SAPA - ECOLI - GREMLIN Contacts

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SAPA - Peptide transport periplasmic protein SapA

UniProt:	Q47622	Sequences: MRQVLSSLLVIAGLVSGQAIAAPESPPHADIRDSGFVYCVSGQVNTFNPSKASSGLIVDTLAAQFYDRLLDVDPYTYRLMPELAESWEVLDNGATYRFHLRRDVPFQKTDWFTPTRKMNADDVVFTFQRIFDRNNPWHNVNGSNFPYFDSLQFADNVKSVRKLDNHTVEFRLAQPDASFLWHLATHYASVMSAEYARKLEKEDRQEQLDRQPVGTGPYQLSEYRAGQFIRLQRHDDFWRGKPLMPQVVVDLGSGGTGRLSKLLTGECDVLAWPAASQLSILRDDPRLRLTLRPGMNVAYLAFNTAKPPLNNPAVRHALALAINNQRLMQSIYYGTAETAASILPRASWAYDNEAKITEYNPAKSREQLKSLGLENLTLKLWVPTRSQAWNPSPLKTAELIQADMAQVGVKVVIVPVEGRFQEARLMDMSHDLTLSGWATDSNDPDSFFRPLLSCAAIHSQTNLAHWCDPKFDSVLRKALSSQQLAARIEAYDEAQSILAQELPILPLASSLRLQAYRYDIKGLVLSPFGNASFAGVYREKQDEVKKP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG20254
Length:	547 (485)
Sequences:	22930 (17381)
Seq/√Len:	789.2

ECOLI - SAPA DDPA DPPA MPPA GSIB OPPA YGIS YEJA NIKA YBAE SGRR
BACSU - OPPA APPA DPPE YHJP
HALSA - Q9HMW4 Q9HMI3
SULSO - Q97VF7 Q97VK5 Q97UG7 Q97UH5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
221_S	232_Q	4.144	1.00
108_K	116_R	3.723	1.00
161_R	169_E	3.189	1.00
163_L	169_E	3.180	1.00
313_A	370_S	3.166	1.00
363_K	366_E	3.092	1.00
102_R	166_H	2.905	1.00
164_D	167_T	2.890	1.00
124_V	128_Q	2.876	1.00
473_S	477_K	2.873	1.00
325_Q	329_Q	2.834	1.00
219_Q	232_Q	2.737	1.00
481_S	486_A	2.706	1.00
124_V	162_K	2.569	1.00
320_L	363_K	2.517	1.00
323_N	326_R	2.436	1.00
366_E	370_S	2.435	1.00
86_S	99_H	2.430	1.00
307_P	310_N	2.425	1.00
35_G	246_Q	2.420	1.00
454_C	467_C	2.405	1.00
193_A	197_R	2.383	1.00
379_K	412_V	2.379	1.00
318_L	404_M	2.358	1.00
379_K	410_K	2.340	1.00
470_K	473_S	2.335	1.00
73_D	78_R	2.327	1.00
88_E	99_H	2.322	1.00
95_T	169_E	2.287	1.00
161_R	171_R	2.259	1.00
118_M	215_T	2.258	1.00
116_R	194_E	2.248	1.00
121_D	162_K	2.220	1.00
312_P	316_H	2.192	1.00
73_D	80_M	2.185	1.00
97_R	169_E	2.172	1.00
466_W	501_E	2.169	1.00
70_L	87_W	2.166	1.00
381_W	414_V	2.158	1.00
313_A	316_H	2.147	1.00
405_A	410_K	2.129	1.00
486_A	489_E	2.117	1.00
454_C	472_D	2.116	1.00
107_Q	234_H	2.114	1.00
105_P	117_K	2.114	1.00
313_A	367_Q	2.108	1.00
230_R	246_Q	2.081	1.00
95_T	171_R	2.057	1.00
306_K	431_D	2.051	1.00
477_K	490_A	2.047	1.00
105_P	236_D	2.046	1.00
90_L	94_A	2.040	1.00
121_D	193_A	1.958	1.00
67_D	82_E	1.954	1.00
