GREMLIN Database
YPJF - Probable toxin YpjF
UniProt: Q46953 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14284
Length: 109 (105)
Sequences: 138 (62)
Seq/√Len: 6.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
7_T12_A4.1930.95
92_V104_L3.3690.86
58_T89_I3.1800.82
3_T16_L2.9590.77
42_P70_Y2.6110.67
42_P63_V2.5330.65
51_E78_R2.2040.54
5_P15_C2.0890.50
79_G85_Q2.0470.48
28_R46_E1.7750.39
3_T11_A1.7270.37
46_E71_E1.6730.35
44_S50_K1.6680.35
11_A17_S1.6590.35
63_V82_W1.6350.34
2_N5_P1.5960.33
75_I92_V1.5660.32
96_R101_T1.5170.30
58_T94_I1.5110.30
2_N13_K1.4870.29
19_V61_D1.4790.29
52_H65_F1.4660.29
5_P10_Q1.4550.28
75_I101_T1.4200.27
95_L101_T1.3970.27
73_V96_R1.3500.25
2_N24_M1.3440.25
13_K20_A1.3390.25
19_V65_F1.3020.24
101_T104_L1.2610.23
77_H85_Q1.2490.23
14_P19_V1.2150.22
43_F59_L1.1930.21
45_D60_A1.1810.21
95_L98_R1.1490.20
61_D81_S1.1390.20
22_W52_H1.1380.20
3_T10_Q1.1320.20
90_S105_K1.1260.20
4_L9_S1.1240.20
5_P12_A1.1210.20
9_S13_K1.1190.20
32_Q69_K1.1170.20
27_T44_S1.1110.20
2_N28_R1.0910.19
6_A32_Q1.0770.19
47_T75_I1.0710.19
78_R82_W1.0640.19
52_H67_V1.0580.18
32_Q105_K1.0530.18
8_I28_R1.0480.18
43_F62_A1.0320.18
4_L50_K1.0200.18
82_W91_V1.0020.17
39_N45_D1.0000.17
60_A91_V0.9960.17
84_Q88_Y0.9910.17
22_W43_F0.9880.17
57_I104_L0.9800.17
66_L83_Q0.9790.17
13_K24_M0.9780.17
41_T74_R0.9680.17
2_N16_L0.9650.16
11_A24_M0.9270.16
98_R103_L0.9260.16
36_L74_R0.9240.16
2_N6_A0.9220.16
4_L7_T0.9180.16
36_L41_T0.9180.16
26_L74_R0.9020.15
46_E61_D0.8990.15
26_L41_T0.8950.15
6_A9_S0.8920.15
70_Y82_W0.8870.15
48_V57_I0.8850.15
81_S90_S0.8830.15
11_A44_S0.8670.15
69_K105_K0.8600.15
26_L36_L0.8490.14
42_P53_I0.8470.14
97_A100_S0.8370.14
55_A65_F0.8350.14
10_Q13_K0.8330.14
82_W92_V0.8300.14
20_A69_K0.8240.14
63_V70_Y0.8180.14
88_Y100_S0.8160.14
18_P94_I0.8090.14
63_V66_L0.8030.14
15_C27_T0.7800.13
22_W62_A0.7720.13
65_F84_Q0.7620.13
69_K104_L0.7510.13
32_Q44_S0.7500.13
28_R39_N0.7410.13
100_S104_L0.7360.12
3_T8_I0.7250.12
7_T13_K0.7220.12
18_P22_W0.7180.12
17_S21_V0.7150.12
24_M32_Q0.7150.12
55_A59_L0.7020.12
15_C20_A0.6990.12
17_S37_T0.6980.12
28_R48_V0.6970.12
73_V86_S0.6950.12
91_V99_R0.6920.12
10_Q17_S0.6890.12
77_H91_V0.6740.12
95_L100_S0.6740.12
5_P31_E0.6690.11
6_A15_C0.6540.11
45_D89_I0.6530.11
63_V90_S0.6520.11
70_Y84_Q0.6510.11
33_H43_F0.6440.11
69_K78_R0.6440.11
28_R66_L0.6440.11
79_G89_I0.6400.11
1_M5_P0.6310.11
10_Q27_T0.6280.11
69_K86_S0.6150.11
77_H87_P0.6130.11
88_Y92_V0.6100.11
4_L31_E0.6090.11
10_Q16_L0.6070.11
6_A21_V0.6070.11
10_Q15_C0.6040.11
7_T15_C0.6020.11
3_T13_K0.6010.11
39_N54_D0.6000.10
40_D74_R0.6000.10
47_T91_V0.5960.10
7_T20_A0.5940.10
18_P21_V0.5900.10
43_F52_H0.5870.10
86_S101_T0.5870.10
42_P89_I0.5870.10
5_P20_A0.5770.10
83_Q88_Y0.5690.10
31_E63_V0.5690.10
59_L62_A0.5550.10
70_Y105_K0.5530.10
22_W59_L0.5500.10
89_I92_V0.5470.10
36_L40_D0.5370.10
31_E54_D0.5360.10
24_M28_R0.5360.10
91_V101_T0.5340.10
56_G74_R0.5240.10
21_V69_K0.5200.09
78_R83_Q0.5200.09
41_T56_G0.5150.09
8_I16_L0.5130.09
55_A62_A0.5090.09
26_L40_D0.5060.09
10_Q20_A0.5040.09
7_T10_Q0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4wbdA 2 0.9358 44.4 0.941 Contact Map
3d3lA 1 0.7248 17 0.952 Contact Map
1vejA 1 0.6055 12.5 0.955 Contact Map
1at3A 3 0.7431 10.9 0.956 Contact Map
2knzA 1 0.4771 10 0.957 Contact Map
2jy5A 1 0.4679 9.9 0.957 Contact Map
1jqkA 3 0.8716 9.4 0.957 Contact Map
1o6eA 4 0.7064 8.9 0.958 Contact Map
2pbkA 2 0.7064 8.9 0.958 Contact Map
4zacA 2 0.4954 8.3 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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