GREMLIN Database
HCAT - Probable 3-phenylpropionic acid transporter
UniProt: Q47142 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13454
Length: 379 (359)
Sequences: 166240 (120237)
Seq/√Len: 6345.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
91_A95_W3.8791.00
86_A99_V3.8531.00
69_L120_T3.8251.00
79_L106_F3.6821.00
88_W161_A3.2101.00
51_A101_I3.1441.00
59_I109_P3.1001.00
83_F99_V2.9761.00
94_A98_L2.7901.00
76_L109_P2.7901.00
122_Q128_D2.7701.00
92_H95_W2.7461.00
64_S324_I2.7261.00
81_L167_V2.6961.00
83_F106_F2.6911.00
319_Q326_L2.6761.00
93_V97_M2.6481.00
235_S238_A2.5911.00
37_T40_T2.5201.00
196_A200_L2.4711.00
266_A317_A2.4271.00
126_P262_R2.4111.00
216_G342_M2.4081.00
212_C338_S2.3921.00
276_C303_T2.3591.00
249_A298_I2.3541.00
70_I74_R2.3341.00
283_I296_V2.2431.00
83_F102_G2.2261.00
55_G105_L2.2101.00
40_T93_V2.1461.00
291_P295_V2.1101.00
172_L176_I2.0851.00
90_G95_W2.0301.00
359_W363_L2.0101.00
154_F158_V1.9851.00
253_I302_G1.9701.00
63_V113_L1.9641.00
289_A292_W1.9321.00
10_A135_W1.9171.00
85_V164_T1.8751.00
90_G99_V1.8611.00
67_S71_S1.8321.00
265_S268_D1.8251.00
259_K263_R1.7991.00
83_F103_F1.7971.00
44_L96_L1.7601.00
280_R303_T1.7061.00
61_P65_D1.7051.00
51_A55_G1.6851.00
47_A97_M1.6801.00
87_F99_V1.6691.00
60_A64_S1.6591.00
285_G359_W1.6541.00
220_A346_A1.6471.00
280_R296_V1.6421.00
161_A165_L1.6411.00
55_G108_S1.6321.00
88_W164_T1.6241.00
197_W200_L1.6211.00
47_A101_I1.5981.00
234_Y238_A1.5931.00
55_G58_L1.5861.00
273_S306_V1.5831.00
278_V369_M1.5711.00
285_G362_A1.5681.00
36_L93_V1.5391.00
36_L40_T1.5331.00
348_F352_Y1.5181.00
278_V366_L1.4941.00
194_W197_W1.4751.00
149_K153_M1.4741.00
257_S306_V1.4691.00
81_L164_T1.4441.00
62_R72_A1.4401.00
58_L61_P1.4361.00
246_G301_C1.4251.00
71_S74_R1.4211.00
158_V161_A1.4161.00
291_P294_I1.4151.00
268_D271_L1.4141.00
71_S75_V1.4061.00
76_L106_F1.4051.00
258_N262_R1.4041.00
271_L369_M1.4021.00
94_A97_M1.3981.00
38_P351_Q1.3921.00
249_A253_I1.3721.00
95_W99_V1.3681.00
75_V79_L1.3451.00
127_L262_R1.3451.00
282_G286_A1.3361.00
217_A365_A1.3361.00
66_P72_A1.3351.00
120_T323_V1.3261.00
62_R66_P1.3231.00
267_R271_L1.3101.00
145_A244_S1.3081.00
230_Q239_V1.3061.00
230_Q236_A1.2891.00
63_V69_L1.2821.00
50_V340_A1.2771.00
81_L168_A1.2741.00
87_F96_L1.2681.00
253_I256_L1.2621.00
256_L259_K1.2591.00
29_V32_K1.2591.00
171_L175_L1.2561.00
260_L264_C1.2381.00
272_I276_C1.2341.00
219_A339_I1.2321.00
275_I369_M1.2321.00
79_L83_F1.2311.00
363_L367_P1.2291.00
31_L41_I1.2231.00
74_R174_F1.2221.00
17_F136_G1.2071.00
238_A241_Y1.2031.00
152_T237_S1.1941.00
85_V89_A1.1901.00
259_K262_R1.1871.00
119_N125_F1.1841.00
193_G196_A1.1691.00
250_E305_T1.1691.00
64_S325_R1.1681.00
349_L353_L1.1561.00
29_V33_G1.1561.00
155_D158_V1.1531.00
192_T195_S1.1521.00
280_R300_H1.1411.00
150_L158_V1.1411.00
118_A132_V1.1361.00
