GREMLIN Database
Y4286 - Putative uncharacterized protein b4286
UniProt: Q47719 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 137 (108)
Sequences: 339 (199)
Seq/√Len: 19.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
23_L85_D3.4921.00
20_R23_L3.4341.00
3_G6_Q2.9470.99
81_S91_M2.8200.99
14_G43_G2.5540.97
49_V65_F2.5520.97
41_V53_M2.5170.97
57_N63_P2.5150.97
87_E90_T2.4620.97
64_V88_A2.1980.94
16_T56_V2.1800.93
31_E57_N2.1620.93
45_H48_A2.1610.93
19_R39_V2.0850.92
5_H13_T2.0380.91
56_V63_P1.9000.87
20_R85_D1.8750.87
79_T103_G1.8490.86
29_L33_S1.8410.86
3_G69_I1.8400.86
17_L59_T1.7640.83
3_G70_A1.6770.80
80_P98_A1.6390.78
14_G52_T1.5930.76
53_M63_P1.5760.75
81_S86_W1.4980.71
19_R40_A1.4910.71
99_K103_G1.4550.69
102_E109_S1.4400.68
68_S71_E1.4210.67
29_L35_G1.3950.66
39_V91_M1.3730.64
54_T58_D1.3500.63
23_L106_R1.3440.63
6_Q43_G1.2810.59
12_D28_R1.2460.57
6_Q69_I1.2300.56
37_L84_C1.1990.54
22_V26_H1.1460.50
39_V100_K1.1420.50
30_P33_S1.1340.50
93_R97_L1.0980.47
14_G48_A1.0630.45
85_D91_M1.0630.45
56_V68_S1.0630.45
75_Q98_A1.0620.45
103_G108_P1.0560.45
22_V40_A1.0490.44
6_Q51_V1.0350.43
6_Q68_S1.0320.43
49_V64_V1.0280.43
55_L59_T1.0150.42
43_G49_V1.0050.41
103_G106_R0.9990.41
29_L50_Q0.9670.39
13_T96_P0.9520.38
47_A54_T0.9370.37
19_R83_C0.9350.37
45_H88_A0.9200.36
40_A99_K0.9050.35
9_Q59_T0.9010.35
15_K75_Q0.8830.34
86_W94_A0.8770.34
4_Y8_N0.8650.33
49_V52_T0.8620.33
9_Q37_L0.8430.32
8_N30_P0.8290.31
29_L34_R0.8220.31
78_C102_E0.8080.30
24_V43_G0.8070.30
11_T66_S0.8030.30
31_E70_A0.8020.30
15_K72_S0.7820.29
21_P52_T0.7730.28
16_T103_G0.7680.28
27_N78_C0.7680.28
19_R59_T0.7670.28
42_A66_S0.7620.28
30_P47_A0.7560.27
69_I97_L0.7440.27
14_G49_V0.7440.27
15_K77_P0.7410.27
87_E108_P0.7330.26
14_G45_H0.7300.26
35_G94_A0.7270.26
58_D109_S0.7240.26
46_P50_Q0.7130.25
94_A98_A0.7080.25
17_L106_R0.6980.25
77_P104_R0.6960.24
23_L84_C0.6920.24
3_G68_S0.6910.24
88_A92_L0.6880.24
24_V28_R0.6850.24
34_R41_V0.6780.24
12_D35_G0.6780.24
53_M85_D0.6780.24
106_R109_S0.6780.24
55_L58_D0.6730.23
22_V110_L0.6710.23
87_E93_R0.6680.23
48_A88_A0.6630.23
55_L107_L0.6610.23
50_Q109_S0.6610.23
19_R86_W0.6610.23
95_F98_A0.6600.23
4_Y10_K0.6590.23
4_Y13_T0.6570.23
40_A78_C0.6540.23
52_T70_A0.6510.22
43_G79_T0.6470.22
18_T75_Q0.6400.22
11_T86_W0.6390.22
33_S47_A0.6320.22
81_S107_L0.6310.21
16_T21_P0.6280.21
5_H85_D0.6250.21
58_D68_S0.6250.21
83_C100_K0.6200.21
102_E106_R0.6140.21
48_A64_V0.6140.21
4_Y24_V0.6130.21
7_T42_A0.6040.20
104_R107_L0.6000.20
71_E89_A0.5950.20
3_G23_L0.5870.20
39_V42_A0.5800.19
59_T106_R0.5790.19
87_E92_L0.5780.19
25_D99_K0.5770.19
7_T46_P0.5710.19
72_S98_A0.5690.19
51_V64_V0.5670.19
41_V110_L0.5660.19
45_H71_E0.5650.19
53_M75_Q0.5630.19
33_S57_N0.5600.19
4_Y16_T0.5600.19
86_W90_T0.5420.18
78_C84_C0.5420.18
27_N94_A0.5340.18
12_D104_R0.5290.17
17_L99_K0.5280.17
23_L83_C0.5280.17
12_D76_Q0.5260.17
57_N92_L0.5240.17
92_L100_K0.5240.17
16_T69_I0.5220.17
81_S98_A0.5200.17
17_L22_V0.5190.17
56_V59_T0.5100.17
74_R95_F0.5090.17
84_C91_M0.5080.17
88_A101_G0.5080.17
20_R39_V0.5070.17
25_D83_C0.5050.17
63_P110_L0.5050.17
56_V98_A0.5040.17
56_V85_D0.5040.17
78_C107_L0.5040.17
66_S105_A0.5010.16
53_M56_V0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4hujA 2 0.6423 98 0.855 Contact Map
1jayA 2 0.7007 96 0.894 Contact Map
2vnsA 2 0.5766 95.8 0.895 Contact Map
2rafA 2 0.7299 95.3 0.899 Contact Map
4ppmA 2 0.1898 94 0.905 Contact Map
2yjzA 1 0.5474 93.4 0.907 Contact Map
3dttA 2 0.7153 87.2 0.92 Contact Map
3aekB 2 0.9197 56.8 0.938 Contact Map
3pdiA 1 0.9781 55 0.938 Contact Map
2ynmD 2 0.8978 44.2 0.942 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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