GREMLIN Database
HCAF - 3-phenylpropionate/cinnamic acid dioxygenase subunit beta
UniProt: Q47140 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13457
Length: 172 (148)
Sequences: 995 (676)
Seq/√Len: 55.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
28_K31_D5.7791.00
22_S103_Q4.5641.00
30_R82_E3.7901.00
117_V139_D3.7201.00
119_Y135_G3.5821.00
12_R143_R3.4111.00
144_L148_N2.7481.00
96_R159_D2.6081.00
38_E71_K2.5381.00
142_R152_L2.4351.00
10_H14_S2.3431.00
80_R86_A2.1411.00
41_R153_E2.0641.00
36_L40_I2.0351.00
10_H15_Q1.9331.00
16_F141_V1.9271.00
37_D152_L1.9191.00
44_M156_I1.7520.99
23_L35_Q1.7410.99
89_E93_S1.6970.99
112_V142_R1.6790.99
99_I102_C1.6360.99
43_T155_D1.6000.98
37_D150_R1.5990.98
23_L31_D1.5930.98
39_E152_L1.5920.98
13_I113_F1.5890.98
33_L74_L1.5780.98
144_L147_D1.5750.98
117_V137_R1.5720.98
12_R149_W1.5540.98
44_M67_F1.5120.98
33_L78_I1.4890.97
11_H14_S1.4880.97
114_A140_K1.4770.97
37_D142_R1.4600.97
22_S26_D1.4430.97
114_A138_F1.4150.96
22_S116_R1.4110.96
108_D114_A1.4030.96
39_E142_R1.3980.96
143_R149_W1.3640.96
96_R118_N1.3590.96
100_S120_L1.3170.95
71_K75_E1.3030.94
19_H103_Q1.2680.94
14_S102_C1.2660.93
11_H15_Q1.2610.93
36_L151_L1.2590.93
139_D154_R1.2550.93
98_L120_L1.2500.93
17_L102_C1.2370.93
16_F36_L1.2160.92
116_R136_T1.2100.92
17_L115_V1.1870.91
23_L158_L1.1690.90
20_E32_W1.1670.90
107_T143_R1.1610.90
19_H23_L1.1580.90
31_D34_A1.1270.89
107_T110_P1.1200.88
101_N118_N1.1100.88
86_A95_T1.0950.87
40_I74_L1.0900.87
19_H22_S1.0890.87
36_L74_L1.0640.86
112_V140_K1.0530.85
43_T65_W1.0510.85
65_W97_H1.0490.85
99_I117_V1.0460.85
122_Y134_V1.0120.83
18_F101_N1.0020.82
76_R83_T0.9990.82
24_L32_W0.9810.81
13_I115_V0.9780.81
122_Y132_F0.9720.80
113_F149_W0.9670.80
107_T114_A0.9400.78
16_F149_W0.9350.77
42_Y117_V0.9200.76
95_T121_L0.9150.76
89_E123_R0.9010.75
91_P125_Q0.8990.75
41_R68_N0.8900.74
22_S105_S0.8840.73
86_A89_E0.8840.73
120_L132_F0.8700.72
137_R154_R0.8690.72
30_R34_A0.8590.71
76_R79_A0.8560.71
23_L26_D0.8560.71
102_C117_V0.8540.71
36_L154_R0.8540.71
144_L150_R0.8520.71
67_F93_S0.8480.70
34_A71_K0.8450.70
20_E24_L0.8340.69
58_G62_P0.8120.67
33_L75_E0.8120.67
108_D111_N0.7840.64
47_T161_A0.7790.64
25_D97_H0.7740.63
24_L95_T0.7710.63
19_H35_Q0.7630.62
42_Y156_I0.7570.61
59_V161_A0.7520.61
123_R131_T0.7480.60
66_I73_Q0.7430.60
45_R80_R0.7410.60
14_S18_F0.7350.59
68_N151_L0.7270.58
140_K153_E0.7240.58
112_V152_L0.7240.58
65_W68_N0.7220.58
98_L118_N0.7170.57
13_I16_F0.7140.57
13_I102_C0.7130.57
107_T140_K0.7080.56
