GREMLIN Database
YAFJ - Putative glutamine amidotransferase YafJ
UniProt: Q47147 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13147
Length: 255 (228)
Sequences: 1616 (981)
Seq/√Len: 65.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_T104_T9.9771.00
71_S74_V4.8041.00
241_M244_E4.3551.00
140_K158_Y3.5821.00
75_V106_A3.4901.00
6_G175_L3.1941.00
6_G182_V3.0781.00
77_H92_H2.8791.00
133_A174_M2.5551.00
90_N126_G2.5481.00
124_P135_C2.5381.00
81_A84_G2.4861.00
111_L133_A2.4241.00
184_A226_I2.3661.00
75_V175_L2.3641.00
15_I38_I2.3421.00
126_G131_E2.3371.00
178_D181_Y2.3051.00
95_T104_T2.2481.00
105_Y174_M2.0991.00
15_I74_V2.0551.00
190_L195_R2.0311.00
41_Y177_S1.9691.00
160_A164_D1.9661.00
90_N131_E1.9581.00
90_N128_T1.9371.00
77_H90_N1.8961.00
128_T131_E1.8921.00
63_L95_T1.8511.00
158_Y162_L1.8501.00
106_A175_L1.8481.00
38_I74_V1.8341.00
181_Y249_C1.8011.00
105_Y134_F1.7621.00
224_T248_F1.7601.00
41_Y104_T1.6880.99
194_T224_T1.6850.99
232_T235_E1.6650.99
137_L152_M1.6580.99
226_I246_R1.6550.99
107_H130_S1.6330.99
75_V177_S1.6000.99
4_L175_L1.5970.99
137_L155_V1.5750.99
32_H78_I1.5640.99
240_I246_R1.5560.99
140_K143_Q1.5350.99
103_W176_L1.4940.99
101_R178_D1.4600.98
42_E47_R1.4530.98
49_F197_A1.4400.98
137_L176_L1.4390.98
122_F142_T1.4050.98
55_S77_H1.4000.98
134_F138_L1.3710.97
1_M5_L1.3690.97
94_F128_T1.3650.97
24_Q28_G1.3540.97
16_C19_F1.3530.97
154_A158_Y1.3300.97
133_A155_V1.3240.97
140_K165_E1.3080.97
77_H106_A1.3060.96
155_V158_Y1.2930.96
53_Q227_A1.2870.96
7_M18_S1.2860.96
13_T17_F1.2570.96
102_N180_R1.2520.96
15_I19_F1.2490.95
71_S177_S1.2450.95
16_C66_D1.2440.95
155_V159_I1.2430.95
113_G116_S1.2340.95
194_T197_A1.2250.95
73_S182_V1.2250.95
61_A231_L1.2100.95
47_R68_P1.2080.95
222_V225_V1.1970.94
184_A245_W1.1890.94
139_H143_Q1.1840.94
143_Q161_S1.1750.94
184_A246_R1.1680.94
32_H56_F1.1280.92
72_C225_V1.1200.92
51_D58_S1.1100.92
163_A174_M1.1080.92
69_I217_T1.1010.91
20_T54_P1.0830.91
8_S73_S1.0810.91
96_R138_L1.0780.90
82_N130_S1.0700.90
43_G70_K1.0680.90
41_Y179_G1.0670.90
103_W128_T1.0650.90
190_L196_R1.0600.90
1_M4_L1.0540.89
4_L106_A1.0340.88
217_T223_V1.0320.88
61_A225_V1.0290.88
82_N110_Q1.0270.88
20_T136_W1.0170.88
193_I242_P1.0120.87
189_N229_Q1.0090.87
180_R249_C1.0030.87
112_T170_G0.9990.87
151_N154_A0.9970.87
191_H194_T0.9890.86
179_G230_P0.9850.86
92_H128_T0.9830.86
36_W40_F0.9710.85
29_T82_N0.9680.85
152_M183_M0.9680.85
75_V182_V0.9670.85
59_P62_K0.9640.85