483_Q	486_A	1.945	1.00
261_K	266_E	1.938	1.00
158_K	173_A	1.935	1.00
89_V	96_Y	1.924	1.00
99_H	167_T	1.916	1.00
468_D	497_I	1.916	1.00
104_V	118_M	1.909	1.00
489_E	493_E	1.896	1.00
35_G	248_V	1.890	1.00
377_T	410_K	1.882	1.00
468_D	501_E	1.882	1.00
85_E	102_R	1.881	1.00
127_F	170_F	1.820	1.00
224_R	227_Q	1.810	1.00
381_W	412_V	1.807	1.00
39_C	267_C	1.795	1.00
73_D	76_T	1.795	1.00
401_Q	405_A	1.784	1.00
222_E	230_R	1.780	1.00
219_Q	235_D	1.768	1.00
471_F	494_A	1.752	1.00
222_E	228_F	1.746	1.00
48_N	129_R	1.743	1.00
470_K	493_E	1.741	1.00
122_D	193_A	1.740	1.00
232_Q	246_Q	1.738	1.00
119_N	122_D	1.736	1.00
123_V	168_V	1.730	1.00
302_F	505_L	1.725	1.00
312_P	501_E	1.722	1.00
478_A	491_Y	1.714	1.00
474_V	493_E	1.712	1.00
424_R	429_S	1.708	1.00
321_A	407_V	1.708	1.00
470_K	497_I	1.703	1.00
37_V	248_V	1.699	1.00
339_A	509_S	1.677	1.00
85_E	99_H	1.664	1.00
496_S	500_Q	1.659	1.00
103_D	117_K	1.657	1.00
159_S	171_R	1.644	1.00
228_F	248_V	1.613	1.00
469_P	473_S	1.610	1.00
221_S	246_Q	1.608	1.00
121_D	165_N	1.602	1.00
478_A	490_A	1.601	1.00
34_S	245_P	1.579	1.00
316_H	363_K	1.577	1.00
121_D	124_V	1.574	1.00
360_N	363_K	1.573	1.00
233_R	245_P	1.565	1.00
423_A	427_D	1.564	1.00
90_L	95_T	1.555	1.00
116_R	192_S	1.554	1.00
108_K	192_S	1.548	1.00
325_Q	338_T	1.542	1.00
119_N	165_N	1.539	1.00
302_F	432_L	1.538	1.00
224_R	228_F	1.534	1.00
85_E	101_R	1.521	1.00
263_L	280_I	1.520	1.00
493_E	496_S	1.515	1.00
474_V	490_A	1.494	1.00
322_I	400_I	1.485	1.00
316_H	502_L	1.465	1.00
18_Q	21_A	1.463	1.00
70_L	98_F	1.454	1.00
305_A	465_H	1.449	1.00
453_S	476_R	1.436	1.00
120_A	162_K	1.433	1.00
394_L	398_E	1.432	1.00
490_A	493_E	1.430	1.00
97_R	167_T	1.430	1.00
279_S	282_R	1.428	1.00
481_S	490_A	1.417	1.00
288_R	518_Y	1.416	1.00
488_I	492_D	1.412	1.00
252_G	261_K	1.412	1.00
218_Y	244_M	1.406	1.00
230_R	248_V	1.406	1.00
362_A	365_R	1.387	1.00
319_A	502_L	1.377	1.00
87_W	98_F	1.376	1.00
67_D	238_W	1.369	1.00
312_P	500_Q	1.363	1.00
90_L	97_R	1.359	1.00
417_E	420_F	1.356	1.00
467_C	472_D	1.355	1.00
365_R	369_K	1.353	1.00
414_V	424_R	1.353	1.00
489_E	492_D	1.340	1.00
497_I	501_E	1.328	1.00
477_K	486_A	1.325	1.00
67_D	215_T	1.315	1.00
403_D	406_Q	1.312	1.00
105_P	234_H	1.311	1.00
286_R	518_Y	1.297	1.00
473_S	476_R	1.292	1.00
318_L	409_V	1.290	1.00
