MBHA - ECOLI - GREMLIN Contacts

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MBHA - Putative protein MbhA

UniProt:	Q47154	Sequences: MAVPEETEKKARDVNEKTALLKKKSATELGELATSINTIARDAHMEANLEMEIVPQGLRVLIKDDQNRNMFERGSAKIMPFFKTLLVELAPVFDSLDNKIIITGHTDAMAYKNNIYNNWNLSGDRALSARRVLEEAGMPEDKVMQVSAMADQMLLDSKNPQSAGNRRIEIMVLTKSASDTLYQYFGQHGDKVVQPLVQKLDKQQVLSQRTR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13143
Length:	211 (165)
Sequences:	2698 (2039)
Seq/√Len:	158.7

ECOLI - MBHA MOTB YIAD PAL YFIB OMPA
BACSU - YTXE MOTB

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
72_E	79_M	4.770	1.00
156_D	161_Q	3.237	1.00
157_S	161_Q	3.222	1.00
158_K	161_Q	3.188	1.00
87_V	132_V	3.137	1.00
122_S	148_A	2.712	1.00
149_M	153_M	2.570	1.00
109_M	162_S	2.529	1.00
120_N	131_R	2.392	1.00
33_A	37_N	2.299	1.00
86_L	132_V	2.236	1.00
108_A	162_S	2.172	1.00
156_D	164_G	2.150	1.00
130_R	146_V	2.049	1.00
73_R	109_M	2.028	1.00
158_K	162_S	1.991	1.00
61_L	169_E	1.987	1.00
123_G	127_L	1.900	1.00
107_D	118_N	1.844	1.00
117_N	120_N	1.818	1.00
76_A	124_D	1.810	1.00
102_I	130_R	1.767	1.00
116_Y	124_D	1.764	1.00
78_I	132_V	1.761	1.00
105_H	153_M	1.717	1.00
83_K	132_V	1.707	1.00
156_D	162_S	1.685	1.00
19_A	23_K	1.651	1.00
113_N	116_Y	1.648	1.00
119_W	123_G	1.647	1.00
26_A	30_G	1.643	1.00
127_L	130_R	1.639	1.00
87_V	136_A	1.606	1.00
117_N	131_R	1.562	1.00
90_A	133_L	1.538	1.00
103_T	149_M	1.530	1.00
25_S	40_A	1.507	1.00
157_S	160_P	1.494	1.00
123_G	148_A	1.492	1.00
18_T	22_K	1.476	1.00
64_D	68_R	1.465	1.00
21_L	25_S	1.457	1.00
20_L	23_K	1.406	1.00
11_A	14_V	1.396	1.00
129_A	168_I	1.393	1.00
110_A	117_N	1.376	1.00
132_V	136_A	1.373	1.00
19_A	26_A	1.362	1.00
101_I	147_S	1.344	1.00
140_E	152_Q	1.343	1.00
103_T	171_M	1.343	1.00
54_V	57_G	1.319	1.00
25_S	28_E	1.306	1.00
132_V	135_E	1.300	1.00
15_N	18_T	1.239	1.00
74_G	117_N	1.216	1.00
27_T	31_E	1.202	1.00
11_A	15_N	1.201	1.00
108_A	158_K	1.199	1.00
101_I	145_Q	1.195	1.00
59_R	171_M	1.184	1.00
108_A	161_Q	1.183	1.00
86_L	129_A	1.171	1.00
59_R	169_E	1.162	1.00
80_P	83_K	1.159	1.00
13_D	17_K	1.158	1.00
134_E	143_V	1.136	1.00
23_K	27_T	1.126	1.00
25_S	29_L	1.123	1.00
27_T	30_G	1.113	1.00
70_M	82_F	1.113	1.00
139_P	142_K	1.111	1.00
116_Y	120_N	1.105	1.00
32_L	36_I	1.096	0.99
105_H	168_I	1.080	0.99
21_L	24_K	1.080	0.99
56_Q	59_R	1.075	0.99
78_I	82_F	1.071	0.99
126_A	148_A	1.068	0.99
16_E	20_L	1.066	0.99
94_D	137_G	1.057	0.99
119_W	150_A	1.042	0.99
15_N	19_A	1.008	0.99
73_R	107_D	1.004	0.99
22_K	26_A	1.002	0.99
29_L	33_A	0.998	0.99
78_I	129_A	0.996	0.99
89_L	93_F	0.995	0.99
134_E	140_E	0.964	0.99
130_R	143_V	0.948	0.99
51_M	54_V	0.930	0.98
73_R	118_N	0.920	0.98
98_N	142_K	0.919	0.98
71_F	168_I	0.912	0.98
17_K	20_L	0.898	0.98
14_V	19_A	0.888	0.98
30_G	33_A	0.885	0.98
145_Q	173_L	0.882	0.98
12_R	28_E	0.881	0.98
19_A	22_K	0.871	0.97
155_L	164_G	0.869	0.97
120_N	124_D	0.864	0.97
64_D	70_M	0.864	0.97
56_Q	103_T	0.856	0.97
50_E	77_K	0.854	0.97
24_K	27_T	0.851	0.97
74_G	118_N	0.850	0.97
93_F	138_M	0.850	0.97
104_G	168_I	0.849	0.97
34_T	38_T	0.840	0.97
116_Y	131_R	0.835	0.97
110_A	118_N	0.832	0.97
30_G	34_T	0.819	0.96
119_W	146_V	0.818	0.96
14_V	17_K	0.814	0.96
86_L	133_L	0.814	0.96
20_L	24_K	0.809	0.96
110_A	113_N	0.807	0.96
70_M	103_T	0.801	0.96
69_N	82_F	0.799	0.96
103_T	147_S	0.799	0.96
88_E	91_P	0.798	0.96
