GREMLIN Database
FDRA - Protein FdrA
UniProt: Q47208 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13399
Length: 555 (439)
Sequences: 1855 (1445)
Seq/√Len: 69.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
107_R110_S4.6771.00
332_F411_R4.5661.00
138_L166_K4.2471.00
106_R110_S4.1751.00
307_E323_N3.9211.00
74_D78_A3.6251.00
195_N254_E3.5621.00
135_N158_Q3.5411.00
388_P392_I3.5241.00
114_K118_A3.4521.00
111_A118_A3.3771.00
125_V133_L3.3751.00
311_L323_N3.2141.00
169_L237_G3.1991.00
109_D136_Q3.0811.00
78_A81_I2.9671.00
121_A137_A2.7311.00
125_V129_Y2.7271.00
74_D80_A2.7161.00
135_N139_D2.6601.00
265_E268_R2.6091.00
157_I161_T2.5761.00
262_P268_R2.5481.00
152_T156_E2.4811.00
137_A142_L2.3941.00
135_N162_R2.3741.00
92_L111_A2.3541.00
146_M159_L2.3071.00
310_R316_S2.2651.00
135_N165_E2.2501.00
197_G221_T2.2231.00
221_T253_S2.1921.00
388_P393_D2.1761.00
372_S376_I2.1521.00
433_S437_K2.1371.00
78_A82_M2.1301.00
262_P265_E2.1291.00
401_I413_L2.1141.00
123_I133_L2.1121.00
367_M406_A2.1001.00
364_H407_K2.0981.00
171_M178_S2.0711.00
298_N301_F2.0561.00
250_D253_S2.0371.00
268_R273_N2.0071.00
469_A473_D1.9931.00
269_L273_N1.9911.00
121_A142_L1.9901.00
74_D81_I1.9711.00
76_G79_Q1.9671.00
330_S411_R1.9461.00
134_A144_V1.9271.00
66_V69_R1.9271.00
337_Y343_A1.9161.00
134_A162_R1.9061.00
361_T409_Q1.8991.00
127_G148_S1.8421.00
96_S104_Q1.8351.00
265_E269_L1.8281.00
334_C410_V1.8211.00
510_N514_I1.8181.00
245_E274_A1.8101.00
350_L355_G1.8091.00
331_G497_S1.8081.00
331_G356_V1.8051.00
436_Q470_T1.8001.00
510_N517_G1.7991.00
99_S104_Q1.7731.00
263_P269_L1.7511.00
75_A78_A1.7441.00
262_P269_L1.7081.00
263_P268_R1.7011.00
66_V70_S1.7001.00
414_L485_A1.6931.00
206_I223_A1.6851.00
316_S321_R1.6660.99
238_I243_A1.6580.99
422_G425_A1.6360.99
109_D139_D1.6280.99
98_S101_A1.6210.99
358_A410_V1.5850.99
307_E311_L1.5830.99
105_V112_C1.5550.99
361_T407_K1.5530.99
514_I518_L1.5420.99
108_W137_A1.5340.99
412_V489_A1.5310.99
265_E270_K1.5120.99
296_D340_G1.5110.99
132_E136_Q1.4960.99
74_D79_Q1.4870.99
369_D378_L1.4780.99
263_P270_K1.4780.99
65_C69_R1.4710.99
75_A79_Q1.4710.99
333_I350_L1.4490.99
375_I385_V1.4320.98
84_Q87_E1.4250.98
262_P273_N1.4240.98
421_F426_D1.4100.98
262_P266_A1.4070.98
163_A170_V1.4050.98
78_A83_Q1.4040.98
402_A406_A1.3980.98
198_V220_I1.3930.98
333_I489_A1.3860.98
192_P214_A1.3850.98
346_A414_L1.3830.98
517_G520_S1.3700.98
77_I81_I1.3670.98
196_I255_V1.3650.98
197_G253_S1.3650.98
264_A268_R1.3590.98
76_G81_I1.3570.98
422_G426_D1.3450.98
270_K273_N1.3440.98
138_L162_R1.3430.98
224_I247_L1.3410.98
67_A70_S1.3390.97
342_L455_T1.3390.97
171_M238_I1.3370.97
418_V422_G1.3350.97
258_F284_A1.3300.97
111_A114_K1.3260.97
266_A269_L1.3220.97
248_S282_T1.3160.97
158_Q161_T1.3040.97
114_K140_R1.3030.97
