GREMLIN Database
HCAR - Hca operon transcriptional activator HcaR
UniProt: Q47141 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13455
Length: 296 (282)
Sequences: 79738 (58144)
Seq/√Len: 3462.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
70_A74_Q3.6231.00
15_A24_K3.3881.00
157_L288_Q2.7031.00
67_D81_R2.4491.00
95_G140_L2.4481.00
11_A24_K2.3211.00
232_V239_T2.2661.00
161_D266_A2.2381.00
158_E161_D2.2251.00
91_Q122_E2.2171.00
172_H188_V2.2131.00
163_P243_G2.1751.00
158_E266_A2.1621.00
91_Q120_L2.1251.00
45_V60_A2.0921.00
20_R23_E2.0891.00
8_Y35_Q2.0541.00
111_M286_I2.0421.00
181_T184_Q2.0401.00
161_D264_S2.0161.00
233_G252_Q1.9971.00
10_V69_L1.9881.00
14_Q69_L1.9861.00
67_D74_Q1.9801.00
93_T122_E1.9641.00
10_V65_L1.9641.00
10_V14_Q1.9291.00
165_V243_G1.9151.00
11_A15_A1.9071.00
11_A14_Q1.9011.00
191_V237_G1.8571.00
71_I75_A1.8571.00
8_Y32_L1.8501.00
13_A57_L1.8311.00
65_L69_L1.8221.00
168_L256_R1.8171.00
49_V56_A1.7391.00
189_N219_V1.7311.00
165_V255_F1.7161.00
63_C81_R1.6861.00
18_F36_I1.6831.00
64_F78_A1.6821.00
156_Y268_L1.6791.00
131_Q143_G1.6611.00
134_K139_E1.6571.00
13_A65_L1.6231.00
15_A20_R1.5921.00
155_D273_K1.5841.00
10_V68_A1.5691.00
112_F283_F1.5561.00
177_E184_Q1.5531.00
14_Q24_K1.5531.00
133_E137_R1.5431.00
229_M247_N1.5371.00
9_F65_L1.5271.00
8_Y27_T1.5021.00
157_L271_W1.4911.00
5_H35_Q1.4791.00
5_H42_C1.4771.00
202_A206_K1.4751.00
67_D70_A1.4751.00
19_T29_Q1.4741.00
46_P49_V1.4631.00
112_F119_T1.4601.00
17_N20_R1.4521.00
5_H38_D1.4511.00
59_A62_E1.4471.00
233_G247_N1.4451.00
11_A25_L1.4411.00
28_S31_S1.4351.00
284_I288_Q1.4251.00
155_D271_W1.4241.00
67_D77_N1.4051.00
271_W284_I1.4051.00
145_M270_A1.4011.00
276_M280_L1.4001.00
102_V226_L1.3781.00
170_V252_Q1.3731.00
147_H268_L1.3731.00
10_V72_L1.3731.00
93_T124_V1.3611.00
89_D118_D1.3491.00
282_D285_A1.3471.00
71_I78_A1.3461.00
51_D56_A1.3441.00
134_K140_L1.3381.00
111_M115_R1.3311.00
269_M284_I1.3221.00
74_Q77_N1.3131.00
162_E244_Y1.3131.00
136_R153_E1.3101.00
64_F79_K1.2991.00
135_I143_G1.2991.00
115_R286_I1.2871.00
168_L238_V1.2781.00
42_C79_K1.2781.00
3_L75_A1.2721.00
113_R219_V1.2671.00
142_V269_M1.2671.00
188_V238_V1.2661.00
142_V280_L1.2631.00
230_N233_G1.2621.00
228_T239_T1.2521.00
66_Q70_A1.2481.00
113_R189_N1.2261.00
67_D78_A1.2191.00
158_E268_L1.2151.00
63_C66_Q1.2051.00
110_P114_L1.2031.00
170_V254_V1.2031.00
178_K254_V1.1851.00
37_R41_N1.1821.00
243_G255_F1.1821.00
27_T31_S1.1721.00
62_E66_Q1.1711.00
156_Y270_A1.1651.00
9_F48_L1.1641.00
110_P234_M1.1621.00
173_P188_V1.1491.00
9_F13_A1.1451.00
111_M114_L1.1421.00
34_S38_D1.1311.00
34_S37_R1.1081.00
122_E221_V1.1071.00
116_Q282_D1.1061.00
179_E259_A1.1041.00
189_N217_N1.0951.00
285_A288_Q1.0911.00
272_K275_E1.0881.00
167_V255_F1.0871.00
70_A77_N1.0871.00
209_F214_S1.0831.00
63_C67_D1.0831.00
6_L68_A1.0811.00
18_F55_V1.0761.00
107_K234_M1.0741.00
33_S37_R1.0711.00
112_F286_I1.0661.00
11_A21_A1.0651.00
180_I184_Q1.0641.00
255_F258_I1.0641.00
