GREMLIN Database
MBHA - Putative protein MbhA
UniProt: Q47154 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13143
Length: 211 (165)
Sequences: 2698 (2039)
Seq/√Len: 158.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
72_E79_M4.7701.00
156_D161_Q3.2371.00
157_S161_Q3.2221.00
158_K161_Q3.1881.00
87_V132_V3.1371.00
122_S148_A2.7121.00
149_M153_M2.5701.00
109_M162_S2.5291.00
120_N131_R2.3921.00
33_A37_N2.2991.00
86_L132_V2.2361.00
108_A162_S2.1721.00
156_D164_G2.1501.00
130_R146_V2.0491.00
73_R109_M2.0281.00
158_K162_S1.9911.00
61_L169_E1.9871.00
123_G127_L1.9001.00
107_D118_N1.8441.00
117_N120_N1.8181.00
76_A124_D1.8101.00
102_I130_R1.7671.00
116_Y124_D1.7641.00
78_I132_V1.7611.00
105_H153_M1.7171.00
83_K132_V1.7071.00
156_D162_S1.6851.00
19_A23_K1.6511.00
113_N116_Y1.6481.00
119_W123_G1.6471.00
26_A30_G1.6431.00
127_L130_R1.6391.00
87_V136_A1.6061.00
117_N131_R1.5621.00
90_A133_L1.5381.00
103_T149_M1.5301.00
25_S40_A1.5071.00
157_S160_P1.4941.00
123_G148_A1.4921.00
18_T22_K1.4761.00
64_D68_R1.4651.00
21_L25_S1.4571.00
20_L23_K1.4061.00
11_A14_V1.3961.00
129_A168_I1.3931.00
110_A117_N1.3761.00
132_V136_A1.3731.00
19_A26_A1.3621.00
101_I147_S1.3441.00
140_E152_Q1.3431.00
103_T171_M1.3431.00
54_V57_G1.3191.00
25_S28_E1.3061.00
132_V135_E1.3001.00
15_N18_T1.2391.00
74_G117_N1.2161.00
27_T31_E1.2021.00
11_A15_N1.2011.00
108_A158_K1.1991.00
101_I145_Q1.1951.00
59_R171_M1.1841.00
108_A161_Q1.1831.00
86_L129_A1.1711.00
59_R169_E1.1621.00
80_P83_K1.1591.00
13_D17_K1.1581.00
134_E143_V1.1361.00
23_K27_T1.1261.00
25_S29_L1.1231.00
27_T30_G1.1131.00
70_M82_F1.1131.00
139_P142_K1.1111.00
116_Y120_N1.1051.00
32_L36_I1.0960.99
105_H168_I1.0800.99
21_L24_K1.0800.99
56_Q59_R1.0750.99
78_I82_F1.0710.99
126_A148_A1.0680.99
16_E20_L1.0660.99
94_D137_G1.0570.99
119_W150_A1.0420.99
15_N19_A1.0080.99
73_R107_D1.0040.99
22_K26_A1.0020.99
29_L33_A0.9980.99
78_I129_A0.9960.99
89_L93_F0.9950.99
134_E140_E0.9640.99
130_R143_V0.9480.99
51_M54_V0.9300.98
73_R118_N0.9200.98
98_N142_K0.9190.98
71_F168_I0.9120.98
17_K20_L0.8980.98
14_V19_A0.8880.98
30_G33_A0.8850.98
145_Q173_L0.8820.98
12_R28_E0.8810.98
19_A22_K0.8710.97
155_L164_G0.8690.97
120_N124_D0.8640.97
64_D70_M0.8640.97
56_Q103_T0.8560.97
50_E77_K0.8540.97
24_K27_T0.8510.97
74_G118_N0.8500.97
93_F138_M0.8500.97
104_G168_I0.8490.97
34_T38_T0.8400.97
116_Y131_R0.8350.97
110_A118_N0.8320.97
30_G34_T0.8190.96
119_W146_V0.8180.96
14_V17_K0.8140.96
86_L133_L0.8140.96
20_L24_K0.8090.96
110_A113_N0.8070.96
70_M103_T0.8010.96
69_N82_F0.7990.96
103_T147_S0.7990.96
88_E91_P0.7980.96
52_E61_L0.7930.96
16_E19_A0.7910.96
58_L172_V0.7900.95
123_G146_V0.7820.95
119_W130_R0.7770.95
28_E31_E0.7760.95
90_A138_M0.7750.95
140_E151_D0.7680.95
74_G107_D0.7560.94