510_N520_S1.3030.97
85_L88_A1.3010.97
432_V436_Q1.2990.97
134_A168_L1.2970.97
514_I517_G1.2950.97
513_V517_G1.2930.97
65_C70_S1.2880.97
266_A273_N1.2860.97
108_W140_R1.2720.97
131_A158_Q1.2710.97
256_L276_K1.2700.97
516_I520_S1.2680.97
107_R136_Q1.2670.96
509_E512_A1.2640.96
194_G219_G1.2610.96
198_V209_L1.2600.96
336_L404_L1.2460.96
417_V422_G1.2280.96
112_C140_R1.2270.96
398_N437_K1.2210.96
151_V228_G1.2110.95
199_I247_L1.2100.95
417_V421_F1.2070.95
161_T165_E1.2050.95
282_T321_R1.1990.95
77_I80_A1.1930.95
265_E273_N1.1920.95
131_A155_D1.1900.95
210_C223_A1.1830.95
268_R271_I1.1750.95
263_P266_A1.1730.95
76_G80_A1.1660.94
197_G247_L1.1620.94
405_G413_L1.1620.94
64_I70_S1.1600.94
200_G204_T1.1560.94
422_G427_P1.1540.94
262_P270_K1.1450.94
175_C340_G1.1430.94
205_G327_P1.1350.94
222_H247_L1.1340.94
362_H366_M1.1270.93
109_D140_R1.1260.93
66_V71_E1.1210.93
517_G521_F1.1090.93
297_E344_A1.1080.93
380_D383_Y1.1070.93
298_N303_S1.1060.93
423_A426_D1.1010.93
175_C225_G1.0990.92
510_N513_V1.0980.92
426_D429_A1.0950.92
263_P273_N1.0880.92
298_N304_S1.0880.92
266_A271_I1.0880.92
434_A438_A1.0860.92
371_D403_D1.0860.92
156_E228_G1.0810.92
452_A478_V1.0800.92
420_G423_A1.0800.92
290_T352_G1.0790.92
387_R396_L1.0780.92
88_A113_Q1.0730.92
153_L156_E1.0630.91
149_D385_V1.0620.91
180_I222_H1.0530.91
399_Q402_A1.0530.91
248_S276_K1.0500.91
75_A80_A1.0450.90
412_V449_Y1.0450.90
123_I130_A1.0440.90
369_D376_I1.0410.90
127_G151_V1.0330.90
353_H490_A1.0270.90
74_D77_I1.0250.90
91_Q102_L1.0230.89
325_I352_G1.0170.89
248_S275_M1.0150.89
423_A427_P1.0120.89
272_V282_T1.0060.89
90_K105_V1.0000.88
240_A260_S0.9940.88
129_Y133_L0.9940.88
138_L168_L0.9900.88
517_G522_A0.9840.88
296_D301_F0.9840.88
108_W112_C0.9830.88
293_V297_E0.9810.87
64_I69_R0.9800.87
418_V421_F0.9790.87
326_A483_P0.9760.87
160_K236_G0.9760.87
512_A517_G0.9740.87
187_F203_G0.9730.87
158_Q162_R0.9710.87
156_E236_G0.9680.87
153_L228_G0.9680.87
108_W111_A0.9680.87
112_C118_A0.9630.86
284_A321_R0.9540.86
395_T399_Q0.9530.86
149_D204_T0.9510.86
262_P271_I0.9490.86
199_I243_A0.9480.86
131_A138_L0.9460.85
405_G448_L0.9440.85
98_S102_L0.9440.85
155_D159_L0.9420.85
265_E271_I0.9410.85
419_I422_G0.9410.85
74_D82_M0.9410.85
517_G526_Q0.9400.85
296_D299_V0.9390.85
290_T293_V0.9320.85
294_A297_E0.9310.84
97_G104_Q0.9290.84
331_G493_I0.9280.84
336_L401_I0.9250.84
97_G106_R0.9250.84
366_M370_A0.9250.84
235_V240_A0.9250.84
421_F427_P0.9240.84
361_T364_H0.9220.84
244_L260_S0.9190.84
347_A350_L0.9180.84
366_M369_D0.9170.84
132_E135_N0.9100.83
200_G259_V0.9090.83
220_I223_A0.9070.83
98_S103_T0.9040.83
144_V163_A0.9010.83
421_F424_T0.8950.82
174_D302_A0.8930.82
289_Y352_G0.8920.82
267_V271_I0.8870.82
283_V324_A0.8840.81
340_G344_A0.8840.81
367_M370_A0.8840.81
518_L521_F0.8800.81
