GREMLIN Database
FEAR - Transcriptional activator FeaR
UniProt: Q47129 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13422
Length: 301 (238)
Sequences: 27124 (23236)
Seq/√Len: 1506.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
254_A289_F3.1871.00
206_D248_R3.1081.00
264_E272_H3.0851.00
250_L289_F3.0331.00
239_L247_N2.9961.00
217_E227_V2.7561.00
252_F255_D2.7161.00
247_N288_R2.6421.00
208_N211_E2.5731.00
204_L208_N2.5531.00
285_F296_Y2.4461.00
253_C281_F2.4451.00
256_A272_H2.2641.00
256_A273_W2.2181.00
234_F244_Y2.1671.00
201_V230_L2.0391.00
201_V223_T1.9591.00
215_R218_W1.9361.00
82_I89_Q1.8891.00
264_E268_G1.8791.00
205_I245_I1.8741.00
209_I248_R1.8701.00
291_M299_K1.8381.00
242_A246_R1.8071.00
204_L222_E1.7771.00
204_L214_L1.7421.00
219_I241_V1.7411.00
256_A264_E1.7371.00
250_L288_R1.7251.00
254_A296_Y1.7211.00
82_I91_Q1.7191.00
84_E89_Q1.7171.00
278_Q282_S1.7011.00
203_T207_D1.6961.00
255_D259_H1.6801.00
77_L117_I1.6691.00
241_V245_I1.6471.00
80_Q91_Q1.6121.00
216_P231_Y1.6081.00
257_I266_L1.6061.00
284_V287_Q1.5901.00
229_S232_R1.5761.00
239_L243_Q1.5711.00
248_R252_F1.5591.00
265_K268_G1.5571.00
252_F256_A1.5511.00
178_C182_P1.5411.00
78_S115_K1.5231.00
229_S233_M1.4981.00
205_I248_R1.4871.00
195_E237_K1.4801.00
280_H284_V1.4791.00
225_M229_S1.4631.00
171_A174_Q1.4621.00
253_C273_W1.4531.00
209_I252_F1.4411.00
228_R232_R1.4381.00
275_F284_V1.4351.00
267_A271_F1.4251.00
206_D244_Y1.4201.00
279_S282_S1.4191.00
202_V206_D1.4171.00
267_A278_Q1.4071.00
252_F273_W1.4061.00
211_E218_W1.4031.00
218_W222_E1.4031.00
86_D104_R1.4011.00
291_M295_E1.3981.00
230_L241_V1.3961.00
210_R272_H1.3931.00
80_Q93_G1.3891.00
231_Y241_V1.3881.00
227_V231_Y1.3861.00
82_I109_Y1.3811.00
84_E107_S1.3751.00
247_N251_D1.3741.00
268_G272_H1.3731.00
246_R284_V1.3601.00
268_G271_F1.3531.00
93_G96_D1.3401.00
269_I273_W1.3381.00
71_F102_A1.3361.00
248_R251_D1.2981.00
240_V243_Q1.2921.00
148_V152_H1.2821.00
217_E221_G1.2801.00
294_G298_R1.2801.00
201_V219_I1.2711.00
282_S292_T1.2621.00
282_S294_G1.2571.00
225_M230_L1.2551.00
197_Q225_M1.2431.00
101_D104_R1.2381.00
262_D297_R1.2291.00
259_H262_D1.2251.00
214_L219_I1.2161.00
72_Y106_C1.2081.00
226_S229_S1.1961.00
254_A258_R1.1931.00
170_E174_Q1.1741.00
264_E269_I1.1701.00
175_A178_C1.1671.00
283_T287_Q1.1511.00
202_V244_Y1.1291.00
292_T295_E1.1181.00
78_S94_A1.1061.00
170_E173_L1.1051.00
66_S106_C1.1051.00
216_P241_V1.0861.00
171_A178_C1.0781.00
220_A227_V1.0691.00
196_R200_K1.0691.00
251_D254_A1.0681.00
68_D106_C1.0641.00
204_L223_T1.0531.00
197_Q223_T1.0481.00
295_E298_R1.0481.00
199_Q203_T1.0431.00
77_L115_K1.0401.00
