GREMLIN Database
TAUA - Taurine-binding periplasmic protein
UniProt: Q47537 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13300
Length: 320 (290)
Sequences: 13586 (10205)
Seq/√Len: 599.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
94_E211_K3.3941.00
238_N241_V3.3091.00
124_R152_E3.2771.00
234_P238_N3.2331.00
213_F217_H3.1911.00
49_S226_K3.1481.00
211_K215_E3.1271.00
92_P211_K3.0101.00
48_E230_D2.9791.00
309_D312_Q2.9531.00
121_I150_Q2.9341.00
24_N54_D2.8491.00
49_S230_D2.8461.00
212_D216_K2.8401.00
222_K226_K2.8101.00
126_A170_I2.6721.00
26_T54_D2.6301.00
45_F228_A2.5851.00
291_I295_Q2.4881.00
24_N52_T2.4821.00
240_D264_P2.4331.00
116_K119_D2.4261.00
233_Q237_A2.3621.00
217_H220_V2.3141.00
177_A181_N2.2941.00
250_S260_E2.2501.00
295_Q299_E2.2051.00
209_V214_A2.1521.00
28_A73_V2.1101.00
44_T230_D2.0891.00
147_K150_Q2.0731.00
115_S119_D2.0591.00
298_K306_V2.0591.00
260_E264_P2.0411.00
75_I209_V1.9751.00
123_K171_D1.9691.00
142_K299_E1.9101.00
42_D241_V1.8881.00
44_T234_P1.8621.00
134_H138_L1.8331.00
156_L164_A1.8021.00
44_T227_S1.8011.00
192_D195_Q1.7811.00
264_P268_K1.7641.00
209_V221_V1.7531.00
41_A254_R1.7471.00
259_P262_D1.7151.00
118_E144_W1.7061.00
229_I233_Q1.7041.00
219_E223_A1.6981.00
146_I150_Q1.6331.00
213_F221_V1.6291.00
214_A221_V1.6211.00
87_A211_K1.6201.00
42_D234_P1.6051.00
182_A186_D1.5721.00
115_S188_K1.5721.00
22_A52_T1.5581.00
141_L146_I1.5251.00
235_Y242_W1.5141.00
124_R154_V1.5141.00
213_F220_V1.5091.00
223_A227_S1.5091.00
75_I224_F1.5041.00
44_T48_E1.5001.00
97_L225_A1.4921.00
75_I221_V1.4871.00
287_N291_I1.4811.00
118_E121_I1.4771.00
234_P241_V1.4761.00
218_P222_K1.4641.00
243_L264_P1.4551.00
78_L208_V1.4541.00
120_L172_G1.4381.00
95_V206_V1.4271.00
241_V250_S1.3891.00
125_I172_G1.3831.00
295_Q306_V1.3491.00
63_S66_R1.3391.00
141_L151_V1.3291.00
49_S223_A1.3291.00
117_P140_A1.3181.00
39_A45_F1.3171.00
58_F67_A1.3141.00
288_K292_D1.3121.00
13_L16_I1.3081.00
117_P144_W1.3031.00
219_E222_K1.2981.00
39_A231_A1.2971.00
124_R171_D1.2871.00
253_A260_E1.2741.00
261_G264_P1.2721.00
26_T56_R1.2681.00
94_E214_A1.2621.00
239_P243_L1.2591.00
287_N311_S1.2511.00
64_I76_G1.2491.00
296_F300_Q1.2371.00
185_K265_G1.2341.00
250_S254_R1.2311.00
265_G268_K1.2291.00
184_E265_G1.2251.00
35_P232_Q1.2251.00
6_R9_L1.2251.00
71_G212_D1.2231.00
161_I173_A1.2181.00
67_A72_D1.2131.00
210_R213_F1.2061.00
170_I173_A1.1921.00
238_N242_W1.1851.00
43_N46_A1.1751.00
26_T74_Q1.1691.00
13_L17_A1.1691.00
111_K168_G1.1481.00
38_V234_P1.1451.00
49_S227_S1.1341.00
68_L76_G1.1341.00
45_F53_V1.1331.00
127_V153_I1.1271.00
250_S253_A1.1271.00
107_A180_V1.1131.00
166_Q186_D1.1101.00
38_V42_D1.1091.00
294_A306_V1.1051.00
114_I119_D1.0951.00
139_A142_K1.0681.00
239_P268_K1.0591.00
96_F225_A1.0461.00
137_L153_I1.0401.00
112_K188_K1.0391.00
157_Q160_A1.0381.00
44_T49_S1.0311.00
96_F209_V1.0261.00
111_K165_W1.0241.00
185_K261_G1.0151.00
139_A143_H1.0151.00
69_A91_V1.0141.00
163_A166_Q1.0081.00
164_A170_I1.0031.00
20_A23_V1.0021.00
51_A223_A1.0021.00
75_I96_F1.0001.00
114_I123_K0.9991.00
13_L18_F0.9961.00
