.82
85_V107_G0.5330.82
73_V100_Y0.5310.82
145_L174_G0.5300.82
11_A179_L0.5260.81
18_P47_Q0.5240.81
86_T90_H0.5240.81
17_T186_V0.5240.81
34_D201_R0.5230.81
56_Y60_A0.5200.81
4_Q172_G0.5190.81
139_K168_A0.5170.80
11_A33_F0.5150.80
11_A41_N0.5150.80
190_A193_A0.5110.80
159_P162_L0.5090.79
49_I79_M0.5070.79
30_D191_Q0.5060.79
14_R169_G0.5060.79
66_T126_K0.5050.79
15_G24_H0.5050.79
98_V120_A0.5040.79
46_E78_R0.5040.79
142_K168_A0.5030.78
53_V57_G0.5030.78
38_I64_A0.5020.78
34_D61_L0.5010.78
18_P21_A0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vhcA 3 0.9902 100 0.452 Contact Map
3vcrA 3 0.9902 100 0.456 Contact Map
1wbhA 3 0.9902 100 0.465 Contact Map
1mxsA 3 0.9902 100 0.469 Contact Map
4bk9A 3 0.9659 100 0.477 Contact Map
2yw3A 4 0.9512 100 0.489 Contact Map
4e38A 3 0.9902 100 0.5 Contact Map
1wa3A 3 0.9659 100 0.521 Contact Map
2v82A 3 0.9707 100 0.57 Contact Map
4qccA 6 0.961 100 0.572 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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