GREMLIN Database
YKFC - Putative uncharacterized protein YkfC
UniProt: Q47688 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13341
Length: 376 (294)
Sequences: 4378 (3506)
Seq/√Len: 204.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
163_S310_R4.2641.00
164_S168_T4.2091.00
289_K293_E4.0281.00
85_Y93_L3.2931.00
164_S167_D3.2011.00
119_E130_R3.0041.00
129_F278_A2.8021.00
349_P352_K2.7941.00
160_G281_F2.6121.00
231_D276_R2.5021.00
127_Y137_H2.4961.00
175_M192_W2.4471.00
177_A229_E2.4031.00
123_H228_N2.4001.00
168_T210_E2.3671.00
174_L222_L2.3331.00
170_H308_K2.3031.00
111_L115_E2.2401.00
230_F299_C2.2171.00
282_V327_F2.1941.00
175_M188_M2.1491.00
228_N232_Q2.1441.00
178_V225_I2.1391.00
300_R313_M2.1011.00
108_R111_L2.0591.00
348_I352_K2.0341.00
111_L221_L2.0001.00
288_T291_Q1.9761.00
162_L303_L1.9721.00
160_G311_L1.9681.00
180_R229_E1.9231.00
158_I292_V1.8951.00
98_I104_R1.8891.00
179_R192_W1.8821.00
70_E102_R1.8501.00
296_R300_R1.8461.00
174_L226_M1.8351.00
28_E109_A1.8311.00
53_K101_L1.8271.00
179_R188_M1.7821.00
165_Y223_S1.7801.00
216_G219_S1.7711.00
71_L190_L1.7351.00
121_D181_R1.7161.00
69_D73_S1.6971.00
348_I351_E1.6831.00
33_A65_Q1.6201.00
230_F302_V1.6161.00
42_G57_Q1.6081.00
192_W196_K1.5961.00
118_W225_I1.5931.00
123_H235_H1.5851.00
179_R185_A1.5751.00
127_Y138_A1.5721.00
83_R199_H1.5691.00
142_V275_C1.5681.00
107_Q216_G1.5391.00
87_P93_L1.5251.00
99_P216_G1.5141.00
283_L299_C1.5051.00
139_I330_H1.5031.00
142_V284_I1.4971.00
326_I331_R1.4931.00
142_V282_V1.4921.00
65_Q69_D1.4851.00
237_R298_E1.4781.00
79_L100_A1.4751.00
89_S92_K1.4651.00
169_V174_L1.4421.00
34_A38_L1.4381.00
173_L307_L1.4221.00
173_L308_K1.4031.00
138_A275_C1.3991.00
230_F234_L1.3971.00
173_L226_M1.3961.00
346_S352_K1.3921.00
300_R304_E1.3881.00
115_E131_P1.3881.00
134_S137_H1.3871.00
304_E310_R1.3831.00
74_G186_R1.3601.00
85_Y201_D1.3551.00
49_D100_A1.3491.00
146_L321_V1.3411.00
169_V212_V1.3381.00
163_S168_T1.3341.00
126_S276_R1.3321.00
85_Y95_P1.3191.00
139_I332_L1.3141.00
285_V292_V1.3081.00
56_L102_R1.3051.00
122_F130_R1.2881.00
158_I296_R1.2831.00
170_H173_L1.2791.00
92_K164_S1.2741.00
175_M195_I1.2711.00
110_M187_F1.2681.00
108_R112_M1.2501.00
213_P216_G1.2471.00
83_R201_D1.2441.00
165_Y169_V1.2321.00
37_T105_I1.2311.00
184_D187_F1.2261.00
48_V100_A1.2221.00
157_V284_I1.2181.00
178_V191_L1.2091.00
297_E300_R1.2071.00
130_R133_R1.1991.00
159_E325_F1.1931.00
181_R228_N1.1891.00
344_V348_I1.1881.00
177_A307_L1.1881.00
66_I70_E1.1871.00
145_Q284_I1.1791.00
172_R192_W1.1761.00
324_G331_R1.1751.00
32_E113_A1.1631.00
68_R72_L1.1591.00
229_E302_V1.1581.00
285_V295_I1.1571.00
108_R217_V1.1451.00
27_P65_Q1.1221.00
290_A293_E1.1111.00
201_D206_R1.1041.00
347_T352_K1.1031.00
29_W112_M1.1021.00
159_E282_V1.0941.00
122_F126_S1.0931.00
346_S349_P1.0891.00
68_R106_V1.0891.00
41_K44_H1.0791.00
163_S314_D1.0761.00
32_E36_I1.0721.00
24_I187_F1.0661.00
156_W320_H1.0471.00
159_E327_F1.0391.00
21_L74_G1.0371.00
111_L217_V1.0371.00
227_L276_R1.0331.00
68_R71_L1.0321.00
135_V277_Y1.0311.00
231_D274_Y1.0301.00
136_H139_I1.0221.00
28_E32_E1.0201.00
311_L316_T1.0181.00
293_E297_E1.0161.00
83_R95_P1.0131.00