222_A228_T1.0621.00
9_F47_L1.0601.00
71_I74_Q1.0581.00
191_V228_T1.0541.00
92_L283_F1.0521.00
281_R285_A1.0501.00
157_L284_I1.0491.00
230_N234_M1.0431.00
229_M233_G1.0421.00
203_P207_A1.0301.00
79_K83_R1.0291.00
108_V287_V1.0271.00
136_R151_S1.0261.00
7_R76_E1.0251.00
12_V21_A1.0221.00
4_R7_R1.0201.00
35_Q38_D1.0191.00
169_P235_G1.0071.00
163_P264_S1.0021.00
76_E80_L0.9991.00
166_V238_V0.9871.00
203_P206_K0.9861.00
73_E77_N0.9841.00
192_S218_I0.9801.00
76_E79_K0.9791.00
27_T32_L0.9781.00
57_L61_G0.9671.00
124_V134_K0.9661.00
64_F68_A0.9631.00
8_Y25_L0.9601.00
112_F116_Q0.9601.00
13_A48_L0.9571.00
182_A260_G0.9571.00
12_V18_F0.9501.00
286_I289_E0.9491.00
134_K137_R0.9411.00
38_D41_N0.9331.00
63_C85_I0.9301.00
9_F57_L0.9291.00
108_V286_I0.9291.00
21_A32_L0.9241.00
277_K280_L0.9231.00
222_A231_L0.9211.00
9_F39_L0.9191.00
115_R289_E0.9181.00
168_L172_H0.9181.00
20_R24_K0.9111.00
95_G131_Q0.9071.00
45_V82_A0.9041.00
120_L217_N0.8981.00
70_A73_E0.8891.00
48_L55_V0.8881.00
140_L143_G0.8861.00
246_N250_T0.8851.00
172_H175_A0.8801.00
66_Q69_L0.8761.00
119_T279_A0.8691.00
176_H189_N0.8671.00
16_L56_A0.8661.00
153_E273_K0.8591.00
184_Q187_G0.8591.00
147_H266_A0.8551.00
172_H189_N0.8551.00
51_D54_K0.8551.00
19_T23_E0.8541.00
189_N218_I0.8531.00
285_A289_E0.8461.00
95_G145_M0.8461.00
98_P224_N0.8451.00
60_A85_I0.8441.00
155_D158_E0.8401.00
168_L173_P0.8381.00
13_A61_G0.8381.00
154_I270_A0.8381.00
132_E136_R0.8371.00
90_R279_A0.8321.00
173_P178_K0.8271.00
124_V140_L0.8251.00
25_L32_L0.8241.00
167_V239_T0.8241.00
94_I142_V0.8221.00
183_A186_D0.8201.00
110_P236_L0.8161.00
276_M281_R0.8151.00
246_N249_N0.8091.00
13_A16_L0.8091.00
29_Q33_S0.8081.00
60_A82_A0.8071.00
37_R46_P0.8051.00
95_G143_G0.8041.00
75_A79_K0.8021.00
16_L62_E0.8021.00
174_L188_V0.8001.00
208_W212_E0.7991.00
172_H176_H0.7941.00
163_P257_P0.7931.00
171_D175_A0.7921.00
14_Q65_L0.7891.00
181_T259_A0.7861.00
247_N252_Q0.7851.00
130_Q133_E0.7841.00
75_A78_A0.7841.00
60_A63_C0.7831.00
113_R236_L0.7821.00
163_P262_V0.7791.00
77_N81_R0.7781.00
9_F64_F0.7781.00
278_P282_D0.7761.00
205_V209_F0.7751.00
90_R119_T0.7731.00
15_A21_A0.7711.00
16_L54_K0.7701.00
3_L72_L0.7701.00
74_Q78_A0.7691.00
4_R35_Q0.7631.00
5_H8_Y0.7621.00
169_P236_L0.7591.00
231_L236_L0.7581.00
7_R11_A0.7541.00
190_F216_P0.7481.00
115_R282_D0.7481.00
12_V48_L0.7471.00
207_A211_Q0.7461.00
142_V283_F0.7451.00
88_E116_Q0.7391.00
112_F282_D0.7371.00
83_R86_V0.7331.00
68_A71_I0.7291.00
96_F101_E0.7281.00
12_V36_I0.7251.00
78_A82_A0.7241.00
18_F32_L0.7241.00
136_R154_I0.7221.00
167_V241_I0.7221.00
233_G250_T0.7201.00
69_L73_E0.7191.00
242_P245_M0.7171.00
208_W211_Q0.7171.00
62_E65_L0.7121.00
169_P172_H0.7111.00
49_V58_T0.7091.00
93_T140_L0.7061.00
57_L62_E0.7051.00
56_A62_E0.7031.00
183_A212_E0.7011.00
31_S35_Q0.6971.00
12_V32_L0.6961.00
282_D286_I0.6921.00
204_I208_W0.6921.00
138_G272_K0.6901.00
186_D214_S0.6901.00
194_D221_V0.6901.00
60_A64_F0.6891.00
59_A63_C0.6861.00
207_A210_A0.6861.00
