GREMLIN Database
YAFV - Hydrolase YafV
UniProt: Q47679 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13334
Length: 256 (240)
Sequences: 13809 (9555)
Seq/√Len: 616.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
130_E135_R3.1101.00
5_K231_E3.1011.00
17_D20_A2.6921.00
180_R183_E2.4971.00
209_V230_A2.3701.00
25_F44_F2.3631.00
81_V94_L2.3321.00
211_N215_E2.3051.00
83_L106_D2.3001.00
7_T35_R2.1851.00
174_Q219_T2.1611.00
139_L150_S2.1551.00
92_R106_D2.1431.00
7_T229_D2.1401.00
26_D65_W2.0021.00
157_D238_R1.9711.00
33_T229_D1.9641.00
220_A228_I1.9361.00
8_L191_C1.9001.00
175_A178_T1.8971.00
30_E72_Q1.8891.00
26_D69_K1.8861.00
88_G121_K1.8661.00
39_V160_L1.8651.00
26_D30_E1.8551.00
38_I75_A1.8501.00
36_D132_R1.8411.00
30_E73_C1.8361.00
8_L189_A1.7971.00
90_V106_D1.7671.00
6_I189_A1.7461.00
93_F138_P1.7201.00
159_A186_A1.7021.00
24_H27_R1.6681.00
187_Y212_P1.6651.00
68_A72_Q1.6451.00
97_E102_V1.6351.00
76_L80_S1.6301.00
9_L38_I1.6071.00
97_E101_T1.5881.00
218_A228_I1.5851.00
131_W134_W1.5591.00
67_T96_V1.5521.00
135_R157_D1.5481.00
35_R229_D1.5471.00
136_I158_L1.5331.00
39_V191_C1.5261.00
210_I216_I1.5171.00
95_L138_P1.5111.00
115_D118_L1.5101.00
92_R104_F1.5061.00
137_L153_L1.5011.00
236_A239_E1.4911.00
25_F40_L1.4661.00
59_Q63_V1.4631.00
29_L38_I1.4541.00
28_Q31_G1.4431.00
27_R31_G1.4381.00
139_L161_Y1.4141.00
189_A209_V1.4101.00
177_L190_G1.4081.00
76_L95_L1.4071.00
98_P132_R1.4021.00
187_Y217_I1.3731.00
23_R27_R1.3731.00
76_L98_P1.3721.00
83_L92_R1.3671.00
29_L69_K1.3581.00
63_V94_L1.3481.00
20_A23_R1.3391.00
22_L65_W1.3391.00
112_R117_H1.3321.00
29_L77_I1.3211.00
69_K73_C1.3181.00
26_D72_Q1.3171.00
24_H225_A1.3101.00
148_V151_R1.3091.00
37_V160_L1.2991.00
9_L40_L1.2981.00
174_Q178_T1.2931.00
103_H127_V1.2921.00
136_I160_L1.2821.00
211_N217_I1.2801.00
239_E243_K1.2751.00
85_T90_V1.2701.00
93_F162_V1.2671.00
70_A77_I1.2651.00
196_S202_H1.2631.00
76_L131_W1.2421.00
14_V20_A1.2371.00
9_L227_R1.2371.00
139_L149_W1.2351.00
30_E69_K1.2281.00
81_V104_F1.2241.00
32_I227_R1.2201.00
206_D219_T1.2171.00
78_A93_F1.2141.00
55_S58_A1.2131.00
65_W68_A1.2091.00
78_A160_L1.2041.00
66_M79_G1.2021.00
78_A95_L1.2021.00
64_N67_T1.1971.00
74_N98_P1.1891.00
221_D224_Q1.1861.00
29_L75_A1.1831.00
20_A24_H1.1791.00
19_P23_R1.1691.00
45_T62_V1.1571.00
211_N236_A1.1541.00
193_R197_D1.1491.00
150_S161_Y1.1471.00
24_H28_Q1.1461.00
150_S159_A1.1311.00
56_S60_D1.1201.00
9_L28_Q1.1141.00
158_L189_A1.1131.00
175_A182_I1.1131.00
11_Q28_Q1.1081.00
78_A138_P1.1041.00
94_L104_F1.1041.00
26_D68_A1.1031.00