221_S	230_R	1.289	1.00
486_A	490_A	1.283	1.00
37_V	250_D	1.279	1.00
162_K	165_N	1.273	1.00
107_Q	219_Q	1.272	1.00
328_M	338_T	1.272	1.00
37_V	268_D	1.266	1.00
108_K	194_E	1.266	1.00
163_L	167_T	1.264	1.00
99_H	166_H	1.260	1.00
117_K	166_H	1.260	1.00
314_V	368_L	1.257	1.00
124_V	160_V	1.257	1.00
192_S	195_Y	1.250	1.00
474_V	497_I	1.247	1.00
477_K	481_S	1.234	1.00
54_S	57_I	1.233	1.00
170_F	179_F	1.232	1.00
158_K	171_R	1.230	1.00
174_Q	480_S	1.227	1.00
418_G	422_E	1.220	1.00
104_V	215_T	1.219	1.00
443_D	487_R	1.218	1.00
261_K	267_C	1.210	1.00
39_C	258_R	1.207	1.00
36_F	269_V	1.203	1.00
399_L	403_D	1.201	1.00
402_A	406_Q	1.199	1.00
231_L	249_V	1.184	1.00
366_E	369_K	1.184	1.00
345_R	509_S	1.182	1.00
309_L	318_L	1.182	1.00
470_K	474_V	1.180	1.00
128_Q	132_D	1.179	1.00
228_F	250_D	1.175	1.00
262_L	515_A	1.167	1.00
81_P	87_W	1.165	1.00
118_M	190_V	1.163	1.00
485_A	488_I	1.159	1.00
328_M	336_A	1.155	1.00
101_R	238_W	1.154	1.00
367_Q	370_S	1.152	1.00
326_R	403_D	1.151	1.00
101_R	104_V	1.148	1.00
361_P	365_R	1.145	1.00
33_D	245_P	1.140	1.00
107_Q	236_D	1.139	1.00
268_D	517_R	1.123	1.00
71_D	82_E	1.122	1.00
288_R	516_Y	1.122	1.00
401_Q	413_I	1.121	1.00
126_T	190_V	1.119	1.00
96_Y	179_F	1.119	1.00
314_V	371_L	1.117	1.00
10_V	13_G	1.110	1.00
301_A	433_T	1.109	1.00
404_M	411_V	1.106	1.00
17_G	20_I	1.103	1.00
83_L	215_T	1.103	1.00
291_L	511_L	1.100	1.00
428_M	465_H	1.100	1.00
466_W	471_F	1.096	1.00
71_D	80_M	1.092	1.00
497_I	500_Q	1.089	1.00
312_P	502_L	1.088	1.00
290_T	516_Y	1.087	1.00
306_K	310_N	1.082	1.00
332_Y	508_A	1.082	1.00
233_R	242_P	1.079	1.00
351_D	354_A	1.078	1.00
117_K	165_N	1.078	1.00
279_S	283_D	1.077	1.00
485_A	489_E	1.072	1.00
321_A	404_M	1.068	1.00
316_H	367_Q	1.065	1.00
309_L	380_L	1.065	1.00
219_Q	234_H	1.064	1.00
263_L	284_D	1.064	1.00
123_V	190_V	1.060	1.00
160_V	168_V	1.057	1.00
88_E	97_R	1.056	1.00
98_F	170_F	1.050	1.00
83_L	104_V	1.048	1.00
61_L	231_L	1.048	1.00
107_Q	213_V	1.048	1.00
268_D	519_D	1.045	1.00
380_L	411_V	1.042	1.00
195_Y	213_V	1.041	1.00
474_V	494_A	1.027	1.00
361_P	407_V	1.025	1.00
477_K	493_E	1.025	1.00
362_A	366_E	1.019	1.00
125_F	193_A	1.019	1.00
401_Q	411_V	1.011	1.00
474_V	477_K	1.005	1.00
402_A	405_A	1.001	1.00
337_E	511_L	0.996	1.00
351_D	496_S	0.993	1.00
351_D	492_D	0.991	1.00
476_R	480_S	0.989	1.00
