GREMLIN Database
INSO2 - Putative transposase InsO for insertion sequence element IS911B
UniProt: Q47718 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG40121
Length: 198 (189)
Sequences: 5989 (4389)
Seq/√Len: 319.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_R74_L3.5361.00
159_E189_Y3.3281.00
108_E111_Q3.0301.00
35_V51_I2.6071.00
28_R66_L2.5901.00
34_Q58_R2.5731.00
32_R73_E2.4281.00
119_Y126_W2.3451.00
52_A56_T2.3351.00
144_A156_K2.3321.00
144_A160_M2.2851.00
10_P13_S2.2721.00
48_A68_G2.1211.00
34_Q37_E2.0451.00
106_V112_V2.0421.00
110_N113_W2.0421.00
63_G66_L2.0391.00
46_A50_S2.0071.00
38_L54_M1.9681.00
113_W161_A1.9191.00
114_C135_L1.9101.00
142_G157_A1.9101.00
110_N165_R1.8531.00
32_R70_L1.8511.00
115_G173_F1.8391.00
115_G175_A1.8341.00
39_H76_L1.8131.00
38_L51_I1.7961.00
34_Q60_Y1.7791.00
107_T111_Q1.7681.00
54_M57_R1.7611.00
31_L62_M1.7481.00
48_A64_R1.7461.00
162_W193_T1.7161.00
100_L112_V1.6661.00
62_M67_A1.6611.00
189_Y193_T1.6081.00
122_T125_R1.5421.00
130_A181_I1.5171.00
130_A157_A1.5121.00
129_L143_W1.5101.00
121_W126_W1.5051.00
113_W171_V1.5041.00
112_V135_L1.5011.00
151_S183_A1.4971.00
155_M189_Y1.4911.00
151_S155_M1.4781.00
133_L140_P1.4761.00
28_R69_R1.4741.00
16_L20_R1.4381.00
171_V195_S1.4261.00
117_V180_I1.4061.00
54_M58_R1.3811.00
149_P179_V1.3661.00
70_L74_L1.3471.00
66_L69_R1.3271.00
120_I129_L1.3251.00
36_L40_G1.3241.00
113_W132_V1.3231.00
36_L74_L1.3191.00
27_R66_L1.3181.00
149_P180_I1.2721.00
39_H44_G1.2701.00
52_A64_R1.2671.00
190_C195_S1.2661.00
151_S185_S1.2651.00
146_S150_D1.2631.00
52_A67_A1.2541.00
85_R88_R1.2531.00
173_F186_S1.2471.00
188_S192_D1.2081.00
12_N15_Y1.1911.00
115_G181_I1.1501.00
108_E136_F1.1441.00
30_V34_Q1.1401.00
173_F195_S1.1341.00
49_R68_G1.1341.00
68_G72_K1.1331.00
30_V60_Y1.1301.00
184_G188_S1.1271.00
146_S153_L1.1251.00
187_G191_G1.1181.00
37_E41_I1.1181.00
34_Q38_L1.1051.00
109_P136_F1.1051.00
162_W195_S1.0821.00
155_M185_S1.0621.00
36_L76_L1.0581.00
122_T127_A1.0451.00
103_Q112_V1.0451.00
115_G130_A1.0431.00
106_V111_Q1.0431.00
56_T61_Q1.0281.00
179_V183_A1.0231.00
12_N16_L1.0211.00
46_A54_M1.0191.00
142_G160_M1.0171.00
159_E163_E1.0131.00
155_M159_E1.0131.00
64_R68_G1.0101.00
40_G44_G1.0071.00
130_A153_L1.0021.00
119_Y128_Y0.9881.00
39_H51_I0.9831.00
31_L34_Q0.9821.00
131_V140_P0.9761.00
117_V149_P0.9751.00
139_K165_R0.9741.00
142_G161_A0.9651.00
179_V182_R0.9561.00
132_V161_A0.9521.00
9_C13_S0.9511.00
65_W68_G0.9441.00
32_R36_L0.9391.00
109_P137_A0.9281.00
189_Y192_D0.9251.00
22_E29_A0.9231.00
129_L145_M0.9201.00
133_L138_R0.9191.00
35_V70_L0.9101.00
51_I71_M0.8991.00
144_A153_L0.8971.00
66_L70_L0.8961.00
99_Y172_M0.8851.00
127_A145_M0.8831.00
158_L173_F0.8811.00
100_L135_L0.8651.00
152_R156_K0.8621.00
70_L73_E0.8611.00
144_A157_A0.8521.00
158_L195_S0.8511.00
148_S153_L0.8441.00
53_T56_T0.8391.00
13_S17_R0.8351.00
152_R185_S0.8341.00
90_G93_H0.8341.00
50_S54_M0.8331.00
157_A161_A0.8321.00
71_M76_L0.8281.00
53_T57_R0.8251.00
48_A52_A0.8211.00
27_R30_V0.8211.00
168_P171_V0.8191.00
150_D153_L0.8071.00
33_S37_E0.8011.00
28_R70_L0.7951.00
175_A186_S0.7941.00
38_L41_I0.7931.00
