GREMLIN Database
MMUP - Probable S-methylmethionine permease
UniProt: Q47689 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13342
Length: 467 (425)
Sequences: 24770 (16129)
Seq/√Len: 782.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
139_F344_M4.4761.00
326_C338_T4.3961.00
386_V390_R3.4491.00
56_A249_I3.2251.00
329_R338_T3.1211.00
235_K239_V3.0451.00
378_L416_F3.0281.00
15_K231_E2.9001.00
230_T236_V2.7681.00
80_H320_E2.7651.00
232_N235_K2.7071.00
96_A317_L2.6411.00
318_S328_A2.6301.00
20_I243_T2.5931.00
171_G258_V2.5151.00
331_T337_L2.4841.00
132_V348_V2.4671.00
16_T243_T2.4611.00
326_C329_R2.4381.00
286_Y290_I2.3821.00
228_G319_N2.3511.00
68_E388_R2.2881.00
169_I173_A2.2271.00
84_A92_G2.2031.00
341_S345_L2.2001.00
315_W319_N2.1861.00
229_E312_R2.1521.00
140_G144_I2.1511.00
136_A348_V2.1361.00
381_C415_G2.1031.00
16_T236_V2.0991.00
16_T20_I2.0951.00
139_F340_L2.0901.00
147_R151_E2.0891.00
437_W441_P2.0791.00
19_L230_T2.0741.00
413_V417_V2.0721.00
143_V337_L2.0551.00
277_L280_E2.0261.00
239_V243_T2.0101.00
158_L162_V1.9961.00
20_I247_R1.9831.00
84_A89_P1.9651.00
132_V351_L1.9641.00
131_C351_L1.9561.00
15_K18_H1.9541.00
87_L386_V1.9361.00
327_F342_V1.9331.00
65_C381_C1.9311.00
441_P444_A1.9191.00
321_R325_A1.9141.00
10_L330_V1.9041.00
267_Q281_K1.8991.00
100_W343_S1.8601.00
57_L61_L1.8531.00
264_P267_Q1.8491.00
87_L382_A1.8431.00
39_I48_T1.8391.00
242_R246_A1.7901.00
441_P445_L1.7761.00
136_A344_M1.7691.00
232_N236_V1.7551.00
410_L414_L1.7461.00
331_T335_V1.7451.00
447_Y451_F1.7391.00
18_H154_F1.7361.00
277_L281_K1.7291.00
417_V421_V1.7211.00
83_A95_V1.7131.00
14_M18_H1.7101.00
142_N304_N1.6991.00
88_G91_T1.6721.00
95_V379_S1.6631.00
51_A209_T1.6611.00
23_S244_T1.6551.00
143_V341_S1.6531.00
111_F303_A1.6431.00
333_N337_L1.6411.00
386_V389_R1.6381.00
135_C347_G1.5981.00
444_A448_G1.5951.00
162_V166_A1.5751.00
107_L347_G1.5731.00
443_V447_Y1.5581.00
246_A250_I1.5531.00
118_M130_W1.5391.00
58_V418_L1.5141.00
11_K334_G1.5131.00
314_L339_A1.5071.00
226_A308_Y1.4971.00
382_A416_F1.4951.00
310_S343_S1.4881.00
338_T342_V1.4771.00
55_G213_V1.4731.00
144_I333_N1.4621.00
87_L91_T1.4621.00
163_T294_V1.4601.00
114_A296_L1.4591.00
280_E288_A1.4571.00
189_G192_N1.4541.00
132_V136_A1.4471.00
445_L449_A1.4431.00
315_W330_V1.4411.00
325_A328_A1.4371.00
135_C344_M1.4291.00
325_A329_R1.4201.00
83_A379_S1.4151.00
190_L193_I1.4141.00
442_F446_C1.4131.00
382_A386_V1.4131.00
232_N239_V1.4131.00
57_L414_L1.4081.00
172_G258_V1.4071.00
63_M245_I1.4021.00
61_L414_L1.4001.00
111_F135_C1.3871.00
76_T228_G1.3741.00
446_C449_A1.3711.00
139_F341_S1.3691.00
445_L451_F1.3641.00
10_L315_W1.3571.00
329_R337_L1.3561.00
18_H150_A1.3421.00
