GREMLIN Database
YAFW - Antitoxin YafW
UniProt: Q47684 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13335
Length: 105 (100)
Sequences: 153 (52)
Seq/√Len: 5.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
59_M73_A5.3280.98
84_T103_T3.9770.90
29_Y36_I2.2590.49
45_C54_H2.2000.47
55_F73_A2.1860.47
16_L102_P2.1460.46
50_E54_H2.0720.43
62_M69_S2.0600.43
61_S79_Y2.0560.43
24_G40_F2.0040.41
5_T15_R1.9970.41
54_H83_L1.8760.37
21_V28_H1.7770.34
7_G14_L1.6760.31
9_Q12_I1.6510.30
36_I103_T1.6490.30
57_L73_A1.6080.29
29_Y35_S1.5810.28
90_L99_A1.5170.27
54_H73_A1.4540.25
51_T80_H1.4290.25
29_Y93_C1.4280.25
89_T96_V1.4030.24
50_E56_I1.3850.24
22_Q63_L1.3450.23
34_A96_V1.3130.22
28_H70_P1.3080.22
21_V70_P1.2970.21
8_L95_Y1.2960.21
29_Y43_I1.2730.21
55_F59_M1.2480.20
50_E83_L1.2460.20
56_I83_L1.2110.20
28_H63_L1.2090.20
12_I75_C1.1960.19
25_N29_Y1.1940.19
23_E28_H1.1750.19
36_I61_S1.1570.19
29_Y69_S1.1420.18
47_K55_F1.1280.18
86_E90_L1.1150.18
4_P98_I1.1150.18
15_R46_R1.1020.17
9_Q15_R1.0970.17
22_Q41_S1.0970.17
30_L38_G1.0630.17
44_E81_N1.0500.16
63_L96_V1.0320.16
78_L102_P1.0230.16
55_F81_N1.0210.16
39_K65_T1.0070.16
40_F58_Q1.0010.16
63_L68_L0.9980.16
44_E80_H0.9830.15
80_H90_L0.9790.15
29_Y45_C0.9680.15
77_T84_T0.9260.14
16_L95_Y0.9240.14
53_P67_E0.9200.14
34_A49_D0.9090.14
16_L57_L0.8950.14
27_L38_G0.8920.14
36_I56_I0.8860.14
47_K83_L0.8780.14
14_L38_G0.8730.13
70_P83_L0.8600.13
27_L30_L0.8600.13
56_I77_T0.8540.13
15_R62_M0.8500.13
4_P24_G0.8490.13
14_L30_L0.8480.13
46_R78_L0.8250.13
71_H77_T0.8160.13
10_R75_C0.8150.13
10_R36_I0.8140.13
40_F70_P0.8140.13
62_M67_E0.8050.12
58_Q67_E0.8040.12
7_G38_G0.8030.12
29_Y64_T0.8030.12
50_E58_Q0.8010.12
55_F90_L0.7960.12
41_S99_A0.7930.12
4_P65_T0.7770.12
7_G30_L0.7740.12
61_S74_H0.7730.12
26_R96_V0.7680.12
37_T96_V0.7640.12
18_A34_A0.7590.12
72_H79_Y0.7520.12
22_Q28_H0.7520.12
36_I43_I0.7480.12
48_L68_L0.7450.12
78_L100_I0.7370.12
49_D93_C0.7350.11
10_R43_I0.7190.11
44_E55_F0.7120.11
73_A87_A0.7000.11
34_A53_P0.6960.11
22_Q70_P0.6940.11
36_I45_C0.6920.11
90_L98_I0.6910.11
14_L17_G0.6870.11
44_E56_I0.6870.11
4_P36_I0.6870.11
6_R95_Y0.6830.11
69_S79_Y0.6710.11
45_C83_L0.6700.11
38_G101_Y0.6580.11
9_Q81_N0.6420.10
14_L27_L0.6390.10
7_G27_L0.6380.10
49_D82_D0.6310.10
30_L101_Y0.6310.10
12_I16_L0.6180.10
95_Y102_P0.6180.10
9_Q39_K0.6160.10
27_L69_S0.6150.10
47_K56_I0.6080.10
16_L100_I0.6060.10
75_C80_H0.6020.10
10_R17_G0.6000.10
64_T76_V0.6000.10
36_I79_Y0.5960.10
44_E102_P0.5960.10
44_E69_S0.5940.10
4_P51_T0.5900.10
24_G65_T0.5870.10
41_S49_D0.5810.10
80_H83_L0.5640.09
22_Q48_L0.5550.09
26_R103_T0.5540.09
24_G58_Q0.5470.09
47_K103_T0.5460.09
17_G71_H0.5450.09
78_L90_L0.5350.09
21_V63_L0.5310.09
25_N51_T0.5290.09
47_K50_E0.5250.09
45_C50_E0.5250.09
56_I80_H0.5200.09
55_F80_H0.5190.09
54_H59_M0.5130.09
75_C90_L0.5100.09
10_R37_T0.5070.09
61_S81_N0.5060.09
22_Q38_G0.5030.09
29_Y103_T0.5020.09
26_R39_K0.5000.09
65_T83_L0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ea9A 1 0.981 100 0.05 Contact Map
2inwA 1 1 100 0.054 Contact Map
3h2tA 2 0.2762 20.1 0.952 Contact Map
4jm1A 1 0.3238 14.6 0.955 Contact Map
1dquA 4 0.9048 11.9 0.957 Contact Map
1d3yA 2 0.6571 8.5 0.96 Contact Map
1xv2A 2 0.6381 8.4 0.96 Contact Map
1rybA 1 0.581 7.4 0.961 Contact Map
3hvmA 1 0.7333 7.3 0.961 Contact Map
3neaA 1 0.5905 6.4 0.962 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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