52_E	61_L	0.793	0.96
16_E	19_A	0.791	0.96
58_L	172_V	0.790	0.95
123_G	146_V	0.782	0.95
119_W	130_R	0.777	0.95
28_E	31_E	0.776	0.95
90_A	138_M	0.775	0.95
140_E	151_D	0.768	0.95
74_G	107_D	0.756	0.94
61_L	155_L	0.752	0.94
119_W	127_L	0.750	0.94
111_Y	114_N	0.750	0.94
57_G	171_M	0.747	0.94
101_I	171_M	0.746	0.94
62_I	173_L	0.735	0.93
93_F	100_I	0.734	0.93
124_D	127_L	0.729	0.93
29_L	58_L	0.728	0.93
31_E	34_T	0.723	0.93
103_T	169_E	0.722	0.93
89_L	92_V	0.722	0.93
12_R	16_E	0.717	0.93
99_K	175_K	0.714	0.92
35_S	95_S	0.712	0.92
23_K	34_T	0.712	0.92
72_E	75_S	0.712	0.92
105_H	173_L	0.709	0.92
120_N	127_L	0.707	0.92
111_Y	117_N	0.705	0.92
117_N	124_D	0.703	0.92
59_R	170_I	0.702	0.92
156_D	159_N	0.702	0.92
93_F	102_I	0.702	0.92
105_H	169_E	0.693	0.91
69_N	146_V	0.693	0.91
44_H	47_A	0.689	0.91
108_A	154_L	0.684	0.91
160_P	163_A	0.683	0.91
175_K	178_S	0.676	0.90
161_Q	164_G	0.675	0.90
25_S	37_N	0.673	0.90
87_V	91_P	0.673	0.90
15_N	20_L	0.672	0.90
108_A	160_P	0.669	0.90
145_Q	149_M	0.663	0.89
129_A	143_V	0.661	0.89
127_L	131_R	0.660	0.89
91_P	94_D	0.654	0.89
57_G	98_N	0.653	0.89
51_M	58_L	0.652	0.89
29_L	32_L	0.649	0.88
119_W	152_Q	0.647	0.88
89_L	161_Q	0.634	0.87
118_N	166_R	0.634	0.87
47_A	50_E	0.632	0.87
62_I	70_M	0.629	0.87
74_G	110_A	0.628	0.87
12_R	19_A	0.627	0.87
53_I	58_L	0.626	0.86
119_W	131_R	0.626	0.86
50_E	63_K	0.625	0.86
99_K	178_S	0.622	0.86
84_T	88_E	0.620	0.86
74_G	109_M	0.619	0.86
154_L	160_P	0.613	0.85
33_A	58_L	0.612	0.85
70_M	152_Q	0.602	0.84
111_Y	116_Y	0.602	0.84
117_N	123_G	0.597	0.84
106_T	158_K	0.597	0.84
149_M	173_L	0.596	0.84
38_T	42_D	0.596	0.84
109_M	151_D	0.592	0.83
34_T	37_N	0.589	0.83
18_T	26_A	0.589	0.83
138_M	142_K	0.587	0.83
117_N	127_L	0.586	0.83
17_K	21_L	0.585	0.83
110_A	115_I	0.584	0.82
31_E	35_S	0.584	0.82
18_T	21_L	0.582	0.82
12_R	18_T	0.580	0.82
57_G	173_L	0.577	0.82
71_F	129_A	0.576	0.82
11_A	18_T	0.576	0.82
56_Q	63_K	0.574	0.81
77_K	83_K	0.573	0.81
25_S	33_A	0.572	0.81
83_K	135_E	0.570	0.81
105_H	152_Q	0.567	0.81
13_D	21_L	0.567	0.81
60_V	119_W	0.566	0.80
71_F	104_G	0.564	0.80
68_R	81_F	0.560	0.80
137_G	143_V	0.559	0.80
137_G	142_K	0.557	0.79
12_R	15_N	0.554	0.79
14_V	22_K	0.554	0.79
72_E	78_I	0.553	0.79
73_R	110_A	0.549	0.78
22_K	25_S	0.544	0.78
88_E	92_V	0.544	0.78
108_A	156_D	0.543	0.78
20_L	26_A	0.541	0.77
89_L	136_A	0.541	0.77
47_A	51_M	0.540	0.77
49_L	170_I	0.537	0.77
60_V	64_D	0.533	0.76
154_L	161_Q	0.529	0.76
12_R	20_L	0.528	0.76
120_N	123_G	0.527	0.76
106_T	170_I	0.527	0.76
37_N	51_M	0.523	0.75
131_R	152_Q	0.520	0.75
102_I	165_N	0.520	0.75
94_D	138_M	0.520	0.75
62_I	85_L	0.518	0.74
68_R	71_F	0.516	0.74
154_L	165_N	0.515	0.74
142_K	154_L	0.514	0.74
93_F	96_L	0.507	0.73
45_M	57_G	0.506	0.73
43_A	47_A	0.505	0.73
26_A	36_I	0.505	0.73
77_K	80_P	0.503	0.72
33_A	53_I	0.500	0.72

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3wpwA	2	0.6872	100	0.295	Contact Map
2zvyA	2	0.8389	100	0.318	Contact Map
3s0yA	4	0.8578	100	0.328	Contact Map
2zovA	2	0.7583	100	0.329	Contact Map
3khnA	2	0.7488	100	0.36	Contact Map
3s06A	3	0.7251	100	0.371	Contact Map
4b62A	1	0.6635	100	0.372	Contact Map
2k1sA	1	0.6919	100	0.375	Contact Map
3ldtA	2	0.6682	100	0.385	Contact Map
2l26A	1	0.7773	100	0.4	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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