GREMLIN Database
ARNE - Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE
UniProt: Q47377 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14344
Length: 111 (106)
Sequences: 685 (488)
Seq/√Len: 47.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
99_F106_I3.3861.00
23_A40_L3.1231.00
89_V94_W2.9981.00
78_T97_V2.9771.00
90_S93_H2.6241.00
99_F102_G2.6221.00
24_T55_L2.5801.00
61_V66_A2.4241.00
6_L61_V2.2931.00
23_A43_A2.2611.00
57_V66_A2.1001.00
54_W67_Y2.0090.99
77_V81_A1.9390.99
17_Q67_Y1.7940.99
13_S70_L1.7120.98
9_A57_V1.6650.98
17_Q21_K1.6440.98
72_L75_V1.6270.98
20_Q43_A1.5710.97
12_L54_W1.5530.97
69_M74_F1.4970.96
9_A13_S1.4740.96
94_W98_A1.4550.95
6_L69_M1.4500.95
13_S50_A1.4410.95
9_A70_L1.4330.95
54_W69_M1.4330.95
13_S51_M1.3930.94
13_S74_F1.3900.94
82_V89_V1.3700.93
65_I93_H1.3560.93
47_L51_M1.3320.92
48_G52_V1.2710.91
74_F107_L1.2660.90
15_A19_C1.2300.89
36_I41_G1.2190.89
13_S16_G1.2140.88
20_Q51_M1.2070.88
16_G63_V1.2010.88
20_Q70_L1.1770.87
4_L79_L1.1730.87
79_L94_W1.1630.86
20_Q80_A1.1430.85
92_R95_C1.1290.84
91_P95_C1.1020.83
17_Q54_W1.0850.82
3_W61_V1.0760.81
98_A102_G1.0760.81
78_T89_V1.0530.80
13_S77_V1.0520.80
48_G51_M1.0440.79
104_I108_G1.0380.79
50_A70_L1.0360.79
47_L50_A1.0350.79
53_L84_L1.0260.78
8_F53_L1.0180.78
29_I48_G1.0130.77
21_K24_T1.0010.76
65_I69_M0.9990.76
19_C42_L0.9940.76
17_Q47_L0.9780.75
62_P81_A0.9700.74
93_H107_L0.9700.74
6_L65_I0.9620.74
43_A93_H0.9440.72
45_A48_G0.9300.71
8_F49_L0.9060.69
78_T81_A0.9050.69
10_S56_L0.9010.69
97_V100_I0.8960.68
95_C105_V0.8900.68
40_L52_V0.8820.67
21_K54_W0.8560.65
21_K67_Y0.8550.64
21_K25_C0.8480.64
63_V85_W0.8380.63
16_G51_M0.8240.62
13_S63_V0.7950.59
102_G105_V0.7940.59
37_V107_L0.7930.59
20_Q47_L0.7930.59
42_L88_P0.7910.58
45_A86_H0.7670.56
48_G53_L0.7630.56
18_L22_Q0.7550.55
18_L80_A0.7530.55
56_L60_N0.7510.54
9_A20_Q0.7490.54
54_W96_G0.7400.53
19_C22_Q0.7370.53
23_A47_L0.7280.52
45_A100_I0.7230.52
25_C52_V0.7210.51
82_V94_W0.7200.51
21_K85_W0.7170.51
65_I81_A0.7090.50
46_C51_M0.6920.49
3_W7_V0.6910.48
32_R60_N0.6910.48
100_I104_I0.6740.47
16_G70_L0.6720.47
88_P93_H0.6550.45
6_L54_W0.6520.45
34_K85_W0.6460.44
91_P98_A0.6460.44
16_G47_L0.6360.43
44_L61_V0.6280.42
3_W10_S0.6230.42
92_R106_I0.6220.42
83_K95_C0.6200.41
64_G74_F0.6200.41
13_S73_N0.6180.41
62_P107_L0.6150.41
69_M93_H0.6140.41
49_L102_G0.6040.40
9_A53_L0.5960.39
78_T93_H0.5920.39
33_R105_V0.5920.39
42_L98_A0.5920.39
12_L17_Q0.5890.38
7_V83_K0.5880.38
102_G106_I0.5860.38
20_Q73_N0.5830.38
45_A95_C0.5810.38
35_H81_A0.5800.38
85_W90_S0.5780.37
42_L72_L0.5750.37
5_T98_A0.5750.37
13_S24_T0.5710.37
52_V91_P0.5660.36
23_A93_H0.5650.36
17_Q60_N0.5650.36
11_L60_N0.5600.36
97_V101_I0.5550.35
20_Q30_N0.5530.35
49_L108_G0.5490.35
89_V102_G0.5480.35
35_H91_P0.5480.35
23_A37_V0.5470.35
25_C66_A0.5450.34
6_L94_W0.5440.34
24_T34_K0.5420.34
26_F45_A0.5340.33
11_L83_K0.5340.33
51_M58_L0.5320.33
3_W72_L0.5300.33
16_G71_S0.5280.33
21_K51_M0.5220.32
46_C49_L0.5210.32
20_Q44_L0.5210.32
9_A77_V0.5200.32
69_M100_I0.5200.32
50_A56_L0.5140.32
36_I108_G0.5070.31
9_A47_L0.5060.31
77_V80_A0.5020.31
80_A83_K0.5020.31
16_G50_A0.5010.31
53_L65_I0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2i68A 2 0.6937 99.7 0.473 Contact Map
3b5dA 2 0.9099 99.7 0.474 Contact Map
3ar4A 1 0.8198 3.6 0.937 Contact Map
3ixzA 1 0.7928 3.1 0.94 Contact Map
4p79A 1 0.7568 2.4 0.943 Contact Map
3j01B 1 0.4595 2 0.946 Contact Map
4w6vA 1 0.9099 1.7 0.948 Contact Map
2zxeA 1 0.8198 1.6 0.948 Contact Map
3wdoA 1 0.7658 1.3 0.951 Contact Map
3x29A 1 0.7207 1 0.955 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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