GREMLIN Database
YAIP - Uncharacterized protein YaiP
UniProt: Q47536 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13298
Length: 398 (341)
Sequences: 11171 (8435)
Seq/√Len: 456.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
42_G71_N5.1531.00
56_P130_G4.7751.00
195_T199_R4.3651.00
33_D110_C3.7271.00
114_F192_M3.2841.00
33_D60_R3.1911.00
71_N74_A3.0891.00
65_N91_T3.0581.00
112_Q133_L2.9211.00
60_R88_V2.8821.00
197_V223_Y2.8681.00
64_V104_G2.8511.00
46_A78_E2.8021.00
112_Q136_I2.5811.00
342_V346_L2.5691.00
65_N68_S2.5601.00
60_R110_C2.5431.00
35_I64_V2.5391.00
73_E77_A2.5231.00
32_I133_L2.5171.00
240_S243_E2.4991.00
200_K221_N2.4091.00
31_C111_D2.3981.00
155_G158_P2.3961.00
140_A226_R2.3541.00
131_Y230_R2.3361.00
46_A50_D2.2981.00
74_A78_E2.2901.00
135_E228_A2.2311.00
32_I129_M2.1871.00
141_D223_Y2.1771.00
33_D108_A2.1541.00
112_Q192_M2.1221.00
136_I192_M2.1181.00
31_C109_T2.0961.00
125_D131_Y2.0911.00
76_M89_A2.0761.00
33_D62_I2.0481.00
31_C110_C2.0241.00
132_M192_M1.9861.00
213_D217_T1.9761.00
36_I52_L1.9381.00
282_V285_G1.9341.00
139_G224_R1.8851.00
56_P125_D1.8551.00
51_N122_V1.8551.00
114_F129_M1.8091.00
325_S328_F1.8081.00
196_D200_K1.8051.00
200_K223_Y1.7991.00
186_I191_G1.7971.00
40_N68_S1.7951.00
63_C76_M1.7691.00
281_V285_G1.7091.00
50_D79_V1.6981.00
46_A75_V1.6671.00
105_L113_V1.6481.00
197_V218_L1.6281.00
49_L79_V1.6271.00
271_G274_S1.6191.00
356_G359_A1.6051.00
97_K101_L1.6011.00
41_E118_A1.5981.00
57_Y133_L1.5781.00
336_P339_P1.5351.00
271_G275_I1.5231.00
108_A195_T1.5041.00
126_Q190_C1.5041.00
64_V100_A1.5031.00
142_A225_I1.4911.00
247_R251_W1.4861.00
137_E224_R1.4781.00
355_Y359_A1.4671.00
50_D82_K1.4521.00
60_R109_T1.4411.00
131_Y134_A1.4401.00
278_M281_V1.4201.00
30_G57_Y1.4091.00
73_E91_T1.4071.00
38_A72_T1.4001.00
313_I317_V1.3921.00
292_T295_N1.3901.00
209_V254_G1.3871.00
30_G133_L1.3801.00
339_P342_V1.3711.00
164_V248_W1.3661.00
104_G108_A1.3571.00
76_M80_K1.3401.00
285_G289_Y1.3271.00
147_P189_A1.3271.00
77_A91_T1.3221.00
112_Q194_R1.3161.00
71_N75_V1.3151.00
74_A77_A1.3111.00
78_E82_K1.2881.00
29_K58_F1.2831.00
113_V195_T1.2771.00
322_G326_A1.2761.00
122_V126_Q1.2681.00
31_C60_R1.2601.00
302_P307_L1.2601.00
344_Y348_A1.2581.00
120_T233_V1.2521.00
55_N129_M1.2491.00
321_I325_S1.2291.00
247_R250_R1.2281.00
271_G277_P1.2251.00
277_P281_V1.2231.00
51_N121_Y1.2181.00
141_D194_R1.2141.00
75_V79_V1.2121.00
54_R124_P1.2111.00
116_S122_V1.2071.00
90_V107_Y1.2061.00
274_S277_P1.2001.00
111_D196_D1.1991.00
142_A218_L1.1961.00
248_W251_W1.1901.00
40_N69_T1.1861.00
113_V198_L1.1791.00
65_N73_E1.1691.00
324_F328_F1.1661.00
110_C195_T1.1661.00
103_N107_Y1.1561.00
258_C262_H1.1561.00
314_W318_V1.1541.00
281_V284_Y1.1421.00