145_A149_K1.1281.00
255_A259_K1.1251.00
275_I279_V1.1241.00
173_G176_I1.1241.00
280_R299_L1.1231.00
70_I179_T1.1201.00
86_A89_A1.1181.00
205_W209_A1.1141.00
271_L373_P1.1081.00
241_Y245_L1.1081.00
359_W362_A1.1071.00
46_G344_V1.1041.00
228_Y232_A1.1001.00
290_L294_I1.0981.00
338_S342_M1.0941.00
53_F340_A1.0931.00
366_L370_F1.0911.00
229_W234_Y1.0881.00
273_S307_C1.0871.00
125_F317_A1.0871.00
46_G340_A1.0861.00
268_D272_I1.0811.00
192_T196_A1.0801.00
278_V282_G1.0791.00
66_P71_S1.0791.00
282_G362_A1.0771.00
40_T97_M1.0751.00
295_V298_I1.0671.00
43_L344_V1.0671.00
178_P181_Q1.0611.00
82_L86_A1.0601.00
277_G365_A1.0591.00
274_A368_A1.0541.00
51_A104_N1.0531.00
127_L131_K1.0511.00
315_I330_Y1.0501.00
74_R175_L1.0471.00
100_M104_N1.0471.00
39_E351_Q1.0441.00
347_G351_Q1.0391.00
12_G110_L1.0371.00
360_V364_V1.0361.00
98_L102_G1.0361.00
204_N208_L1.0351.00
202_R206_R1.0301.00
48_G52_R1.0251.00
67_S72_A1.0231.00
201_V205_W1.0171.00
273_S303_T1.0141.00
172_L175_L1.0091.00
196_A199_A1.0091.00
193_G197_W1.0061.00
191_S194_W1.0041.00
39_E43_L1.0011.00
60_A324_I0.9981.00
33_G157_R0.9981.00
360_V363_L0.9981.00
189_Q192_T0.9881.00
80_T106_F0.9861.00
199_A205_W0.9841.00
86_A95_W0.9821.00
252_I255_A0.9801.00
148_G240_G0.9761.00
215_Q335_M0.9761.00
287_T296_V0.9731.00
281_W285_G0.9701.00
72_A75_V0.9651.00
27_W41_I0.9621.00
264_C269_M0.9581.00
283_I286_A0.9571.00
89_A161_A0.9561.00
248_V252_I0.9541.00
53_F332_A0.9491.00
210_C372_R0.9471.00
48_G104_N0.9461.00
43_L47_A0.9461.00
356_G359_W0.9451.00
88_W157_R0.9441.00
74_R78_L0.9441.00
42_G46_G0.9431.00
57_L61_P0.9421.00
276_C280_R0.9421.00
64_S69_L0.9411.00
31_L36_L0.9391.00
252_I256_L0.9351.00
42_G224_F0.9351.00
271_L275_I0.9331.00
19_S22_I0.9321.00
295_V299_L0.9311.00
211_V330_Y0.9311.00
69_L116_A0.9271.00
47_A51_A0.9261.00
265_S269_M0.9201.00
95_W98_L0.9141.00
229_W293_L0.9131.00
227_I231_A0.9121.00
74_R171_L0.9101.00
202_R205_W0.9071.00
112_P115_D0.9051.00
190_E193_G0.9031.00
261_F310_A0.8951.00
164_T168_A0.8941.00
362_A366_L0.8921.00
71_S179_T0.8831.00
271_L274_A0.8821.00
48_G107_F0.8821.00
38_P231_A0.8811.00
75_V78_L0.8771.00
237_S241_Y0.8741.00
119_N323_V0.8671.00
69_L179_T0.8621.00
264_C268_D0.8591.00
137_S250_E0.8581.00
81_L171_L0.8531.00
278_V365_A0.8531.00
313_R317_A0.8491.00
278_V362_A0.8491.00
292_W295_V0.8481.00
161_A164_T0.8471.00
108_S112_P0.8431.00
287_T292_W0.8411.00
40_T43_L0.8401.00
127_L259_K0.8381.00
249_A252_I0.8371.00
80_T167_V0.8361.00
309_L313_R0.8341.00
67_S179_T0.8321.00
117_L121_W0.8281.00
146_L149_K0.8261.00
26_F30_W0.8251.00
50_V53_F0.8211.00
56_S331_S0.8191.00
78_L82_L0.8171.00
158_V162_L0.8161.00
279_V283_I0.8141.00
26_F151_V0.8131.00
55_G59_I0.8101.00
280_R283_I0.8091.00
348_F351_Q0.8081.00
84_A103_F0.8071.00
19_S100_M0.8051.00
337_G341_I0.8041.00
150_L154_F0.8031.00
44_L97_M0.8011.00
361_M365_A0.8001.00