153_A180_R0.9580.84
136_W162_L0.9540.84
191_H196_R0.9520.84
193_I197_A0.9510.84
73_S177_S0.9490.84
120_G139_H0.9460.84
175_L184_A0.9440.83
161_S165_E0.9430.83
152_M155_V0.9360.83
118_E132_K0.9350.83
20_T24_Q0.9110.81
90_N134_F0.9040.81
191_H239_K0.9020.81
181_Y247_L0.8950.80
14_D17_F0.8890.80
35_G79_R0.8810.79
60_I64_V0.8780.79
3_E9_A0.8780.79
155_V160_A0.8770.79
213_F217_T0.8710.78
77_H126_G0.8710.78
228_T248_F0.8700.78
7_M13_T0.8640.78
196_R222_V0.8590.77
29_T55_S0.8570.77
78_I230_P0.8470.76
135_C173_N0.8450.76
40_F69_I0.8430.76
143_Q154_A0.8420.76
47_R69_I0.8420.76
144_R246_R0.8400.76
225_V231_L0.8350.75
62_K241_M0.8330.75
35_G108_N0.8230.74
88_L183_M0.8220.74
72_C250_L0.8210.74
92_H134_F0.8200.74
2_C5_L0.8080.73
45_G102_N0.8060.73
41_Y178_D0.7990.72
10_N232_T0.7980.72
22_L31_P0.7980.72
182_V248_F0.7950.72
188_T191_H0.7910.71
3_E30_G0.7860.71
48_T95_T0.7860.71
144_R147_R0.7790.70
10_N15_I0.7760.70
62_K66_D0.7750.70
15_I18_S0.7750.70
7_M10_N0.7730.69
174_M185_Y0.7590.68
51_D88_L0.7540.68
79_R108_N0.7500.67
180_R250_L0.7500.67
48_T82_N0.7500.67
173_N227_A0.7470.67
62_K117_L0.7420.66
33_K57_N0.7400.66
224_T227_A0.7390.66
188_T192_W0.7370.66
19_F235_E0.7360.66
9_A21_G0.7330.65
116_S166_L0.7310.65
3_E8_S0.7240.64
145_Y148_T0.7160.63
116_S154_A0.7160.63
82_N171_V0.7130.63
83_R110_Q0.7070.63
12_P17_F0.7030.62
41_Y71_S0.7010.62
92_H131_E0.6990.62
49_F60_I0.6990.62
32_H80_Q0.6970.61
5_L19_F0.6960.61
111_L170_G0.6950.61
36_W54_P0.6940.61
2_C6_G0.6930.61
35_G129_D0.6920.61
141_L173_N0.6890.61
57_N85_E0.6890.61
102_N226_I0.6880.60
57_N148_T0.6880.60
52_P91_T0.6860.60
4_L173_N0.6850.60
142_T146_P0.6850.60
9_A20_T0.6830.60
1_M6_G0.6820.60
160_A169_K0.6820.60
157_K161_S0.6810.60
164_D236_T0.6810.60
96_R135_C0.6760.59
3_E7_M0.6750.59
4_L77_H0.6730.59
153_A157_K0.6710.58
91_T128_T0.6690.58
121_N136_W0.6680.58
143_Q157_K0.6600.57
184_A240_I0.6590.57
19_F61_A0.6550.57
126_G134_F0.6540.57
226_I236_T0.6540.57
155_V176_L0.6530.56
79_R129_D0.6520.56
132_K162_L0.6520.56
153_A183_M0.6490.56
30_G80_Q0.6480.56
148_T236_T0.6480.56
40_F49_F0.6470.56
26_G29_T0.6470.56
121_N229_Q0.6430.55
171_V189_N0.6420.55
56_F78_I0.6420.55
10_N222_V0.6410.55
9_A13_T0.6390.55
183_M247_L0.6390.55
42_E68_P0.6360.54
87_A127_E0.6360.54
188_T193_I0.6310.54
5_L13_T0.6310.54
22_L25_R0.6310.54
182_V249_C0.6310.54
102_N163_A0.6300.54
73_S184_A0.6300.54
137_L141_L0.6270.53
81_A129_D0.6230.53
19_F38_I0.6220.53
51_D91_T0.6200.53