99_H	102_R	0.989	1.00
382_V	411_V	0.984	1.00
85_E	166_H	0.980	1.00
179_F	183_L	0.979	1.00
400_I	404_M	0.976	1.00
319_A	324_N	0.974	1.00
363_K	367_Q	0.970	1.00
122_D	125_F	0.966	1.00
194_E	198_K	0.965	1.00
128_Q	131_F	0.965	1.00
36_F	244_M	0.964	1.00
83_L	123_V	0.963	1.00
120_A	163_L	0.961	1.00
478_A	494_A	0.958	1.00
232_Q	235_D	0.957	1.00
96_Y	180_L	0.954	1.00
267_C	270_L	0.953	1.00
281_L	287_L	0.952	1.00
329_Q	334_G	0.951	1.00
233_R	241_K	0.950	1.00
313_A	371_L	0.950	1.00
471_F	498_L	0.949	1.00
97_R	163_L	0.947	1.00
326_R	330_S	0.947	1.00
327_L	396_T	0.947	1.00
445_D	479_L	0.944	1.00
121_D	125_F	0.941	1.00
316_H	320_L	0.940	1.00
420_F	424_R	0.940	1.00
416_V	424_R	0.940	1.00
106_F	122_D	0.935	1.00
397_A	413_I	0.935	1.00
120_A	168_V	0.934	1.00
125_F	196_A	0.930	1.00
302_F	318_L	0.929	1.00
257_G	261_K	0.926	1.00
260_S	263_L	0.925	1.00
384_T	413_I	0.924	1.00
466_W	503_P	0.924	1.00
449_R	479_L	0.922	1.00
319_A	505_L	0.921	1.00
328_M	508_A	0.920	1.00
96_Y	172_L	0.915	1.00
68_R	82_E	0.914	1.00
259_L	281_L	0.912	1.00
208_L	212_P	0.911	1.00
282_R	291_L	0.908	1.00
453_S	472_D	0.907	1.00
70_L	180_L	0.905	1.00
471_F	475_L	0.904	1.00
484_L	488_I	0.904	1.00
384_T	415_P	0.902	1.00
43_Q	223_Y	0.901	1.00
395_K	398_E	0.900	1.00
36_F	520_I	0.898	1.00
84_A	98_F	0.897	1.00
65_F	231_L	0.897	1.00
361_P	406_Q	0.896	1.00
67_D	237_F	0.896	1.00
70_L	84_A	0.896	1.00
471_F	497_I	0.893	1.00
259_L	263_L	0.892	1.00
172_L	179_F	0.890	1.00
287_L	515_A	0.889	1.00
316_H	500_Q	0.887	1.00
176_D	182_H	0.883	1.00
337_E	345_R	0.883	1.00
323_N	403_D	0.883	1.00
332_Y	336_A	0.882	1.00
277_Q	280_I	0.876	1.00
90_L	93_G	0.873	1.00
102_R	117_K	0.872	1.00
99_H	164_D	0.865	1.00
494_A	497_I	0.858	1.00
107_Q	220_L	0.856	1.00
107_Q	214_G	0.853	1.00
284_D	287_L	0.849	1.00
425_L	433_T	0.848	1.00
218_Y	242_P	0.846	1.00
359_Y	406_Q	0.844	1.00
156_N	176_D	0.842	1.00
279_S	333_Y	0.842	1.00
70_L	79_L	0.840	1.00
364_S	407_V	0.840	1.00
178_S	443_D	0.838	1.00
108_K	213_V	0.837	1.00
380_L	432_L	0.835	1.00
492_D	496_S	0.831	1.00
301_A	464_A	0.831	1.00
475_L	494_A	0.829	1.00
32_R	243_L	0.828	1.00
477_K	480_S	0.828	1.00
320_L	357_T	0.827	1.00
124_V	168_V	0.824	1.00
154_A	157_V	0.823	1.00
162_K	168_V	0.821	1.00
94_A	171_R	0.821	1.00
68_R	189_S	0.820	1.00
223_Y	229_I	0.820	1.00