88_R91_H0.7901.00
13_S16_L0.7831.00
65_W69_R0.7811.00
52_A63_G0.7771.00
139_K164_T0.7751.00
86_Y91_H0.7741.00
63_G69_R0.7701.00
39_H78_S0.7670.99
14_G18_K0.7610.99
119_Y149_P0.7550.99
130_A154_T0.7510.99
156_K159_E0.7500.99
91_H95_A0.7400.99
5_F8_E0.7400.99
186_S190_C0.7390.99
77_V80_Q0.7380.99
93_H182_R0.7360.99
117_V154_T0.7340.99
91_H182_R0.7340.99
183_A186_S0.7290.99
69_R73_E0.7280.99
165_R171_V0.7270.99
48_A71_M0.7250.99
100_L172_M0.7240.99
37_E58_R0.7230.99
45_S50_S0.7200.99
163_E166_G0.7170.99
113_W165_R0.7090.99
35_V74_L0.7070.99
38_L58_R0.6960.99
35_V38_L0.6910.99
31_L60_Y0.6910.99
41_I58_R0.6890.99
95_A182_R0.6860.99
186_S189_Y0.6850.99
19_N22_E0.6840.99
26_G32_R0.6840.99
17_R21_P0.6800.99
29_A33_S0.6780.99
35_V71_M0.6770.99
39_H77_V0.6740.99
173_F190_C0.6740.99
158_L190_C0.6710.99
166_G169_V0.6710.99
48_A67_A0.6630.99
88_R182_R0.6620.99
146_S149_P0.6590.98
96_I99_Y0.6590.98
93_H96_I0.6590.98
160_M164_T0.6540.98
132_V157_A0.6510.98
17_R20_R0.6500.98
112_V172_M0.6470.98
103_Q172_M0.6460.98
35_V67_A0.6440.98
185_S188_S0.6430.98
9_C14_G0.6400.98
27_R31_L0.6390.98
32_R39_H0.6380.98
72_K77_V0.6370.98
100_L104_F0.6350.98
180_I183_A0.6340.98
96_I100_L0.6300.98
11_L15_Y0.6290.98
90_G94_V0.6240.98
114_C174_Q0.6200.98
4_Y14_G0.6150.98
162_W167_K0.6120.98
98_N172_M0.6110.98
188_S191_G0.6090.97
23_K26_G0.6060.97
185_S189_Y0.6050.97
4_Y11_L0.6050.97
177_K182_R0.6050.97
86_Y89_G0.5990.97
108_E169_V0.5980.97
106_V135_L0.5970.97
68_G78_S0.5950.97
106_V136_F0.5940.97
120_I127_A0.5920.97
158_L189_Y0.5880.97
111_Q136_F0.5880.97
49_R64_R0.5870.97
30_V33_S0.5870.97
113_W141_V0.5850.97
110_N171_V0.5840.97
137_A165_R0.5820.97
110_N161_A0.5810.97
118_T174_Q0.5800.97
55_A67_A0.5790.97
46_A51_I0.5780.97
125_R147_F0.5720.96
16_L19_N0.5710.96
182_R186_S0.5700.96
23_K27_R0.5690.96
149_P153_L0.5680.96
98_N177_K0.5640.96
117_V129_L0.5630.96
18_K21_P0.5590.96
93_H177_K0.5530.96
33_S36_L0.5480.95
28_R73_E0.5480.95
34_Q55_A0.5470.95
114_C133_L0.5470.95
135_L141_V0.5460.95
96_I187_G0.5460.95
155_M186_S0.5450.95
141_V165_R0.5440.95
62_M65_W0.5390.95
4_Y9_C0.5390.95
162_W171_V0.5380.95
146_S152_R0.5360.95
146_S156_K0.5350.95
115_G186_S0.5350.95
151_S154_T0.5340.95
117_V153_L0.5320.95
141_V171_V0.5290.94
157_A181_I0.5280.94
18_K22_E0.5280.94
158_L186_S0.5260.94
28_R31_L0.5260.94
120_I126_W0.5260.94
55_A58_R0.5240.94
68_G77_V0.5210.94
143_W160_M0.5200.94
184_G191_G0.5180.94
184_G187_G0.5180.94
151_S184_G0.5160.94
118_T131_V0.5160.94
36_L39_H0.5090.93
70_L76_L0.5090.93
28_R32_R0.5080.93
97_P101_E0.5070.93
154_T186_S0.5070.93
149_P154_T0.5020.93
135_L138_R0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4u7bA 2 0.9596 99.9 0.545 Contact Map
4fcyA 4 0.9293 99.9 0.551 Contact Map
3oymA 3 0.9192 99.8 0.645 Contact Map
1bcoA 1 0.4747 99.8 0.656 Contact Map
1cxqA 2 0.4646 99.7 0.694 Contact Map
4cf8A 2 0.4141 99.7 0.696 Contact Map
4fw1A 2 0.4697 99.6 0.7 Contact Map
2x78A 2 0.4495 99.6 0.708 Contact Map
4fw2A 2 0.4646 99.6 0.711 Contact Map
1ex4A 5 0.4242 99.6 0.713 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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