67_A71_E0.8780.81
85_L89_L0.8760.81
199_I258_F0.8750.81
146_M170_V0.8740.81
108_W121_A0.8730.80
268_R272_V0.8710.80
495_P499_A0.8710.80
293_V300_W0.8690.80
360_D364_H0.8680.80
111_A137_A0.8680.80
94_Q104_Q0.8660.80
245_E275_M0.8650.80
433_S470_T0.8640.80
118_A142_L0.8640.80
135_N166_K0.8630.80
433_S436_Q0.8610.80
240_A258_F0.8610.80
360_D410_V0.8600.79
510_N523_L0.8520.79
430_S433_S0.8510.79
111_A140_R0.8480.79
66_V91_Q0.8440.78
64_I71_E0.8430.78
371_D399_Q0.8420.78
293_V299_V0.8420.78
245_E271_I0.8420.78
367_M403_D0.8410.78
494_H497_S0.8390.78
420_G425_A0.8380.78
134_A170_V0.8370.78
513_V526_Q0.8360.78
157_I235_V0.8330.77
398_N402_A0.8310.77
522_A526_Q0.8300.77
364_H408_P0.8300.77
226_L243_A0.8260.77
174_D296_D0.8250.77
334_C358_A0.8250.77
466_Q469_A0.8230.76
174_D340_G0.8230.76
124_S147_F0.8230.76
284_A316_S0.8230.76
96_S106_R0.8220.76
122_L185_L0.8200.76
130_A146_M0.8200.76
510_N518_L0.8190.76
241_L271_I0.8190.76
126_A148_S0.8180.76
244_L256_L0.8140.76
421_F425_A0.8030.75
145_M178_S0.8030.75
407_K448_L0.8020.75
174_D187_F0.8000.74
451_I489_A0.7960.74
377_D382_F0.7930.74
508_L511_V0.7910.74
359_D362_H0.7910.74
402_A445_N0.7830.73
269_L274_A0.7800.72
393_D396_L0.7790.72
138_L141_N0.7780.72
510_N526_Q0.7780.72
293_V296_D0.7740.72
299_V303_S0.7720.72
114_K142_L0.7710.72
248_S279_G0.7700.72
424_T427_P0.7690.71
131_A135_N0.7690.71
111_A142_L0.7670.71
400_L404_L0.7660.71
435_W450_A0.7660.71
418_V423_A0.7660.71
299_V305_L0.7660.71
160_K164_R0.7650.71
426_D430_S0.7630.71
293_V340_G0.7620.71
436_Q474_A0.7610.71
286_F323_N0.7610.71
151_V156_E0.7610.71
134_A159_L0.7600.71
309_A312_A0.7590.70
300_W305_L0.7590.70
130_A148_S0.7580.70
333_I355_G0.7570.70
197_G226_L0.7550.70
174_D300_W0.7510.70
371_D400_L0.7470.69
332_F356_V0.7460.69
510_N525_L0.7450.69
266_A270_K0.7450.69
365_G379_G0.7440.69
65_C68_I0.7410.69
270_K274_A0.7410.69
86_E89_L0.7390.68
510_N521_F0.7390.68
64_I67_A0.7380.68
76_G82_M0.7340.68
508_L517_G0.7330.68
510_N516_I0.7310.68
452_A471_L0.7280.67
376_I385_V0.7280.67
108_W168_L0.7260.67
299_V302_A0.7250.67
175_C316_S0.7230.67
159_L170_V0.7210.66
126_A129_Y0.7190.66
75_A81_I0.7180.66
339_G344_A0.7180.66
508_L516_I0.7170.66
298_N305_L0.7160.66
299_V340_G0.7160.66
93_A96_S0.7150.66
87_E91_Q0.7140.66
184_P338_T0.7110.65
200_G206_I0.7100.65
420_G424_T0.7090.65
90_K111_A0.7080.65
126_A203_G0.7080.65
151_V155_D0.7080.65
141_N166_K0.7070.65
144_V168_L0.7070.65
511_V515_N0.7070.65
368_L400_L0.7060.65
510_N519_R0.7060.65
91_Q104_Q0.7050.65
68_I71_E0.7040.65
328_V484_E0.7030.65
289_Y307_E0.7030.65
134_A163_A0.7020.64
309_A315_L0.7020.64
198_V257_A0.7010.64
150_N153_L0.7000.64
361_T408_P0.7000.64
289_Y325_I0.6980.64
198_V223_A0.6970.64
267_V270_K0.6950.64
67_A85_L0.6940.64
360_D377_D0.6930.63
89_L102_L0.6920.63
