GREMLIN Database
MMUM - Homocysteine S-methyltransferase
UniProt: Q47690 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13343
Length: 310 (284)
Sequences: 4370 (2730)
Seq/√Len: 162.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
52_R101_K5.3941.00
59_Y66_A3.8001.00
44_L95_S3.4111.00
56_L105_A3.1061.00
94_K97_E2.9791.00
75_P152_P2.9651.00
56_L60_R2.8421.00
122_V154_V2.8241.00
89_K159_D2.8211.00
52_R105_A2.8081.00
304_A308_A2.6971.00
70_S95_S2.5341.00
142_S145_A2.5251.00
65_C119_A2.4891.00
119_A164_L2.3971.00
52_R56_L2.3341.00
100_R104_E2.3021.00
86_A90_A2.2331.00
59_Y116_L2.1901.00
301_A304_A2.1521.00
52_R102_A2.1351.00
147_Q185_A2.1231.00
96_V160_A2.1081.00
53_E57_D2.0791.00
10_L15_D2.0701.00
154_V183_L2.0681.00
210_R241_H2.0121.00
147_Q181_E1.9991.00
236_T283_Q1.9851.00
154_V186_Y1.9821.00
192_W224_A1.9511.00
158_L189_A1.9281.00
89_K93_G1.9281.00
224_A251_V1.8971.00
176_I193_F1.8911.00
151_R185_A1.8511.00
282_P286_A1.8511.00
151_R155_E1.7911.00
100_R103_R1.7851.00
305_A308_A1.7731.00
93_G159_D1.7651.00
18_L307_K1.7171.00
217_A247_V1.6921.00
47_N50_L1.6811.00
56_L102_A1.6481.00
103_R118_V1.6461.00
194_S251_V1.6271.00
30_R53_E1.5821.00
120_G162_A1.5811.00
89_K155_E1.5781.00
167_C179_L1.5391.00
167_C183_L1.5301.00
208_P211_D1.5261.00
79_A84_D1.5211.00
93_G97_E1.5081.00
239_L250_L1.5031.00
281_L306_L1.5011.00
59_Y103_R1.4981.00
294_G298_T1.4971.00
184_T188_R1.4771.00
240_Q287_A1.4711.00
72_Q77_G1.4701.00
52_R98_L1.4681.00
9_A14_Q1.4651.00
97_E101_K1.4491.00
93_G160_A1.4341.00
92_I153_R1.4341.00
180_A222_V1.4121.00
143_V181_E1.4081.00
26_E57_D1.4061.00
89_K156_A1.3771.00
151_R186_Y1.3751.00
30_R34_L1.3741.00
224_A291_L1.3571.00
65_C164_L1.3481.00
170_L176_I1.3471.00
89_K152_P1.3331.00
275_A305_A1.3331.00
60_R106_Y1.3301.00
9_A12_D1.3221.00
232_L272_E1.3111.00
156_A160_A1.3091.00
74_T77_G1.2761.00
49_E53_E1.2691.00
120_G157_L1.2681.00
30_R57_D1.2671.00
57_D300_P1.2611.00
75_P149_F1.2551.00
10_L117_L1.2511.00
10_L14_Q1.2461.00
44_L69_A1.2411.00
197_L238_A1.2401.00
26_E29_A1.2371.00
209_L238_A1.2291.00
165_L183_L1.2271.00
265_K268_H1.2241.00
274_C302_D1.2221.00
64_Q114_G1.2071.00
23_M54_V1.2031.00
96_V157_L1.2021.00
213_V247_V1.2001.00
155_E186_Y1.2001.00
289_A292_I1.1971.00
154_V165_L1.1951.00
242_L250_L1.1921.00
31_G34_L1.1761.00
63_A303_I1.1721.00
90_A94_K1.1611.00
121_S253_Y1.1541.00
273_H276_Q1.1491.00
50_L53_E1.1471.00
10_L17_L1.1451.00
294_G303_I1.1411.00
281_L292_I1.1361.00
18_L306_L1.1261.00
57_D60_R1.1181.00
177_E215_L1.1131.00
73_A91_L1.1101.00
26_E30_R1.1001.00
68_T96_V1.0971.00
237_A240_Q1.0931.00
76_A149_F1.0901.00
65_C291_L1.0891.00
59_Y106_Y1.0820.99
22_A25_T1.0810.99
278_A305_A1.0760.99
67_I166_A1.0730.99
27_L51_I1.0700.99
45_V91_L1.0700.99
167_C170_L1.0610.99
299_T302_D1.0560.99
78_F83_L1.0540.99
252_V289_A1.0520.99
167_C176_I1.0490.99
213_V248_L1.0450.99
27_L54_V1.0410.99
77_G126_G1.0360.99
277_L306_L1.0340.99
11_L223_V1.0320.99
19_L253_Y1.0230.99
15_D64_Q1.0230.99
166_A253_Y1.0200.99
239_L252_V1.0150.99
272_E276_Q1.0150.99