252_G	267_C	0.818	1.00
324_N	338_T	0.817	1.00
15_V	18_Q	0.812	1.00
128_Q	160_V	0.810	1.00
43_Q	251_L	0.809	1.00
390_N	393_P	0.802	1.00
445_D	491_Y	0.802	1.00
420_F	423_A	0.801	1.00
262_L	270_L	0.801	1.00
262_L	287_L	0.799	1.00
293_P	511_L	0.799	1.00
104_V	166_H	0.797	1.00
274_A	277_Q	0.796	1.00
64_Q	231_L	0.794	1.00
300_L	400_I	0.793	1.00
98_F	180_L	0.792	1.00
94_A	158_K	0.788	1.00
449_R	453_S	0.787	1.00
258_R	270_L	0.785	1.00
493_E	497_I	0.785	1.00
50_S	129_R	0.777	1.00
94_A	174_Q	0.772	1.00
320_L	367_Q	0.771	1.00
233_R	244_M	0.771	1.00
65_F	220_L	0.769	1.00
445_D	449_R	0.769	1.00
383_P	424_R	0.769	1.00
122_D	126_T	0.769	1.00
296_N	438_A	0.769	1.00
323_N	359_Y	0.769	1.00
83_L	118_M	0.768	1.00
260_S	264_T	0.766	1.00
49_P	191_M	0.766	1.00
320_L	359_Y	0.766	1.00
342_I	506_P	0.766	1.00
156_N	174_Q	0.763	1.00
89_V	93_G	0.762	1.00
311_N	371_L	0.760	1.00
14_L	17_G	0.760	1.00
367_Q	371_L	0.760	1.00
373_L	376_L	0.760	1.00
373_L	377_T	0.757	1.00
452_L	504_I	0.755	1.00
38_Y	269_V	0.754	1.00
311_N	373_L	0.753	1.00
347_S	350_Y	0.750	1.00
34_S	244_M	0.750	1.00
31_I	34_S	0.750	1.00
462_N	465_H	0.748	1.00
66_Y	214_G	0.748	1.00
126_T	191_M	0.747	1.00
281_L	515_A	0.742	1.00
286_R	517_R	0.742	1.00
321_A	361_P	0.741	1.00
394_L	415_P	0.740	1.00
469_P	472_D	0.738	1.00
453_S	475_L	0.736	1.00
453_S	467_C	0.733	1.00
383_P	416_V	0.733	1.00
318_L	432_L	0.732	1.00
304_T	503_P	0.732	1.00
368_L	373_L	0.732	1.00
305_A	428_M	0.729	1.00
278_L	282_R	0.728	1.00
11_I	14_L	0.728	1.00
291_L	513_L	0.728	1.00
235_D	245_P	0.727	1.00
317_A	368_L	0.727	1.00
231_L	247_V	0.726	1.00
322_I	404_M	0.722	1.00
220_L	229_I	0.722	1.00
398_E	413_I	0.722	1.00
405_A	409_V	0.720	1.00
322_I	327_L	0.718	1.00
157_V	160_V	0.717	1.00
314_V	373_L	0.717	1.00
61_L	229_I	0.717	1.00
452_L	498_L	0.716	1.00
341_S	495_Q	0.714	1.00
404_M	432_L	0.713	1.00
194_E	197_R	0.713	1.00
104_V	238_W	0.712	1.00
300_L	432_L	0.712	1.00
13_G	16_S	0.708	1.00
9_L	12_A	0.706	1.00
74_P	524_V	0.706	1.00
100_L	118_M	0.705	1.00
291_L	335_T	0.704	1.00
466_W	497_I	0.704	1.00
302_F	309_L	0.703	1.00
405_A	411_V	0.703	1.00
120_A	124_V	0.702	1.00
398_E	401_Q	0.702	1.00
82_E	238_W	0.702	1.00
270_L	273_P	0.702	1.00
92_N	95_T	0.701	1.00
98_F	183_L	0.698	1.00
320_L	358_E	0.698	1.00
87_W	180_L	0.697	1.00
232_Q	245_P	0.694	1.00