96_F221_V0.9891.00
162_I166_Q0.9891.00
38_V251_K0.9871.00
61_G82_P0.9791.00
83_L208_V0.9771.00
220_V223_A0.9771.00
10_L13_L0.9721.00
28_A58_F0.9641.00
288_K291_I0.9551.00
233_Q236_I0.9521.00
107_A189_V0.9431.00
40_Q46_A0.9341.00
239_P242_W0.9291.00
121_I146_I0.9271.00
165_W170_I0.9251.00
110_V190_L0.9221.00
5_S8_T0.9171.00
26_T73_V0.9151.00
243_L260_E0.9131.00
212_D215_E0.9101.00
18_F21_Q0.9061.00
44_T231_A0.9061.00
286_V289_A0.9051.00
88_S304_P0.9041.00
209_V213_F0.9021.00
178_P181_N0.8981.00
298_K305_A0.8971.00
125_I151_V0.8951.00
240_D243_L0.8941.00
9_L12_A0.8901.00
163_A167_R0.8851.00
295_Q298_K0.8841.00
38_V231_A0.8761.00
261_G265_G0.8721.00
140_A144_W0.8711.00
294_A298_K0.8711.00
292_D295_Q0.8711.00
109_V180_V0.8681.00
227_S230_D0.8671.00
110_V189_V0.8571.00
213_F218_P0.8561.00
240_D250_S0.8551.00
207_W224_F0.8531.00
7_N10_L0.8521.00
67_A73_V0.8511.00
232_Q236_I0.8481.00
185_K262_D0.8421.00
68_L208_V0.8401.00
25_V213_F0.8391.00
45_F227_S0.8381.00
41_A251_K0.8321.00
108_L174_Y0.8321.00
84_A294_A0.8281.00
60_S63_S0.8241.00
75_I220_V0.8231.00
79_G82_P0.8231.00
110_V188_K0.8221.00
50_G223_A0.8221.00
39_A44_T0.8181.00
182_A185_K0.8151.00
38_V235_Y0.8151.00
74_Q210_R0.8121.00
71_G210_R0.8121.00
110_V172_G0.8121.00
23_V217_H0.8111.00
108_L172_G0.8081.00
160_A163_A0.8071.00
51_A220_V0.8071.00
285_P288_K0.8041.00
87_A313_Y0.8001.00
113_T188_K0.7981.00
234_P242_W0.7951.00
27_V53_V0.7951.00
291_I310_Y0.7951.00
129_F155_N0.7941.00
33_A37_K0.7861.00
189_V192_D0.7841.00
184_E189_V0.7831.00
223_A226_K0.7821.00
228_A232_Q0.7781.00
13_L19_Q0.7771.00
137_L141_L0.7711.00
107_A110_V0.7711.00
177_A180_V0.7701.00
78_L83_L0.7671.00
141_L144_W0.7651.00
137_L174_Y0.7641.00
94_E215_E0.7641.00
306_V309_D0.7611.00
126_A161_I0.7601.00
130_I134_H0.7581.00
112_K187_G0.7551.00
6_R10_L0.7551.00
65_V86_A0.7511.00
41_A255_L0.7471.00
138_L148_P0.7421.00
234_P237_A0.7371.00
231_A235_Y0.7371.00
211_K214_A0.7311.00
31_T57_K0.7311.00
221_V225_A0.7311.00
165_W173_A0.7271.00
268_K271_T0.7261.00
254_R257_G0.7231.00
273_L276_Q0.7201.00
89_Q304_P0.7171.00
142_K300_Q0.7151.00
92_P212_D0.7151.00
207_W228_A0.7091.00
226_K230_D0.7061.00
23_V220_V0.7031.00
27_V224_F0.7031.00
42_D251_K0.7011.00
227_S231_A0.6991.00
80_S290_I0.6971.00
37_K41_A0.6961.00
134_H153_I0.6961.00
224_F228_A0.6931.00
38_V242_W0.6921.00
291_I294_A0.6911.00
140_A196_V0.6911.00
214_A218_P0.6891.00
16_I19_Q0.6881.00
46_A49_S0.6881.00
236_I239_P0.6871.00
294_A310_Y0.6861.00
133_T176_W0.6851.00
284_G287_N0.6821.00
129_F134_H0.6801.00
215_E218_P0.6801.00
298_K303_V0.6791.00
139_A292_D0.6781.00
51_A224_F0.6781.00
40_Q55_W0.6771.00
258_V263_V0.6751.00
68_L73_V0.6751.00
34_E252_L0.6721.00
83_L95_V0.6671.00
51_A227_S0.6641.00
164_A169_D0.6631.00
138_L153_I0.6591.00
12_A18_F0.6581.00
80_S206_V0.6501.00
8_T11_A0.6491.00
135_Y296_F0.6491.00
175_V179_A0.6471.00
285_P290_I0.6471.00
14_A17_A0.6461.00
109_V175_V0.6421.00
17_A20_A0.6401.00
75_I213_F0.6371.00
110_V113_T0.6361.00
87_A312_Q0.6351.00
209_V224_F0.6341.00
213_F216_K0.6311.00
86_A93_I0.6301.00
65_V208_V0.6301.00
121_I147_K0.6271.00