224_N227_V0.6831.00
175_A254_V0.6831.00
181_T260_G0.6821.00
179_E257_P0.6791.00
171_D235_G0.6711.00
111_M289_E0.6701.00
141_D280_L0.6691.00
49_V54_K0.6661.00
168_L254_V0.6661.00
77_N80_L0.6661.00
7_R10_V0.6641.00
187_G217_N0.6631.00
93_T141_D0.6631.00
73_E76_E0.6621.00
64_F82_A0.6601.00
171_D174_L0.6571.00
168_L174_L0.6561.00
202_A221_V0.6561.00
201_L205_V0.6551.00
220_Q231_L0.6541.00
193_T228_T0.6531.00
120_L221_V0.6511.00
40_E45_V0.6501.00
206_K210_A0.6471.00
102_V230_N0.6461.00
204_I207_A0.6431.00
96_F105_L0.6411.00
23_E26_H0.6391.00
174_L177_E0.6351.00
92_L279_A0.6341.00
170_V251_G0.6341.00
190_F238_V0.6341.00
67_D71_I0.6321.00
278_P281_R0.6311.00
68_A72_L0.6301.00
36_I40_E0.6271.00
40_E50_R0.6251.00
144_L287_V0.6251.00
171_D254_V0.6241.00
130_Q134_K0.6211.00
205_V208_W0.6171.00
166_V185_L0.6151.00
80_L84_K0.6101.00
160_F267_L0.6071.00
101_E128_T0.6071.00
21_A25_L0.6061.00
142_V284_I0.6051.00
107_K110_P0.6041.00
271_W281_R0.6011.00
89_D120_L0.6011.00
201_L204_I0.5991.00
209_F216_P0.5971.00
4_R38_D0.5931.00
166_V240_L0.5901.00
7_R72_L0.5901.00
194_D223_T0.5891.00
92_L142_V0.5891.00
202_A205_V0.5851.00
135_I270_A0.5851.00
146_R265_I0.5841.00
155_D274_G0.5821.00
12_V17_N0.5811.00
63_C82_A0.5801.00
222_A227_V0.5801.00
228_T232_V0.5781.00
105_L108_V0.5781.00
43_V82_A0.5771.00
107_K111_M0.5761.00
90_R118_D0.5751.00
164_L240_L0.5741.00
57_L65_L0.5701.00
173_P177_E0.5701.00
174_L180_I0.5701.00
4_R8_Y0.5681.00
283_F287_V0.5671.00
45_V49_V0.5661.00
135_I154_I0.5661.00
162_E265_I0.5651.00
48_L57_L0.5641.00
43_V64_F0.5641.00
30_P34_S0.5611.00
116_Q119_T0.5591.00
172_H238_V0.5571.00
9_F61_G0.5571.00
231_L237_G0.5571.00
202_A208_W0.5561.00
114_L175_A0.5551.00
84_K88_E0.5541.00
31_S34_S0.5541.00
109_L121_I0.5541.00
166_V190_F0.5531.00
72_L76_E0.5531.00
18_F54_K0.5511.00
195_P221_V0.5481.00
28_S34_S0.5471.00
248_F251_G0.5471.00
203_P208_W0.5461.00
179_E184_Q0.5451.00
159_L269_M0.5431.00
95_G124_V0.5431.00
131_Q138_G0.5431.00
247_N250_T0.5411.00
100_A104_L0.5401.00
66_Q81_R0.5391.00
72_L75_A0.5371.00
199_G202_A0.5371.00
18_F29_Q0.5361.00
43_V46_P0.5341.00
133_E139_E0.5341.00
8_Y36_I0.5321.00
206_K209_F0.5311.00
13_A62_E0.5281.00
177_E180_I0.5271.00
80_L83_R0.5271.00
193_T225_I0.5221.00
147_H156_Y0.5211.00
67_D82_A0.5171.00
173_P176_H0.5161.00
225_I242_P0.5161.00
27_T35_Q0.5141.00
104_L108_V0.5121.00
107_K230_N0.5081.00
280_L284_I0.5061.00
46_P60_A0.5051.00
16_L55_V0.5041.00
78_A81_R0.5031.00
84_K87_Q0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2h98A 2 0.7027 100 0.065 Contact Map
2h9bA 2 0.7027 100 0.067 Contact Map
1ixcA 4 0.9899 100 0.071 Contact Map
2esnA 3 0.9797 100 0.09 Contact Map
1al3A 1 0.7061 100 0.094 Contact Map
1uthA 2 0.75 100 0.097 Contact Map
4x6gA 4 0.9932 100 0.097 Contact Map
3fxqA 3 0.973 100 0.099 Contact Map
3fzvA 4 0.9561 100 0.1 Contact Map
3szpA 3 0.9662 100 0.117 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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