294_A298_E1.0111.00
30_L65_Q1.0091.00
338_R341_E1.0081.00
163_S312_N1.0041.00
33_A36_I1.0021.00
317_K325_F1.0011.00
77_Q193_K0.9981.00
285_V291_Q0.9971.00
87_P92_K0.9961.00
344_V351_E0.9881.00
21_L25_T0.9881.00
157_V282_V0.9841.00
127_Y141_T0.9831.00
106_V190_L0.9811.00
233_Y298_E0.9761.00
227_L281_F0.9751.00
312_N315_K0.9721.00
160_G316_T0.9651.00
345_V349_P0.9641.00
125_L235_H0.9630.99
81_A97_G0.9520.99
78_P193_K0.9510.99
344_V347_T0.9440.99
123_H232_Q0.9430.99
143_K147_T0.9430.99
169_V226_M0.9430.99
22_R26_Q0.9430.99
226_M307_L0.9380.99
78_P194_T0.9340.99
36_I112_M0.9330.99
199_H208_A0.9320.99
174_L177_A0.9170.99
342_M348_I0.9150.99
175_M196_K0.9140.99
63_E102_R0.9110.99
34_A61_A0.9080.99
233_Y236_E0.9060.99
46_P50_G0.9060.99
205_F208_A0.9040.99
46_P52_N0.9030.99
110_M190_L0.9000.99
282_V325_F0.8960.99
153_R286_K0.8880.99
38_L57_Q0.8840.99
122_F228_N0.8800.99
36_I108_R0.8790.99
168_T309_L0.8780.99
74_G189_T0.8780.99
99_P103_D0.8730.99
302_V307_L0.8700.99
173_L176_K0.8680.99
28_E36_I0.8610.99
319_P325_F0.8600.99
156_W289_K0.8590.99
23_L26_Q0.8590.99
83_R205_F0.8580.99
54_T58_A0.8570.99
31_A35_R0.8520.99
33_A40_S0.8440.99
234_L274_Y0.8440.99
64_L68_R0.8420.99
173_L177_A0.8420.99
70_E75_H0.8390.99
168_T310_R0.8370.99
29_W32_E0.8310.99
46_P49_D0.8280.98
28_E33_A0.8260.98
291_Q294_A0.8250.98
40_S43_A0.8230.98
64_L105_I0.8150.98
63_E68_R0.8140.98
345_V348_I0.8130.98
125_L141_T0.8130.98
347_T351_E0.8120.98
154_G286_K0.8120.98
198_G208_A0.8050.98
178_V222_L0.8040.98
176_K179_R0.8010.98
295_I299_C0.7980.98
43_A54_T0.7970.98
346_S351_E0.7960.98
224_N276_R0.7950.98
84_V96_L0.7940.98
130_R224_N0.7920.98
161_D215_G0.7880.98
87_P90_N0.7880.98
114_M183_S0.7870.98
177_A228_N0.7860.98
118_W181_R0.7830.98
141_T144_L0.7800.98
333_I336_R0.7790.98
107_Q217_V0.7770.98
81_A216_G0.7770.98
344_V352_K0.7690.98
60_L64_L0.7690.98
107_Q213_P0.7680.98
184_D188_M0.7660.97
24_I110_M0.7650.97
159_E319_P0.7590.97
145_Q273_A0.7580.97
230_F303_L0.7490.97
283_L295_I0.7470.97
342_M351_E0.7460.97
342_M346_S0.7400.97
128_G212_V0.7390.97
166_F220_P0.7370.97
33_A109_A0.7370.97
94_R161_D0.7330.97
172_R176_K0.7320.97
280_D315_K0.7320.97
129_F220_P0.7280.97
114_M178_V0.7260.97
30_L33_A0.7250.96
165_Y168_T0.7240.96
127_Y133_R0.7240.96
303_L311_L0.7200.96
60_L63_E0.7180.96
166_F212_V0.7160.96
141_T273_A0.7160.96
343_R348_I0.7150.96
81_A99_P0.7150.96
142_V145_Q0.7110.96
347_T350_Q0.7100.96
233_Y306_S0.7100.96
211_G215_G0.7090.96
170_H174_L0.7080.96
109_A112_M0.7080.96
78_P81_A0.7070.96
195_I213_P0.7070.96
345_V351_E0.7070.96
109_A113_A0.7060.96
154_G284_I0.7060.96
94_R280_D0.7030.96
56_L63_E0.7030.96
195_I198_G0.7010.96
232_Q235_H0.7000.96
94_R215_G0.6990.96
146_L284_I0.6980.96
21_L71_L0.6980.96
331_R335_K0.6970.96
110_M194_T0.6940.96
30_L109_A0.6930.95
92_K314_D0.6930.95
101_L104_R0.6870.95
160_G319_P0.6840.95
28_E31_A0.6830.95
33_A37_T0.6820.95
125_L231_D0.6810.95
126_S228_N0.6790.95
178_V182_I0.6770.95
143_K346_S0.6750.95
90_N314_D0.6730.95
35_R39_S0.6680.94
141_T145_Q0.6660.94
175_M179_R0.6650.94
158_I318_I0.6630.94
157_V325_F0.6630.94
166_F171_H0.6590.94
160_G299_C0.6540.94
234_L283_L0.6540.94
