GREMLIN Database
YAFP - Uncharacterized N-acetyltransferase YafP
UniProt: Q47158 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13153
Length: 150 (142)
Sequences: 3850 (3109)
Seq/√Len: 260.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
94_S122_Y3.4221.00
7_R62_I3.0101.00
23_R84_D2.9761.00
101_I124_F2.7701.00
7_R13_D2.7501.00
116_K120_E2.7011.00
71_I100_L2.5981.00
106_E145_R2.5341.00
97_L122_Y2.4971.00
61_A92_V2.4141.00
59_W99_P2.3801.00
71_I78_I2.2351.00
68_V87_Y2.2111.00
35_P39_S2.2051.00
19_A23_R2.0911.00
99_P102_K1.9091.00
22_I26_T1.8801.00
69_G83_V1.8461.00
20_I67_P1.8151.00
117_P120_E1.8001.00
23_R85_P1.7701.00
127_V145_R1.7551.00
34_S37_Q1.7451.00
9_Y17_L1.6491.00
60_V67_P1.6381.00
120_E126_T1.6321.00
99_P103_S1.6141.00
71_I96_L1.5981.00
78_I97_L1.5881.00
87_Y90_R1.5791.00
62_I65_A1.5751.00
63_I68_V1.4521.00
63_I90_R1.4361.00
16_Q20_I1.4041.00
28_T88_T1.3911.00
22_I42_A1.3891.00
32_H114_T1.3841.00
68_V92_V1.3631.00
20_I24_A1.3621.00
62_I67_P1.3381.00
98_K122_Y1.3091.00
24_A88_T1.2831.00
69_G92_V1.2681.00
63_I87_Y1.2671.00
23_R86_E1.2511.00
15_Q46_E1.2471.00
14_F18_C1.2441.00
56_S72_S1.2101.00
105_S109_V1.1891.00
116_K126_T1.1751.00
128_K143_Y1.1751.00
57_Q103_S1.1461.00
6_I59_W1.1431.00
126_T142_F1.1421.00
131_R138_W1.1261.00
11_P54_A1.1181.00
94_S98_K1.1131.00
30_S38_I1.1061.00
7_R60_V1.0961.00
16_Q19_A1.0941.00
72_S80_M1.0861.00
88_T114_T1.0831.00
83_V92_V1.0691.00
6_I99_P1.0641.00
9_Y60_V1.0501.00
130_Q143_Y1.0481.00
129_Q140_T1.0441.00
66_Q87_Y1.0341.00
130_Q141_N1.0321.00
126_T129_Q1.0301.00
131_R140_T1.0131.00
133_E136_G1.0121.00
125_Q145_R0.9931.00
26_T38_I0.9891.00
120_E144_M0.9871.00
9_Y13_D0.9751.00
116_K144_M0.9631.00
63_I66_Q0.9631.00
52_K80_M0.9611.00
96_L100_L0.9271.00
9_Y14_F0.9191.00
133_E138_W0.9191.00
98_K102_K0.9191.00
21_F49_W0.9081.00
21_F70_F0.9061.00
51_E55_K0.9031.00
29_A32_H0.8961.00
66_Q86_E0.8851.00
24_A83_V0.8741.00
21_F80_M0.8691.00
8_N103_S0.8541.00
98_K101_I0.8541.00
16_Q67_P0.8541.00
20_I84_D0.8490.99
94_S121_R0.8430.99
17_L70_F0.8300.99
66_Q84_D0.8220.99
25_V82_F0.8190.99
77_Y106_E0.8170.99
19_A84_D0.8100.99
84_D87_Y0.8070.99
15_Q19_A0.8070.99
24_A29_A0.8040.99
115_A118_F0.7940.99
73_R79_D0.7910.99
76_H104_E0.7870.99
27_M85_P0.7740.99
5_Q8_N0.7680.99
44_I49_W0.7670.99
23_R27_M0.7640.99
25_V32_H0.7630.99
77_Y108_T0.7620.99
45_D49_W0.7620.99
26_T43_Q0.7600.99