275_I278_V0.8001.00
272_I275_I0.7991.00
67_S70_I0.7991.00
78_L81_L0.7941.00
84_A164_T0.7941.00
357_V360_V0.7921.00
33_G156_Y0.7901.00
85_V161_A0.7881.00
129_Y313_R0.7871.00
8_W173_G0.7871.00
76_L113_L0.7851.00
117_L177_R0.7841.00
18_F143_G0.7821.00
316_A327_Q0.7821.00
73_L117_L0.7791.00
242_L294_I0.7781.00
345_F348_F0.7771.00
165_L168_A0.7761.00
170_M174_F0.7751.00
49_L53_F0.7741.00
170_M173_G0.7731.00
203_Q206_R0.7731.00
190_E194_W0.7701.00
245_L294_I0.7701.00
209_A213_L0.7691.00
370_F373_P0.7681.00
61_P325_R0.7681.00
14_F139_A0.7651.00
224_F347_G0.7631.00
299_L303_T0.7621.00
30_W156_Y0.7601.00
142_I145_A0.7581.00
84_A163_L0.7571.00
274_A369_M0.7551.00
253_I257_S0.7551.00
213_L364_V0.7521.00
191_S197_W0.7481.00
100_M103_F0.7481.00
19_S163_L0.7451.00
162_L165_L0.7381.00
256_L260_L0.7381.00
129_Y316_A0.7361.00
28_S32_K0.7341.00
112_P116_A0.7341.00
21_G140_F0.7341.00
151_V159_I0.7321.00
211_V215_Q0.7321.00
59_I108_S0.7251.00
214_L307_C0.7241.00
91_A94_A0.7231.00
328_A332_A0.7231.00
171_L174_F0.7231.00
201_V318_R0.7221.00
163_L166_G0.7211.00
244_S248_V0.7171.00
191_S196_A0.7141.00
357_V361_M0.7141.00
77_A170_M0.7121.00
344_V348_F0.7091.00
141_V248_V0.7081.00
12_G73_L0.7061.00
87_F90_G0.7051.00
45_L223_G0.7051.00
36_L41_I0.7041.00
80_T107_F0.7011.00
109_P113_L0.6991.00
54_L57_L0.6981.00
44_L93_V0.6981.00
213_L368_A0.6971.00
87_F103_F0.6971.00
31_L38_P0.6951.00
100_M111_V0.6941.00
14_F142_I0.6931.00
234_Y290_L0.6921.00
119_N129_Y0.6921.00
277_G303_T0.6881.00
294_I298_I0.6871.00
39_E344_V0.6871.00
119_N316_A0.6861.00
48_G100_M0.6861.00
43_L97_M0.6841.00
220_A361_M0.6821.00
15_T19_S0.6821.00
134_L255_A0.6811.00
175_L178_P0.6811.00
286_A359_W0.6791.00
229_W232_A0.6791.00
234_Y242_L0.6781.00
350_Y353_L0.6781.00
10_A131_K0.6761.00
140_F247_V0.6761.00
283_I287_T0.6741.00
158_V165_L0.6741.00
144_S244_S0.6731.00
197_W322_E0.6731.00
91_A157_R0.6711.00
296_V299_L0.6691.00
282_G285_G0.6661.00
54_L58_L0.6631.00
306_V310_A0.6621.00
292_W296_V0.6621.00
227_I230_Q0.6601.00
22_I159_I0.6601.00
316_A323_V0.6581.00
169_S173_G0.6581.00
225_S297_Q0.6571.00
81_L85_V0.6561.00
238_A290_L0.6531.00
157_R161_A0.6511.00
82_L85_V0.6481.00
84_A100_M0.6461.00
149_K152_T0.6421.00
174_F178_P0.6411.00
20_Y52_R0.6401.00
59_I62_R0.6401.00
365_A369_M0.6381.00
121_W181_Q0.6361.00
247_V251_V0.6351.00
367_P371_L0.6341.00
137_S251_V0.6331.00
63_V72_A0.6311.00
148_G244_S0.6281.00
86_A90_G0.6261.00
135_W139_A0.6261.00
46_G343_T0.6261.00
89_A95_W0.6251.00
149_K241_Y0.6241.00
134_L251_V0.6221.00
143_G147_T0.6221.00
208_L212_C0.6221.00
208_L330_Y0.6201.00
257_S260_L0.6201.00
98_L101_I0.6191.00
340_A344_V0.6191.00
19_S80_T0.6171.00
273_S310_A0.6171.00
49_L343_T0.6171.00
246_G297_Q0.6161.00
274_A307_C0.6131.00
205_W208_L0.6121.00
179_T182_P0.6121.00
13_Y17_F0.6111.00
253_I305_T0.6101.00