59_P214_S0.6150.52
114_Y134_F0.6150.52
91_T188_T0.6150.52
112_T143_Q0.6140.52
137_L157_K0.6130.52
193_I196_R0.6100.51
33_K91_T0.6090.51
120_G165_E0.6070.51
13_T221_D0.6040.51
170_G173_N0.6030.51
21_G78_I0.6020.51
75_V104_T0.6020.51
69_I137_L0.5990.50
32_H40_F0.5970.50
74_V141_L0.5960.50
38_I61_A0.5920.49
152_M165_E0.5910.49
27_G103_W0.5900.49
82_N85_E0.5900.49
102_N178_D0.5890.49
36_W175_L0.5880.49
133_A159_I0.5860.49
21_G24_Q0.5850.49
94_F105_Y0.5850.49
49_F64_V0.5840.48
23_V33_K0.5830.48
157_K160_A0.5800.48
182_V246_R0.5790.48
13_T19_F0.5760.47
12_P19_F0.5760.47
55_S92_H0.5760.47
103_W137_L0.5730.47
240_I249_C0.5710.47
14_D19_F0.5700.47
32_H36_W0.5690.47
75_V163_A0.5680.47
5_L225_V0.5670.46
13_T157_K0.5650.46
12_P245_W0.5650.46
32_H108_N0.5630.46
47_R71_S0.5630.46
41_Y134_F0.5610.46
10_N70_K0.5600.46
80_Q91_T0.5570.45
37_G93_P0.5570.45
23_V46_C0.5560.45
68_P75_V0.5560.45
121_N169_K0.5550.45
36_W186_C0.5540.45
6_G106_A0.5540.45
160_A187_S0.5530.45
127_E131_E0.5500.44
189_N193_I0.5500.44
159_I168_Q0.5500.44
115_K180_R0.5460.44
190_L194_T0.5460.44
22_L185_Y0.5450.44
121_N142_T0.5450.44
20_T56_F0.5440.44
118_E121_N0.5400.43
71_S91_T0.5400.43
156_F241_M0.5380.43
26_G78_I0.5380.43
96_R102_N0.5370.43
61_A135_C0.5360.43
47_R60_I0.5360.43
156_F236_T0.5340.43
40_F54_P0.5340.43
226_I233_G0.5340.43
154_A159_I0.5340.43
196_R229_Q0.5340.43
112_T240_I0.5340.43
13_T217_T0.5330.43
144_R158_Y0.5320.42
18_S74_V0.5310.42
61_A64_V0.5300.42
136_W140_K0.5260.42
187_S243_G0.5260.42
38_I105_Y0.5250.42
31_P80_Q0.5230.41
55_S90_N0.5220.41
105_Y152_M0.5210.41
35_G81_A0.5210.41
55_S91_T0.5200.41
215_S246_R0.5140.40
156_F172_F0.5130.40
66_D159_I0.5130.40
233_G236_T0.5120.40
47_R88_L0.5120.40
112_T151_N0.5110.40
144_R162_L0.5100.40
41_Y46_C0.5090.40
125_V223_V0.5060.39
114_Y118_E0.5050.39
68_P88_L0.5020.39
3_E228_T0.5020.39
124_P247_L0.5010.39
46_C229_Q0.5010.39
197_A239_K0.5000.39
49_F59_P0.5000.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mdnA 4 0.8039 100 0.417 Contact Map
1te5A 2 0.9882 100 0.434 Contact Map
4zflA 5 0.8275 100 0.473 Contact Map
4amvA 2 0.8235 100 0.59 Contact Map
1xffA 2 0.8235 100 0.611 Contact Map
1ao0A 3 0.8275 100 0.621 Contact Map
1ecfA 4 0.8902 100 0.626 Contact Map
1ea0A 1 0.8745 99.9 0.71 Contact Map
1ofdA 1 0.8667 99.8 0.724 Contact Map
1jgtA 2 0.6902 99.7 0.752 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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