66_I69_D0.6520.94
224_N227_L0.6510.94
162_L312_N0.6490.94
71_L106_V0.6460.93
342_M347_T0.6440.93
156_W292_V0.6440.93
71_L74_G0.6430.93
117_I184_D0.6420.93
215_G279_D0.6410.93
162_L168_T0.6410.93
343_R347_T0.6370.93
298_E301_G0.6360.93
198_G213_P0.6360.93
146_L334_R0.6360.93
154_G273_A0.6330.93
341_E345_V0.6330.93
162_L309_L0.6290.93
340_G344_V0.6250.92
344_V349_P0.6250.92
275_C284_I0.6250.92
185_A189_T0.6200.92
174_L212_V0.6180.92
121_D228_N0.6160.92
201_D204_L0.6160.92
118_W182_I0.6120.92
297_E301_G0.6120.92
223_S227_L0.6120.92
39_S108_R0.6090.91
199_H205_F0.6090.91
107_Q194_T0.6080.91
145_Q275_C0.6050.91
346_S350_Q0.6030.91
32_E35_R0.6030.91
159_E317_K0.6020.91
272_V295_I0.6010.91
76_Y193_K0.6010.91
299_C303_L0.6010.91
40_S53_K0.6010.91
140_R144_L0.5990.91
69_D72_L0.5970.90
194_T198_G0.5960.90
134_S277_Y0.5950.90
271_A286_K0.5950.90
218_I222_L0.5940.90
70_E73_S0.5940.90
32_E112_M0.5930.90
230_F281_F0.5920.90
234_L299_C0.5910.90
31_A34_A0.5900.90
317_K326_I0.5900.90
342_M349_P0.5880.90
162_L223_S0.5880.90
191_L195_I0.5880.90
201_D205_F0.5870.90
190_L193_K0.5870.90
167_D214_Q0.5860.90
23_L27_P0.5850.90
294_A297_E0.5790.89
67_L71_L0.5770.89
117_I181_R0.5770.89
88_K214_Q0.5760.89
46_P98_I0.5750.89
96_L108_R0.5740.89
84_V87_P0.5740.89
189_T193_K0.5700.88
276_R281_F0.5700.88
105_I109_A0.5660.88
191_L222_L0.5630.88
119_E122_F0.5610.88
142_V157_V0.5610.88
342_M345_V0.5600.87
335_K338_R0.5590.87
158_I285_V0.5580.87
47_G50_G0.5560.87
343_R346_S0.5540.87
82_R198_G0.5540.87
161_D280_D0.5510.87
141_T275_C0.5500.87
206_R210_E0.5500.87
63_E71_L0.5490.86
164_S312_N0.5480.86
162_L227_L0.5480.86
339_Y343_R0.5470.86
165_Y226_M0.5460.86
59_R62_V0.5430.86
200_I208_A0.5410.86
195_I212_V0.5400.86
301_G306_S0.5400.86
122_F221_L0.5400.86
167_D220_P0.5380.85
292_V318_I0.5360.85
21_L24_I0.5360.85
29_W113_A0.5340.85
99_P194_T0.5320.85
38_L105_I0.5310.85
177_A226_M0.5310.85
333_I337_S0.5300.85
296_R311_L0.5300.85
281_F299_C0.5290.84
47_G94_R0.5280.84
88_K161_D0.5260.84
138_A231_D0.5250.84
75_H106_V0.5240.84
290_A294_A0.5230.84
107_Q198_G0.5230.84
275_C327_F0.5220.84
321_V334_R0.5220.84
212_V223_S0.5220.84
111_L116_P0.5220.84
56_L105_I0.5220.84
115_E221_L0.5220.84
25_T28_E0.5210.84
80_P83_R0.5210.84
95_P98_I0.5200.83
96_L104_R0.5200.83
194_T218_I0.5190.83
126_S224_N0.5180.83
88_K315_K0.5180.83
122_F225_I0.5170.83
173_L229_E0.5170.83
142_V332_L0.5170.83
51_V56_L0.5160.83
23_L113_A0.5140.83
34_A37_T0.5120.82
156_W318_I0.5110.82
117_I120_S0.5100.82
52_N56_L0.5090.82
225_I278_A0.5080.82
85_Y92_K0.5070.82
194_T213_P0.5060.82
337_S343_R0.5040.81
143_K332_L0.5040.81
103_D107_Q0.5010.81
322_N334_R0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3kylA 1 0.8378 100 0.532 Contact Map
4wfzA 1 0.859 100 0.662 Contact Map
1xr5A 1 0.8617 100 0.663 Contact Map
4nyzA 1 0.8723 99.4 0.811 Contact Map
4xpcA 1 0.6223 99.4 0.82 Contact Map
3bsoA 1 0.867 99.3 0.822 Contact Map
4ol8A 2 0.6888 99.2 0.83 Contact Map
4wywA 1 0.8723 99.2 0.83 Contact Map
4mh8A 1 0.7074 99.2 0.832 Contact Map
4g1qB 2 0.7154 99.1 0.842 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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