39_Y94_N1.1411.00
56_P124_P1.1361.00
60_R108_A1.1241.00
161_R165_K1.1221.00
321_I326_A1.1221.00
244_E248_W1.1131.00
77_A80_K1.1091.00
101_L115_L1.1091.00
342_V345_V1.1061.00
34_A114_F1.1061.00
59_C129_M1.1021.00
77_A81_R1.1011.00
173_R176_Q1.0931.00
321_I324_F1.0911.00
76_M79_V1.0901.00
50_D54_R1.0831.00
348_A351_I1.0751.00
52_L61_V1.0751.00
346_L349_Y1.0701.00
35_I104_G1.0631.00
277_P285_G1.0631.00
353_I356_G1.0621.00
282_V286_V1.0621.00
33_D195_T1.0601.00
324_F327_W1.0561.00
315_V319_C1.0431.00
62_I88_V1.0391.00
341_S345_V1.0371.00
316_G321_I1.0331.00
309_M317_V1.0311.00
47_Q50_D1.0241.00
143_V228_A1.0221.00
103_N106_N1.0201.00
317_V321_I1.0201.00
135_E226_R1.0201.00
270_F274_S1.0121.00
272_I275_I1.0051.00
45_L63_C1.0051.00
62_I108_A0.9991.00
345_V349_Y0.9991.00
285_G288_I0.9981.00
314_W317_V0.9981.00
291_T295_N0.9971.00
343_V346_L0.9971.00
149_T237_E0.9951.00
26_S29_K0.9921.00
79_V82_K0.9751.00
311_P315_V0.9741.00
52_L122_V0.9731.00
345_V348_A0.9671.00
279_L285_G0.9651.00
278_M282_V0.9641.00
280_L284_Y0.9611.00
279_L282_V0.9581.00
244_E247_R0.9581.00
338_A342_V0.9561.00
275_I278_M0.9521.00
142_A186_I0.9511.00
120_T235_P0.9491.00
62_I104_G0.9481.00
194_R223_Y0.9481.00
123_P234_Y0.9461.00
97_K188_G0.9421.00
271_G278_M0.9361.00
313_I316_G0.9311.00
48_S52_L0.9251.00
141_D218_L0.9251.00
66_D96_G0.9251.00
29_K130_G0.9221.00
317_V324_F0.9211.00
278_M285_G0.9161.00
68_S72_T0.9011.00
101_L203_F0.8961.00
333_L341_S0.8921.00
38_A45_L0.8911.00
337_L340_L0.8901.00
342_V349_Y0.8901.00
88_V107_Y0.8881.00
272_I276_F0.8881.00
102_M106_N0.8871.00
341_S346_L0.8841.00
355_Y358_I0.8831.00
340_L345_V0.8831.00
201_F218_L0.8811.00
66_D94_N0.8751.00
274_S278_M0.8721.00
275_I285_G0.8721.00
235_P238_C0.8691.00
48_S53_L0.8681.00
341_S348_A0.8671.00
75_V78_E0.8651.00
93_K96_G0.8641.00
218_L223_Y0.8631.00
161_R164_V0.8621.00
45_L76_M0.8621.00
318_V322_G0.8591.00
280_L285_G0.8581.00
317_V320_V0.8581.00
337_L346_L0.8551.00
34_A129_M0.8491.00
333_L337_L0.8441.00
34_A59_C0.8441.00
45_L72_T0.8441.00
290_L293_W0.8431.00
125_D130_G0.8401.00
132_M145_G0.8381.00
341_S344_Y0.8361.00
274_S281_V0.8361.00
329_H332_W0.8351.00
322_G325_S0.8311.00
90_V103_N0.8311.00
105_L198_L0.8251.00
337_L344_Y0.8221.00
144_G147_P0.8221.00
277_P280_L0.8171.00
40_N70_D0.8131.00
275_I281_V0.8111.00
275_I279_L0.8101.00
196_D199_R0.8051.00
311_P314_W0.8031.00
333_L336_P0.8021.00
194_R197_V0.8011.00
277_P282_V0.7971.00
315_V318_V0.7971.00
309_M313_I0.7961.00
157_L161_R0.7951.00
42_G75_V0.7911.00
38_A63_C0.7891.00
292_T296_E0.7881.00
156_L159_H0.7881.00
321_I328_F0.7861.00
73_E89_A0.7861.00
159_H162_A0.7831.00
322_G327_W0.7821.00
254_G257_V0.7781.00
66_D119_D0.7771.00
318_V321_I0.7761.00
