GREMLIN Database
CBL - HTH-type transcriptional regulator cbl
UniProt: Q47083 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14264
Length: 316 (285)
Sequences: 79581 (58143)
Seq/√Len: 3444.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
72_R76_E3.5691.00
15_Q25_M3.3991.00
161_F292_N2.6871.00
98_A143_A2.5111.00
69_I83_L2.4071.00
234_V241_G2.3111.00
114_A294_G2.2351.00
11_E25_M2.2131.00
176_H192_W2.2131.00
167_H245_E2.2051.00
165_R269_T2.1871.00
162_P165_R2.1751.00
94_V125_E2.1591.00
21_E24_N2.1161.00
14_R71_E2.0921.00
94_V123_R2.0861.00
162_P269_T2.0751.00
231_K251_Q2.0691.00
185_T188_S2.0291.00
8_I36_H2.0131.00
46_I62_P2.0051.00
10_R67_L1.9861.00
235_A255_N1.9761.00
96_T125_E1.9691.00
114_A290_L1.9581.00
165_R267_A1.9441.00
69_I76_E1.9421.00
10_R71_E1.9131.00
11_E14_R1.9011.00
195_I239_G1.8981.00
172_V259_L1.8961.00
19_L37_I1.8951.00
73_I77_A1.8811.00
8_I33_V1.8591.00
11_E15_Q1.8581.00
10_R14_R1.8531.00
13_A59_M1.8331.00
169_S245_E1.8241.00
67_L71_E1.8091.00
134_I146_G1.7571.00
50_V58_G1.7211.00
66_L80_V1.7161.00
181_I188_S1.7151.00
193_P221_V1.6871.00
235_A251_Q1.6701.00
169_S258_R1.6661.00
160_A271_W1.6551.00
65_A83_L1.6501.00
115_F287_F1.6411.00
137_L142_E1.6171.00
14_R25_M1.5951.00
9_I67_L1.5821.00
13_A67_L1.5801.00
10_R70_A1.5701.00
15_Q21_E1.5591.00
8_I28_T1.5421.00
159_V276_R1.5421.00
90_D121_E1.5161.00
115_F122_V1.5151.00
136_T140_N1.5101.00
20_T30_Q1.4851.00
61_E64_K1.4781.00
5_Q36_H1.4751.00
29_S32_G1.4441.00
161_F274_L1.4391.00
47_E50_V1.4351.00
5_Q43_E1.4351.00
5_Q39_E1.4331.00
204_R208_D1.4331.00
18_N21_E1.4251.00
10_R74_L1.4201.00
11_E26_L1.4061.00
69_I72_R1.3991.00
288_L292_N1.3961.00
150_E271_W1.3881.00
148_A273_G1.3821.00
174_H255_N1.3671.00
159_V274_L1.3641.00
69_I79_N1.3571.00
73_I80_V1.3561.00
274_L288_L1.3311.00
92_S121_E1.3231.00
105_R228_D1.3211.00
114_A118_L1.3191.00
272_L288_L1.3161.00
96_T127_I1.3161.00
286_R289_E1.3031.00
139_Q157_Q1.3031.00
145_I284_V1.3011.00
280_Q284_V1.2831.00
166_W246_Q1.2741.00
138_L146_G1.2721.00
137_L143_A1.2701.00
66_L81_R1.2681.00
43_E81_R1.2681.00
145_I272_L1.2641.00
192_W240_I1.2551.00
230_I241_G1.2541.00
172_V240_I1.2511.00
116_R221_V1.2511.00
52_R58_G1.2451.00
3_F77_A1.2401.00
76_E79_N1.2241.00
118_L290_L1.2141.00
38_R42_D1.2051.00
245_E258_R1.2021.00
64_K68_V1.2021.00
251_Q255_N1.1991.00
232_T235_A1.1981.00
68_V72_R1.1911.00
211_F216_L1.1881.00
245_E249_G1.1851.00
69_I80_V1.1831.00
65_A68_V1.1801.00
182_S257_I1.1711.00
116_R193_P1.1701.00
174_H257_I1.1671.00
113_K117_E1.1661.00
114_A117_E1.1601.00
129_G133_E1.1581.00
9_I49_F1.1521.00
177_P192_W1.1501.00
160_A273_G1.1441.00
162_P271_W1.1441.00
195_I230_I1.1441.00
28_T32_G1.1291.00
249_G252_E1.1181.00
95_L287_F1.1161.00
9_I13_A1.1141.00
9_I48_I1.1121.00
113_K236_L1.0981.00
35_R38_R1.0971.00
34_S38_R1.0971.00
193_P219_D1.0931.00
125_E223_S1.0891.00
35_R39_E1.0881.00
289_E292_N1.0851.00
12_A22_V1.0821.00
7_K78_S1.0781.00
275_K278_Q1.0751.00
119_F286_R1.0691.00
224_A230_I1.0691.00
55_R58_G1.0681.00
104_A128_Q1.0671.00