114_A134_F1.3391.00
311_G340_L1.3341.00
63_M241_I1.3271.00
161_V165_I1.3131.00
73_M85_R1.3121.00
407_W411_V1.3121.00
289_D293_F1.3061.00
16_T239_V1.2991.00
168_I254_G1.2971.00
40_I48_T1.2951.00
273_S277_L1.2951.00
233_P238_P1.2901.00
421_V425_G1.2881.00
86_Y383_S1.2861.00
236_V239_V1.2691.00
14_M19_L1.2681.00
27_V248_L1.2631.00
17_R21_M1.2591.00
250_I254_G1.2541.00
435_A439_G1.2541.00
433_R436_L1.2521.00
49_L257_F1.2431.00
314_L323_L1.2321.00
138_I303_A1.2321.00
171_G262_L1.2271.00
47_G206_I1.2191.00
280_E285_P1.2181.00
81_V85_R1.2131.00
175_I261_A1.2111.00
62_V381_C1.2091.00
128_W132_V1.2091.00
439_G443_V1.2051.00
65_C412_P1.2021.00
64_Q242_R1.2001.00
176_F179_I1.1991.00
100_W314_L1.1981.00
14_M150_A1.1961.00
34_F113_A1.1961.00
173_A178_F1.1851.00
110_S302_A1.1771.00
124_Q127_V1.1691.00
19_L240_A1.1681.00
90_A450_Y1.1591.00
167_F171_G1.1561.00
23_S223_I1.1511.00
93_Y97_W1.1491.00
416_F420_L1.1421.00
408_Y412_P1.1411.00
231_E236_V1.1381.00
389_R392_L1.1351.00
434_I437_W1.1331.00
75_E81_V1.1321.00
338_T341_S1.1281.00
265_M268_V1.1251.00
141_L152_G1.1231.00
410_L413_V1.1211.00
172_G176_F1.1201.00
22_L226_A1.1201.00
13_T231_E1.1071.00
385_F413_V1.1061.00
66_L79_F1.1041.00
152_G156_F1.1031.00
166_A170_L1.1021.00
420_L424_V1.0891.00
409_P413_V1.0891.00
399_S402_H1.0841.00
151_E155_W1.0831.00
83_A91_T1.0821.00
126_P129_V1.0801.00
80_H316_S1.0791.00
176_F180_P1.0791.00
378_L420_L1.0761.00
129_V133_V1.0701.00
153_E304_N1.0691.00
441_P446_C1.0681.00
24_L247_R1.0671.00
330_V334_G1.0561.00
85_R391_H1.0551.00
384_H412_P1.0551.00
437_W448_G1.0521.00
403_Y406_P1.0481.00
72_A399_S1.0441.00
319_N328_A1.0421.00
70_S82_Y1.0411.00
401_L404_R1.0391.00
68_E71_V1.0361.00
115_G130_W1.0281.00
75_E85_R1.0191.00
133_V137_I1.0181.00
139_F143_V1.0171.00
446_C450_Y1.0161.00
72_A401_L1.0151.00
447_Y450_Y1.0121.00
392_L401_L1.0071.00
432_Q435_A1.0051.00
271_E277_L1.0051.00
173_A177_G0.9971.00
146_T308_Y0.9931.00
227_A237_I0.9921.00
345_L349_L0.9881.00
118_M122_F0.9861.00
429_D433_R0.9841.00
24_L248_L0.9771.00
407_W410_L0.9721.00
136_A140_G0.9701.00
189_G194_T0.9691.00
427_A430_P0.9641.00
440_L444_A0.9621.00
156_F301_S0.9581.00
125_V129_V0.9561.00
433_R437_W0.9541.00
434_I441_P0.9521.00
307_L344_M0.9491.00
161_V251_F0.9481.00
430_P433_R0.9461.00
165_I169_I0.9431.00
143_V335_V0.9431.00
437_W444_A0.9421.00
207_L421_V0.9421.00
423_C426_L0.9421.00
427_A431_A0.9371.00
137_I300_L0.9351.00
21_M154_F0.9351.00
177_G180_P0.9321.00
138_I304_N0.9321.00
436_L439_G0.9321.00
378_L419_C0.9281.00
193_I196_E0.9281.00
218_S373_V0.9241.00
283_G287_A0.9231.00
119_Q123_P0.9231.00
53_L253_I0.9221.00
431_A445_L0.9181.00
168_I258_V0.9161.00
437_W442_F0.9161.00