281_V286_V0.7741.00
190_C233_V0.7731.00
282_V289_Y0.7721.00
315_V322_G0.7681.00
78_E81_R0.7671.00
169_I173_R0.7661.00
151_L158_P0.7661.00
158_P161_R0.7651.00
82_K85_D0.7601.00
98_G210_E0.7571.00
317_V325_S0.7551.00
80_K87_F0.7541.00
320_V328_F0.7501.00
323_A327_W0.7491.00
98_G102_M0.7481.00
135_E143_V0.7481.00
90_V104_G0.7451.00
210_E213_D0.7431.00
337_L341_S0.7421.00
96_G119_D0.7381.00
275_I282_V0.7381.00
282_V288_I0.7371.00
36_I48_S0.7361.00
320_V327_W0.7351.00
340_L344_Y0.7341.00
353_I357_L0.7321.00
286_V289_Y0.7321.00
319_C322_G0.7311.00
105_L108_A0.7311.00
38_A118_A0.7301.00
203_F206_R0.7281.00
334_L344_Y0.7231.00
132_M143_V0.7231.00
356_G360_F0.7211.00
302_P305_V0.7161.00
45_L49_L0.7131.00
294_F298_I0.7131.00
29_K57_Y0.7121.00
274_S280_L0.7091.00
320_V325_S0.7071.00
274_S284_Y0.7041.00
154_A158_P0.7011.00
33_D109_T0.6991.00
310_F313_I0.6981.00
338_A345_V0.6971.00
334_L337_L0.6921.00
280_L283_L0.6921.00
136_I194_R0.6901.00
279_L284_Y0.6891.00
345_V351_I0.6891.00
258_C261_L0.6881.00
244_E251_W0.6881.00
145_G190_C0.6831.00
92_Q95_T0.6821.00
310_F316_G0.6821.00
336_P340_L0.6811.00
73_E76_M0.6791.00
281_V287_G0.6791.00
114_F126_Q0.6781.00
160_I163_T0.6781.00
53_L86_R0.6751.00
48_S51_N0.6731.00
344_Y347_L0.6711.00
158_P163_T0.6701.00
102_M105_L0.6681.00
308_A315_V0.6681.00
238_C247_R0.6661.00
257_V262_H0.6631.00
318_V325_S0.6601.00
342_V348_A0.6591.00
171_M175_L0.6591.00
120_T189_A0.6581.00
337_L342_V0.6581.00
334_L341_S0.6581.00
132_M231_C0.6581.00
136_I140_A0.6571.00
280_L286_V0.6561.00
264_R268_S0.6551.00
70_D74_A0.6551.00
339_P343_V0.6541.00
56_P59_C0.6541.00
274_S282_V0.6541.00
245_W249_R0.6491.00
354_I358_I0.6491.00
346_L350_A0.6481.00
140_A143_V0.6471.00
55_N122_V0.6461.00
157_L163_T0.6451.00
132_M136_I0.6441.00
274_S279_L0.6441.00
72_T76_M0.6421.00
274_S285_G0.6401.00
334_L338_A0.6390.99
40_N72_T0.6390.99
317_V322_G0.6390.99
53_L87_F0.6360.99
34_A55_N0.6340.99
251_W254_G0.6340.99
270_F277_P0.6330.99
215_T225_I0.6330.99
270_F275_I0.6320.99
25_P28_K0.6320.99
147_P235_P0.6310.99
321_I327_W0.6300.99
293_W296_E0.6290.99
193_F218_L0.6290.99
116_S190_C0.6260.99
156_L160_I0.6260.99
144_G149_T0.6260.99
47_Q121_Y0.6260.99
316_G319_C0.6240.99
123_P232_I0.6240.99
115_L191_G0.6240.99
295_N299_T0.6230.99
48_S116_S0.6190.99
46_A79_V0.6180.99
188_G211_D0.6170.99
131_Y228_A0.6160.99
49_L76_M0.6150.99
46_A82_K0.6140.99
337_L345_V0.6140.99
265_L269_R0.6100.99
310_F314_W0.6080.99
61_V87_F0.6060.99
100_A104_G0.6050.99
311_P322_G0.6050.99
278_M284_Y0.6040.99
351_I355_Y0.6030.99
274_S286_V0.6020.99
121_Y150_A0.6000.99
32_I112_Q0.5990.99
141_D197_V0.5990.99
238_C251_W0.5990.99
172_K175_L0.5980.99
36_I63_C0.5960.99
271_G276_F0.5960.99
209_V212_L0.5960.99
36_I116_S0.5960.99
