GREMLIN Database
NAC - Nitrogen assimilation regulatory protein nac
UniProt: Q47005 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14265
Length: 305 (283)
Sequences: 79552 (57778)
Seq/√Len: 3434.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
70_A74_Q3.5981.00
15_I24_V3.3331.00
159_Q288_M2.6431.00
67_H81_A2.4551.00
96_G142_L2.4441.00
11_K24_V2.4091.00
160_A265_S2.2321.00
160_A163_K2.2281.00
174_C187_M2.2091.00
113_A290_V2.2081.00
163_K265_S2.2051.00
92_Q124_Y2.2051.00
229_I236_A2.1721.00
45_Q60_A2.1271.00
92_Q122_V2.0751.00
8_Y35_Q2.0711.00
165_D240_E2.0551.00
10_V69_R2.0491.00
113_A286_L2.0221.00
163_K263_S2.0061.00
67_H74_Q1.9881.00
20_Q23_E1.9861.00
167_F240_E1.9811.00
10_V14_D1.9801.00
230_A251_N1.9791.00
11_K15_I1.9241.00
180_D183_A1.9231.00
94_S124_Y1.9231.00
11_K14_D1.8891.00
10_V65_Y1.8881.00
226_T246_L1.8801.00
170_G255_S1.8601.00
230_A246_L1.8601.00
14_D69_R1.8321.00
13_V57_P1.8231.00
71_I75_C1.8211.00
65_Y69_R1.8061.00
8_Y32_L1.8041.00
190_F234_G1.7971.00
167_F254_M1.7661.00
188_N216_I1.7441.00
49_I56_T1.6941.00
63_I81_A1.6791.00
158_S267_S1.6711.00
136_K141_Q1.6581.00
13_V65_Y1.6531.00
64_L78_A1.6241.00
15_I20_Q1.6031.00
157_S272_A1.5911.00
18_L36_V1.5461.00
67_H70_A1.5381.00
10_V68_A1.5331.00
159_Q270_L1.5091.00
135_E139_N1.5051.00
17_S20_Q1.5001.00
14_D24_V1.4891.00
5_R42_E1.4771.00
5_R38_T1.4681.00
5_R35_Q1.4511.00
9_F65_Y1.4401.00
88_A120_E1.4371.00
11_K25_L1.4361.00
46_Q49_I1.4331.00
114_V283_V1.4331.00
284_K288_M1.4331.00
8_Y27_I1.4311.00
147_I269_N1.4211.00
67_H77_Q1.4171.00
176_G183_A1.4151.00
157_S270_L1.4131.00
28_A31_A1.4031.00
270_L284_K1.3971.00
51_T56_T1.3881.00
19_T29_Q1.3861.00
104_S223_A1.3861.00
136_K142_L1.3671.00
117_E286_L1.3661.00
282_A285_E1.3651.00
114_V121_I1.3631.00
74_Q77_Q1.3621.00
149_E267_S1.3621.00
94_S126_H1.3591.00
59_D62_K1.3501.00
276_L280_A1.3461.00
90_S120_E1.3461.00
137_L145_A1.3331.00
199_R203_D1.3321.00
113_A117_E1.3241.00
172_Q251_N1.3211.00
164_E241_S1.3191.00
71_I78_A1.3151.00
10_V72_L1.3071.00
64_L79_Q1.2941.00
268_L284_K1.2861.00
138_I155_G1.2811.00
66_T70_A1.2801.00
225_L236_A1.2621.00
227_A230_A1.2601.00
187_M235_V1.2561.00
172_Q253_W1.2561.00
67_H78_A1.2491.00
170_G235_V1.2461.00
246_L251_N1.2461.00
144_M268_L1.2401.00
160_A267_S1.2291.00
115_R216_I1.2241.00
115_R188_N1.2161.00
42_E79_Q1.2141.00
112_Q116_A1.2131.00
240_E254_M1.2121.00
63_I66_T1.2071.00
3_F75_C1.2031.00
27_I31_A1.2021.00
144_M280_A1.1921.00
244_R248_G1.1891.00
34_Q38_T1.1791.00
177_Q253_W1.1761.00
112_Q231_S1.1731.00
175_P187_M1.1701.00
158_S269_N1.1621.00
170_G174_C1.1511.00
178_S258_T1.1511.00
9_F48_L1.1501.00
9_F13_V1.1411.00
240_E244_R1.1361.00
128_N136_K1.1321.00
63_I67_H1.1281.00
109_P231_S1.1181.00
62_K66_T1.1151.00
124_Y218_E1.1101.00
118_F282_A1.1061.00
179_V183_A1.1051.00
254_M257_I1.1011.00
34_Q37_A1.1011.00
286_L290_V1.0931.00
188_N214_K1.0921.00
6_L68_A1.0891.00
37_A41_G1.0891.00
159_Q284_K1.0881.00
113_A116_A1.0821.00
70_A77_Q1.0811.00