415_G419_C0.9131.00
249_I253_I0.9091.00
160_K298_A0.9031.00
257_F261_A0.9031.00
264_P281_K0.9031.00
118_M296_L0.9011.00
77_G81_V0.9001.00
445_L450_Y0.9001.00
13_T147_R0.8981.00
221_E225_I0.8971.00
443_V446_C0.8971.00
337_L341_S0.8971.00
448_G451_F0.8901.00
173_A176_F0.8871.00
109_S215_F0.8861.00
192_N195_A0.8851.00
243_T247_R0.8841.00
269_G272_K0.8831.00
143_V331_T0.8831.00
114_A300_L0.8811.00
388_R392_L0.8801.00
61_L411_V0.8791.00
202_G205_P0.8761.00
421_V424_V0.8761.00
262_L278_V0.8721.00
91_T379_S0.8701.00
17_R154_F0.8681.00
381_C416_F0.8641.00
285_P289_D0.8621.00
10_L312_R0.8621.00
441_P448_G0.8611.00
432_Q436_L0.8601.00
167_F279_F0.8601.00
84_A320_E0.8601.00
323_L327_F0.8571.00
97_W323_L0.8531.00
274_P279_F0.8531.00
28_I31_G0.8521.00
175_I178_F0.8491.00
400_E404_R0.8491.00
406_P410_L0.8471.00
18_H151_E0.8471.00
109_S366_S0.8461.00
88_G451_F0.8461.00
399_S404_R0.8451.00
429_D432_Q0.8451.00
49_L260_A0.8421.00
151_E154_F0.8401.00
438_C442_F0.8331.00
130_W133_V0.8321.00
331_T334_G0.8321.00
60_W64_Q0.8311.00
378_L382_A0.8311.00
168_I172_G0.8311.00
440_L443_V0.8301.00
284_I287_A0.8291.00
208_M212_A0.8281.00
175_I179_I0.8261.00
439_G442_F0.8191.00
10_L229_E0.8151.00
114_A299_I0.8141.00
389_R409_P0.8141.00
77_G80_H0.8081.00
444_A447_Y0.8081.00
412_P419_C0.8071.00
385_F412_P0.8071.00
222_L309_A0.8061.00
431_A434_I0.8051.00
344_M348_V0.8041.00
88_G92_G0.7981.00
327_F338_T0.7981.00
128_W351_L0.7981.00
191_S194_T0.7971.00
140_G143_V0.7971.00
69_L384_H0.7901.00
412_P416_F0.7891.00
71_V402_H0.7881.00
16_T240_A0.7851.00
90_A94_T0.7811.00
415_G418_L0.7811.00
56_A217_F0.7811.00
274_P278_V0.7811.00
405_A408_Y0.7771.00
115_G131_C0.7771.00
422_A426_L0.7751.00
50_L206_I0.7741.00
172_G254_G0.7731.00
368_I372_A0.7721.00
391_H399_S0.7711.00
61_L65_C0.7711.00
419_C422_A0.7671.00
13_T17_R0.7661.00
60_W242_R0.7661.00
384_H388_R0.7651.00
53_L57_L0.7631.00
108_G365_L0.7611.00
112_T365_L0.7611.00
28_I160_K0.7591.00
45_A260_A0.7581.00
47_G199_F0.7581.00
218_S377_W0.7571.00
135_C351_L0.7561.00
432_Q445_L0.7551.00
83_A383_S0.7541.00
383_S387_F0.7541.00
409_P412_P0.7521.00
203_G206_I0.7501.00
175_I180_P0.7501.00
430_P434_I0.7491.00
385_F389_R0.7481.00
138_I307_L0.7461.00
144_I148_F0.7451.00
273_S276_V0.7451.00
279_F282_V0.7441.00
115_G118_M0.7411.00
32_L255_T0.7391.00
437_W440_L0.7371.00
17_R151_E0.7361.00
29_G33_F0.7361.00
99_Y103_W0.7331.00
203_G207_L0.7301.00
345_L348_V0.7291.00
336_P339_A0.7261.00
69_L82_Y0.7201.00
270_V274_P0.7191.00
168_I255_T0.7181.00
434_I445_L0.7181.00
400_E403_Y0.7171.00
48_T256_V0.7141.00
439_G445_L0.7141.00
437_W446_C0.7131.00
279_F284_I0.7101.00
148_F151_E0.7061.00
27_V244_T0.7061.00
20_I240_A0.7051.00