90_V121_K1.0911.00
177_L210_I1.0841.00
22_L26_D1.0841.00
105_Y127_V1.0771.00
55_S60_D1.0661.00
28_Q227_R1.0531.00
35_R38_I1.0501.00
142_Y146_F1.0501.00
56_S62_V1.0471.00
128_I135_R1.0271.00
174_Q208_R1.0261.00
14_V17_D1.0241.00
83_L104_F1.0201.00
19_P61_D1.0191.00
63_V96_V1.0191.00
76_L79_G1.0141.00
170_S206_D1.0091.00
156_Y159_A1.0061.00
103_H129_V1.0011.00
5_K229_D0.9951.00
171_L178_T0.9891.00
95_L129_V0.9881.00
177_L188_V0.9851.00
206_D222_A0.9841.00
235_A238_R0.9821.00
64_N68_A0.9821.00
171_L174_Q0.9781.00
181_A188_V0.9761.00
238_R242_E0.9701.00
55_S59_Q0.9701.00
76_L102_V0.9631.00
68_A71_Q0.9541.00
10_Q207_S0.9481.00
5_K33_T0.9481.00
134_W157_D0.9321.00
11_Q25_F0.9311.00
70_A100_G0.9281.00
23_R65_W0.9261.00
65_W69_K0.9161.00
69_K72_Q0.9131.00
105_Y143_D0.9111.00
56_S59_Q0.9101.00
177_L208_R0.9081.00
131_W136_I0.9041.00
8_L228_I0.9041.00
217_I230_A0.8991.00
60_D63_V0.8971.00
235_A239_E0.8911.00
167_A202_H0.8881.00
137_L156_Y0.8861.00
128_I156_Y0.8851.00
67_T101_T0.8831.00
208_R216_I0.8781.00
175_A179_A0.8691.00
233_S236_A0.8651.00
130_E133_G0.8641.00
25_F79_G0.8631.00
63_V67_T0.8561.00
32_I35_R0.8551.00
79_G96_V0.8541.00
181_A210_I0.8531.00
59_Q64_N0.8531.00
173_W190_G0.8471.00
187_Y237_L0.8431.00
151_R184_N0.8431.00
7_T227_R0.8401.00
218_A230_A0.8271.00
194_V224_Q0.8261.00
8_L209_V0.8231.00
33_T227_R0.8121.00
18_G22_L0.8111.00
43_M120_Y0.8111.00
134_W158_L0.8091.00
6_I232_L0.8071.00
216_I219_T0.8071.00
85_T106_D0.8011.00
4_L134_W0.7991.00
36_D98_P0.7991.00
19_P65_W0.7981.00
108_R149_W0.7951.00
50_M54_A0.7911.00
11_Q44_F0.7841.00
7_T32_I0.7821.00
144_L161_Y0.7751.00
27_R30_E0.7691.00
234_M238_R0.7681.00
76_L97_E0.7651.00
236_A240_Y0.7621.00
220_A225_A0.7551.00
23_R26_D0.7511.00
134_W234_M0.7501.00
70_A73_C0.7481.00
126_R149_W0.7421.00
157_D234_M0.7411.00
213_Q240_Y0.7401.00
84_Q89_S0.7391.00
98_P101_T0.7361.00
24_H224_Q0.7341.00
179_A183_E0.7311.00
40_L44_F0.7311.00
12_P194_V0.7301.00
32_I38_I0.7301.00
107_K141_C0.7291.00
149_W153_L0.7261.00
8_L207_S0.7251.00
109_H143_D0.7251.00
180_R184_N0.7231.00
7_T38_I0.7221.00
29_L73_C0.7211.00
58_A63_V0.7171.00
187_Y236_A0.7141.00
4_L133_G0.7101.00
29_L40_L0.7101.00
11_Q24_H0.7081.00
43_M48_F0.7081.00
46_S62_V0.7051.00
161_Y188_V0.7041.00
172_H176_L0.7041.00
208_R219_T0.6931.00
171_L175_A0.6931.00
25_F66_M0.6891.00
32_I75_A0.6881.00
4_L232_L0.6871.00
77_I80_S0.6851.00
91_N107_K0.6851.00
36_D133_G0.6841.00
76_L132_R0.6801.00
10_Q205_G0.6781.00
144_L177_L0.6761.00
237_L241_R0.6751.00
179_A182_I0.6711.00
187_Y232_L0.6711.00