138_F155_D0.7050.56
108_D146_D0.7050.56
154_R159_D0.6990.55
27_W93_S0.6900.54
47_T92_P0.6850.54
26_D116_R0.6830.54
147_D150_R0.6810.53
68_N160_Q0.6800.53
105_S140_K0.6790.53
160_Q164_T0.6780.53
13_I149_W0.6730.53
23_L28_K0.6660.52
26_D136_T0.6650.52
106_E112_V0.6650.52
20_E154_R0.6580.51
137_R156_I0.6570.51
44_M162_V0.6540.50
105_S114_A0.6460.50
106_E147_D0.6450.50
115_V141_V0.6430.49
35_Q141_V0.6400.49
39_E120_L0.6380.49
75_E79_A0.6370.49
89_E163_I0.6300.48
13_I141_V0.6280.48
61_P64_T0.6230.47
108_D112_V0.6230.47
51_Q85_M0.6230.47
35_Q151_L0.6230.47
12_R106_E0.6210.47
106_E114_A0.6210.47
45_R154_R0.6140.46
9_L104_I0.6130.46
104_I133_Y0.6120.46
13_I17_L0.6080.46
84_G90_E0.6080.46
19_H99_I0.6070.45
68_N154_R0.6060.45
116_R138_F0.6040.45
30_R75_E0.5980.44
19_H148_N0.5980.44
63_T160_Q0.5920.44
13_I104_I0.5850.43
69_D77_R0.5850.43
140_K152_L0.5830.43
146_D150_R0.5820.43
75_E97_H0.5810.43
14_S41_R0.5800.43
143_R148_N0.5780.42
47_T154_R0.5770.42
127_E152_L0.5750.42
48_V161_A0.5730.42
87_W93_S0.5710.42
90_E149_W0.5700.41
39_E112_V0.5690.41
100_S121_L0.5690.41
136_T159_D0.5680.41
69_D133_Y0.5680.41
128_R131_T0.5650.41
104_I112_V0.5640.41
31_D38_E0.5630.41
152_L155_D0.5610.41
36_L97_H0.5600.40
141_V149_W0.5590.40
79_A159_D0.5590.40
43_T121_L0.5580.40
19_H104_I0.5560.40
102_C125_Q0.5530.40
19_H153_E0.5520.40
143_R150_R0.5470.39
65_W161_A0.5460.39
141_V148_N0.5430.39
107_T144_L0.5410.38
39_E150_R0.5410.38
154_R160_Q0.5400.38
138_F157_V0.5360.38
126_K161_A0.5340.38
27_W69_D0.5330.38
47_T63_T0.5300.37
89_E159_D0.5300.37
141_V151_L0.5300.37
96_R124_A0.5290.37
87_W123_R0.5270.37
123_R154_R0.5260.37
22_S43_T0.5260.37
18_F102_C0.5250.37
124_A130_E0.5240.37
38_E148_N0.5240.37
103_Q116_R0.5230.37
35_Q72_D0.5230.37
105_S115_V0.5210.36
64_T80_R0.5200.36
76_R135_G0.5190.36
48_V139_D0.5190.36
12_R110_P0.5120.36
100_S117_V0.5110.35
86_A90_E0.5090.35
15_Q103_Q0.5090.35
93_S135_G0.5090.35
110_P146_D0.5080.35
85_M116_R0.5050.35
14_S101_N0.5040.35
61_P127_E0.5040.35
80_R95_T0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2bmoB 3 0.9942 100 0.322 Contact Map
3gzxB 3 0.9942 100 0.387 Contact Map
1uliB 3 0.9884 100 0.394 Contact Map
2gbwB 3 0.9826 100 0.399 Contact Map
2b1xB 3 0.9593 100 0.41 Contact Map
1wqlB 3 0.9826 100 0.412 Contact Map
3e99A 3 0.843 100 0.474 Contact Map
3ebyA 3 0.8779 99.9 0.543 Contact Map
3ejvA 3 0.8314 99.6 0.695 Contact Map
2rgqA 3 0.7733 99.6 0.699 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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