115_F290_L1.0631.00
183_P262_R1.0601.00
72_R79_N1.0601.00
6_L70_A1.0591.00
290_L294_G1.0571.00
171_L258_R1.0521.00
11_E22_V1.0511.00
129_G137_L1.0491.00
73_I76_E1.0481.00
285_W289_E1.0401.00
111_V291_C1.0311.00
173_P237_G1.0221.00
139_Q155_D1.0191.00
65_A69_I1.0151.00
258_R261_T1.0131.00
161_F288_L1.0071.00
36_H39_E1.0071.00
110_E236_L1.0071.00
4_Q7_K1.0041.00
59_M63_G1.0031.00
232_T236_L1.0011.00
231_K235_A0.9991.00
184_L188_S0.9951.00
176_H179_T0.9921.00
81_R85_D0.9901.00
171_L248_S0.9891.00
205_S208_D0.9811.00
170_L240_I0.9751.00
8_I26_L0.9741.00
78_S82_R0.9711.00
250_E253_E0.9671.00
28_T33_V0.9641.00
167_H267_A0.9631.00
186_L263_H0.9591.00
78_S81_R0.9571.00
129_G134_I0.9541.00
118_L293_A0.9501.00
12_A19_L0.9461.00
66_L70_A0.9411.00
196_T220_I0.9381.00
13_A49_F0.9351.00
115_F119_F0.9341.00
98_A134_I0.9331.00
75_N79_N0.9331.00
9_I59_M0.9321.00
137_L140_N0.9261.00
224_A233_Y0.9261.00
290_L293_A0.9241.00
152_L155_D0.9221.00
127_I137_L0.9181.00
176_H193_P0.9131.00
172_V176_H0.9101.00
46_I84_A0.9081.00
111_V290_L0.9061.00
13_A63_G0.9041.00
281_R284_V0.9011.00
157_Q276_R0.8981.00
9_I40_L0.8971.00
22_V33_V0.8951.00
123_R219_D0.8791.00
39_E42_D0.8791.00
176_H180_Q0.8781.00
143_A146_G0.8691.00
21_E25_M0.8681.00
101_H226_D0.8671.00
248_S251_Q0.8651.00
68_V71_E0.8611.00
194_L218_A0.8581.00
122_V283_Y0.8541.00
172_V177_P0.8541.00
17_Y58_G0.8541.00
98_A148_A0.8531.00
158_L273_G0.8501.00
188_S191_K0.8441.00
20_T24_N0.8401.00
193_P220_I0.8361.00
150_E269_T0.8331.00
180_Q193_P0.8321.00
52_R55_R0.8311.00
171_L241_G0.8301.00
97_I145_I0.8301.00
289_E293_A0.8291.00
177_P182_S0.8241.00
135_A139_Q0.8231.00
72_R75_N0.8211.00
159_V162_P0.8091.00
205_S209_D0.8091.00
13_A17_Y0.8081.00
26_L33_V0.8051.00
127_I143_A0.7941.00
210_A214_K0.7941.00
17_Y64_K0.7881.00
207_I211_F0.7871.00
9_I66_L0.7871.00
12_A37_I0.7861.00
62_P84_A0.7821.00
93_G283_Y0.7811.00
38_R47_E0.7801.00
187_E190_A0.7791.00
98_A146_G0.7781.00
133_E136_T0.7731.00
30_Q34_S0.7701.00
12_A49_F0.7701.00
76_E80_V0.7671.00
113_K238_L0.7671.00
178_L192_W0.7651.00
91_T119_F0.7641.00
77_A80_V0.7631.00
173_P238_L0.7601.00
4_Q36_H0.7571.00
14_R67_L0.7561.00
93_G122_V0.7551.00
17_Y55_R0.7521.00
175_D179_T0.7481.00
145_I287_F0.7481.00
65_A87_F0.7471.00
3_F74_L0.7461.00
185_T262_R0.7451.00
233_Y238_L0.7451.00
282_N286_R0.7421.00
118_L286_R0.7401.00
167_H260_D0.7361.00
15_Q22_V0.7351.00
79_N83_L0.7351.00
204_R223_S0.7301.00
85_D88_T0.7281.00
111_V294_G0.7281.00
62_P87_F0.7281.00
139_Q158_L0.7271.00
171_L243_V0.7241.00
114_A293_A0.7231.00
59_M64_K0.7231.00
58_G64_K0.7221.00
116_R238_L0.7181.00
62_P65_A0.7171.00
77_A81_R0.7151.00
32_G36_H0.7141.00
5_Q8_I0.7131.00
235_A253_E0.7101.00
96_T143_A0.7091.00
19_L33_V0.7051.00
70_A73_I0.7041.00
115_F286_R0.7021.00
80_V84_A0.7011.00
172_V257_I0.7001.00
7_K11_E0.6961.00
147_I291_C0.6911.00
244_A247_S0.6891.00
12_A33_V0.6871.00
50_V60_T0.6861.00
179_T257_I0.6801.00
278_Q281_R0.6781.00
190_A216_L0.6781.00
172_V178_L0.6771.00
99_T104_A0.6771.00
173_P176_H0.6711.00