149_Q153_R1.0391.00
233_M236_D1.0331.00
246_R287_Q1.0021.00
149_Q152_H1.0021.00
233_M237_K0.9891.00
266_L269_I0.9781.00
294_G297_R0.9761.00
197_Q233_M0.9741.00
242_A280_H0.9731.00
228_R231_Y0.9701.00
81_A92_I0.9681.00
65_G105_P0.9651.00
218_W221_G0.9651.00
152_H156_Q0.9631.00
171_A175_A0.9631.00
210_R252_F0.9621.00
250_L284_V0.9501.00
249_R273_W0.9431.00
219_I222_E0.9411.00
200_K222_E0.9391.00
289_F296_Y0.9331.00
204_L219_I0.9321.00
282_S286_K0.9201.00
234_F241_V0.9191.00
277_D283_T0.9181.00
284_V288_R0.9181.00
200_K203_T0.9051.00
76_Q81_A0.9031.00
213_I218_W0.9021.00
223_T230_L0.8981.00
172_A175_A0.8921.00
200_K223_T0.8881.00
198_F233_M0.8861.00
209_I214_L0.8851.00
201_V234_F0.8821.00
75_F97_I0.8801.00
243_Q247_N0.8771.00
81_A114_S0.8741.00
291_M296_Y0.8671.00
198_F201_V0.8671.00
208_N222_E0.8641.00
243_Q246_R0.8621.00
213_I276_S0.8571.00
286_K292_T0.8511.00
216_P227_V0.8511.00
137_C141_L0.8501.00
198_F202_V0.8491.00
254_A285_F0.8471.00
205_I241_V0.8471.00
256_A269_I0.8471.00
280_H283_T0.8371.00
225_M233_M0.8361.00
199_Q202_V0.8271.00
80_Q111_Q0.8261.00
211_E214_L0.8261.00
246_R288_R0.8261.00
174_Q178_C0.8231.00
85_Q88_R0.8171.00
258_R296_Y0.8171.00
198_F237_K0.8161.00
242_A245_I0.8151.00
270_G278_Q0.8081.00
209_I273_W0.8071.00
257_I269_I0.8031.00
295_E299_K0.8021.00
205_I244_Y0.7991.00
194_R236_D0.7951.00
250_L281_F0.7951.00
257_I297_R0.7951.00
262_D269_I0.7941.00
83_M98_T0.7941.00
84_E87_E0.7901.00
156_Q160_N0.7881.00
123_R127_E0.7821.00
253_C256_A0.7791.00
65_G107_S0.7731.00
153_R157_E0.7691.00
251_D288_R0.7661.00
169_S172_A0.7651.00
74_V118_S0.7641.00
285_F291_M0.7641.00
161_N165_S0.7621.00
71_F99_L0.7621.00
209_I245_I0.7611.00
208_N218_W0.7581.00
231_Y235_A0.7541.00
271_F276_S0.7521.00
166_E169_S0.7491.00
253_C269_I0.7461.00
140_R143_A0.7451.00
219_I223_T0.7451.00
195_E199_Q0.7441.00
206_D252_F0.7431.00
244_Y248_R0.7421.00
195_E233_M0.7391.00
214_L218_W0.7321.00
231_Y240_V0.7271.00
175_A181_R0.7271.00
204_L218_W0.7271.00
243_Q288_R0.7251.00
72_Y120_L0.7241.00
76_Q79_G0.7231.00
84_E109_Y0.7221.00
202_V234_F0.7201.00
245_I249_R0.7191.00
76_Q100_L0.7131.00
173_L179_L0.7121.00
201_V204_L0.7121.00
92_I98_T0.7101.00
145_L149_Q0.7041.00
239_L244_Y0.7031.00
219_I230_L0.7001.00
279_S292_T0.6991.00
150_L153_R0.6981.00
168_E171_A0.6971.00
165_S169_S0.6941.00
216_P242_A0.6881.00
231_Y242_A0.6881.00
82_I85_Q0.6861.00
76_Q92_I0.6851.00
78_S100_L0.6851.00
141_L144_D0.6851.00
250_L275_F0.6841.00
155_L159_M0.6821.00
197_Q200_K0.6811.00
137_C140_R0.6811.00
81_A91_Q0.6791.00
277_D280_H0.6741.00
286_K295_E0.6731.00
167_T174_Q0.6711.00
178_C181_R0.6701.00
265_K269_I0.6671.00