285_E288_M1.0731.00
11_K21_A1.0721.00
226_T230_A1.0701.00
169_V254_M1.0671.00
227_A231_S1.0561.00
138_I153_V1.0531.00
71_I74_Q1.0491.00
281_Q285_E1.0421.00
103_A127_E1.0411.00
18_L55_V1.0391.00
110_L287_L1.0331.00
245_S249_A1.0261.00
165_D263_S1.0251.00
33_S37_A1.0251.00
79_Q83_H1.0191.00
73_R77_Q1.0181.00
9_F47_L1.0141.00
35_Q38_T1.0091.00
114_V286_L1.0021.00
171_T232_G0.9991.00
219_I225_L0.9991.00
126_H136_K0.9971.00
286_L289_S0.9941.00
12_I21_A0.9921.00
206_F211_L0.9811.00
4_R7_K0.9761.00
200_L203_D0.9761.00
64_L68_A0.9751.00
181_V259_T0.9751.00
93_V283_V0.9691.00
191_L215_V0.9671.00
169_V243_A0.9651.00
190_F225_L0.9631.00
38_T41_G0.9591.00
12_I18_L0.9491.00
114_V118_F0.9431.00
76_E79_Q0.9411.00
13_V48_L0.9391.00
27_I32_L0.9381.00
76_E80_L0.9341.00
7_K76_E0.9331.00
168_L235_V0.9291.00
8_Y25_L0.9261.00
200_L204_E0.9251.00
136_K139_N0.9221.00
21_A32_L0.9221.00
57_P61_G0.9201.00
20_Q24_V0.9131.00
9_F57_P0.9121.00
219_I228_A0.9111.00
9_F39_L0.9051.00
70_A73_R0.9031.00
277_S280_A0.9021.00
110_L286_L0.8981.00
170_G175_P0.8981.00
117_E289_S0.8971.00
149_E265_S0.8791.00
16_G56_T0.8781.00
96_G145_A0.8731.00
99_P221_S0.8711.00
45_Q82_V0.8711.00
75_C79_Q0.8681.00
48_L55_V0.8631.00
66_T69_R0.8621.00
246_L249_A0.8551.00
157_S160_A0.8531.00
122_V214_K0.8531.00
19_T23_E0.8501.00
134_N138_I0.8491.00
188_N215_V0.8471.00
112_Q233_M0.8441.00
142_L145_A0.8391.00
205_A209_R0.8381.00
51_T54_G0.8351.00
96_G147_I0.8321.00
271_P274_A0.8321.00
126_H142_L0.8301.00
25_L32_L0.8281.00
121_I279_Q0.8271.00
183_A186_Q0.8241.00
60_A63_I0.8211.00
110_L290_V0.8191.00
182_N185_A0.8171.00
91_G279_Q0.8171.00
95_I144_M0.8171.00
115_R233_M0.8171.00
77_Q81_A0.8151.00
180_D258_T0.8091.00
276_L281_Q0.8081.00
156_V269_N0.8061.00
285_E289_S0.8041.00
13_V16_G0.8031.00
74_Q78_A0.8011.00
75_C78_A0.8001.00
63_I85_V0.7991.00
13_V61_G0.7981.00
60_A82_V0.7971.00
278_P282_A0.7971.00
16_G62_K0.7931.00
14_D65_Y0.7911.00
15_I21_A0.7901.00
9_F64_L0.7901.00
169_V236_A0.7881.00
165_D261_S0.7811.00
165_D256_R0.7811.00
29_Q33_S0.7811.00
174_C188_N0.7761.00
16_G54_G0.7751.00
7_K11_K0.7751.00
4_R35_Q0.7741.00
37_A46_Q0.7671.00
170_G253_W0.7621.00
189_L213_A0.7591.00
171_T233_M0.7591.00
69_R73_R0.7581.00
171_T174_C0.7561.00
3_F72_L0.7481.00
205_A208_L0.7471.00
12_I48_L0.7471.00
62_K65_Y0.7451.00
228_A233_M0.7431.00
5_R8_Y0.7431.00
78_A82_V0.7421.00
83_H86_G0.7411.00
204_E208_L0.7381.00
60_A85_V0.7361.00
155_G272_A0.7351.00
185_A211_L0.7341.00
144_M283_V0.7341.00
169_V247_C0.7321.00
221_S224_T0.7311.00
117_E282_A0.7271.00
140_H271_P0.7261.00
113_A289_S0.7261.00
18_L32_L0.7261.00
68_A71_I0.7251.00
49_I58_T0.7251.00
202_V206_F0.7231.00
169_V238_L0.7231.00
97_F103_A0.7201.00
178_S256_R0.7201.00
114_V282_A0.7161.00
91_G121_I0.7161.00
12_I32_L0.7141.00
138_I156_V0.7131.00
282_A286_L0.7061.00
243_A246_L0.7041.00
247_C250_V0.7031.00
59_D63_I0.7021.00
247_C254_M0.7011.00
7_K10_V0.7011.00
143_D280_A0.6991.00
201_R205_A0.6951.00
60_A64_L0.6911.00
89_L118_F0.6901.00