133_L136_Q0.6910.63
263_P271_I0.6910.63
138_L144_V0.6900.63
364_H368_L0.6890.63
407_K410_V0.6890.63
70_S78_A0.6880.63
490_A494_H0.6880.63
376_I384_T0.6860.63
486_T490_A0.6840.62
358_A400_L0.6840.62
296_D300_W0.6790.62
213_I220_I0.6780.62
355_G490_A0.6780.62
296_D305_L0.6770.62
365_G378_L0.6760.61
131_A162_R0.6740.61
360_D382_F0.6730.61
125_V130_A0.6730.61
162_R166_K0.6720.61
113_Q140_R0.6710.61
70_S91_Q0.6690.61
288_G305_L0.6670.60
131_A159_L0.6670.60
270_K315_L0.6660.60
171_M243_A0.6660.60
357_E380_D0.6640.60
517_G527_S0.6620.60
509_E521_F0.6620.60
206_I225_G0.6620.60
507_L511_V0.6600.60
290_T351_A0.6600.60
398_N438_A0.6590.60
523_L528_A0.6580.59
65_C71_E0.6580.59
513_V519_R0.6580.59
272_V276_K0.6580.59
198_V210_C0.6570.59
93_A126_A0.6570.59
480_S484_E0.6570.59
353_H494_H0.6570.59
514_I519_R0.6550.59
264_A269_L0.6550.59
508_L512_A0.6550.59
196_I213_I0.6550.59
71_E78_A0.6540.59
94_Q106_R0.6520.59
512_A516_I0.6490.58
148_S175_C0.6490.58
113_Q118_A0.6440.58
354_L490_A0.6420.58
75_A82_M0.6400.57
510_N527_S0.6400.57
516_I523_L0.6400.57
431_L481_S0.6370.57
69_R87_E0.6370.57
408_P448_L0.6370.57
514_I528_A0.6360.57
66_V76_G0.6360.57
160_K167_G0.6360.57
90_K113_Q0.6350.57
509_E516_I0.6320.56
174_D301_F0.6300.56
180_I246_M0.6280.56
509_E520_S0.6280.56
468_I480_S0.6270.56
513_V520_S0.6270.56
244_L271_I0.6250.56
349_L353_H0.6230.55
93_A104_Q0.6230.55
268_R274_A0.6190.55
174_D383_Y0.6190.55
77_I82_M0.6190.55
469_A472_E0.6170.55
339_G346_A0.6170.55
432_V439_C0.6160.54
498_P502_Q0.6150.54
204_T386_G0.6140.54
112_C137_A0.6130.54
329_S475_G0.6120.54
100_Q104_Q0.6110.54
74_D83_Q0.6100.54
368_L404_L0.6070.53
206_I386_G0.6060.53
138_L165_E0.6060.53
509_E519_R0.6060.53
517_G525_L0.6030.53
457_T480_S0.6030.53
247_L498_P0.6030.53
203_G383_Y0.6020.53
346_A485_A0.6020.53
449_Y492_L0.6020.53
196_I429_A0.6000.53
363_Q366_M0.6000.53
69_R78_A0.6000.53
358_A364_H0.5980.52
333_I412_V0.5960.52
85_L91_Q0.5960.52
468_I472_E0.5930.52
151_V261_K0.5920.52
472_E478_V0.5910.51
295_R379_G0.5910.51
339_G385_V0.5900.51
135_N138_L0.5870.51
149_D174_D0.5860.51
164_R237_G0.5860.51
171_M450_A0.5850.51
82_M88_A0.5840.51
199_I226_L0.5840.51
84_Q89_L0.5830.50
76_G83_Q0.5820.50
244_L258_F0.5820.50
260_S284_A0.5820.50
511_V514_I0.5810.50
149_D225_G0.5810.50
103_T469_A0.5770.50
91_Q105_V0.5770.50
271_I274_A0.5770.50
518_L523_L0.5760.50
92_L108_W0.5760.50
507_L510_N0.5750.50
68_I121_A0.5740.49
401_I438_A0.5730.49
247_L280_K0.5730.49
297_E301_F0.5710.49
338_T456_G0.5700.49
141_N182_G0.5700.49
359_D379_G0.5690.49
364_H409_Q0.5680.49
417_V423_A0.5680.49
123_I134_A0.5670.49
502_Q506_S0.5640.48
179_M186_A0.5630.48
67_A91_Q0.5630.48
156_E205_G0.5620.48
514_I526_Q0.5610.48
66_V78_A0.5600.48
516_I519_R0.5600.48
206_I342_L0.5590.48
513_V516_I0.5580.47