125_I137_L0.6251.00
283_T286_V0.6231.00
74_Q213_F0.6231.00
234_P251_K0.6181.00
13_L20_A0.6181.00
262_D266_L0.6161.00
217_H221_V0.6141.00
39_A227_S0.6141.00
76_G208_V0.6141.00
126_A156_L0.6131.00
291_I311_S0.6121.00
266_L270_N0.6111.00
15_F18_F0.6081.00
16_I20_A0.6081.00
229_I232_Q0.6051.00
7_N11_A0.6021.00
138_L142_K0.6011.00
193_S197_G0.6011.00
114_I117_P0.6001.00
108_L120_L0.6001.00
104_N194_E0.5991.00
68_L210_R0.5981.00
298_K301_G0.5961.00
40_Q255_L0.5951.00
36_A228_A0.5941.00
292_D296_F0.5911.00
5_S9_L0.5911.00
230_D233_Q0.5901.00
92_P210_R0.5881.00
21_Q217_H0.5881.00
284_G288_K0.5871.00
218_P221_V0.5871.00
7_N13_L0.5861.00
52_T55_W0.5851.00
35_P231_A0.5811.00
301_G304_P0.5771.00
45_F51_A0.5771.00
123_K172_G0.5771.00
17_A21_Q0.5721.00
110_V114_I0.5711.00
191_T195_Q0.5711.00
122_G150_Q0.5711.00
85_V89_Q0.5711.00
12_A15_F0.5701.00
74_Q217_H0.5701.00
56_R67_A0.5681.00
95_V98_L0.5671.00
27_V75_I0.5671.00
37_K40_Q0.5671.00
181_N269_G0.5651.00
39_A42_D0.5641.00
95_V290_I0.5621.00
238_N243_L0.5611.00
269_G272_Y0.5601.00
181_N185_K0.5601.00
65_V78_L0.5591.00
188_K191_T0.5581.00
265_G269_G0.5571.00
181_N184_E0.5571.00
253_A263_V0.5560.99
106_E110_V0.5560.99
294_A303_V0.5550.99
168_G171_D0.5550.99
99_A207_W0.5550.99
138_L300_Q0.5540.99
19_Q23_V0.5520.99
66_R70_S0.5510.99
184_E269_G0.5500.99
118_E146_I0.5490.99
289_A292_D0.5490.99
97_L207_W0.5490.99
35_P235_Y0.5470.99
31_T37_K0.5460.99
133_T174_Y0.5440.99
243_L267_V0.5430.99
124_R169_D0.5400.99
98_L101_K0.5400.99
12_A17_A0.5390.99
126_A154_V0.5390.99
124_R170_I0.5380.99
222_K225_A0.5380.99
293_T297_L0.5370.99
263_V266_L0.5350.99
162_I165_W0.5350.99
102_L201_A0.5340.99
85_V88_S0.5340.99
190_L193_S0.5320.99
29_Y57_K0.5320.99
86_A91_V0.5310.99
79_G131_S0.5300.99
116_K144_W0.5290.99
95_V285_P0.5290.99
11_A14_A0.5260.99
251_K255_L0.5260.99
241_V251_K0.5260.99
193_S196_V0.5250.99
15_F19_Q0.5250.99
158_P161_I0.5230.99
46_A52_T0.5220.99
67_A70_S0.5210.99
142_K148_P0.5210.99
105_S110_V0.5210.99
262_D265_G0.5200.99
25_V75_I0.5200.99
58_F64_I0.5200.99
73_V76_G0.5200.99
106_E132_T0.5190.99
181_N265_G0.5190.99
225_A229_I0.5180.99
173_A183_L0.5180.99
35_P38_V0.5160.99
34_E37_K0.5160.99
19_Q22_A0.5160.99
161_I164_A0.5150.99
23_V51_A0.5140.99
121_I141_L0.5130.99
240_D268_K0.5130.99
77_N99_A0.5120.99
80_S293_T0.5110.99
269_G273_L0.5110.99
148_P153_I0.5100.99
131_S134_H0.5090.99
177_A269_G0.5090.99
270_N273_L0.5070.99
271_T274_T0.5070.99
127_V155_N0.5070.99
207_W225_A0.5060.99
34_E38_V0.5030.99
88_S303_V0.5020.99
138_L149_G0.5020.99
107_A111_K0.5010.99
142_K147_K0.5010.99
139_A296_F0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2g29A 1 0.9062 100 0.329 Contact Map
4nmyA 1 0.9 100 0.334 Contact Map
3qslA 1 0.925 100 0.344 Contact Map
2x26A 1 0.8844 100 0.357 Contact Map
3ix1A 2 0.9 100 0.362 Contact Map
2de3A 1 0.8844 100 0.362 Contact Map
2i49A 1 0.9062 100 0.368 Contact Map
3un6A 1 0.8656 100 0.373 Contact Map
2x7qA 1 0.8719 100 0.379 Contact Map
4eswA 2 0.9 100 0.407 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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