GREMLIN Database
YAFL - Probable endopeptidase YafL
UniProt: Q47151 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13149
Length: 249 (211)
Sequences: 2914 (2603)
Seq/√Len: 179.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
207_L224_I3.7051.00
129_Q132_K3.3471.00
138_G144_G3.0891.00
184_L239_A2.8261.00
127_E213_I2.7191.00
216_P221_T2.6901.00
130_L213_I2.6801.00
220_E223_R2.6021.00
123_I207_L2.5981.00
180_A183_D2.5901.00
139_T165_R2.5301.00
127_E224_I2.4881.00
236_F239_A2.4821.00
193_H201_D2.2771.00
166_T169_E2.2001.00
151_V205_V2.1901.00
140_R144_G2.1691.00
178_I240_R2.1151.00
151_V189_L2.0941.00
152_F165_R2.0301.00
151_V170_M1.9591.00
132_K145_F1.9331.00
145_F153_Y1.9121.00
217_R220_E1.8951.00
125_R153_Y1.8671.00
214_E225_S1.8421.00
76_Q80_E1.8191.00
164_P175_R1.7971.00
125_R157_K1.7841.00
132_K140_R1.7821.00
167_A171_Y1.7671.00
75_R79_R1.7381.00
189_L203_M1.7311.00
192_F212_F1.7251.00
191_F203_M1.6861.00
216_P219_G1.6581.00
125_R145_F1.6491.00
120_E124_H1.6481.00
133_P144_G1.6231.00
176_A240_R1.5941.00
126_L213_I1.5931.00
192_F204_G1.5431.00
181_N236_F1.5141.00
71_K74_L1.4621.00
212_F227_L1.4391.00
132_K144_G1.4261.00
42_M46_A1.4161.00
119_T123_I1.4081.00
211_Q224_I1.4041.00
31_H35_S1.3991.00
216_P223_R1.3981.00
153_Y157_K1.3961.00
171_Y200_A1.3861.00
45_R49_L1.3731.00
151_V163_L1.3591.00
150_L154_A1.3551.00
171_Y238_G1.3341.00
84_Q88_W1.3301.00
125_R128_Q1.3181.00
181_N184_L1.3171.00
70_S74_L1.3121.00
82_I86_P1.3101.00
130_L221_T1.3081.00
216_P220_E1.3031.00
193_H199_I1.2981.00
132_K138_G1.2981.00
152_F156_N1.2951.00
79_R83_K1.2951.00
83_K87_E1.2791.00
77_H81_Q1.2671.00
74_L78_N1.2541.00
192_F236_F1.2511.00
125_R129_Q1.2461.00
81_Q85_H1.2441.00
217_R221_T1.2281.00
193_H235_H1.2011.00
60_A63_I1.1911.00
77_H80_E1.1881.00
86_P90_P1.1781.00
218_T221_T1.1711.00
63_I67_N1.1671.00
164_P169_E1.1561.00
86_P89_F1.1531.00
71_K75_R1.1441.00
130_L224_I1.1331.00
83_K86_P1.1301.00
168_N200_A1.1141.00
139_T152_F1.1121.00
204_G212_F1.1111.00
49_L53_Q1.1071.00
78_N82_I1.1061.00
28_T31_H1.1041.00
52_Y56_L1.0981.00
27_A30_S1.0971.00
192_F201_D1.0961.00
126_L205_V1.0911.00
123_I213_I1.0901.00
179_V183_D1.0871.00
72_R76_Q1.0861.00
35_S39_R1.0771.00
184_L227_L1.0751.00
169_E172_H1.0531.00
56_L60_A1.0511.00
76_Q79_R1.0481.00
98_R101_Q1.0230.99
141_P145_F1.0230.99
81_Q84_Q1.0230.99
125_R158_I1.0230.99
135_V138_G1.0150.99
41_R44_N1.0080.99
32_I36_Y1.0070.99
181_N228_A1.0030.99
124_H127_E0.9990.99
84_Q87_E0.9890.99
135_V218_T0.9740.99
95_A99_R0.9690.99
62_Y65_E0.9690.99
123_I127_E0.9690.99
211_Q226_R0.9640.99
145_F222_I0.9620.99
154_A158_I0.9610.99
184_L190_L0.9570.99
85_H89_F0.9560.99
152_F166_T0.9550.99
20_P23_S0.9490.99
58_K62_Y0.9490.99
89_F92_P0.9440.99
125_R154_A0.9410.99
171_Y237_L0.9300.99
164_P167_A0.9280.99
118_I121_V0.9240.99
46_A50_K0.9190.99
120_E186_R0.9150.99
165_R169_E0.9130.99
105_E108_H0.9100.99
80_E84_Q0.9090.99
135_V144_G0.9030.99
156_N162_K0.8970.99
127_E207_L0.8950.99
167_A200_A0.8920.99
105_E109_F0.8900.99
69_E73_A0.8780.98
168_N171_Y0.8760.98
129_Q140_R0.8750.98
75_R78_N0.8750.98
34_F37_A0.8740.98
90_P94_K0.8690.98
68_A72_R0.8640.98
171_Y176_A0.8610.98
55_H58_K0.8590.98
69_E72_R0.8560.98
29_T36_Y0.8550.98
122_A158_I0.8550.98
214_E223_R0.8540.98
73_A76_Q0.8490.98
210_G227_L0.8430.98
73_A77_H0.8410.98
78_N81_Q0.8390.98
40_Q44_N0.8350.98
99_R102_A0.8290.98
73_A81_Q0.8260.98
186_R207_L0.8230.98
152_F170_M0.8220.98
129_Q150_L0.8220.98