512_A515_N0.5570.47
235_V339_G0.5570.47
211_S338_T0.5560.47
405_G450_A0.5550.47
285_L345_E0.5540.47
96_S100_Q0.5540.47
235_V263_P0.5540.47
69_R85_L0.5530.47
209_L333_I0.5530.47
120_L183_T0.5520.47
370_A399_Q0.5520.47
341_T348_G0.5510.47
250_D280_K0.5510.47
336_L400_L0.5510.47
79_Q83_Q0.5500.47
339_G350_L0.5500.47
509_E513_V0.5500.47
206_I337_Y0.5490.46
346_A368_L0.5480.46
517_G528_A0.5480.46
417_V420_G0.5480.46
420_G426_D0.5470.46
148_S189_N0.5470.46
321_R498_P0.5450.46
150_N261_K0.5450.46
133_L164_R0.5420.46
253_S256_L0.5420.46
221_T280_K0.5410.45
451_I458_E0.5410.45
373_H383_Y0.5390.45
334_C404_L0.5390.45
498_P501_Q0.5390.45
132_E406_A0.5390.45
90_K103_T0.5380.45
520_S526_Q0.5380.45
386_G456_G0.5370.45
427_P430_S0.5370.45
174_D293_V0.5370.45
418_V435_W0.5360.45
248_S271_I0.5360.45
436_Q473_D0.5340.45
253_S280_K0.5330.44
288_G348_G0.5330.44
300_W340_G0.5320.44
452_A476_I0.5320.44
150_N299_V0.5310.44
335_G346_A0.5310.44
149_D175_C0.5310.44
333_I414_L0.5300.44
225_G259_V0.5290.44
221_T246_M0.5290.44
70_S87_E0.5280.44
176_G207_Q0.5280.44
136_Q139_D0.5270.44
224_I243_A0.5260.44
64_I90_K0.5260.44
490_A493_I0.5260.44
184_P456_G0.5250.44
174_D380_D0.5250.44
67_A77_I0.5240.43
185_L482_L0.5240.43
66_V85_L0.5240.43
514_I521_F0.5240.43
247_L253_S0.5240.43
509_E515_N0.5230.43
301_F305_L0.5230.43
130_A134_A0.5230.43
333_I485_A0.5220.43
134_A252_K0.5220.43
153_L300_W0.5210.43
296_D344_A0.5210.43
90_K137_A0.5200.43
384_T400_L0.5190.43
194_G253_S0.5190.43
418_V427_P0.5190.43
187_F286_F0.5190.43
81_I452_A0.5180.43
161_T167_G0.5180.43
334_C407_K0.5180.43
496_L500_A0.5170.43
69_R76_G0.5170.43
515_N518_L0.5170.43
508_L518_L0.5170.43
114_K136_Q0.5160.42
515_N528_A0.5160.42
150_N174_D0.5150.42
121_A199_I0.5140.42
123_I377_D0.5130.42
214_A459_R0.5130.42
165_E473_D0.5130.42
206_I237_G0.5130.42
66_V77_I0.5130.42
243_A247_L0.5120.42
337_Y340_G0.5120.42
509_E517_G0.5100.42
71_E84_Q0.5100.42
187_F373_H0.5100.42
92_L291_P0.5100.42
342_L483_P0.5090.42
99_S132_E0.5080.42
156_E160_K0.5070.41
339_G420_G0.5070.41
108_W142_L0.5060.41
139_D166_K0.5060.41
142_L168_L0.5050.41
322_R495_P0.5040.41
520_S528_A0.5040.41
120_L185_L0.5040.41
512_A519_R0.5030.41
471_L475_G0.5020.41
301_F364_H0.5010.41
428_A467_Q0.5000.41
213_I486_T0.5000.41
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2csuA 2 0.7351 100 0.431 Contact Map
3dmyA 2 0.7784 100 0.44 Contact Map
3pffA 2 0.5441 100 0.631 Contact Map
3mwdB 1 0.4991 100 0.649 Contact Map
2fp4A 1 0.5135 100 0.681 Contact Map
2yv1A 1 0.4595 100 0.687 Contact Map
2nu8A 1 0.4865 100 0.694 Contact Map
1oi7A 1 0.4559 100 0.698 Contact Map
2yv2A 1 0.4613 100 0.699 Contact Map
3ff4A 1 0.2126 99.9 0.86 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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