122_V153_R1.0150.99
283_Q287_A1.0140.99
53_E56_L1.0110.99
226_G251_V1.0100.99
143_V177_E1.0010.99
30_R33_N0.9980.99
176_I195_F0.9980.99
161_G189_A0.9840.99
63_A66_A0.9840.99
67_I253_Y0.9820.99
192_W251_V0.9790.99
88_S92_I0.9770.99
29_A301_A0.9740.99
209_L227_I0.9710.99
19_L291_L0.9700.99
11_L249_P0.9680.99
258_E297_R0.9630.99
251_V291_L0.9590.99
197_L227_I0.9570.99
180_A216_L0.9560.99
64_Q307_K0.9500.99
158_L187_P0.9500.99
8_R188_R0.9440.99
199_D202_H0.9390.99
145_A148_A0.9380.99
16_I285_Q0.9370.99
177_E219_Y0.9350.98
73_A92_I0.9260.98
155_E159_D0.9240.98
26_E58_Y0.9230.98
227_I238_A0.9160.98
56_L106_Y0.9120.98
66_A116_L0.9060.98
143_V147_Q0.9040.98
213_V245_L0.9010.98
21_G58_Y0.8810.98
19_L65_C0.8810.98
44_L70_S0.8800.98
88_S156_A0.8800.98
222_V248_L0.8790.98
180_A191_A0.8740.98
180_A219_Y0.8670.98
119_A166_A0.8640.97
170_L193_F0.8640.97
285_Q292_I0.8610.97
96_V162_A0.8590.97
183_L191_A0.8560.97
158_L186_Y0.8550.97
260_Y271_G0.8500.97
197_L209_L0.8470.97
240_Q244_G0.8470.97
193_F222_V0.8470.97
125_Y146_F0.8470.97
158_L165_L0.8430.97
41_A73_A0.8420.97
203_L207_T0.8410.97
143_V178_A0.8390.97
127_A140_H0.8360.97
51_I54_V0.8330.97
213_V246_T0.8330.97
243_H250_L0.8310.97
178_A182_L0.8300.97
141_C146_F0.8300.97
100_R118_V0.8270.97
23_M51_I0.8240.97
99_A118_V0.8150.96
222_V225_L0.8140.96
55_H99_A0.8100.96
236_T287_A0.8090.96
182_L186_Y0.8050.96
17_L64_Q0.8040.96
75_P148_A0.8020.96
169_T228_N0.8000.96
193_F216_L0.7990.96
44_L98_L0.7920.96
54_V58_Y0.7910.96
195_F203_L0.7890.96
211_D214_A0.7890.96
275_A279_D0.7880.96
122_V165_L0.7870.96
97_E160_A0.7830.96
49_E52_R0.7810.95
32_C50_L0.7790.95
195_F212_V0.7770.95
236_T240_Q0.7770.95
42_K46_E0.7770.95
93_G156_A0.7770.95
32_C35_A0.7760.95
167_C180_A0.7760.95
106_Y113_A0.7710.95
195_F227_I0.7690.95
66_A99_A0.7690.95
217_A248_L0.7670.95
150_H175_E0.7650.95
117_L164_L0.7620.95
83_L86_A0.7590.95
67_I121_S0.7550.95
92_I156_A0.7540.95
130_A142_S0.7530.94
213_V225_L0.7530.94
266_T270_H0.7500.94
209_L242_L0.7500.94
94_K98_L0.7490.94
8_R12_D0.7450.94
283_Q286_A0.7330.94
59_Y102_A0.7320.94
43_V46_E0.7290.93
256_S297_R0.7260.93
100_R163_D0.7170.93
55_H98_L0.7140.93
154_V182_L0.7130.93
70_S121_S0.7090.93
184_T220_P0.7090.93
66_A103_R0.7090.93
92_I120_G0.7070.92
196_T204_S0.7070.92
186_Y189_A0.7070.92
169_T255_N0.7040.92
43_V47_N0.7020.92
154_V158_L0.7000.92
17_L65_C0.6990.92
96_V118_V0.6950.92
26_E300_P0.6930.92
235_T252_V0.6920.92
120_G165_L0.6920.92
26_E299_T0.6900.91
68_T118_V0.6890.91
266_T269_H0.6870.91
265_K270_H0.6870.91
76_A141_C0.6820.91
17_L117_L0.6810.91
238_A241_H0.6800.91
32_C36_D0.6790.91
26_E54_V0.6780.91
144_E148_A0.6780.91
261_D268_H0.6780.91
101_K105_A0.6780.91
265_K269_H0.6770.91
41_A72_Q0.6750.91
102_A105_A0.6750.91
157_L160_A0.6730.90
279_D282_P0.6720.90
33_N36_D0.6690.90
274_C278_A0.6680.90
217_A246_T0.6650.90
22_A54_V0.6600.90
143_V174_S0.6600.90
45_V86_A0.6540.89
45_V83_L0.6530.89
249_P290_R0.6520.89
121_S153_R0.6520.89
173_F207_T0.6500.89
64_Q116_L0.6480.89
147_Q178_A0.6480.89