436_L440_L0.7011.00
50_L53_L0.7001.00
392_L399_S0.6991.00
138_I300_L0.6981.00
13_T146_T0.6971.00
25_G157_S0.6961.00
150_A154_F0.6941.00
327_F339_A0.6931.00
142_N340_L0.6901.00
238_P241_I0.6901.00
175_I258_V0.6891.00
64_Q406_P0.6891.00
435_A442_F0.6881.00
132_V352_F0.6881.00
62_V419_C0.6881.00
199_F206_I0.6861.00
128_W131_C0.6841.00
134_F303_A0.6831.00
104_T346_G0.6801.00
80_H84_A0.6781.00
66_L380_I0.6771.00
106_A369_S0.6771.00
435_A445_L0.6761.00
86_Y386_V0.6761.00
72_A392_L0.6741.00
232_N238_P0.6741.00
385_F409_P0.6731.00
97_W441_P0.6721.00
143_V333_N0.6721.00
194_T197_G0.6721.00
274_P282_V0.6721.00
307_L311_G0.6711.00
436_L445_L0.6711.00
435_A441_P0.6701.00
428_F431_A0.6691.00
434_I447_Y0.6681.00
28_I33_F0.6671.00
178_F181_M0.6641.00
50_L54_I0.6631.00
311_G339_A0.6621.00
332_K337_L0.6621.00
428_F432_Q0.6611.00
26_G306_G0.6601.00
72_A402_H0.6601.00
326_C342_V0.6601.00
278_V282_V0.6591.00
207_L425_G0.6591.00
143_V340_L0.6581.00
312_R315_W0.6561.00
59_V220_T0.6551.00
431_A444_A0.6521.00
434_I451_F0.6501.00
49_L53_L0.6501.00
120_Y123_P0.6491.00
142_N308_Y0.6491.00
106_A110_S0.6481.00
192_N196_E0.6471.00
432_Q437_W0.6471.00
393_Q401_L0.6471.00
437_W445_L0.6461.00
247_R250_I0.6461.00
114_A118_M0.6451.00
105_V368_I0.6451.00
286_Y289_D0.6451.00
314_L342_V0.6441.00
52_Y216_A0.6431.00
389_R393_Q0.6431.00
118_M134_F0.6401.00
36_T256_V0.6391.00
108_G111_F0.6381.00
65_C405_A0.6381.00
270_V273_S0.6371.00
247_R251_F0.6371.00
198_W201_H0.6361.00
444_A450_Y0.6361.00
423_C431_A0.6351.00
419_C423_C0.6311.00
401_L405_A0.6311.00
438_C441_P0.6301.00
76_T315_W0.6301.00
318_S327_F0.6291.00
136_A139_F0.6281.00
26_G305_S0.6261.00
28_I251_F0.6261.00
102_T373_V0.6261.00
44_G47_G0.6261.00
224_G241_I0.6261.00
49_L253_I0.6261.00
434_I443_V0.6261.00
67_G71_V0.6251.00
290_I294_V0.6251.00
433_R445_L0.6241.00
190_L194_T0.6221.00
439_G444_A0.6221.00
228_G315_W0.6221.00
418_L422_A0.6201.00
103_W306_G0.6191.00
205_P208_M0.6191.00
17_R20_I0.6191.00
86_Y387_F0.6181.00
80_H96_A0.6171.00
254_G258_V0.6151.00
38_Y363_V0.6151.00
79_F221_E0.6141.00
146_T226_A0.6141.00
98_L376_V0.6121.00
70_S224_G0.6111.00
393_Q400_E0.6111.00
120_Y292_N0.6111.00
23_S27_V0.6091.00
106_A109_S0.6091.00
258_V261_A0.6081.00
157_S160_K0.6051.00
431_A435_A0.6041.00
87_L383_S0.6041.00
10_L13_T0.6041.00
372_A376_V0.6031.00
230_T237_I0.6031.00
269_G274_P0.6021.00
434_I446_C0.5991.00
298_A301_S0.5991.00
408_Y411_V0.5991.00
39_I43_T0.5971.00
135_C348_V0.5961.00
237_I241_I0.5931.00
433_R444_A0.5921.00
69_L86_Y0.5901.00
437_W443_V0.5901.00
225_I309_A0.5901.00
445_L448_G0.5891.00
20_I23_S0.5891.00
279_F287_A0.5881.00
111_F115_G0.5871.00
218_S221_E0.5871.00
63_M220_T0.5861.00
35_N366_S0.5841.00