61_L155_L0.7520.94
119_W127_L0.7500.94
111_Y114_N0.7500.94
57_G171_M0.7470.94
101_I171_M0.7460.94
62_I173_L0.7350.93
93_F100_I0.7340.93
124_D127_L0.7290.93
29_L58_L0.7280.93
31_E34_T0.7230.93
103_T169_E0.7220.93
89_L92_V0.7220.93
12_R16_E0.7170.93
99_K175_K0.7140.92
35_S95_S0.7120.92
23_K34_T0.7120.92
72_E75_S0.7120.92
105_H173_L0.7090.92
120_N127_L0.7070.92
111_Y117_N0.7050.92
117_N124_D0.7030.92
59_R170_I0.7020.92
156_D159_N0.7020.92
93_F102_I0.7020.92
105_H169_E0.6930.91
69_N146_V0.6930.91
44_H47_A0.6890.91
108_A154_L0.6840.91
160_P163_A0.6830.91
175_K178_S0.6760.90
161_Q164_G0.6750.90
25_S37_N0.6730.90
87_V91_P0.6730.90
15_N20_L0.6720.90
108_A160_P0.6690.90
145_Q149_M0.6630.89
129_A143_V0.6610.89
127_L131_R0.6600.89
91_P94_D0.6540.89
57_G98_N0.6530.89
51_M58_L0.6520.89
29_L32_L0.6490.88
119_W152_Q0.6470.88
89_L161_Q0.6340.87
118_N166_R0.6340.87
47_A50_E0.6320.87
62_I70_M0.6290.87
74_G110_A0.6280.87
12_R19_A0.6270.87
53_I58_L0.6260.86
119_W131_R0.6260.86
50_E63_K0.6250.86
99_K178_S0.6220.86
84_T88_E0.6200.86
74_G109_M0.6190.86
154_L160_P0.6130.85
33_A58_L0.6120.85
70_M152_Q0.6020.84
111_Y116_Y0.6020.84
117_N123_G0.5970.84
106_T158_K0.5970.84
149_M173_L0.5960.84
38_T42_D0.5960.84
109_M151_D0.5920.83
34_T37_N0.5890.83
18_T26_A0.5890.83
138_M142_K0.5870.83
117_N127_L0.5860.83
17_K21_L0.5850.83
110_A115_I0.5840.82
31_E35_S0.5840.82
18_T21_L0.5820.82
12_R18_T0.5800.82
57_G173_L0.5770.82
71_F129_A0.5760.82
11_A18_T0.5760.82
56_Q63_K0.5740.81
77_K83_K0.5730.81
25_S33_A0.5720.81
83_K135_E0.5700.81
105_H152_Q0.5670.81
13_D21_L0.5670.81
60_V119_W0.5660.80
71_F104_G0.5640.80
68_R81_F0.5600.80
137_G143_V0.5590.80
137_G142_K0.5570.79
12_R15_N0.5540.79
14_V22_K0.5540.79
72_E78_I0.5530.79
73_R110_A0.5490.78
22_K25_S0.5440.78
88_E92_V0.5440.78
108_A156_D0.5430.78
20_L26_A0.5410.77
89_L136_A0.5410.77
47_A51_M0.5400.77
49_L170_I0.5370.77
60_V64_D0.5330.76
154_L161_Q0.5290.76
12_R20_L0.5280.76
120_N123_G0.5270.76
106_T170_I0.5270.76
37_N51_M0.5230.75
131_R152_Q0.5200.75
102_I165_N0.5200.75
94_D138_M0.5200.75
62_I85_L0.5180.74
68_R71_F0.5160.74
154_L165_N0.5150.74
142_K154_L0.5140.74
93_F96_L0.5070.73
45_M57_G0.5060.73
43_A47_A0.5050.73
26_A36_I0.5050.73
77_K80_P0.5030.72
33_A53_I0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3wpwA 2 0.6872 100 0.295 Contact Map
2zvyA 2 0.8389 100 0.318 Contact Map
3s0yA 4 0.8578 100 0.328 Contact Map
2zovA 2 0.7583 100 0.329 Contact Map
3khnA 2 0.7488 100 0.36 Contact Map
3s06A 3 0.7251 100 0.371 Contact Map
4b62A 1 0.6635 100 0.372 Contact Map
2k1sA 1 0.6919 100 0.375 Contact Map
3ldtA 2 0.6682 100 0.385 Contact Map
2l26A 1 0.7773 100 0.4 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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