36_F	247_V	0.691	1.00
12_A	15_V	0.690	1.00
487_R	491_Y	0.687	1.00
132_D	135_N	0.687	1.00
162_K	169_E	0.685	1.00
39_C	252_G	0.684	1.00
50_S	130_I	0.683	1.00
327_L	399_L	0.681	1.00
91_D	95_T	0.681	1.00
318_L	505_L	0.681	1.00
88_E	91_D	0.681	1.00
368_L	371_L	0.680	1.00
10_V	14_L	0.680	1.00
404_M	407_V	0.679	1.00
239_R	242_P	0.679	1.00
30_D	243_L	0.678	1.00
398_E	402_A	0.677	1.00
389_W	394_L	0.677	1.00
381_W	431_D	0.676	1.00
66_Y	212_P	0.675	1.00
64_Q	247_V	0.674	1.00
250_D	261_K	0.673	1.00
374_E	377_T	0.670	1.00
369_K	374_E	0.669	1.00
52_A	62_A	0.668	1.00
192_S	213_V	0.668	1.00
65_F	214_G	0.668	1.00
125_F	197_R	0.667	1.00
378_L	409_V	0.665	1.00
348_W	484_L	0.664	1.00
416_V	420_F	0.663	1.00
52_A	57_I	0.662	1.00
177_A	487_R	0.660	1.00
89_V	180_L	0.660	1.00
219_Q	236_D	0.659	1.00
69_L	84_A	0.659	1.00
269_V	520_I	0.659	1.00
368_L	372_G	0.658	1.00
421_Q	433_T	0.657	1.00
220_L	223_Y	0.657	1.00
131_F	173_A	0.657	1.00
368_L	407_V	0.657	1.00
160_V	170_F	0.656	1.00
321_A	359_Y	0.656	1.00
298_A	393_P	0.652	1.00
373_L	378_L	0.651	1.00
72_V	184_A	0.651	1.00
254_G	257_G	0.650	1.00
106_F	118_M	0.650	1.00
94_A	175_P	0.648	1.00
252_G	258_R	0.647	1.00
45_N	54_S	0.645	1.00
373_L	409_V	0.643	1.00
106_F	190_V	0.643	1.00
503_P	506_P	0.643	1.00
119_N	166_H	0.642	1.00
306_K	429_S	0.642	1.00
103_D	166_H	0.638	1.00
349_A	488_I	0.637	1.00
72_V	79_L	0.637	1.00
369_K	373_L	0.637	1.00
43_Q	225_A	0.635	1.00
472_D	476_R	0.635	1.00
156_N	173_A	0.635	1.00
229_I	251_L	0.633	1.00
384_T	397_A	0.632	1.00
490_A	494_A	0.631	1.00
327_L	400_I	0.630	1.00
476_R	479_L	0.629	1.00
484_L	487_R	0.629	1.00
58_V	186_H	0.629	1.00
118_M	166_H	0.629	1.00
127_F	183_L	0.626	1.00
309_L	314_V	0.625	1.00
517_R	520_I	0.625	1.00
391_P	395_K	0.625	1.00
262_L	517_R	0.624	1.00
227_Q	250_D	0.623	1.00
34_S	243_L	0.622	1.00
11_I	15_V	0.622	1.00
106_F	194_E	0.622	1.00
207_Q	210_R	0.622	1.00
304_T	464_A	0.621	1.00
285_P	518_Y	0.621	1.00
382_V	397_A	0.619	1.00
106_F	214_G	0.618	1.00
128_Q	159_S	0.618	1.00
98_F	168_V	0.616	1.00
124_V	161_R	0.615	1.00
311_N	314_V	0.615	1.00
120_A	166_H	0.614	1.00
325_Q	328_M	0.614	1.00
400_I	411_V	0.612	1.00
378_L	382_V	0.611	1.00
365_R	407_V	0.611	1.00
174_Q	476_R	0.609	1.00
284_D	518_Y	0.608	1.00
125_F	129_R	0.607	1.00
318_L	380_L	0.607	1.00