70_S237_I0.5801.00
442_F448_G0.5791.00
255_T275_F0.5791.00
310_S314_L0.5791.00
150_A304_N0.5781.00
24_L157_S0.5781.00
139_F307_L0.5771.00
435_A440_L0.5771.00
434_I438_C0.5761.00
110_S113_A0.5761.00
229_E336_P0.5761.00
108_G350_A0.5721.00
243_T246_A0.5701.00
233_P236_V0.5691.00
39_I213_V0.5691.00
352_F355_V0.5681.00
412_P426_L0.5681.00
414_L417_V0.5671.00
442_F449_A0.5671.00
145_S148_F0.5671.00
427_A433_R0.5651.00
180_P261_A0.5651.00
234_R400_E0.5641.00
312_R330_V0.5631.00
435_A438_C0.5611.00
434_I448_G0.5611.00
234_R402_H0.5591.00
442_F445_L0.5581.00
22_L25_G0.5581.00
435_A451_F0.5581.00
197_G200_P0.5561.00
387_F391_H0.5561.00
117_C295_I0.5551.00
174_A177_G0.5551.00
159_V294_V0.5531.00
391_H401_L0.5521.00
293_F297_T0.5521.00
159_V163_T0.5511.00
79_F225_I0.5511.00
55_G217_F0.5481.00
418_L421_V0.5471.00
55_G214_N0.5461.00
54_I210_M0.5441.00
80_H92_G0.5431.00
433_R439_G0.5421.00
121_W292_N0.5411.00
134_F138_I0.5411.00
221_E377_W0.5401.00
195_A198_W0.5391.00
255_T259_L0.5391.00
170_L174_A0.5381.00
342_V346_G0.5381.00
192_N197_G0.5381.00
387_F392_L0.5361.00
430_P435_A0.5351.00
434_I444_A0.5341.00
433_R446_C0.5331.00
26_G222_L0.5321.00
148_F152_G0.5321.00
408_Y413_V0.5311.00
72_A387_F0.5311.00
137_I141_L0.5311.00
121_W293_F0.5301.00
12_R231_E0.5301.00
98_L102_T0.5301.00
146_T150_A0.5281.00
68_E406_P0.5271.00
78_A224_G0.5271.00
407_W412_P0.5261.00
149_F308_Y0.5261.00
434_I442_F0.5261.00
218_S369_S0.5251.00
21_M157_S0.5241.00
216_A252_F0.5241.00
275_F279_F0.5241.00
62_V221_E0.5231.00
95_V376_V0.5221.00
373_V376_V0.5221.00
63_M67_G0.5211.00
154_F158_L0.5201.00
83_A92_G0.5191.00
314_L318_S0.5191.00
121_W296_L0.5191.00
43_T46_A0.5191.00
435_A443_V0.5191.00
162_V165_I0.5191.00
108_G347_G0.5181.00
190_L261_A0.5181.00
431_A448_G0.5161.00
110_S303_A0.5151.00
363_V366_S0.5141.00
349_L352_F0.5131.00
431_A446_C0.5131.00
417_V420_L0.5121.00
49_L52_Y0.5121.00
110_S299_I0.5101.00
104_T343_S0.5091.00
170_L284_I0.5091.00
52_Y256_V0.5091.00
269_G273_S0.5081.00
69_L387_F0.5061.00
14_M146_T0.5051.00
87_L90_A0.5051.00
39_I209_T0.5051.00
434_I439_G0.5041.00
117_C276_V0.5041.00
107_L110_S0.5011.00
28_I35_N0.5011.00
437_W447_Y0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.8929 100 0.306 Contact Map
4djkA 2 0.8779 100 0.361 Contact Map
3giaA 1 0.9101 100 0.367 Contact Map
2jlnA 1 0.9036 99 0.855 Contact Map
3dh4A 3 0.9143 98.8 0.862 Contact Map
2xq2A 2 0.9165 98.8 0.863 Contact Map
2a65A 2 0.9251 97.9 0.897 Contact Map
4wgvA 2 0.7773 97.7 0.899 Contact Map
4xp4A 1 0.9272 97.4 0.906 Contact Map
4us3A 1 0.8308 96.8 0.914 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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