GREMLIN Database
YFEK - Uncharacterized protein YfeK
UniProt: Q47702 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12644
Length: 124 (110)
Sequences: 140 (122)
Seq/√Len: 11.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
28_R116_D3.6180.99
33_L57_V3.6110.99
42_L96_I3.1230.96
28_R42_L2.9510.95
45_V50_E2.5590.89
111_L114_Q2.3850.85
31_A115_T2.3470.84
35_G111_L2.2920.83
25_E28_R2.2430.82
42_L107_F2.2220.81
52_T55_E2.1460.79
14_T51_H1.8870.69
37_A57_V1.8520.67
40_K107_F1.8040.65
61_R65_G1.7970.65
43_I50_E1.6610.58
40_K96_I1.6450.58
42_L116_D1.5870.55
83_S88_T1.5800.54
49_D95_K1.5800.54
67_T81_V1.5120.51
9_I14_T1.4590.49
44_F60_L1.4590.49
50_E99_K1.4580.48
41_D91_P1.4420.48
62_L66_N1.3660.44
96_I99_K1.3420.43
29_I100_S1.3280.42
8_V13_M1.3260.42
36_L60_L1.3110.41
29_I103_N1.3000.41
31_A111_L1.2980.41
61_R109_H1.2590.39
44_F83_S1.2440.38
96_I107_F1.2420.38
44_F91_P1.2340.38
42_L66_N1.1990.36
28_R96_I1.1980.36
37_A101_D1.1760.35
75_E116_D1.1750.35
28_R64_L1.1740.35
57_V61_R1.1710.35
70_R86_S1.1690.35
35_G83_S1.1410.33
30_N61_R1.1410.33
67_T70_R1.1330.33
40_K44_F1.1280.33
36_L108_L1.1230.33
66_N96_I1.1150.32
29_I78_I1.0960.31
108_L111_L1.0840.31
24_H64_L1.0600.30
29_I94_V1.0460.29
54_Y84_S1.0130.28
74_A97_P1.0110.28
60_L67_T0.9680.26
57_V68_R0.9680.26
40_K78_I0.9680.26
33_L108_L0.9500.26
67_T86_S0.9450.25
20_K54_Y0.9420.25
48_G78_I0.9420.25
28_R107_F0.9390.25
50_E101_D0.9380.25
81_V94_V0.9200.25
97_P101_D0.9100.24
74_A112_I0.9060.24
81_V107_F0.9060.24
26_E68_R0.9040.24
25_E42_L0.9030.24
78_I107_F0.9030.24
84_S107_F0.8940.24
81_V96_I0.8920.24
62_L107_F0.8910.23
42_L104_A0.8860.23
104_A107_F0.8810.23
88_T106_P0.8760.23
81_V87_I0.8740.23
9_I16_P0.8660.23
51_H87_I0.8520.22
10_T22_T0.8520.22
33_L64_L0.8500.22
51_H55_E0.8430.22
9_I13_M0.8400.22
32_M112_I0.8350.22
30_N54_Y0.8330.21
66_N81_V0.8300.21
24_H79_D0.8220.21
10_T49_D0.8200.21
62_L88_T0.8150.21
44_F95_K0.8150.21
41_D105_Q0.8080.21
79_D93_I0.7930.20
13_M91_P0.7700.19
75_E112_I0.7590.19
33_L58_S0.7580.19
10_T15_L0.7570.19
60_L112_I0.7560.19
31_A35_G0.7540.19
97_P102_E0.7370.18
25_E74_A0.7370.18
9_I18_Y0.7140.18
10_T24_H0.7090.18
62_L83_S0.7000.17
74_A88_T0.6960.17
65_G73_T0.6930.17
28_R75_E0.6870.17
54_Y83_S0.6720.17
105_Q110_A0.6710.17
14_T101_D0.6670.16
35_G114_Q0.6630.16
30_N73_T0.6620.16
13_M51_H0.6550.16
23_A65_G0.6490.16
94_V97_P0.6430.16
32_M107_F0.6340.16
66_N88_T0.6300.15
96_I116_D0.6240.15
55_E58_S0.6110.15
45_V91_P0.6090.15
8_V51_H0.6070.15
60_L86_S0.6060.15
10_T117_K0.6050.15
28_R81_V0.6050.15
45_V60_L0.6010.15
64_L115_T0.6000.15
33_L67_T0.5990.15
42_L62_L0.5970.15
16_P43_I0.5930.15
83_S91_P0.5900.14
12_L30_N0.5880.14
8_V65_G0.5880.14
29_I114_Q0.5850.14
67_T80_K0.5840.14
35_G94_V0.5770.14
44_F67_T0.5710.14
7_L11_L0.5650.14
45_V62_L0.5650.14
15_L19_A0.5650.14
76_Q83_S0.5630.14
34_E68_R0.5630.14
52_T61_R0.5630.14
47_N51_H0.5610.14
30_N110_A0.5520.14
66_N107_F0.5510.14
79_D109_H0.5480.13
41_D84_S0.5470.13
39_K94_V0.5410.13
9_I15_L0.5380.13
13_M108_L0.5320.13
37_A53_C0.5300.13
12_L49_D0.5300.13
69_N99_K0.5280.13
74_A117_K0.5240.13
25_E71_I0.5200.13
8_V12_L0.5180.13
22_T70_R0.5180.13
50_E96_I0.5170.13
60_L95_K0.5130.13
80_K87_I0.5120.13
26_E34_E0.5110.13
22_T117_K0.5040.12
62_L67_T0.5030.12
83_S90_K0.5010.12
103_N106_P0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2esnA 3 0.9435 59.5 0.92 Contact Map
3fzvA 4 0.8871 58.9 0.92 Contact Map
2h9bA 2 0.2661 56.6 0.922 Contact Map
1ixcA 4 0.9516 54.6 0.923 Contact Map
2mmvA 2 0.3306 51.1 0.924 Contact Map
2h98A 2 0.2661 50.4 0.924 Contact Map
1al3A 1 0.2984 47.5 0.926 Contact Map
1t3uA 4 0.3629 43.8 0.927 Contact Map
3wiwA 1 0.6935 42.8 0.928 Contact Map
3fxqA 3 0.9516 42 0.928 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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