GREMLIN Database
YFIP - DTW domain-containing protein YfiP
UniProt: Q47319 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14223
Length: 232 (194)
Sequences: 1047 (733)
Seq/√Len: 52.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
168_A207_T5.2151.00
133_F189_L5.0401.00
135_M186_A4.6681.00
74_I186_A4.6101.00
86_W89_T3.3901.00
106_P132_L3.2031.00
54_R82_V2.9271.00
136_L146_M2.8451.00
31_C34_C2.8431.00
108_V134_I2.8031.00
95_L99_V2.6661.00
93_Q97_E2.6541.00
115_A160_S2.6361.00
56_C132_L2.5881.00
107_M131_P2.2291.00
71_G83_A2.2051.00
174_A179_Q2.1161.00
118_Q159_I2.1051.00
75_A81_T2.0821.00
57_L71_G2.0481.00
142_E145_K2.0161.00
28_V37_P1.9931.00
69_N72_R1.9611.00
55_F78_L1.9421.00
169_Y180_Y1.8640.99
50_Q79_P1.7980.99
147_F158_V1.7900.99
29_R38_E1.7780.99
59_M71_G1.7620.99
107_M121_V1.6920.99
66_K69_N1.6550.98
55_F135_M1.6260.98
109_V135_M1.6100.98
55_F133_F1.6030.98
66_K142_E1.5900.98
36_L213_Y1.5900.98
141_P173_E1.5440.98
115_A119_R1.5290.97
71_G81_T1.5150.97
54_R132_L1.4940.97
105_Q129_K1.4900.97
49_A78_L1.4700.97
101_N129_K1.4470.96
72_R76_D1.4420.96
142_E149_K1.4180.96
161_V178_G1.3870.95
97_E100_Q1.3860.95
151_P154_D1.3600.95
116_D120_E1.3570.95
162_D165_R1.3510.95
46_I205_H1.3490.95
53_S195_D1.3440.94
58_L86_W1.3380.94
48_P79_P1.3250.94
48_P155_N1.3210.94
71_G190_L1.3070.94
94_D97_E1.2830.93
110_F143_A1.2780.93
34_C41_C1.2720.93
60_F161_V1.2660.93
86_W150_S1.2560.92
146_M150_S1.2410.92
31_C41_C1.2410.92
142_E173_E1.2320.91
70_T189_L1.1980.90
37_P40_L1.1980.90
61_D65_M1.1980.90
171_L181_C1.1980.90
87_S142_E1.1970.90
161_V189_L1.1890.90
109_V193_A1.1840.90
108_V138_G1.1640.89
170_R211_T1.1590.89
88_R150_S1.1550.89
96_L152_Y1.1550.89
206_F209_F1.1100.87
59_M68_S1.1050.86
110_F171_L1.0990.86
116_D122_I1.0750.85
169_Y206_F1.0740.85
59_M181_C1.0740.85
73_L183_A1.0710.84
155_N197_G1.0690.84
28_V36_L1.0560.84
210_K217_K1.0560.84
136_L186_A1.0520.83
36_L171_L1.0250.82
144_R148_R1.0190.81
73_L141_P1.0120.81
165_R188_A1.0040.80
195_D198_A1.0020.80
87_S149_K0.9850.79
88_R91_P0.9810.79
153_L156_L0.9640.78
63_E184_E0.9630.78
108_V156_L0.9630.78
77_I187_I0.9600.77
36_L208_R0.9520.77
99_V152_Y0.9400.76
53_S194_G0.9290.75
67_P72_R0.9230.74
96_L101_N0.9170.74
45_T208_R0.9090.73
58_L153_L0.8820.71
205_H209_F0.8770.71
132_L142_E0.8760.71
109_V185_V0.8760.71
134_I196_T0.8750.70
54_R78_L0.8730.70
94_D166_L0.8710.70
68_S171_L0.8660.70
145_K149_K0.8630.69
183_A205_H0.8600.69
55_F161_V0.8590.69
95_L134_I0.8490.68
68_S205_H0.8460.68
210_K213_Y0.8300.66
169_Y172_R0.8300.66
117_E215_A0.8280.66
183_A202_L0.8240.66
103_D156_L0.8060.64
154_D158_V0.8020.64
55_F186_A0.8000.64
191_D199_A0.7990.63
105_Q131_P0.7930.63
58_L99_V0.7900.63
87_S145_K0.7890.62
78_L189_L0.7820.62
147_F154_D0.7810.62
123_F197_G0.7810.62
200_A204_E0.7800.62
177_E197_G0.7740.61
210_K214_L0.7720.61
61_D87_S0.7680.60
125_P193_A0.7650.60
64_P173_E0.7620.60
115_A120_E0.7540.59
112_A158_V0.7530.59
89_T213_Y0.7490.58
50_Q117_E0.7480.58
108_V201_G0.7480.58
73_L209_F0.7400.57
115_A118_Q0.7360.57
66_K71_G0.7300.56
59_M169_Y0.7230.56
69_N206_F0.7220.56
42_L73_L0.7210.56
138_G206_F0.7210.56
67_P76_D0.7190.55
33_R215_A0.7150.55
29_R167_S0.7150.55