73_R104_E0.7570.99
107_L124_F0.7540.99
40_A137_A0.7530.99
21_F25_V0.7530.99
78_I81_L0.7520.99
37_Q41_W0.7520.99
132_V139_F0.7410.99
127_V143_Y0.7390.99
29_A38_I0.7390.99
101_I122_Y0.7360.99
25_V41_W0.7350.99
24_A28_T0.7320.98
24_A85_P0.7300.98
21_F82_F0.7270.98
50_K54_A0.7270.98
108_T143_Y0.7230.98
9_Y58_V0.7160.98
109_V119_F0.7110.98
5_Q62_I0.7100.98
26_T35_P0.7070.98
17_L67_P0.7060.98
126_T144_M0.7040.98
116_K142_F0.7030.98
97_L124_F0.7030.98
16_Q66_Q0.6970.98
113_I142_F0.6960.98
61_A68_V0.6960.98
104_E107_L0.6950.98
49_W53_L0.6880.98
89_R121_R0.6860.98
13_D60_V0.6810.98
37_Q139_F0.6810.98
15_Q50_K0.6800.98
77_Y110_D0.6710.97
111_A129_Q0.6700.97
52_K79_D0.6690.97
25_V29_A0.6670.97
61_A69_G0.6650.97
8_N57_Q0.6560.97
52_K56_S0.6510.97
17_L53_L0.6490.97
61_A96_L0.6470.97
85_P88_T0.6410.97
61_A95_A0.6400.96
70_F80_M0.6360.96
11_P50_K0.6360.96
32_H82_F0.6290.96
29_A88_T0.6240.96
53_L56_S0.6230.96
18_C43_Q0.6210.96
31_Q35_P0.6180.96
29_A93_A0.6170.96
9_Y53_L0.6170.96
4_I63_I0.6110.95
58_V72_S0.6100.95
83_V96_L0.6080.95
59_W103_S0.6060.95
14_F49_W0.6000.95
118_F122_Y0.5960.95
95_A98_K0.5960.95
40_A135_R0.5930.95
129_Q142_F0.5900.95
82_F118_F0.5900.95
26_T39_S0.5880.94
87_Y92_V0.5850.94
18_C46_E0.5840.94
26_T42_A0.5800.94
46_E50_K0.5750.94
17_L49_W0.5630.93
89_R117_P0.5620.93
28_T38_I0.5550.93
8_N59_W0.5510.92
92_V95_A0.5510.92
80_M119_F0.5500.92
71_I81_L0.5500.92
48_R52_K0.5490.92
37_Q137_A0.5490.92
49_W52_K0.5490.92
132_V137_A0.5480.92
113_I117_P0.5460.92
52_K72_S0.5390.91
78_I104_E0.5350.91
39_S43_Q0.5340.91
7_R10_Q0.5330.91
97_L101_I0.5330.91
36_Q137_A0.5320.91
112_S117_P0.5320.91
27_M86_E0.5310.91
4_I61_A0.5290.91
76_H106_E0.5280.91
83_V93_A0.5190.90
18_C21_F0.5180.90
62_I68_V0.5180.90
18_C45_D0.5150.90
134_C139_F0.5080.89
19_A66_Q0.5070.89
38_I42_A0.5060.89
93_A114_T0.5010.88
97_L100_L0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2fiwA 2 0.9867 99.9 0.344 Contact Map
3fncA 2 0.9867 99.9 0.406 Contact Map
1tiqA 1 0.9867 99.9 0.406 Contact Map
3fixA 2 0.9333 99.9 0.413 Contact Map
4e2aA 2 0.98 99.9 0.413 Contact Map
1gheA 1 0.96 99.8 0.416 Contact Map
2oh1A 1 0.9067 99.8 0.42 Contact Map
3dr6A 2 0.9467 99.8 0.423 Contact Map
2j8mA 2 0.9467 99.8 0.426 Contact Map
2kcwA 1 0.9533 99.8 0.427 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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