404_M	409_V	0.607	1.00
95_T	161_R	0.606	1.00
100_L	166_H	0.605	1.00
116_R	122_D	0.605	1.00
66_Y	215_T	0.605	1.00
233_R	240_G	0.604	1.00
244_M	520_I	0.604	1.00
306_K	309_L	0.604	1.00
133_R	136_P	0.603	1.00
383_P	414_V	0.603	1.00
311_N	372_G	0.603	1.00
297_V	339_A	0.603	1.00
65_F	212_P	0.603	1.00
240_G	243_L	0.602	1.00
298_A	396_T	0.602	1.00
288_R	521_K	0.602	1.00
382_V	434_L	0.601	1.00
396_T	400_I	0.600	1.00
416_V	421_Q	0.600	1.00
516_Y	523_L	0.600	1.00
218_Y	233_R	0.598	1.00
7_S	13_G	0.597	1.00
100_L	104_V	0.596	1.00
335_T	513_L	0.592	1.00
453_S	458_H	0.592	1.00
259_L	277_Q	0.591	1.00
8_L	11_I	0.591	1.00
305_A	310_N	0.590	1.00
319_A	357_T	0.589	1.00
356_I	499_A	0.588	1.00
391_P	394_L	0.587	1.00
299_Y	504_I	0.587	1.00
79_L	180_L	0.586	1.00
471_F	474_V	0.584	1.00
368_L	409_V	0.584	1.00
351_D	495_Q	0.583	1.00
377_T	412_V	0.581	1.00
33_D	243_L	0.580	1.00
7_S	10_V	0.579	1.00
353_E	492_D	0.579	1.00
106_F	215_T	0.579	1.00
153_F	157_V	0.577	1.00
9_L	13_G	0.577	1.00
119_N	193_A	0.575	1.00
448_F	494_A	0.575	1.00
87_W	99_H	0.575	1.00
125_F	194_E	0.574	1.00
255_G	258_R	0.573	1.00
304_T	310_N	0.571	1.00
262_L	267_C	0.571	1.00
68_R	215_T	0.570	1.00
30_D	34_S	0.569	1.00
359_Y	403_D	0.568	1.00
128_Q	193_A	0.568	1.00
69_L	123_V	0.568	1.00
118_M	126_T	0.568	1.00
120_A	164_D	0.567	1.00
8_L	12_A	0.566	1.00
322_I	505_L	0.566	1.00
361_P	368_L	0.565	1.00
502_L	505_L	0.565	1.00
40_V	249_V	0.564	1.00
396_T	508_A	0.564	1.00
218_Y	246_Q	0.563	1.00
67_D	239_R	0.563	1.00
234_H	237_F	0.563	1.00
205_Q	208_L	0.562	1.00
37_V	267_C	0.562	1.00
108_K	195_Y	0.560	1.00
208_L	211_Q	0.560	1.00
320_L	364_S	0.559	1.00
273_P	515_A	0.559	1.00
30_D	33_D	0.558	1.00
381_W	384_T	0.557	1.00
235_D	241_K	0.556	1.00
35_G	230_R	0.555	1.00
378_L	384_T	0.555	1.00
322_I	507_L	0.553	1.00
71_D	239_R	0.552	1.00
353_E	496_S	0.552	1.00
482_Q	486_A	0.551	1.00
269_V	516_Y	0.551	1.00
191_M	196_A	0.550	1.00
328_M	332_Y	0.550	1.00
220_L	231_L	0.550	1.00
128_Q	162_K	0.548	1.00
360_N	366_E	0.548	1.00
441_S	446_S	0.544	1.00
355_K	358_E	0.544	1.00
481_S	487_R	0.544	1.00
81_P	86_S	0.544	1.00
478_A	487_R	0.543	1.00
250_D	266_E	0.543	1.00
212_P	220_L	0.541	1.00
210_R	225_A	0.541	1.00
474_V	478_A	0.541	1.00
300_L	507_L	0.540	1.00
320_L	360_N	0.539	1.00
116_R	193_A	0.539	1.00
278_L	289_L	0.539	1.00