36_L69_N0.7130.55
95_L100_Q0.7070.54
174_A180_Y0.7070.54
82_V161_V0.7070.54
150_S167_S0.7060.54
139_T198_A0.7050.54
97_E101_N0.7020.54
206_F210_K0.7000.53
32_Q50_Q0.6960.53
158_V185_V0.6950.53
119_R122_I0.6900.52
32_Q38_E0.6890.52
60_F142_E0.6880.52
31_C43_C0.6880.52
116_D119_R0.6860.52
146_M153_L0.6850.52
71_G76_D0.6830.52
191_D204_E0.6810.51
107_M132_L0.6810.51
174_A216_G0.6800.51
189_L192_M0.6800.51
68_S142_E0.6760.51
54_R104_Y0.6760.51
187_I203_G0.6750.51
72_R138_G0.6740.51
75_A143_A0.6730.50
53_S78_L0.6720.50
57_L186_A0.6720.50
178_G188_A0.6680.50
96_L150_S0.6660.50
170_R203_G0.6620.49
45_T212_R0.6590.49
35_L179_Q0.6570.49
34_C43_C0.6560.49
215_A219_Q0.6560.49
79_P82_V0.6520.48
98_L104_Y0.6520.48
32_Q35_L0.6510.48
116_D127_A0.6510.48
54_R130_P0.6500.48
42_L178_G0.6480.48
70_T78_L0.6450.48
174_A178_G0.6450.48
47_T162_D0.6420.47
67_P146_M0.6380.47
83_A138_G0.6380.47
61_D74_I0.6350.47
44_S79_P0.6310.46
110_F194_G0.6310.46
137_D140_W0.6290.46
120_E124_T0.6270.46
36_L42_L0.6260.46
70_T205_H0.6230.45
55_F74_I0.6220.45
141_P212_R0.6200.45
114_Y158_V0.6180.45
208_R211_T0.6160.45
46_I76_D0.6160.45
126_P197_G0.6140.44
89_T92_S0.6130.44
96_L100_Q0.6130.44
166_L177_E0.6130.44
43_C137_D0.6110.44
88_R96_L0.6100.44
95_L98_L0.6090.44
64_P138_G0.6090.44
204_E207_T0.6080.44
36_L89_T0.6070.44
68_S71_G0.6060.43
44_S200_A0.6050.43
82_V94_D0.6030.43
103_D129_K0.6020.43
175_Q209_F0.5990.43
69_N157_P0.5980.43
72_R157_P0.5970.43
171_L175_Q0.5970.43
122_I127_A0.5950.42
61_D139_T0.5940.42
110_F145_K0.5910.42
38_E117_E0.5900.42
75_A83_A0.5900.42
47_T205_H0.5890.42
176_A179_Q0.5880.42
61_D68_S0.5880.42
138_G172_R0.5840.41
69_N73_L0.5830.41
36_L68_S0.5820.41
163_L188_A0.5760.40
106_P131_P0.5690.40
123_F127_A0.5680.40
138_G159_I0.5600.39
128_G191_D0.5600.39
179_Q209_F0.5600.39
64_P181_C0.5590.39
183_A206_F0.5590.39
51_A194_G0.5580.39
122_I196_T0.5540.38
93_Q128_G0.5540.38
78_L186_A0.5530.38
58_L146_M0.5520.38
66_K74_I0.5510.38
147_F169_Y0.5510.38
49_A194_G0.5500.38
104_Y130_P0.5490.38
89_T152_Y0.5480.38
44_S123_F0.5470.38
59_M64_P0.5470.38
62_T161_V0.5470.38
50_Q197_G0.5460.37
62_T142_E0.5460.37
118_Q189_L0.5460.37
119_R124_T0.5450.37
91_P96_L0.5450.37
122_I211_T0.5410.37
53_S133_F0.5400.37
77_I205_H0.5340.36
132_L174_A0.5320.36
50_Q126_P0.5310.36
135_M185_V0.5280.36
210_K216_G0.5220.35
28_V40_L0.5220.35
99_V156_L0.5220.35
67_P169_Y0.5190.35
39_K125_P0.5160.35
55_F62_T0.5140.34
63_E137_D0.5120.34
161_V199_A0.5120.34
132_L160_S0.5110.34
123_F159_I0.5110.34
97_E128_G0.5090.34
58_L136_L0.5060.34
67_P71_G0.5050.33
174_A209_F0.5040.33
109_V158_V0.5040.33
149_K173_E0.5030.33
211_T215_A0.5030.33
106_P129_K0.5020.33
179_Q213_Y0.5010.33
52_K195_D0.5010.33
162_D192_M0.5000.33
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mo0A 1 0.2457 23.6 0.954 Contact Map
3tdqA 2 0.3405 9.8 0.961 Contact Map
2hzmA 1 0.5302 6.8 0.964 Contact Map
4o1iA 2 0.4655 5 0.966 Contact Map
2r25B 1 0.5431 4.8 0.966 Contact Map
1rrkA 1 0.4009 4.6 0.967 Contact Map
3j6pD 1 0.4569 3.8 0.968 Contact Map
3pqaA 4 0.3534 3.5 0.969 Contact Map
1f75A 2 0.3578 3.5 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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