271_G281_V0.5950.99
210_E254_G0.5950.99
174_T229_N0.5950.99
273_F277_P0.5910.99
160_I164_V0.5900.99
197_V200_K0.5900.99
21_L24_K0.5900.99
114_F132_M0.5890.99
146_I227_Q0.5890.99
80_K86_R0.5880.99
204_S261_L0.5860.99
320_V324_F0.5840.99
39_Y67_G0.5840.99
168_M172_K0.5820.99
364_R367_Q0.5820.99
38_A41_E0.5790.99
144_G186_I0.5790.99
97_K210_E0.5780.99
338_A341_S0.5760.99
355_Y360_F0.5760.99
336_P341_S0.5730.99
236_Q239_N0.5720.99
92_Q103_N0.5700.99
284_Y288_I0.5690.99
42_G72_T0.5670.99
63_C66_D0.5660.99
312_L316_G0.5650.99
155_G159_H0.5620.99
333_L340_L0.5620.99
270_F273_F0.5610.99
168_M173_R0.5600.99
122_V190_C0.5590.99
341_S349_Y0.5590.99
102_M203_F0.5570.99
265_L268_S0.5550.99
317_V328_F0.5550.99
237_E247_R0.5540.99
263_K266_L0.5540.99
207_T213_D0.5540.99
129_M192_M0.5530.99
314_W322_G0.5520.99
318_V326_A0.5520.99
158_P162_A0.5500.98
208_K254_G0.5490.98
165_K169_I0.5490.98
247_R254_G0.5480.98
323_A326_A0.5480.98
98_G101_L0.5470.98
282_V287_G0.5470.98
37_P100_A0.5470.98
95_T99_G0.5450.98
188_G210_E0.5450.98
219_V225_I0.5440.98
111_D194_R0.5440.98
259_M262_H0.5440.98
354_I359_A0.5440.98
335_V340_L0.5440.98
165_K187_S0.5420.98
319_C324_F0.5420.98
284_Y287_G0.5420.98
335_V339_P0.5420.98
318_V327_W0.5410.98
66_D91_T0.5410.98
170_V174_T0.5410.98
346_L351_I0.5410.98
272_I282_V0.5400.98
308_A311_P0.5390.98
314_W328_F0.5390.98
314_W325_S0.5390.98
242_R246_R0.5350.98
350_A354_I0.5330.98
253_V257_V0.5320.98
55_N130_G0.5320.98
315_V325_S0.5310.98
41_E45_L0.5310.98
315_V321_I0.5300.98
170_V173_R0.5300.98
157_L160_I0.5290.98
329_H336_P0.5290.98
163_T166_L0.5280.98
88_V91_T0.5240.98
56_P123_P0.5240.98
41_E44_C0.5240.98
209_V213_D0.5210.98
339_P345_V0.5210.98
322_G328_F0.5200.98
142_A149_T0.5200.98
41_E117_D0.5190.98
354_I357_L0.5190.98
33_D104_G0.5190.98
147_P165_K0.5190.98
289_Y295_N0.5180.98
316_G327_W0.5170.98
342_V347_L0.5170.98
257_V261_L0.5160.98
339_P344_Y0.5150.98
290_L295_N0.5140.98
137_E226_R0.5140.98
105_L115_L0.5130.98
308_A322_G0.5130.98
313_I322_G0.5120.98
353_I359_A0.5110.98
311_P325_S0.5090.98
285_G293_W0.5070.97
271_G285_G0.5060.97
168_M176_Q0.5040.97
340_L346_L0.5040.97
347_L351_I0.5010.97
119_D235_P0.5010.97
189_A247_R0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4p02A 1 0.9372 100 0.385 Contact Map
2z86A 2 0.6834 100 0.544 Contact Map
3bcvA 2 0.4472 100 0.562 Contact Map
2bo4A 4 0.8291 100 0.575 Contact Map
1qg8A 1 0.5302 100 0.583 Contact Map
3l7iA 4 0.103 100 0.583 Contact Map
2d7iA 1 0.8719 100 0.587 Contact Map
4fixA 3 0.8794 100 0.588 Contact Map
3ckjA 2 0.6859 100 0.591 Contact Map
1xhbA 1 0.8719 100 0.598 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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