97_E132_R0.6711.00
60_D64_N0.6691.00
109_H146_F0.6671.00
66_M77_I0.6651.00
173_W177_L0.6621.00
25_F29_L0.6611.00
37_V78_A0.6611.00
108_R126_R0.6611.00
139_L153_L0.6571.00
17_D21_N0.6531.00
50_M53_A0.6531.00
61_D64_N0.6491.00
95_L136_I0.6471.00
57_L84_Q0.6471.00
215_E236_A0.6461.00
164_N193_R0.6451.00
43_M82_A0.6431.00
81_V84_Q0.6421.00
67_T71_Q0.6401.00
148_V152_N0.6361.00
62_V81_V0.6321.00
126_R152_N0.6311.00
129_V136_I0.6261.00
31_G227_R0.6241.00
82_A120_Y0.6241.00
35_R75_A0.6221.00
61_D65_W0.6211.00
97_E103_H0.6201.00
159_A188_V0.6181.00
151_R247_W0.6151.00
85_T88_G0.6061.00
111_F142_Y0.6051.00
167_A170_S0.6021.00
97_E100_G0.5981.00
176_L179_A0.5971.00
165_W169_R0.5951.00
194_V223_H0.5881.00
26_D73_C0.5881.00
44_F79_G0.5871.00
19_P22_L0.5861.00
126_R129_V0.5821.00
12_P24_H0.5821.00
147_P151_R0.5791.00
135_R154_N0.5751.00
170_S204_R0.5721.00
14_V21_N0.5711.00
83_L94_L0.5701.00
173_W176_L0.5701.00
46_S82_A0.5701.00
178_T216_I0.5701.00
166_P169_R0.5691.00
4_L37_V0.5681.00
174_Q206_D0.5671.00
18_G62_V0.5661.00
62_V65_W0.5611.00
14_V24_H0.5601.00
91_N141_C0.5591.00
51_E54_A0.5591.00
22_L69_K0.5561.00
45_T66_M0.5541.00
164_N203_Y0.5521.00
174_Q216_I0.5511.00
137_L159_A0.5501.00
28_Q32_I0.5470.99
37_V133_G0.5450.99
12_P225_A0.5450.99
111_F145_R0.5450.99
83_L90_V0.5430.99
8_L218_A0.5430.99
91_N140_V0.5420.99
48_F141_C0.5400.99
49_A52_A0.5390.99
167_A204_R0.5390.99
12_P193_R0.5390.99
79_G94_L0.5380.99
37_V95_L0.5370.99
169_R172_H0.5370.99
174_Q210_I0.5360.99
193_R203_Y0.5350.99
22_L66_M0.5330.99
103_H138_P0.5330.99
116_E120_Y0.5320.99
244_F247_W0.5320.99
116_E119_H0.5300.99
196_S200_G0.5300.99
234_M237_L0.5260.99
42_E141_C0.5250.99
25_F69_K0.5190.99
126_R153_L0.5180.99
192_N207_S0.5180.99
76_L133_G0.5180.99
145_R176_L0.5180.99
18_G56_S0.5140.99
93_F140_V0.5120.99
22_L45_T0.5120.99
49_A53_A0.5110.99
178_T210_I0.5110.99
43_M46_S0.5080.99
127_V154_N0.5080.99
111_F141_C0.5080.99
145_R165_W0.5070.99
105_Y123_G0.5060.99
111_F165_W0.5050.99
48_F120_Y0.5050.99
70_A101_T0.5020.99
153_L156_Y0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2e11A 2 0.9961 100 0.158 Contact Map
4izuA 2 0.9375 100 0.181 Contact Map
2vhhA 5 0.9961 100 0.193 Contact Map
3p8kA 2 0.9883 100 0.195 Contact Map
2w1vA 2 0.9883 100 0.196 Contact Map
3ivzA 2 0.9609 100 0.203 Contact Map
3wuyA 2 0.9492 100 0.211 Contact Map
1uf5A 4 0.9922 100 0.215 Contact Map
1emsA 3 0.9883 100 0.219 Contact Map
2dyuA 5 0.9766 100 0.224 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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