62_P66_L0.6711.00
185_T263_H0.6701.00
41_E46_I0.6671.00
187_E214_K0.6671.00
226_D229_V0.6661.00
96_T144_D0.6651.00
209_D212_A0.6651.00
71_E75_N0.6651.00
50_V55_R0.6651.00
210_A213_R0.6651.00
191_K219_D0.6631.00
144_D284_V0.6601.00
178_L181_I0.6601.00
75_N78_S0.6591.00
207_I210_A0.6591.00
209_D213_R0.6581.00
280_Q285_W0.6581.00
198_R223_S0.6581.00
99_T108_L0.6561.00
205_S210_A0.6521.00
197_Y230_I0.6481.00
79_N82_R0.6461.00
222_L233_Y0.6451.00
64_K67_L0.6451.00
70_A74_L0.6441.00
95_L283_Y0.6431.00
175_D257_I0.6421.00
141_G275_K0.6361.00
41_E51_R0.6351.00
66_L84_A0.6351.00
183_P260_D0.6341.00
61_E65_A0.6341.00
286_R290_L0.6311.00
37_I41_E0.6291.00
22_V26_L0.6271.00
206_R210_A0.6211.00
92_S123_R0.6191.00
123_R223_S0.6181.00
174_H254_E0.6181.00
24_N27_F0.6161.00
170_L189_I0.6161.00
175_D237_G0.6151.00
208_D212_A0.6131.00
105_R232_T0.6111.00
194_L240_I0.6111.00
167_H264_L0.6101.00
138_L273_G0.6081.00
7_K10_R0.6061.00
208_D211_F0.6061.00
69_I73_I0.5971.00
12_A18_N0.5971.00
164_F270_V0.5951.00
65_A84_A0.5941.00
95_L145_I0.5941.00
198_R225_Q0.5941.00
4_Q39_E0.5901.00
128_Q226_D0.5891.00
128_Q225_Q0.5891.00
159_V277_G0.5871.00
145_I288_L0.5871.00
175_D178_L0.5851.00
177_P180_Q0.5851.00
177_P181_I0.5851.00
282_N285_W0.5841.00
19_L55_R0.5831.00
82_R86_L0.5781.00
233_Y239_G0.5771.00
287_F291_C0.5771.00
170_L242_L0.5761.00
108_L111_V0.5761.00
230_I234_V0.5751.00
59_M67_L0.5741.00
44_L84_A0.5681.00
133_E137_L0.5681.00
31_S35_R0.5681.00
49_F59_M0.5671.00
170_L194_L0.5661.00
211_F218_A0.5661.00
112_I124_L0.5641.00
166_W268_N0.5631.00
138_L158_L0.5621.00
110_E114_A0.5601.00
32_G35_R0.5561.00
46_I50_V0.5541.00
134_I141_G0.5521.00
44_L66_L0.5511.00
224_A229_V0.5501.00
149_S268_N0.5481.00
168_H242_L0.5471.00
29_S35_R0.5451.00
274_L285_W0.5411.00
7_K74_L0.5411.00
110_E113_K0.5391.00
178_L184_L0.5391.00
261_T264_L0.5361.00
68_V83_L0.5341.00
199_Q223_S0.5341.00
4_Q8_I0.5331.00
44_L47_E0.5301.00
176_H240_I0.5301.00
227_S244_A0.5271.00
206_R209_D0.5261.00
19_L51_R0.5231.00
243_V248_S0.5231.00
183_P188_S0.5211.00
74_L77_A0.5211.00
74_L78_S0.5201.00
37_I49_F0.5201.00
119_F122_V0.5171.00
93_G121_E0.5161.00
176_H181_I0.5151.00
150_E160_A0.5141.00
8_I37_I0.5121.00
147_I272_L0.5111.00
190_A217_L0.5111.00
98_A127_I0.5081.00
103_Q107_S0.5081.00
117_E179_T0.5061.00
203_G207_I0.5051.00
15_Q18_N0.5041.00
69_I84_A0.5031.00
251_Q254_E0.5021.00
284_V288_L0.5011.00
93_G119_F0.5001.00
82_R85_D0.5001.00
172_V179_T0.5001.00
47_E62_P0.5001.00
105_R226_D0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1al3A 1 0.7247 100 0.099 Contact Map
1ixcA 4 0.9241 100 0.104 Contact Map
4x6gA 4 0.9557 100 0.106 Contact Map
2esnA 3 0.9241 100 0.107 Contact Map
1uthA 2 0.7152 100 0.109 Contact Map
3fxqA 3 0.9241 100 0.111 Contact Map
3fzvA 4 0.9051 100 0.111 Contact Map
2h98A 2 0.6709 100 0.115 Contact Map
2h9bA 2 0.6646 100 0.121 Contact Map
3szpA 3 0.9146 100 0.136 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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