201_V205_I0.6671.00
68_D72_Y0.6671.00
246_R280_H0.6661.00
270_G275_F0.6651.00
169_S173_L0.6621.00
74_V102_A0.6601.00
82_I111_Q0.6581.00
201_V241_V0.6541.00
232_R236_D0.6521.00
157_E161_N0.6521.00
269_I297_R0.6521.00
100_L106_C0.6511.00
125_L128_Q0.6501.00
70_W120_L0.6501.00
181_R185_H0.6471.00
145_L148_V0.6451.00
74_V100_L0.6441.00
276_S280_H0.6431.00
194_R237_K0.6411.00
81_A108_L0.6391.00
281_F285_F0.6381.00
266_L294_G0.6371.00
167_T170_E0.6371.00
162_P165_S0.6371.00
263_D269_I0.6351.00
83_M108_L0.6351.00
146_P149_Q0.6321.00
235_A240_V0.6311.00
214_L249_R0.6291.00
150_L155_L0.6271.00
140_R144_D0.6261.00
196_R237_K0.6211.00
114_S118_S0.6181.00
175_A182_P0.6131.00
123_R126_L0.6081.00
78_S113_S0.6081.00
221_G224_G0.6071.00
177_V181_R0.6061.00
74_V116_Q0.6051.00
73_T99_L0.6051.00
167_T171_A0.6041.00
277_D287_Q0.6031.00
124_T127_E0.6011.00
175_A179_L0.6011.00
86_D105_P0.6001.00
271_F278_Q0.5981.00
259_H263_D0.5971.00
203_T206_D0.5961.00
153_R156_Q0.5961.00
71_F74_V0.5931.00
256_A259_H0.5901.00
281_F293_P0.5881.00
168_E172_A0.5871.00
251_D255_D0.5841.00
254_A291_M0.5831.00
279_S283_T0.5821.00
155_L158_S0.5781.00
80_Q84_E0.5781.00
214_L245_I0.5751.00
275_F280_H0.5751.00
74_V98_T0.5751.00
194_R197_Q0.5721.00
201_V222_E0.5661.00
251_D289_F0.5661.00
153_R175_A0.5631.00
166_E170_E0.5611.00
85_Q100_L0.5611.00
257_I296_Y0.5601.00
246_R250_L0.5591.00
219_I249_R0.5591.00
100_L114_S0.5571.00
175_A180_L0.5571.00
76_Q116_Q0.5571.00
220_A223_T0.5521.00
146_P153_R0.5521.00
96_D138_A0.5461.00
146_P150_L0.5451.00
216_P228_R0.5441.00
198_F230_L0.5431.00
266_L278_Q0.5411.00
80_Q83_M0.5411.00
136_I139_E0.5401.00
284_V289_F0.5401.00
138_A141_L0.5381.00
205_I214_L0.5341.00
154_L158_S0.5341.00
209_I249_R0.5331.00
255_D258_R0.5321.00
147_M150_L0.5321.00
124_T128_Q0.5311.00
74_V83_M0.5281.00
278_Q281_F0.5271.00
201_V233_M0.5211.00
259_H264_E0.5121.00
115_K118_S0.5121.00
228_R235_A0.5111.00
168_E175_A0.5101.00
129_Y134_K0.5091.00
196_R199_Q0.5091.00
198_F223_T0.5091.00
149_Q156_Q0.5081.00
139_E142_D0.5041.00
108_L116_Q0.5041.00
67_D105_P0.5021.00
76_Q80_Q0.5011.00
73_T97_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3gbgA 1 0.8239 100 0.312 Contact Map
3mklA 1 0.3621 100 0.516 Contact Map
3oouA 1 0.3455 100 0.517 Contact Map
3oioA 1 0.3588 100 0.521 Contact Map
1bl0A 1 0.3488 100 0.521 Contact Map
2k9sA 1 0.3522 100 0.522 Contact Map
3mn2A 1 0.3455 99.9 0.523 Contact Map
3w6vA 1 0.3455 99.9 0.528 Contact Map
3lsgA 2 0.3389 99.9 0.535 Contact Map
1d5yA 1 0.3488 99.9 0.546 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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