47_F	229_I	0.537	1.00
325_Q	358_E	0.537	1.00
422_E	426_M	0.536	1.00
302_F	319_A	0.536	1.00
47_F	223_Y	0.536	1.00
350_Y	354_A	0.536	1.00
157_V	170_F	0.535	1.00
29_A	32_R	0.535	1.00
64_Q	249_V	0.534	1.00
462_N	466_W	0.533	1.00
107_Q	215_T	0.533	1.00
383_P	430_H	0.532	1.00
380_L	384_T	0.532	1.00
299_Y	435_S	0.532	1.00
282_R	335_T	0.532	1.00
454_C	458_H	0.531	1.00
261_K	264_T	0.531	1.00
129_R	196_A	0.530	1.00
403_D	407_V	0.530	1.00
418_G	435_S	0.529	1.00
17_G	21_A	0.528	1.00
411_V	432_L	0.527	1.00
265_G	517_R	0.527	1.00
85_E	100_L	0.527	1.00
421_Q	425_L	0.526	1.00
468_D	471_F	0.525	1.00
397_A	434_L	0.525	1.00
128_Q	156_N	0.524	1.00
500_Q	503_P	0.522	1.00
152_Q	155_D	0.522	1.00
495_Q	499_A	0.522	1.00
372_G	375_N	0.522	1.00
423_A	426_M	0.521	1.00
93_G	482_Q	0.520	1.00
481_S	484_L	0.520	1.00
514_Q	523_L	0.520	1.00
314_V	318_L	0.520	1.00
335_T	511_L	0.519	1.00
155_D	158_K	0.519	1.00
100_L	120_A	0.517	1.00
66_Y	208_L	0.517	1.00
16_S	19_A	0.517	1.00
308_P	431_D	0.516	1.00
256_T	277_Q	0.516	1.00
125_F	191_M	0.515	1.00
335_T	338_T	0.515	1.00
106_F	119_N	0.514	1.00
327_L	507_L	0.513	1.00
326_R	399_L	0.513	1.00
331_I	399_L	0.513	1.00
100_L	123_V	0.512	1.00
375_N	378_L	0.512	1.00
309_L	432_L	0.511	1.00
33_D	246_Q	0.511	1.00
273_P	281_L	0.511	1.00
494_A	498_L	0.510	1.00
76_T	80_M	0.510	1.00
62_A	66_Y	0.509	1.00
106_F	116_R	0.508	1.00
256_T	260_S	0.506	1.00
300_L	505_L	0.506	1.00
434_L	507_L	0.506	1.00
70_L	184_A	0.505	1.00
422_E	425_L	0.505	1.00
363_K	370_S	0.503	1.00
470_K	500_Q	0.503	1.00
293_P	337_E	0.502	1.00
316_H	357_T	0.502	1.00
120_A	165_N	0.502	1.00
308_P	373_L	0.502	1.00
46_T	209_D	0.501	1.00
120_A	167_T	0.501	1.00
278_L	513_L	0.501	1.00
118_M	123_V	0.501	1.00
449_R	476_R	0.501	1.00
117_K	122_D	0.501	1.00
118_M	122_D	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4qflA	1	0.9232	100	0.113	Contact Map
3m8uA	1	0.9104	100	0.159	Contact Map
1dpeA	1	0.9086	100	0.161	Contact Map
1xocA	2	0.8885	100	0.162	Contact Map
4fajA	1	0.8848	100	0.166	Contact Map
3tpaA	1	0.9086	100	0.166	Contact Map
3zs6A	1	0.8995	100	0.166	Contact Map
4tozA	1	0.9196	100	0.17	Contact Map
4gl8A	1	0.8903	100	0.172	Contact Map
4wedA	1	0.8501	100	0.173	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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