GREMLIN Database
DINJ - Antitoxin DinJ
UniProt: Q47150 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13142
Length: 86 (83)
Sequences: 364 (276)
Seq/√Len: 30.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
77_A81_F3.3271.00
33_L37_T2.8701.00
23_L41_V2.8181.00
65_S68_G2.7161.00
81_F85_G2.7061.00
40_K44_E2.6401.00
77_A85_G2.3370.99
29_T47_L2.0470.98
15_L42_A1.7890.95
38_L41_V1.6870.93
35_R39_T1.6840.93
64_N74_A1.6430.92
61_S64_N1.6320.91
5_A13_E1.6280.91
82_D85_G1.6060.91
8_R34_V1.6040.91
68_G71_V1.5370.89
11_I38_L1.5020.87
30_I38_L1.4730.86
31_S35_R1.4680.86
29_T32_D1.4130.84
40_K51_L1.3970.83
28_L36_I1.2840.78
3_A13_E1.2710.77
32_D47_L1.2630.76
22_V26_M1.2420.75
6_F34_V1.2200.74
61_S65_S1.1780.71
19_A32_D1.1340.68
17_N21_D1.1200.67
64_N69_I1.1070.66
64_N68_G1.0880.65
15_L76_D1.0790.64
33_L36_I1.0760.64
79_D82_D1.0720.64
20_A29_T1.0710.64
56_Q60_Q1.0600.63
56_Q66_E1.0290.61
72_H83_K1.0260.60
54_P60_Q1.0190.60
59_I62_I1.0150.59
24_A73_K0.9940.58
22_V42_A0.9860.57
67_A71_V0.9760.56
70_D74_A0.9680.56
7_V32_D0.9410.54
6_F9_A0.9300.53
4_N37_T0.9300.53
54_P58_T0.9250.52
21_D63_K0.9180.52
32_D35_R0.9010.50
37_T41_V0.8980.50
29_T53_E0.8980.50
62_I73_K0.8890.50
34_V38_L0.8840.49
37_T49_F0.8800.49
22_V41_V0.8550.47
76_D81_F0.8390.46
23_L37_T0.8350.45
69_I79_D0.8290.45
63_K67_A0.8210.44
19_A35_R0.8130.43
74_A83_K0.8020.43
61_S71_V0.7990.42
77_A83_K0.7960.42
20_A31_S0.7910.42
38_L42_A0.7880.42
19_A42_A0.7860.41
8_R31_S0.7810.41
32_D39_T0.7740.40
33_L49_F0.7630.40
62_I65_S0.7490.39
34_V52_R0.7460.38
65_S85_G0.7450.38
56_Q70_D0.7370.38
67_A75_K0.7280.37
26_M35_R0.7130.36
78_D81_F0.7040.35
16_K49_F0.7040.35
3_A44_E0.7010.35
14_D73_K0.7010.35
25_G43_R0.6960.35
75_K78_D0.6950.35
36_I78_D0.6930.34
11_I36_I0.6890.34
22_V46_A0.6860.34
36_I51_L0.6740.33
68_G74_A0.6700.33
63_K85_G0.6650.32
50_D77_A0.6610.32
25_G32_D0.6550.32
12_D16_K0.6550.32
76_D83_K0.6420.31
31_S40_K0.6410.31
17_N33_L0.6400.31
20_A55_N0.6380.31
50_D66_E0.6350.30
64_N72_H0.6150.29
78_D82_D0.6130.29
47_L51_L0.6120.29
46_A49_F0.6100.29
35_R47_L0.6060.28
4_N69_I0.6040.28
11_I47_L0.5990.28
75_K80_L0.5940.28
9_A22_V0.5930.28
4_N7_V0.5920.28
45_K56_Q0.5780.27
23_L35_R0.5780.27
57_L79_D0.5700.26
9_A38_L0.5690.26
77_A84_L0.5640.26
5_A40_K0.5630.26
59_I67_A0.5520.25
14_D56_Q0.5470.25
36_I43_R0.5410.24
13_E31_S0.5400.24
67_A77_A0.5330.24
17_N67_A0.5290.24
18_Q31_S0.5240.23
31_S44_E0.5210.23
23_L42_A0.5170.23
29_T40_K0.5100.23
59_I63_K0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4q2uA 5 0.9767 100 0.195 Contact Map
4fxeA 4 0.8837 99.8 0.386 Contact Map
1bazA 4 0.5581 91.1 0.839 Contact Map
2k9iA 2 0.5814 87.4 0.85 Contact Map
2gpeA 2 0.5116 83.3 0.858 Contact Map
1p94A 2 0.5349 82.4 0.859 Contact Map
2ay0A 2 0.5349 81.2 0.861 Contact Map
2cpgA 2 0.5233 78 0.865 Contact Map
2mdvA 2 0.4419 77.5 0.866 Contact Map
1nlaA 2 0.5814 75.6 0.868 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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