285_Q289_A0.6480.89
191_A222_V0.6460.89
48_P94_K0.6440.88
254_P281_L0.6430.88
147_Q151_R0.6430.88
41_A44_L0.6400.88
215_L218_G0.6370.88
100_R160_A0.6340.88
106_Y114_G0.6340.88
44_L51_I0.6340.88
220_P248_L0.6340.88
156_A159_D0.6330.88
11_L291_L0.6320.88
173_F215_L0.6320.88
212_V216_L0.6300.87
30_R54_V0.6290.87
55_H102_A0.6290.87
44_L94_K0.6290.87
23_M69_A0.6280.87
104_E114_G0.6270.87
276_Q279_D0.6260.87
233_E280_Y0.6240.87
96_V120_G0.6240.87
32_C43_V0.6240.87
180_A215_L0.6240.87
103_R116_L0.6220.87
227_I235_T0.6220.87
30_R50_L0.6220.87
24_A40_S0.6190.86
241_H245_L0.6170.86
239_L287_A0.6150.86
241_H244_G0.6140.86
278_A306_L0.6130.86
75_P88_S0.6090.86
240_Q283_Q0.6080.85
194_S253_Y0.6080.85
53_E60_R0.6070.85
101_K104_E0.6050.85
72_Q126_G0.6050.85
39_W78_F0.6040.85
23_M55_H0.6040.85
122_V150_H0.6020.85
45_V94_K0.6000.85
198_R230_I0.5980.84
157_L165_L0.5970.84
300_P303_I0.5960.84
252_V284_W0.5960.84
260_Y267_W0.5960.84
147_Q182_L0.5960.84
50_L57_D0.5940.84
113_A116_L0.5940.84
158_L188_R0.5940.84
272_E277_L0.5930.84
51_I69_A0.5910.84
166_A192_W0.5910.84
204_S230_I0.5890.84
74_T149_F0.5810.83
216_L225_L0.5810.83
235_T238_A0.5790.83
174_S177_E0.5760.82
31_G35_A0.5750.82
173_F177_E0.5740.82
92_I157_L0.5730.82
74_T128_Y0.5720.82
172_N205_D0.5720.82
176_I216_L0.5710.82
207_T215_L0.5710.82
96_V156_A0.5710.82
203_L212_V0.5690.81
211_D215_L0.5680.81
19_L67_I0.5680.81
30_R35_A0.5660.81
58_Y298_T0.5660.81
122_V183_L0.5640.81
126_G175_E0.5640.81
154_V187_P0.5620.81
104_E115_T0.5590.80
277_L298_T0.5580.80
182_L185_A0.5580.80
16_I290_R0.5540.80
64_Q115_T0.5530.80
163_D190_R0.5530.80
120_G161_G0.5500.79
281_L284_W0.5490.79
68_T99_A0.5480.79
18_L63_A0.5470.79
60_R304_A0.5460.79
124_P169_T0.5460.79
180_A184_T0.5450.79
301_A305_A0.5430.78
8_R223_V0.5420.78
167_C193_F0.5420.78
246_T249_P0.5420.78
162_A165_L0.5400.78
230_I235_T0.5390.78
187_P190_R0.5390.78
75_P85_E0.5330.77
60_R105_A0.5320.77
24_A300_P0.5320.77
183_L186_Y0.5310.77
252_V281_L0.5290.77
24_A34_L0.5210.76
254_P277_L0.5210.76
267_W270_H0.5210.76
260_Y269_H0.5190.75
280_Y284_W0.5180.75
70_S96_V0.5170.75
22_A58_Y0.5160.75
236_T284_W0.5160.75
25_T257_G0.5160.75
29_A57_D0.5150.75
280_Y283_Q0.5150.75
210_R214_A0.5140.75
227_I254_P0.5120.74
126_G149_F0.5120.74
273_H277_L0.5110.74
66_A118_V0.5100.74
179_L182_L0.5090.74
213_V242_L0.5080.74
152_P155_E0.5070.74
226_G254_P0.5070.74
119_A192_W0.5050.73
28_E40_S0.5050.73
169_T229_C0.5040.73
277_L281_L0.5040.73
39_W81_R0.5030.73
105_A114_G0.5030.73
128_Y171_P0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cczA 1 0.8839 100 0.158 Contact Map
1q7zA 1 0.9194 100 0.16 Contact Map
4m3pA 4 0.8839 100 0.197 Contact Map
2e6fA 2 0.5323 96.8 0.92 Contact Map
3eooA 4 0.829 96.5 0.923 Contact Map
4ef8A 2 0.5419 95.6 0.929 Contact Map
3hgjA 2 0.6065 95.6 0.929 Contact Map
1zlpA 4 0.8129 95.2 0.931 Contact Map
3gr7A 3 0.6161 94.9 0.932 Contact Map
1z41A 3 0.6129 94.2 0.934 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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