51_Q55_H0.8220.98
25_A28_T0.8180.97
165_R168_N0.8110.97
129_Q154_A0.8080.97
70_S73_A0.8060.97
204_G214_E0.8050.97
59_Q63_I0.8020.97
96_S99_R0.7970.97
140_R145_F0.7960.97
53_Q57_K0.7930.97
25_A29_T0.7920.97
180_A184_L0.7910.97
186_R206_Y0.7890.97
88_W92_P0.7880.97
171_Y191_F0.7870.97
122_A155_Y0.7820.97
153_Y156_N0.7800.97
80_E83_K0.7800.97
21_F25_A0.7750.96
155_Y163_L0.7620.96
82_I85_H0.7620.96
127_E130_L0.7550.96
30_S34_F0.7520.96
190_L204_G0.7510.96
18_C21_F0.7500.96
190_L239_A0.7490.96
18_C22_S0.7340.95
60_A64_V0.7330.95
181_N190_L0.7310.95
92_P96_S0.7290.95
22_S25_A0.7280.95
19_L22_S0.7230.95
53_Q56_L0.7180.95
119_T186_R0.7170.95
57_K60_A0.7140.94
122_A154_A0.7090.94
214_E228_A0.6980.94
89_F93_L0.6980.94
191_F200_A0.6940.94
102_A108_H0.6910.93
192_F228_A0.6880.93
132_K222_I0.6770.93
25_A31_H0.6760.93
184_L236_F0.6750.93
21_F28_T0.6720.92
100_W103_L0.6720.92
38_A42_M0.6700.92
181_N239_A0.6700.92
45_R48_L0.6640.92
26_S30_S0.6600.92
213_I224_I0.6590.92
85_H88_W0.6560.92
28_T32_I0.6560.92
24_F28_T0.6540.91
139_T149_G0.6530.91
216_P222_I0.6530.91
132_K142_D0.6490.91
102_A106_N0.6480.91
88_W91_A0.6460.91
63_I66_G0.6410.91
171_Y239_A0.6400.91
31_H42_M0.6390.90
72_R75_R0.6330.90
54_T58_K0.6230.89
220_E225_S0.6200.89
101_Q104_A0.6170.89
172_H176_A0.6150.89
93_L96_S0.6110.88
236_F240_R0.6040.88
87_E91_A0.6030.88
167_A203_M0.6020.88
139_T166_T0.6010.88
128_Q132_K0.5960.87
139_T145_F0.5920.87
106_N109_F0.5900.87
93_L97_D0.5890.87
128_Q153_Y0.5890.87
21_F24_F0.5880.86
129_Q153_Y0.5860.86
99_R103_L0.5850.86
200_A237_L0.5840.86
71_K81_Q0.5830.86
136_W144_G0.5810.86
79_R82_I0.5790.86
163_L176_A0.5780.86
136_W149_G0.5760.85
138_G149_G0.5750.85
177_T183_D0.5750.85
201_D235_H0.5740.85
79_R86_P0.5740.85
96_S100_W0.5720.85
152_F163_L0.5710.85
233_Q236_F0.5700.85
121_V124_H0.5690.85
98_R102_A0.5680.85
23_S26_S0.5660.84
57_K61_S0.5640.84
121_V158_I0.5620.84
21_F26_S0.5610.84
201_D212_F0.5580.84
141_P153_Y0.5540.83
31_H59_Q0.5520.83
129_Q145_F0.5520.83
32_I35_S0.5490.83
206_Y210_G0.5460.82
70_S77_H0.5460.82
71_K77_H0.5420.82
62_Y67_N0.5420.82
172_H178_I0.5410.82
133_P221_T0.5400.81
155_Y161_A0.5390.81
62_Y66_G0.5390.81
45_R63_I0.5380.81
167_A170_M0.5370.81
101_Q106_N0.5360.81
81_Q86_P0.5350.81
167_A191_F0.5340.81
50_K53_Q0.5330.81
135_V139_T0.5320.81
59_Q62_Y0.5320.81
90_P93_L0.5310.80
50_K54_T0.5280.80
154_A157_K0.5260.80
123_I186_R0.5260.80
155_Y176_A0.5240.80
100_W107_N0.5240.80
81_Q87_E0.5230.79
206_Y209_D0.5200.79
61_S64_V0.5180.79
87_E90_P0.5180.79
171_Y236_F0.5170.79
105_E111_S0.5170.79
151_V203_M0.5170.79
48_L51_Q0.5160.79
207_L211_Q0.5130.78
201_D214_E0.5120.78
172_H175_R0.5120.78
27_A39_R0.5110.78
45_R59_Q0.5100.78
77_H85_H0.5090.78
227_L236_F0.5080.77
184_L206_Y0.5070.77
139_T156_N0.5070.77
104_A107_N0.5060.77
44_N47_R0.5050.77
129_Q158_I0.5040.77
56_L63_I0.5020.77
129_Q144_G0.5020.77
206_Y211_Q0.5010.76
212_F234_D0.5010.76
24_F27_A0.5010.76
18_C25_A0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4q4gX 1 0.5502 100 0.33 Contact Map
2k1gA 1 0.5181 100 0.421 Contact Map
4hpeA 1 0.7068 100 0.442 Contact Map
4xcmA 2 0.8273 100 0.443 Contact Map
4fdyA 1 0.9157 100 0.445 Contact Map
3h41A 1 0.8233 100 0.446 Contact Map
3npfA 2 0.9076 100 0.457 Contact Map
3pbiA 1 0.7108 100 0.462 Contact Map
4lj1A 1 0.4739 100 0.465 Contact Map
2hbwA 1 0.8153 100 0.475 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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