104_S227_A0.6891.00
239_P242_A0.6881.00
12_I36_V0.6821.00
94_S143_D0.6811.00
49_I54_G0.6791.00
56_T62_K0.6761.00
173_D232_G0.6751.00
193_S218_E0.6741.00
31_A35_Q0.6731.00
204_E207_S0.6721.00
94_S142_L0.6711.00
64_L82_V0.6681.00
67_H71_I0.6621.00
198_I202_V0.6571.00
57_P62_K0.6571.00
192_P225_L0.6571.00
73_R76_E0.6541.00
274_A277_S0.6481.00
182_N209_R0.6481.00
180_D259_T0.6461.00
77_Q80_L0.6461.00
168_L237_V0.6451.00
23_E26_H0.6441.00
109_P112_Q0.6411.00
217_G228_A0.6351.00
203_D207_S0.6351.00
278_P281_Q0.6351.00
243_A247_C0.6311.00
7_K72_L0.6291.00
127_E220_E0.6291.00
122_V218_E0.6281.00
201_R204_E0.6281.00
173_D253_W0.6281.00
40_E45_Q0.6261.00
186_Q214_K0.6231.00
202_V205_A0.6221.00
245_S248_G0.6211.00
189_L235_V0.6181.00
144_M284_K0.6171.00
97_F107_T0.6151.00
109_P113_A0.6141.00
107_T110_L0.6141.00
9_F61_G0.6121.00
40_E50_R0.6111.00
148_Y264_L0.6071.00
168_L184_I0.6071.00
4_R38_T0.6071.00
80_L84_N0.6041.00
36_V40_E0.6041.00
99_P129_S0.6001.00
172_Q250_V0.5971.00
193_S220_E0.5941.00
174_C235_V0.5931.00
199_R218_E0.5891.00
68_A72_L0.5881.00
12_I17_S0.5861.00
43_L64_L0.5851.00
93_V144_M0.5841.00
21_A25_L0.5831.00
203_D206_F0.5821.00
72_L76_E0.5821.00
118_F121_I0.5791.00
4_R8_Y0.5781.00
93_V279_Q0.5751.00
176_G179_V0.5741.00
48_L57_P0.5731.00
270_L281_Q0.5731.00
45_Q49_I0.5731.00
206_F213_A0.5711.00
43_L82_V0.5711.00
90_S122_V0.5701.00
31_A34_Q0.5681.00
164_E264_L0.5661.00
63_I82_V0.5661.00
96_G126_H0.5631.00
161_L268_L0.5631.00
283_V287_L0.5621.00
137_L156_V0.5621.00
219_I224_T0.5591.00
162_L266_L0.5581.00
13_V62_K0.5581.00
166_L237_V0.5541.00
200_L205_A0.5521.00
96_G128_N0.5501.00
230_A249_A0.5491.00
18_L29_Q0.5461.00
91_G120_E0.5461.00
127_E221_S0.5451.00
149_E158_S0.5421.00
102_A106_I0.5411.00
30_P34_Q0.5411.00
137_L269_N0.5391.00
225_L229_I0.5391.00
80_L83_H0.5391.00
43_L46_Q0.5381.00
238_L243_A0.5371.00
27_I35_Q0.5351.00
157_S273_R0.5331.00
194_D218_E0.5331.00
109_P227_A0.5321.00
198_I201_R0.5311.00
168_L189_L0.5311.00
28_A34_Q0.5301.00
108_M112_Q0.5291.00
228_A234_G0.5291.00
18_L54_G0.5281.00
57_P65_Y0.5281.00
199_R205_A0.5271.00
106_I110_L0.5261.00
97_F125_L0.5241.00
46_Q60_A0.5231.00
146_V287_L0.5231.00
84_N89_L0.5211.00
8_Y36_V0.5211.00
16_G55_V0.5211.00
66_T81_A0.5161.00
182_N211_L0.5151.00
222_I239_P0.5121.00
197_A200_L0.5121.00
78_A81_A0.5111.00
81_A84_N0.5111.00
45_Q86_G0.5111.00
122_V216_I0.5101.00
138_I141_Q0.5101.00
8_Y21_A0.5061.00
112_Q115_R0.5061.00
280_A284_K0.5021.00
71_I79_Q0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2esnA 3 0.9541 100 0.093 Contact Map
3fxqA 3 0.9541 100 0.094 Contact Map
1uthA 2 0.7377 100 0.095 Contact Map
4x6gA 4 0.9836 100 0.097 Contact Map
1ixcA 4 0.9475 100 0.099 Contact Map
3fzvA 4 0.9311 100 0.1 Contact Map
2h98A 2 0.6852 100 0.106 Contact Map
1al3A 1 0.7148 100 0.112 Contact Map
2h9bA 2 0.6885 100 0.113 Contact Map
3szpA 3 0.941 100 0.118 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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