99_V102_G0.6101.00
13_Y132_V0.6051.00
14_F135_W0.6051.00
224_F227_I0.6041.00
28_S31_L0.6031.00
70_I178_P0.6001.00
22_I147_T0.6001.00
238_A242_L0.5991.00
15_T166_G0.5991.00
294_I297_Q0.5991.00
73_L114_T0.5971.00
245_L298_I0.5961.00
87_F160_L0.5951.00
144_S243_W0.5951.00
195_S198_L0.5951.00
271_L278_V0.5941.00
183_Q188_Q0.5931.00
314_Y318_R0.5931.00
369_M373_P0.5921.00
148_G241_Y0.5921.00
56_S328_A0.5911.00
211_V335_M0.5911.00
209_A212_C0.5911.00
74_R170_M0.5901.00
168_A172_L0.5901.00
224_F346_A0.5891.00
26_F159_I0.5881.00
312_M316_A0.5871.00
80_T110_L0.5871.00
300_H304_F0.5861.00
42_G347_G0.5851.00
49_L52_R0.5831.00
118_A128_D0.5821.00
173_G177_R0.5821.00
363_L370_F0.5811.00
358_F362_A0.5801.00
18_F163_L0.5791.00
206_R371_L0.5791.00
53_F336_G0.5791.00
59_I112_P0.5771.00
52_R336_G0.5761.00
301_C305_T0.5751.00
74_R77_A0.5751.00
223_G226_A0.5751.00
59_I72_A0.5721.00
212_C216_G0.5721.00
269_M272_I0.5711.00
147_T159_I0.5691.00
341_I345_F0.5671.00
350_Y355_H0.5671.00
115_D132_V0.5661.00
39_E42_G0.5661.00
229_W242_L0.5621.00
56_S332_A0.5611.00
40_T94_A0.5601.00
87_F100_M0.5591.00
40_T44_L0.5581.00
134_L137_S0.5581.00
126_P313_R0.5571.00
127_L130_G0.5561.00
110_L174_F0.5561.00
363_L366_L0.5551.00
37_T351_Q0.5541.00
277_G280_R0.5501.00
364_V368_A0.5501.00
145_A148_G0.5461.00
242_L245_L0.5461.00
149_K154_F0.5461.00
285_G288_T0.5451.00
262_R265_S0.5441.00
27_W30_W0.5441.00
206_R210_C0.5431.00
139_A143_G0.5401.00
162_L166_G0.5391.00
298_I301_C0.5371.00
138_V142_I0.5361.00
260_L263_R0.5361.00
367_P370_F0.5361.00
209_A371_L0.5351.00
256_L302_G0.5351.00
169_S172_L0.5341.00
46_G50_V0.5321.00
203_Q318_R0.5321.00
216_G364_V0.5301.00
221_Y225_S0.5291.00
18_F21_G0.5281.00
126_P258_N0.5281.00
368_A372_R0.5271.00
213_L217_A0.5251.00
18_F22_I0.5241.00
148_G236_A0.5201.00
133_R137_S0.5201.00
365_A368_A0.5201.00
163_L167_V0.5181.00
141_V244_S0.5161.00
349_L352_Y0.5161.00
177_R180_I0.5161.00
191_S199_A0.5161.00
242_L290_L0.5151.00
324_I328_A0.5141.00
350_Y357_V0.5141.00
46_G49_L0.5111.00
134_L138_V0.5111.00
38_P350_Y0.5091.00
78_L171_L0.5091.00
249_A301_C0.5091.00
43_L46_G0.5091.00
30_W34_I0.5081.00
260_L269_M0.5081.00
344_V347_G0.5081.00
255_A258_N0.5061.00
63_V324_I0.5061.00
241_Y244_S0.5061.00
177_R181_Q0.5031.00
323_V327_Q0.5021.00
116_A324_I0.5011.00
217_A220_A0.5001.00
60_A63_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gfpA 2 0.971 100 0.177 Contact Map
2cfqA 1 0.9921 100 0.202 Contact Map
1pw4A 1 0.971 100 0.204 Contact Map
3wdoA 1 0.9894 100 0.206 Contact Map
4j05A 3 0.9499 100 0.215 Contact Map
3o7qA 1 0.9894 100 0.216 Contact Map
4pypA 1 0.9842 100 0.234 Contact Map
4xnjA 1 0.9842 100 0.273 Contact Map
4w6vA 1 0.9657 100 0.284 Contact Map
4zw9A 1 0.9894 100 0.284 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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